Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2019 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway

  • Authors:
    • Yue Cui
    • Yongqiang Wang
    • Gang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2015-2023
    |
    Published online on: March 5, 2019
       https://doi.org/10.3892/ijmm.2019.4123
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Barbaloin (Bar) has a myocardial protective effect, but its mechanism of action is uncertain. The endoplasmic reticulum stress (ERS)‑mediated apoptosis pathway serves an important role in the pathogenesis of myocardial ischemia‑reperfusion injury (MIRI). Inhibiting ERS may significantly improve the progression of MIRI and serve a role in its prevention. Therefore, based on current knowledge of ERS‑mediated cardiomyocyte apoptosis and the cardioprotective effect of Bar, the purpose of the present study was to further evaluate the myocardial protective effect and potential mechanisms of Bar pretreatment in MIRI. The present study established a MIR rat model and randomly divided these rats into four groups. Prior to myocardial ischemia, Bar (20 mg/kg) was administered to rats once daily for 1 week. Myocardial blood serum lactate dehydrogenase and creatine kinase were subsequently measured. A terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay was used to evaluate the myocardial protective effect of Bar pretreatment on MIRI. To assess whether the ERS signaling pathway was involved in the myocardial protection mechanism of Bar pretreatment, the expression levels of ERS‑associated proteins, protein canopy homolog 2 (CNPY2), glucose regulatory protein 78, transcriptional activator 4, C/EBP‑homologous protein (CHOP), PKR endoplasmic reticulum kinase (PERK), caspase‑12 and caspase‑3 were detected by western blot analysis, immunohistochemistry or reverse transcription‑quantitative polymerase chain reaction. The results confirmed that Bar pretreatment significantly reduced the damage and the level of apoptosis caused by MIR. Bar pretreatment significantly inhibited the expression of ERS‑associated proteins in cardiomyocytes. In addition, the immunohistochemistry results demonstrated that Bar pretreatment significantly inhibited the CNPY2‑positive cell apoptosis ratio of cardiomyocytes. Therefore, the results of the current study suggested that CNPY2 is present in cardiomyocytes and participates in the development of MIRI by initiating the PERK‑CHOP signaling pathway. Bar pretreatment may attenuate MIRI by inhibiting the CNPY2‑PERK apoptotic pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Puaschitz NG, Assmus J, Strand E, Karlsson T, Vinknes KJ, Lysne V, Drevon CA, Tell GS, Dierkes J and Nygård O: Adherence to the Healthy Nordic Food Index and the incidence of acute myocardial infarction and mortality among patients with stable angina pectoris. J Hum Nutr Diet. 32:86–97. 2019. View Article : Google Scholar

2 

Prondzinsky R, Lemm H, Geppert A, Buerke M, Russ M and Werdan K: Infarct-related cardiogenic shock: Prognosis and treatment. Med Klin Intensivmed Notfmed. 113:267–276. 2018.In German. View Article : Google Scholar : PubMed/NCBI

3 

Zhou H, Ma Q, Zhu P, Ren J, Reiter RJ and Chen Y: Protective role of melatonin in cardiac ischemia-reperfusion injury: From pathogenesis to targeted therapy. J Pineal Res. Epub. Feb 8–2018.Epub ahead of print. View Article : Google Scholar

4 

Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY and Li CJ: Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem. 46:1650–1667. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Muntean DM, Sturza A, Dănilă MD, Borza C, Duicu OM and Mornoș C: The role of mitochondrial reactive oxygen species in cardiovascular injury and protective strategies. Oxid Med Cell Longev. 2016:82549422016. View Article : Google Scholar : PubMed/NCBI

6 

Ye G, Fu Q, Jiang L and Li Z: Vascular smooth muscle cells activate PI3K/Akt pathway to attenuate myocardial ischemia/reperfusion-induced apoptosis and autophagy by secreting bFGF. Biomed Pharmacother. 107:1779–1785. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Zhang W, Zhang Y, Ding K, Zhang H, Zhao Q, Liu Z and Xu Y: Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes. Biomed Pharmacother. 106:1063–1071. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Xia P, Liu Y and Cheng Z: Signaling pathways in cardiac myocyte apoptosis. Biomed Res Int. 2016:95832682016. View Article : Google Scholar

9 

Haunstetter A and Izumo S: Apoptosis: Basic mechanisms and implications for cardiovascular disease. Circul Res. 82:1111–1129. 1998. View Article : Google Scholar

10 

Baines CP and Molkentin JD: STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol. 38:47–62. 2005. View Article : Google Scholar

11 

Bernecker OY, Huq F, Heist EK, Podesser BK and Hajjar RJ: Apoptosis in heart failure and the senescent heart. Cardiovasc Toxicol. 3:183–190. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Mattson MP and Kroemer G: Mitochondria in cell death: Novel targets for neuroprotection and cardioprotection. Trends Mol Med. 9:196–205. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Rao RV, Ellerby HM and Bredesen DE: Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ. 11:372–380. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Minamino T and Kitakaze M: ER stress in cardiovascular disease. J Mol Cell Cardiol. 48:1105–1110. 2010. View Article : Google Scholar

15 

Zhang C, Tang Y, Li Y, Xie L, Zhuang W, Liu J and Gong J: Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats. PLoS One. 12:e01790422017. View Article : Google Scholar : PubMed/NCBI

16 

Kalogeris T, Baines CP, Krenz M and Korthuis RJ: Ischemia/reperfusion. Compr Physiol. 7:113–170. 2016. View Article : Google Scholar

17 

Xu C, Bailly-Maitre B and Reed JC: Endoplasmic reticulum stress: Cell life and death decisions. J Clin Invest. 115:2656–2664. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Singab AN, El-Hefnawy HM, Esmat A, Gad HA and Nazeam JA: A systemic review on Aloe arborescens pharmacological profile: Biological activities and pilot clinical trials. Phytother Res. 29:1858–1867. 2015. View Article : Google Scholar

19 

Anuszewska EL: Mechanisms of therapeutic action of aloe. Wiad Lek. 68:168–172. 2015.In Polish.

20 

Akaberi M, Sobhani Z, Javadi B, Sahebkar A and Emami SA: Therapeutic effects of Aloe spp. in traditional and modern medicine: A review. Biomed Pharmacother. 84:759–772. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Patel DK, Patel K and Tahilyani V: Barbaloin: A concise report of its pharmacological and analytical aspects. Asian Pac J Trop Biomed. 2:835–838. 2012. View Article : Google Scholar

22 

Cao ZZ, Tian YJ, Hao J, Zhang PH, Liu ZP, Jiang WZ, Zeng ML, Zhang PP and Ma JH: Barbaloin inhibits ventricular arrhythmias in rabbits by modulating voltage-gated ion channels. Acta Pharmacol Sin. 39:357–370. 2018. View Article : Google Scholar :

23 

Zhang P, Liu X, Huang G, Bai C, Zhang Z and Li H: Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK. Biochem Biophys Res Commun. 490:1215–1220. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Chimenti S, Carlo E, Masson S, Bai A and Latini R: Myocardial infarction: Animal models. Methods Mol Med. 98:217–226. 2004.PubMed/NCBI

25 

Li F, Zheng X, Fan X, Zhai K, Tan Y, Kou J and Yu B: YiQiFuMai powder injection attenuates ischemia/reperfusion-induced myocardial apoptosis through AMPK activation. Rejuvenation Res. 19:495–508. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Qi X, Vallentin A, Churchill E and Mochly-Rosen D: DeltaPKC participates in the endoplasmic reticulum stress-induced response in cultured cardiac myocytes and ischemic heart. J Mol Cell Cardiol. 43:420–428. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

28 

Guo J, Mihic A, Wu J, Zhang Y, Singh K, Dhingra S, Weisel RD and Li RK: Canopy 2 attenuates the transition from compensatory hypertrophy to dilated heart failure in hypertrophic cardiomyopathy. Eur Heart J. 36:2530–2540. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Hatta K, Guo J, Ludke A, Dhingra S, Singh K, Huang ML, Weisel RD and Li RK: Expression of CNPY2 in mouse tissues: Quantification and localization. PLoS One. 9:e1113702014. View Article : Google Scholar : PubMed/NCBI

30 

Ding S, Fan Z, Lin C, Dai Q, Zhou J, Huang H, Xu Y and Zhong C: Therapeutic effects of ischemic-preconditioned exosomes in cardiovascular diseases. Adv Exp Med Biol. 998:271–281. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Yasuda S and Shimokawa H: Acute myocardial infarction: The enduring challenge for cardiac protection and survival. Circ J. 73:2000–2008. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Kalra S, Bhatt H and Kirtane AJ: Stenting in primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Methodist Debakey Cardiovasc J. 14:14–22. 2018.PubMed/NCBI

33 

Piper HM, Kasseckert SA, Schlüter KD and Abdallah Y: Pathophysiology of myocardial reperfusion injury. Dtsch Med Wochenschr. 133:586–590. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Crow MT, Mani K, Nam YJ and Kitsis RN: The mitochondrial death pathway and cardiac myocyte apoptosis. Circ Res. 95:957–970. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Xu T, Ding W, Tariq MA, Wang Y, Wan Q, Li M and Wang J: Molecular mechanism and therapy application of necrosis during myocardial injury. J Cell Mol Med. 22:2547–2557. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Khosravi-Far R and Esposti MD: Death receptor signals to mitochondria. Cancer Biol Ther. 3:1051–1057. 2004. View Article : Google Scholar

37 

Tabas I and Ron D: Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol. 13:184–190. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Gorman AM, Healy SJ, Jäger R and Samali A: Stress management at the ER: Regulators of ER stress-induced apoptosis. Pharmacol Ther. 134:306–316. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Iurlaro R and Muñoz-Pinedo C: Cell death induced by endoplasmic reticulum stress. FEBS J. 283:2640–2652. 2016. View Article : Google Scholar

40 

Ferri KF and Kroemer G: Organelle- specific initiation of cell death pathways. Nat Cell Biol. 3:E255–E263. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Yuksel Y, Guven M, Kaymaz B, Sehitoglu MH, Aras AB, Akman T, Tosun M and Cosar M: Effects of aloe vera on spinal cord ischemia-reperfusion injury of rats. J Invest Surg. 29:389–398. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Guven M, Gölge UH, Aslan E, Sehitoglu MH, Aras AB, Akman T and Cosar M: The effect of aloe vera on ischemia-reperfusion injury of sciatic nerve in rats. Biomed Pharmacother. 79:201–207. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Lu ZQ, Deng YJ and Lu JX: Effect of aloe polysaccharide on caspase-3 expression following cerebral ischemia and reper-fusion injury in rats. Mol Med Rep. 6:371–374. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Sahin H, Yener AU, Karaboga I, Sehitoglu MH, Dogu T, Altinisik HB, Altinisik U and Simsek T: Protective effect of gel form of gastric gavage applicated aloe vera on ischemia reperfusion injury in renal and lung tissue. Cell Mol Biol (Noisy-le-grand). 63:34–39. 2017. View Article : Google Scholar

45 

Ron D and Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 8:519–529. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Hong F, Liu B, Wu BX, Morreall J, Roth B, Davies C, Sun S, Diehl JA and Li Z: CNPY2 is a key initiator of the PERK-CHOP pathway of the unfolded protein response. Nat Struct Mol Biol. 24:834–839. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Urra H and Hetz C: Fine-tuning PERK signaling to control cell fate under stress. Nat Struct Mol Biol. 24:789–790. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cui Y, Wang Y and Liu G: Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway. Int J Mol Med 43: 2015-2023, 2019.
APA
Cui, Y., Wang, Y., & Liu, G. (2019). Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway. International Journal of Molecular Medicine, 43, 2015-2023. https://doi.org/10.3892/ijmm.2019.4123
MLA
Cui, Y., Wang, Y., Liu, G."Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway". International Journal of Molecular Medicine 43.5 (2019): 2015-2023.
Chicago
Cui, Y., Wang, Y., Liu, G."Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway". International Journal of Molecular Medicine 43, no. 5 (2019): 2015-2023. https://doi.org/10.3892/ijmm.2019.4123
Copy and paste a formatted citation
x
Spandidos Publications style
Cui Y, Wang Y and Liu G: Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway. Int J Mol Med 43: 2015-2023, 2019.
APA
Cui, Y., Wang, Y., & Liu, G. (2019). Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway. International Journal of Molecular Medicine, 43, 2015-2023. https://doi.org/10.3892/ijmm.2019.4123
MLA
Cui, Y., Wang, Y., Liu, G."Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway". International Journal of Molecular Medicine 43.5 (2019): 2015-2023.
Chicago
Cui, Y., Wang, Y., Liu, G."Protective effect of Barbaloin in a rat model of myocardial ischemia reperfusion injury through the regulation of the CNPY2‑PERK pathway". International Journal of Molecular Medicine 43, no. 5 (2019): 2015-2023. https://doi.org/10.3892/ijmm.2019.4123
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team