Open Access

hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3

  • Authors:
    • Jie Cheng
    • Weiwei Hu
    • Fenghui Zheng
    • Yongfa Wu
    • Maoquan Li
  • View Affiliations

  • Published online on: June 29, 2020     https://doi.org/10.3892/ijmm.2020.4664
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) regulate the expression of genes that are critical for various biological and pathological processes. Previous studies have reported that the expression of hsa_circ_0058092 is decreased in patients with diabetes mellitus (DM); however, the specific role of this circRNA in DM is unknown. In the present study, endothelial progenitor cells (EPCs) were isolated and a decreased hsa_circ_0058092 expression was found under conditions of hyperglycemia (HG). The overexpression of hsa_circ_0058092 protected the EPCs against HG‑induced damage by preserving cell survival, proliferation, migration and angiogenic differentiation. The overexpression of hsa_circ_0058092 also decreased the HG‑induced increase in NADPH‑oxidase proteins and inflammatory cytokines. Further investigation revealed that the overexpression of hsa_circ_0058092 enhanced FOXO3 expression, which was mediated through the interaction with miR‑217. Furthermore, the upregulation of miR‑217 or the downregulation of FOXO3 abolished the protective effects of hsa_circ_0058092 against HG‑induced EPC damage. On the whole, these data suggest that hsa_circ_0058092 acts via the miR‑217/FOXO3 pathway to protect against EPCs HG‑induced damage, and to preserve the migration and angiogenesis of EPCs.

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Copy and paste a formatted citation
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Spandidos Publications style
Cheng J, Hu W, Zheng F, Wu Y and Li M: hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3. Int J Mol Med 0: 0-0, 1899
APA
Cheng, J., Hu, W., Zheng, F., Wu, Y., & Li, M. (1899). hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3. International Journal of Molecular Medicine, 0, 0-0. https://doi.org/10.3892/ijmm.2020.4664
MLA
Cheng, J., Hu, W., Zheng, F., Wu, Y., Li, M."hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3". International Journal of Molecular Medicine 0.0 (1899): 0-0.
Chicago
Cheng, J., Hu, W., Zheng, F., Wu, Y., Li, M."hsa_circ_0058092 protects against hyperglycemia‑induced endothelial progenitor cell damage via miR‑217/FOXO3". International Journal of Molecular Medicine 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ijmm.2020.4664