Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2019 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2019 Volume 43 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes

  • Authors:
    • Kun Chen
    • Zheng‑Tao Lv
    • Chen‑He Zhou
    • Shuang Liang
    • Wen Huang
    • Zheng‑Gang Wang
    • Wen‑Tao Zhu
    • Yu‑Ting Wang
    • Xing‑Zhi Jing
    • Hui Lin
    • Feng‑Jing Guo
    • Peng Cheng
    • An‑Min Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China, Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R. China, Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, P.R. China, Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
  • Pages: 2241-2251
    |
    Published online on: March 21, 2019
       https://doi.org/10.3892/ijmm.2019.4141
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoarthritis (OA) is the most common type of degenerative joint disease and secreted inflammatory molecules serve a pivotal role in it. Peimine has been reported to have anti‑inflammatory activity. In order to investigate the potential therapeutic role of Peimine in OA, mouse articular chondrocytes were treated with IL‑1β and different doses of Peimine in vitro. The data revealed that Peimine not only suppressed IL‑1β‑induced production of nitric oxide (NO) and prostaglandin E2, but also reduced the protein levels of inducible NO synthase (iNOS) and cyclooxygenase‑2 (COX‑2). In addition, Peimine inhibited the IL‑1β‑induced mRNA expression of matrix metalloproteinase (MMP)‑1, MMP‑3, MMP‑9, MMP‑13, a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‑4 and ADAMTS‑5. Furthermore, Peimine inhibited IL‑1β‑induced activation of the mitogen‑activated protein kinase (MAPK) pathway. The protective effect of Peimine on IL‑1β‑treated chondrocytes was attenuated following activation of the MAPK pathway, as demonstrated by the increased expression levels of MMP‑3, MMP‑13, ADAMTS‑5, iNOS and COX‑2 compared with the Peimine group. The in vivo data suggested that Peimine limited the development of OA in the mouse model. In general, the data indicate that Peimine suppresses IL‑1β‑induced inflammation in mouse chondrocytes by inhibiting the MAPK pathway, suggesting a promising therapeutic role for Peimine in the treatment of OA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Chen D, Shen J, Zhao W, Wang T, Han L, Hamilton JL and Im HJ: Osteoarthritis: Toward a comprehensive understanding of pathological mechanism. Bone Res. 5:160442017. View Article : Google Scholar : PubMed/NCBI

2 

Buckwalter JA, Saltzman C and Brown T: The impact of osteoarthritis: Implications for research. Clin Orthop Relat Res. (Suppl 427): S6–S15. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Bitton R: The economic burden of osteoarthritis. Am J Manag Care. 15(Suppl 8): S230–S235. 2009.PubMed/NCBI

4 

Goldring MB and Otero M: Inflammation in osteoarthritis. Curr Opin Rheumatol. 23:471–478. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Liu-Bryan R and Terkeltaub R: Emerging regulators of the inflammatory process in osteoarthritis. Nat Rev Rheumatol. 11:35–44. 2015. View Article : Google Scholar :

6 

Daheshia M and Yao JQ: The interleukin 1β pathway in the pathogenesis of osteoarthritis. J Rheumatol. 35:2306–2312. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Park C, Jeong JW, Lee DS, Yim MJ, Lee JM, Han MH, Kim S, Kim HS, Kim GY, Park EK, et al: Sargassum serratifolium extract attenuates interleukin-1β-induced oxidative stress and inflammatory response in chondrocytes by suppressing the activation of NF-κB, p38 MAPK, and PI3K/Akt. Int J Mol Sci. 19:E23082018. View Article : Google Scholar

8 

Ding QH, Cheng Y, Chen WP, Zhong HM and Wang XH: Celastrol, an inhibitor of heat shock protein 90beta potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes. Eur J Pharmacol. 708:1–7. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Roman-Blas JA and Jimenez SA: NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthritis Cartilage. 14:839–848. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Chen WP, Hu ZN, Jin LB and Wu LD: Licochalcone A inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-catenin signaling pathways in rat chondrocytes. Cell Physiol Biochem. 43:937–944. 2017. View Article : Google Scholar

11 

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J and Herrero-Beaumont G: Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartilage. 11:290–298. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Frisbie DD, Ghivizzani SC, Robbins PD, Evans CH and McIlwraith CW: Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther. 9:12–20. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Clements KM, Price JS, Chambers MG, Visco DM, Poole AR and Mason RM: Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum. 48:3452–3463. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Chevalier X, Giraudeau B, Conrozier T, Marliere J, Kiefer P and Goupille P: Safety study of intraarticular injection of interleukin 1 receptor antagonist in patients with painful knee osteoarthritis: A multicenter study. J Rheumatol. 32:1317–1323. 2005.PubMed/NCBI

15 

Yi PF, Wu YC, Dong HB, Guo Y, Wei Q, Zhang C, Song Z, Qin QQ, Lv S, Wu SC and Fu BD: Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 35:567–572. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Xu J, Zhao W, Pan L, Zhang A, Chen Q, Xu K, Lu H and Chen Y: Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia. 111:1–6. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Cho IH, Lee MJ, Kim JH, Han NY, Shin KW, Sohn Y and Jung HS: Fritillaria ussuriensis extract inhibits the production of inflammatory cytokine and MAPKs in mast cells. Biosci Biotechnol Biochem. 75:1440–1445. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Park JH, Lee B, Kim HK, Kim EY, Kim JH, Min JH, Kim S, Sohn Y and Jung HS: Peimine inhibits the production of proinflammatory cytokines through regulation of the phosphorylation of NF-kappaB and MAPKs in HMC-1 cells. Pharmacogn Mag. 13(Suppl 2): S359–S364. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Wu K, Mo C, Xiao H, Jiang Y, Ye B and Wang S: Imperialine and verticinone from bulbs of Fritillaria wabuensis inhibit pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Planta Med. 81:821–829. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Gosset M, Berenbaum F, Thirion S and Jacques C: Primary culture and phenotyping of murine chondrocytes. Nat Protoc. 3:1253–1260. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Chen K, Lv ZT, Cheng P, Zhu WT, Liang S, Yang Q, Parkman VA, Zhou CH, Jing XZ, Liu H, et al: Boldine ameliorates estrogen deficiency-induced bone loss via inhibiting bone resorption. Front Pharmacol. 9:10462018. View Article : Google Scholar : PubMed/NCBI

22 

Schindelin J, Rueden CT, Hiner MC and Eliceiri KW: The ImageJ ecosystem: An open platform for biomedical image analysis. Mol Reprod Dev. 82:518–529. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

24 

Shohet RV, Kisanuki YY, Zhao XS, Siddiquee Z, Franco F and Yanagisawa M: Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy. Proc Natl Acad Sci USA. 101:2088–2093. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Mu X, Urso ML, Murray K, Fu F and Li Y: Relaxin regulates MMP expression and promotes satellite cell mobilization during muscle healing in both young and aged mice. Am J Pathol. 177:2399–2410. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Li S, Zhang Y, Sun Y, Cao W and Cui L: Exposure to fermentation supernatant of Staphylococcus aureus accelerated dedifferentiation of chondrocytes and production of antimicrobial peptides. J Orthop Res. 36:443–451. 2018.

27 

Kim JH, Lee G, Won Y, Lee M, Kwak JS, Chun CH and Chun JS: Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis. Proc Natl Acad Sci USA. 112:9424–9429. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D and van den Berg WB: Osteoarthritis cartilage histopathology: Grading and staging. Osteoarthritis Cartilage. 14:13–29. 2006. View Article : Google Scholar

29 

Chowdhury TT, Bader DL and Lee DA: Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun. 285:1168–1174. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Yang G, Im HJ and Wang JH: Repetitive mechanical stretching modulates IL-1beta induced COX-2, MMP-1 expression, and PGE2 production in human patellar tendon fibroblasts. Gene. 363:166–172. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Kaminska B: MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta. 1754:253–262. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Loeser RF, Erickson EA and Long DL: Mitogen-activated protein kinases as therapeutic targets in osteoarthritis. Curr Opin Rheumatol. 20:581–586. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Brittberg M, Gomoll AH, Canseco JA, Far J, Lind M and Hui J: Cartilage repair in the degenerative ageing knee. Acta Orthop. 87:26–38. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Helmick CG, Felson DT, Lawrence RC, Gabriel S, Hirsch R, Kwoh CK, Liang MH, Kremers HM, Mayes MD, Merkel PA, et al: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I Arthritis Rheum. 58:15–25. 2008. View Article : Google Scholar

35 

Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, et al: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II Arthritis Rheum. 58:26–35. 2008. View Article : Google Scholar

36 

Huang X, Pan Q, Mao Z, Zhang R, Ma X, Xi Y and You H: Sinapic acid inhibits the IL-1β-induced inflammation via MAPK down-regulation in rat chondrocytes. Inflammation. 41:562–568. 2018. View Article : Google Scholar

37 

Pan T, Shi X, Chen H, Chen R, Wu D, Lin Z, Zhang J and Pan J: Geniposide suppresses interleukin-1β-induced inflammation and apoptosis in rat chondrocytes via the PI3K/Akt/NF-κB signaling pathway. Inflammation. 41:390–399. 2018. View Article : Google Scholar

38 

Pelletier JP, McCollum R, Cloutier JM and Martel-Pelletier J: Synthesis of metalloproteases and interleukin 6 (IL-6) in human osteoarthritic synovial membrane is an IL-1 mediated process. J Rheumatol Suppl. 43:109–114. 1995.PubMed/NCBI

39 

Amin AR, Dave M, Attur M and Abramson SB: COX-2, NO, and cartilage damage and repair. Curr Rheumatol Rep. 2:447–453. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Abramson SB, Attur M, Amin AR and Clancy R: Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis. Curr Rheumatol Rep. 3:535–541. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Fan Z, Bau B, Yang H, Soeder S and Aigner T: Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum. 52:136–143. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Elliott S, Hays E, Mayor M, Sporn M and Vincenti M: The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chon-drocytes. Arthritis Res Ther. 5:R285–R291. 2003. View Article : Google Scholar

43 

Arasapam G, Scherer M, Cool JC, Foster BK and Xian CJ: Roles of COX-2 and iNOS in the bony repair of the injured growth plate cartilage. J Cell Biochem. 99:450–461. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Nah SS, Choi IY, Lee CK, Oh JS, Kim YG, Moon HB and Yoo B: Effects of advanced glycation end products on the expression of COX-2, PGE2 and NO in human osteoarthritic chondrocytes. Rheumatology (Oxford). 47:425–431. 2008. View Article : Google Scholar

45 

Loeser RF: Molecular mechanisms of cartilage destruction: Mechanics, inflammatory mediators, and aging collide. Arthritis Rheum. 54:1357–1360. 2006. View Article : Google Scholar : PubMed/NCBI

46 

Ishiguro N, Kojima T and Poole AR: Mechanism of cartilage destruction in osteoarthritis. Nagoya J Med Sci. 65:73–84. 2002.

47 

van den Berg WB: Osteoarthritis year 2010 in review: Pathomechanisms. Osteoarthritis Cartilage. 19:338–341. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Huang K and Wu LD: Aggrecanase and aggrecan degradation in osteoarthritis: A review. J Int Med Res. 36:1149–1160. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Johnson GL and Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 298:1911–1912. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen K, Lv ZT, Zhou CH, Liang S, Huang W, Wang ZG, Zhu WT, Wang YT, Jing XZ, Lin H, Lin H, et al: Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. Int J Mol Med 43: 2241-2251, 2019.
APA
Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z. ... Chen, A. (2019). Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. International Journal of Molecular Medicine, 43, 2241-2251. https://doi.org/10.3892/ijmm.2019.4141
MLA
Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z., Zhu, W., Wang, Y., Jing, X., Lin, H., Guo, F., Cheng, P., Chen, A."Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes". International Journal of Molecular Medicine 43.5 (2019): 2241-2251.
Chicago
Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z., Zhu, W., Wang, Y., Jing, X., Lin, H., Guo, F., Cheng, P., Chen, A."Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes". International Journal of Molecular Medicine 43, no. 5 (2019): 2241-2251. https://doi.org/10.3892/ijmm.2019.4141
Copy and paste a formatted citation
x
Spandidos Publications style
Chen K, Lv ZT, Zhou CH, Liang S, Huang W, Wang ZG, Zhu WT, Wang YT, Jing XZ, Lin H, Lin H, et al: Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. Int J Mol Med 43: 2241-2251, 2019.
APA
Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z. ... Chen, A. (2019). Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. International Journal of Molecular Medicine, 43, 2241-2251. https://doi.org/10.3892/ijmm.2019.4141
MLA
Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z., Zhu, W., Wang, Y., Jing, X., Lin, H., Guo, F., Cheng, P., Chen, A."Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes". International Journal of Molecular Medicine 43.5 (2019): 2241-2251.
Chicago
Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z., Zhu, W., Wang, Y., Jing, X., Lin, H., Guo, F., Cheng, P., Chen, A."Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes". International Journal of Molecular Medicine 43, no. 5 (2019): 2241-2251. https://doi.org/10.3892/ijmm.2019.4141
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team