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Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4

  • Authors:
    • Zhongrong Guo
    • Wen Chen
    • Guisen Dai
    • Yuanliang Huang
  • View Affiliations / Copyright

    Affiliations: First Department of General Surgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, P.R. China, Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Hepatobiliary Surgery, Longyan First Hospital, Longyan, Fujian 364000, P.R. China, Interventional Diagnosis and Treatment Section, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361001, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 141-150
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    Published online on: October 31, 2019
       https://doi.org/10.3892/ijmm.2019.4391
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Abstract

Liver cancer is a worldwide threat to human health. High expression levels of C‑X‑C chemokine receptor type 4 (CXCR4) have been reported to promote the migration and invasion capacities of liver cancer cells. Cordycepin, extracted from Cordyceps militaris, has anti‑inflammatory, antioxidant and anticancerous properties. Therefore, in the present study, migration assays, western blotting, reverse transcription‑quantitative PCR and immunofluorescence analyses were conducted to determine whether cordycepin was able to suppress the migration and invasion abilities of liver cancer cells by inhibiting CXCR4 expression. The results suggested that cordycepin notably inhibited migration and invasion, and decreased the expression of CXCR4 in a dose‑dependent manner. Activation of phosphorylated (p‑) NF‑κB inhibitor α (IκBα) and p‑P65, the principal components of the NF‑κB signaling pathway, was also downregulated. In addition, cordycepin markedly suppressed the nuclear translocation of P65, but had no effect on the expression of total IκBα (t‑IκBα) and total P65 (t‑P65). JSH‑23, an inhibitor of the NF‑κB pathway, impaired the migration of liver cancer cells, and was found to act synergistically with cordycepin. Furthermore, cordycepin treatment reduced the chemotactic migration ability of liver cancer cells to stromal cell‑derived factor 1 (SDF1), which was significantly enhanced following treatment with JSH‑23. Collectively, the present results indicated that cordycepin inhibited the nuclear translocation of P65 by preventing p‑IκBα activation; this resulted in the downregulation of CXCR4 expression, and subsequently, in the impaired migration and invasion abilities of liver cancer cells and attenuated reactivity to SDF1. The current study revealed a novel mechanism for the antimetastatic activity of cordycepin and its potential to exert positive synergistic effects with other compounds for the treatment of liver cancer.
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1 

Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, Bonaventure A, Valkov M, Johnson CJ, Estève J, et al CONCORD Working Group: Global surveillance of trends in cancer survival 2000-14 (CONCORD 3): analysis of individual records for 37,513,025 patients diagnosed with one of 18 cancers from 322 population based registries in 71 countries. Lancet. 391:1023–1075. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Chen W, Zheng R, Zhang S, Zeng H, Zuo T, Xia C, Yang Z and He J: Cancer incidence and mortality in China in 2013: an analysis based on urbanization level. Chin J Cancer Res. 29:1–10. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Zheng R, Qu C, Zhang S, Zeng H, Sun K, Gu X, Xia C, Yang Z, Li H, Wei W, et al: Liver cancer incidence and mortality in China: Temporal trends and projections to 2030. Chin J Cancer Res. 30:571–579. 2018. View Article : Google Scholar

6 

Liu CY, Chen KF and Chen PJ: Treatment of Liver Cancer. Cold Spring Harb Perspect Med. 5:a0215352015. View Article : Google Scholar : PubMed/NCBI

7 

Shiani A, Narayanan S, Pena L and Friedman M: The Role of Diagnosis and Treatment of Underlying Liver Disease for the Prognosis of Primary Liver Cancer. Cancer control. 24:10732748177292402017. View Article : Google Scholar : PubMed/NCBI

8 

Li S, Yang F and Ren X: Immunotherapy for hepatocellular carcinoma. Drug Discov Ther. 9:363–371. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Yu S, Wang Y, Jing L, Claret FX, Li Q, Tian T, Liang X, Ruan Z, Jiang L, Yao Y, et al: Autophagy in the 'inflammation-carcinogenesis' pathway of liver and HCC immunotherapy. Cancer Lett. 411:82–89. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Klungboonkrong V, Das D and McLennan G: Molecular Mechanisms and Targets of Therapy for Hepatocellular Carcinoma. J Vasc Interv Radiol. 28:949–955. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Kudo M and Arizumi T: Transarterial Chemoembolization in Combination with a Molecular Targeted Agent: Lessons Learned from Negative Trials (Post-TACE, BRISK-TA, SPACE, ORIENTAL, and TACE-2). Oncology. 93(Suppl 1): 127–134. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Tohme S, Simmons RL and Tsung A: Surgery for Cancer: A Trigger for Metastases. Cancer Res. 77:1548–1552. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Zeeshan R and Mutahir Z: Cancer metastasis - tricks of the trade. Bosn J Basic Med Sci. 17:172–182. 2017.PubMed/NCBI

14 

Chaffer CL and Weinberg RA: A perspective on cancer cell metastasis. Science. 331:1559–1564. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Ai J, Tang Q, Wu Y, Xu Y, Feng T, Zhou R, Chen Y, Gao X, Zhu Q, Yue X, et al: The role of polymeric immunoglobulin receptor in inflammation-induced tumor metastasis of human hepatocellular carcinoma. J Natl Cancer Inst. 103:1696–1712. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US, Chen Y, Qin LX, Tang ZY, et al: Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment. Cancer Cell. 10:99–111. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M, Agdashian D, Terabe M, Berzofsky JA, Fako V, et al: Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science. 360:eaan59312018. View Article : Google Scholar : PubMed/NCBI

18 

Song T, Dou C, Jia Y, Tu K and Zheng X: TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma. Oncotarget. 6:12061–12079. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Wang J, Huang Y, Zhang J, Xing B, Xuan W, Wang H, Huang H, Yang J and Tang J: High co-expression of the SDF1/CXCR4 axis in hepatocarcinoma cells is regulated by AnnexinA7 in vitro and in vivo. Cell Commun Signal. 16:222018. View Article : Google Scholar : PubMed/NCBI

20 

Gao PT, Ding GY, Yang X, Dong RZ, Hu B, Zhu XD, Cai JB, Ji Y, Shi GM, Shen YH, et al: Invasive potential of hepatocellular carcinoma is enhanced by loss of selenium-binding protein 1 and subsequent upregulation of CXCR4. Am J Cancer Res. 8:1040–1049. 2018.PubMed/NCBI

21 

Li M, Lu Y, Xu Y, Wang J, Zhang C, Du Y, Wang L, Li L, Wang B, Shen J, et al: Horizontal transfer of exosomal CXCR4 promotes murine hepatocarcinoma cell migration, invasion and lymphangiogenesis. Gene. 676:101–109. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Chen Y, Liu YC, Sung YC, Ramjiawan RR, Lin TT, Chang CC, Jeng KS, Chang CF, Liu CH, Gao DY, et al: Overcoming sorafenib evasion in hepatocellular carcinoma using CXCR4-targeted nanoparticles to co-deliver MEK-inhibitors. Sci Rep. 7:441232017. View Article : Google Scholar : PubMed/NCBI

23 

Li X, Li P, Chang Y, Xu Q, Wu Z, Ma Q and Wang Z: The SDF-1/CXCR4 axis induces epithelial-mesenchymal transition in hepatocellular carcinoma. Mol Cell Biochem. 392:77–84. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Wang X, Zhang W, Ding Y, Guo X, Yuan Y and Li D: CRISPR/Cas9-mediated genome engineering of CXCR4 decreases the malignancy of hepatocellular carcinoma cells in vitro and in vivo. Oncol Rep. 37:3565–3571. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Xia R, Sheng X, Xu X, Yu C and Lu H: Hesperidin induces apoptosis and G0/G1 arrest in human non-small cell lung cancer A549 cells. Int J Mol Med. 41:464–472. 2018.

26 

Xia R, Xu G, Huang Y, Sheng X, Xu X and Lu H: Hesperidin suppresses the migration and invasion of non-small cell lung cancer cells by inhibiting the SDF-1/CXCR-4 pathway. Life Sci. 201:111–120. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ieranò C, Cerchia L, Lucarelli E, Scala S and Zannetti A: A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion. Cancer Lett. 370:100–107. 2016. View Article : Google Scholar

28 

Kaemmerer D, Schindler R, Mußbach F, Dahmen U, Altendorf-Hofmann A, Dirsch O, Sänger J, Schulz S and Lupp A: Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: Tumor capillaries as promising targets. BMC Cancer. 17:8962017. View Article : Google Scholar : PubMed/NCBI

29 

Mardomi A, Sabzichi M, Hussein Somi M, Shanehbandi D, Rahbarghazi R, Taj Sanjarani O and Samadi N: Trafficking mechanism of bone marrow-derived mesenchymal stem cells toward hepatocellular carcinoma HepG2 cells by modulating Endoglin, CXCR4 and TGF-β. Cell Mol Biol (Noisy-le-grand). 62:81–86. 2016.

30 

Chen YC, Chen YH, Pan BS, Chang MM and Huang BM: Functional study of Cordyceps sinensis and cordycepin in male reproduction: A review. Yao Wu Shi Pin Fen Xi. 25:197–205. 2017.

31 

Tuli HS, Sharma AK, Sandhu SS and Kashyap D: Cordycepin: A bioactive metabolite with therapeutic potential. Life Sci. 93:863–869. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Yoon SY, Park SJ and Park YJ: The Anticancer Properties of Cordycepin and Their Underlying Mechanisms. Int J Mol Sci. 19:E30272018. View Article : Google Scholar : PubMed/NCBI

33 

Wei C, Yao X, Jiang Z, Wang Y, Zhang D, Chen X, Fan X, Xie C, Cheng J, Fu J, et al: Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway. Pharmacol Res. 144:79–89. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Wang Y, Lv Y, Liu TS, Yan WD, Chen LY, Li ZH, Piao YS, An RB, Lin ZH and Ren XS: Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway. Life Sci. 223:110–119. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

36 

Shao LW, Huang LH, Yan S, Jin JD and Ren SY: Cordycepin induces apoptosis in human liver cancer HepG2 cells through extrinsic and intrinsic signaling pathways. Oncol Lett. 12:995–1000. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Lai Y, Fan L, Zhao Y, Ge H, Feng X, Wang Q, Zhang X, Peng Y, Wang X and Tao L: Cx32 suppresses extrinsic apoptosis in human cervical cancer cells via the NF-κB signalling pathway. Int J Oncol. 51:1159–1168. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Ikeda M, Okusaka T, Sato Y, Furuse J, Mitsunaga S, Ueno H, Morizane C, Inaba Y, Kobayashi T and Arai Y: A Phase I/II trial of continuous hepatic intra-arterial infusion of 5-fluoro-uracil, mitoxantrone and cisplatin for advanced hepatocellular carcinoma. Jpn J Clin Oncol. 47:512–519. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Kumamoto T, Tanaka K, Matsuo K, Takeda K, Nojiri K, Mori R, Taniguchi K, Matsuyama R, Ueda M, Akiyama H, et al: Adjuvant hepatic arterial infusion chemotherapy with 5-Fluorouracil and interferon after curative resection of hepatocellular carcinoma: A preliminary report. Anticancer Res. 33:5585–5590. 2013.PubMed/NCBI

40 

Zhang W, Zhong Y, Cui H, Wang L, Yang R, Su Z, Xiang B and Wei Q: Combination of calcineurin B subunit (CnB) and 5-fluoro-uracil reverses 5-fluorouracil-induced immunosuppressive effect and enhances the antitumor activity in hepatocellular carcinoma. Oncol Lett. 14:6135–6142. 2017.PubMed/NCBI

41 

Sun T, Liu H and Ming L: Multiple Roles of Autophagy in the Sorafenib Resistance of Hepatocellular Carcinoma. Cell Physiol Biochem. 44:716–727. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Zhu YJ, Zheng B, Wang HY and Chen L: New knowledge of the mechanisms of sorafenib resistance in liver cancer. Acta Pharmacol Sin. 38:614–622. 2017. View Article : Google Scholar : PubMed/NCBI

43 

De Clercq E: Curious (Old and New) Antiviral Nucleoside Analogues with Intriguing Therapeutic Potential. Curr Med Chem. 22:3866–3880. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Du Y, Yu J, Du L, Tang J and Feng WH: Cordycepin enhances Epstein-Barr virus lytic infection and Epstein-Barr virus-positive tumor treatment efficacy by doxorubicin. Cancer Lett. 376:240–248. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Lee JB, Adrower C, Qin C, Fischer PM, de Moor CH and Gershkovich P: Development of Cordycepin Formulations for Preclinical and Clinical Studies. AAPS PharmSciTech. 18:3219–3226. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Ryu E, Son M, Lee M, Lee K, Cho JY, Cho S, Lee SK, Lee YM, Cho H, Sung GH, et al: Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience. 1:866–881. 2014. View Article : Google Scholar

47 

Bai H, Weng Y, Bai S, Jiang Y, Li B, He F, Zhang R, Yan S, Deng F, Wang J, et al: CCL5 secreted from bone marrow stromal cells stimulates the migration and invasion of Huh7 hepatocellular carcinoma cells via the PI3K-Akt pathway. Int J Oncol. 45:333–343. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Lee JH, Hur W, Hong SW, Kim JH, Kim SM, Lee EB and Yoon SK: ELK3 promotes the migration and invasion of liver cancer stem cells by targeting HIF-1α. Oncol Rep. 37:813–822. 2017. View Article : Google Scholar

49 

Lin XL, Liu M, Liu Y, Hu H, Pan Y, Zou W, Fan X and Hu X: Transforming growth factor β1 promotes migration and invasion in HepG2 cells: Epithelial-to-mesenchymal transition via JAK/STAT3 signaling. Int J Mol Med. 41:129–136. 2018.

50 

Xie X, Zhu H, Zhang J, Wang M, Zhu L, Guo Z, Shen W and Wang D: Solamargine inhibits the migration and invasion of HepG2 cells by blocking epithelial-to-mesenchymal transition. Oncol Lett. 14:447–452. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Pectasides E, Miksad R, Pyatibrat S, Srivastava A and Bullock A: Spontaneous Regression of Hepatocellular Carcinoma with Multiple Lung Metastases: A Case Report and Review of the Literature. Dig Dis Sci. 61:2749–2754. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Yang T, Lu JH, Lin C, Shi S, Chen TH, Zhao RH, Wang Y and Wu MC: Concomitant lung metastasis in patients with advanced hepa-tocellular carcinoma. World J Gastroenterol. 18:2533–2539. 2012. View Article : Google Scholar : PubMed/NCBI

53 

Bhatia R, Ravulapati S, Befeler A, Dombrowski J, Gadani S and Poddar N: Hepatocellular carcinoma with bone metastases: Incidence, prognostic significance, and management-single-center experience. J Gastrointest Cancer. 48:321–325. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Hong YM, Yoon KT, Cho M, Kang DH, Kim HW, Choi CW, Park SB, Heo J, Woo HY, Lim W, et al: Bone marrow metastasis presenting as bicytopenia originating from hepatocellular carcinoma. Clin Mol Hepatol. 22:267–271. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Di Stadio CS, Altieri F, Minopoli G, Miselli G, Rippa E and Arcari P: Role of human GKN1 on APP processing in gastric cancer. Biochimie. 135:149–153. 2017. View Article : Google Scholar : PubMed/NCBI

56 

Hoesel B and Schmid JA: The complexity of NF-κB signaling in inflammation and cancer. Mol Cancer. 12:862013. View Article : Google Scholar

57 

DiDonato JA, Mercurio F and Karin M: NF-κB and the link between inflammation and cancer. Immunol Rev. 246:379–400. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Sokolova O and Naumann M: NF-κB Signaling in gastric cancer. Toxins (Basel). 9:E1192017. View Article : Google Scholar

59 

Thiel G, Ulrich M, Mukaida N and Rössler OG: Resveratrol stimulation induces interleukin-8 gene transcription via NF-κB. Pharmacol Res. 134:238–245. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo Z, Chen W, Dai G and Huang Y: Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. Int J Mol Med 45: 141-150, 2020.
APA
Guo, Z., Chen, W., Dai, G., & Huang, Y. (2020). Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. International Journal of Molecular Medicine, 45, 141-150. https://doi.org/10.3892/ijmm.2019.4391
MLA
Guo, Z., Chen, W., Dai, G., Huang, Y."Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4". International Journal of Molecular Medicine 45.1 (2020): 141-150.
Chicago
Guo, Z., Chen, W., Dai, G., Huang, Y."Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4". International Journal of Molecular Medicine 45, no. 1 (2020): 141-150. https://doi.org/10.3892/ijmm.2019.4391
Copy and paste a formatted citation
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Spandidos Publications style
Guo Z, Chen W, Dai G and Huang Y: Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. Int J Mol Med 45: 141-150, 2020.
APA
Guo, Z., Chen, W., Dai, G., & Huang, Y. (2020). Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4. International Journal of Molecular Medicine, 45, 141-150. https://doi.org/10.3892/ijmm.2019.4391
MLA
Guo, Z., Chen, W., Dai, G., Huang, Y."Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4". International Journal of Molecular Medicine 45.1 (2020): 141-150.
Chicago
Guo, Z., Chen, W., Dai, G., Huang, Y."Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4". International Journal of Molecular Medicine 45, no. 1 (2020): 141-150. https://doi.org/10.3892/ijmm.2019.4391
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