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NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway

Retraction in: /10.3892/ijmm.2023.5288
  • Authors:
    • Zhibo Zheng
    • Shuai Xiang
    • Yingjie Wang
    • Yulei Dong
    • Zeng Li
    • Yongbo Xiang
    • Yanyan Bian
    • Bin Feng
    • Bo Yang
    • Xisheng Weng
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China, Department of Orthopedic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 151-161
    |
    Published online on: November 8, 2019
       https://doi.org/10.3892/ijmm.2019.4398
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Abstract

Nuclear receptor subfamily 4 group A member 1 (NR4A1)‑induced chondrocyte death plays a critical role in the development of osteoarthritis through poorly defined mechanisms. The present study aimed to investigate the role of NR4A1 in regulating chondrocyte death in response to tumor necrosis factor‑α (TNF‑α) and cycloheximide (CHX) treatment, with a focus on mitochondrial fission and the AMP‑activated protein kinase (AMPK) signaling pathway. The results demonstrated that NR4A1 was significantly upregulated in TNF‑α and CHX exposed chondrocytes. Increased NR4A1 triggered mitochondrial fission via the AMPK/dynamin‑related protein 1 (Drp1) pathway, resulting in mitochondrial dysfunction, and mitochondrial permeability transition pore (mPTP) opening‑related cell death. Furthermore, excessive mitochondrial fission impaired chondrocyte migration through imbalance of F‑actin homeostasis. Inhibiting NR4A1 attenuated TNF‑α and CHX‑induced mitochondrial fission and, thus, reduced mitochondrial dysfunction in chondrocytes, mPTP opening‑related cell death and migration injury. Altogether, the present data confirmed that mitochondrial fission was involved in NR4A1‑mediated chondrocyte injury via regulation of mitochondrial dysfunction, mPTP opening‑induced cell death and F‑actin‑related migratory inhibition.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng Z, Xiang S, Wang Y, Dong Y, Li Z, Xiang Y, Bian Y, Feng B, Yang B, Weng X, Weng X, et al: NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288. Int J Mol Med 45: 151-161, 2020.
APA
Zheng, Z., Xiang, S., Wang, Y., Dong, Y., Li, Z., Xiang, Y. ... Weng, X. (2020). NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288. International Journal of Molecular Medicine, 45, 151-161. https://doi.org/10.3892/ijmm.2019.4398
MLA
Zheng, Z., Xiang, S., Wang, Y., Dong, Y., Li, Z., Xiang, Y., Bian, Y., Feng, B., Yang, B., Weng, X."NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288". International Journal of Molecular Medicine 45.1 (2020): 151-161.
Chicago
Zheng, Z., Xiang, S., Wang, Y., Dong, Y., Li, Z., Xiang, Y., Bian, Y., Feng, B., Yang, B., Weng, X."NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288". International Journal of Molecular Medicine 45, no. 1 (2020): 151-161. https://doi.org/10.3892/ijmm.2019.4398
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Z, Xiang S, Wang Y, Dong Y, Li Z, Xiang Y, Bian Y, Feng B, Yang B, Weng X, Weng X, et al: NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288. Int J Mol Med 45: 151-161, 2020.
APA
Zheng, Z., Xiang, S., Wang, Y., Dong, Y., Li, Z., Xiang, Y. ... Weng, X. (2020). NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288. International Journal of Molecular Medicine, 45, 151-161. https://doi.org/10.3892/ijmm.2019.4398
MLA
Zheng, Z., Xiang, S., Wang, Y., Dong, Y., Li, Z., Xiang, Y., Bian, Y., Feng, B., Yang, B., Weng, X."NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288". International Journal of Molecular Medicine 45.1 (2020): 151-161.
Chicago
Zheng, Z., Xiang, S., Wang, Y., Dong, Y., Li, Z., Xiang, Y., Bian, Y., Feng, B., Yang, B., Weng, X."NR4A1 promotes TNF‑α‑induced chondrocyte death and migration injury via activating the AMPK/Drp1/mitochondrial fission pathway Retraction in /10.3892/ijmm.2023.5288". International Journal of Molecular Medicine 45, no. 1 (2020): 151-161. https://doi.org/10.3892/ijmm.2019.4398
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