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Article Open Access

Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p

  • Authors:
    • Wei Song
    • Kuangjing Wang
    • Xiaozhong Yang
    • Weijie Dai
    • Zhining Fan
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Endoscopy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Gastroenterology, The Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1377-1388
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    Published online on: July 28, 2020
       https://doi.org/10.3892/ijmm.2020.4687
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a type of digestive tract malignant tumor that severely threatens human health. The long non‑coding RNA BRAF activated non‑coding RNA (BANCR) and insulin‑like growth factor 1 receptor (IGF1R) are associated with various types of cancer; however, it remains unclear whether BANCR can regulate IGF1R expression in ESCC. In the present study, the expression levels of BANCR, IGF1R mRNA and microRNA‑338‑3p (miRNA/miR‑338‑3p) in ESCC tissues or cells were detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). The levels of IGF1R, E‑cadherin, N‑cadherin, Vimentin, p‑Raf‑1, p‑MEK1/2 and p‑ERK1/2 were measured by western blot analysis. The proliferation, migration and invasion of ESCC cells were determined by 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide (MTT) or Transwell assays. The relationship between miR‑338‑3p and BANCR or IGF1R was predicted using starBase2.0 and confirmed by dual‑luciferase reporter assay. The role of BANCR in ESCC in vivo was confirmed through a tumor xenograft assay. It was found that BANCR and IGF1R were upregulated, while miR‑338‑3p was downregulated in ESCC tissues and cells. Both BANCR and IGF1R knockdown suppressed the proliferation, migration, invasion and epithelial‑mesenchymal transition (EMT) of ESCC cells. IGF1R enhancement reversed BANCR knockdown‑mediated effects on the proliferation, migration, invasion and EMT of ESCC cells. BANCR regulated the Raf/MEK/ERK pathway by regulating IGF1R expression. Notably, BANCR regulated IGF1R expression by sponging miR‑338‑3p. Moreover, BANCR silencing inhibited tumor growth in vivo. On the whole, the findings of the present study demonstrate that BANCR inhibition blocks ESCC progression by inactivating the IGF1R/Raf/MEK/ERK pathway by sponging miR‑338‑3p.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar

2 

Kang X, Chen K, Li Y, Li J, D'Amico TA and Chen X: Personalized targeted therapy for esophageal squamous cell carcinoma. World J Gastroenterol. 21:7648–7658. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 68:7–30. 2019. View Article : Google Scholar

4 

Abnet CC, Arnold M and Wei WQ: Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 154:360–373. 2018. View Article : Google Scholar :

5 

Wang C, Wang J, Chen Z, Gao Y and He J: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: A systematic review. Chin J Cancer. 36:652017. View Article : Google Scholar : PubMed/NCBI

6 

Li J, Qi Z, Hu YP and Wang YX: Possible biomarkers for predicting lymph node metastasis of esophageal squamous cell carcinoma: A review. J Int Med Res. 47:544–556. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Salehi S, Taheri MN, Azarpira N, Zare A and Behzad-Behbahani A1: State of the art technologies to explore long non-coding RNAs in cancer. J Cell Mol Med. 21:3120–3140. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Li X, Wu Z, Fu X and Han W: lncRNAs: Insights into their function and mechanics in underlying disorders. Mutat Res Rev Mutat Res. 762:1–21. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Forrest ME and Khalil AM: Review: Regulation of the cancer epigenome by long non-coding RNAs. Cancer Lett. 407:106–112. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Flockhart RJ, Webster DE, Qu K, Mascarenhas N, Kovalski J, Kretz M and Khavari PA: BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration. Genome Res. 22:1006–1014. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Wang Y, Lin X, Fu X, Yan W, Lin F, Kuang P, Luo Y, Lin E, Hong X and Wu G: Long non-coding RNA BANCR regulates cancer stem cell markers in papillary thyroid cancer via the RAF/MEK/ERK signaling pathway. Oncol Rep. 40:859–866. 2018.PubMed/NCBI

12 

Shen X, Bai Y, Luo B and Zhou X: Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer. Biol Res. 50:322017. View Article : Google Scholar : PubMed/NCBI

13 

Zhou T and Gao Y: Increased expression of lncRNA BANCR and its prognostic significance in human hepatocellular carcinoma. World J Surg Oncol. 14:82016. View Article : Google Scholar : PubMed/NCBI

14 

Liu Z, Yang T, Xu Z and Cao X: Upregulation of the long non-coding RNA BANCR correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma. Biomed Pharmacother. 82:406–412. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Chen Q, Zheng Y, Wu B, Chen X, Sun F, Ge P and Wang P: BANCR regulates the cell invasion and migration in esophageal squamous cell carcinoma through Wnt/β-catenin signaling pathway. Onco Targets Ther. 12:9319–9327. 2019. View Article : Google Scholar :

16 

Anfossi S, Fu X, Nagvekar R and Calin GA: MicroRNAs, regulatory messengers inside and outside cancer cells. Adv Exp Med Biol. 1056:87–108. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Abba ML, Patil N, Leupold JH, Moniuszko M, Utikal J, Niklinski J and Allgayer H: MicroRNAs as novel targets and tools in cancer therapy. Cancer Lett. 387:84–94. 2017. View Article : Google Scholar

18 

Li Z, Wu X, Gu L, Shen Q, Luo W, Deng C, Zhou Q, Chen X, Li Y, Lim Z, et al: Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis. Cell Death Dis. 8:e28882017. View Article : Google Scholar : PubMed/NCBI

19 

Liu H, Deng H, Zhao Y, Li C and Liang Y: lncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res. 37:2792018. View Article : Google Scholar : PubMed/NCBI

20 

Wang L, Wei Z, Wu K, Dai W, Zhang C, Peng J and He Y: Long noncoding RNA B3GALT5-AS1 suppresses colon cancer liver metastasis via repressing microRNA-203. Aging (Albany NY). 10:3662–3682. 2018. View Article : Google Scholar

21 

Zhang R, Shi H, Ren F, Liu Z, Ji P, Zhang W and Wang W: Down-regulation of miR-338-3p and Up-regulation of MACC1 indicated poor prognosis of epithelial ovarian cancer patients. J Cancer. 10:1385–1392. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Y, Zhang D, Lv J, Wang S and Zhang Q: lncRNA SNHG15 acts as an oncogene in prostate cancer by regulating miR-338-3p/FKBP1A axis. Gene. 705:44–50. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Luan X and Wang Y: lncRNA XLOC_006390 facilitates cervical cancer tumorigenesis and metastasis as a ceRNA against miR-331-3p and miR-338-3p. J Gynecol Oncol. 29:e952018. View Article : Google Scholar : PubMed/NCBI

24 

Li X, Li Z, Yang G and Pan Z: MicroRNA-338-3p suppresses tumor growth of esophageal squamous cell carcinoma in vitro and in vivo. Mol Med Rep. 12:3951–3957. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Sharmila G, Bhat FA, Arunkumar R, Elumalai P, Raja Singh P, Senthilkumar K and Arunakaran J: Chemopreventive effect of quercetin, a natural dietary flavonoid on prostate cancer in in vivo model. Clin Nutr. 33:718–726. 2014. View Article : Google Scholar

26 

Ma W, Zhang T, Pan J, Shi N, Fan Q, Wang L and Lu SH: Assessment of insulin-like growth factor 1 receptor as an oncogene in esophageal squamous cell carcinoma and its potential implication in chemotherapy. Oncol Rep. 32:1601–1609. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Kong KL, Kwong DL, Chan TH, Law SY, Chen L, Li Y, Qin YR and Guan XY: MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut. 61:33–42. 2012. View Article : Google Scholar

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

29 

Li Y, Chen D, Gao X, Li X and Shi G: lncRNA NEAT1 regulates cell viability and invasion in esophageal squamous cell carcinoma through the miR-129/CTBP2 axis. Dis Markers. 2017:53146492017. View Article : Google Scholar : PubMed/NCBI

30 

Chen M, Liu P, Chen Y, Chen Z, Shen M, Liu X, Li X, Li A, Lin Y, Yang R, et al: Long noncoding RNA FAM201A mediates the radiosensitivity of esophageal squamous cell cancer by regulating ATM and mTOR expression via miR-101. Front Genet. 9:6112018. View Article : Google Scholar : PubMed/NCBI

31 

Chang ZW, Jia YX, Zhang WJ, Song LJ, Gao M, Li MJ, Zhao RH, Li J, Zhong YL, Sun QZ, et al: lncRNA-TUSC7/miR-224 affected chemotherapy resistance of esophageal squamous cell carcinoma by competitively regulating DESC1. J Exp Clin Cancer Res. 37:562018. View Article : Google Scholar : PubMed/NCBI

32 

Wu Y, Hu L, Liang Y, Li J, Wang K, Chen X, Meng H, Guan X, Yang K and Bai Y: Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2. Mol Cancer. 16:1502017. View Article : Google Scholar : PubMed/NCBI

33 

Mei LL, Qiu YT, Huang MB, Wang WJ, Bai J and Shi ZZ: miR-99a suppresses proliferation, migration and invasion of esophageal squamous cell carcinoma cells through inhibiting the IGF1R signaling pathway. Cancer Biomark. 20:527–537. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Ke K, Sun Z and Wang Z: Downregulation of long non-coding RNA GAS5 promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma. Oncol Lett. 16:1801–1808. 2018.PubMed/NCBI

35 

Zhang Q, Zhao X, Zhang C, Wang W, Li F, Liu D, Wu K, Zhu D, Liu S, Shen C, et al: Overexpressed PKMYT1 promotes tumor progression and associates with poor survival in esophageal squamous cell carcinoma. Cancer Manag Res. 11:7813–7824. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Bertrand FE, Steelman LS, Chappell WH, Abrams SL, Shelton JG, White ER, Ludwig DL and McCubrey JA: Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells. Leukemia. 20:1254–1260. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Guo L, Bai Y, Ji S and Ma H: MicroRNA98 suppresses cell growth and invasion of retinoblastoma via targeting the IGF1R/k-Ras/Raf/MEK/ERK signaling pathway. Int J Oncol. 54:807–820. 2019.PubMed/NCBI

38 

Sundaram GM and Veera Bramhachari P: Molecular interplay of pro-inflammatory transcription factors and non-coding RNAs in esophageal squamous cell carcinoma. Tumour Biol. 39:10104283177057602017. View Article : Google Scholar : PubMed/NCBI

39 

Tan D, Wu Y, Hu L, He P, Xiong G, Bai Y and Yang K: Long noncoding RNA H19 is up-regulated in esophageal squamous cell carcinoma and promotes cell proliferation and metastasis. Dis Esophagus. 30:1–9. 2017.

40 

Bao J, Zhou C, Zhang J, Mo J, Ye Q, He J and Diao J: Upregulation of the long noncoding RNA FOXD2-AS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer Biomark. 21:527–533. 2018. View Article : Google Scholar

41 

Sadeghpour S and Ghorbian S: Evaluation of the potential clinical prognostic value of lncRNA-BANCR gene in esophageal squamous cell carcinoma. Mol Biol Rep. 46:991–995. 2019. View Article : Google Scholar

42 

He A, Liu Y, Chen Z, Li J, Chen M, Liu L, Liao X, Lv Z, Zhan Y, Zhuang C, et al: Over-expression of long noncoding RNA BANCR inhibits malignant phenotypes of human bladder cancer. J Exp Clin Cancer Res. 35:1252016. View Article : Google Scholar : PubMed/NCBI

43 

Yang L and Liu G: lncRNA BANCR suppresses cell viability and invasion and promotes apoptosis in non-small-cell lung cancer cells in vitro and in vivo. Cancer Manag Res. 11:3565–3574. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Tay Y, Rinn J and Pandolfi PP: The multilayered complexity of ceRNA crosstalk and competition. Nature. 505:344–352. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Gao H, Gong N, Ma Z, Miao X, Chen J, Cao Y and Zhang G: lncRNA ZEB2-AS1 promotes pancreatic cancer cell growth and invasion through regulating the miR-204/HMGB1 axis. Int J Biol Macromol. 116:545–551. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Guo H, Yang S, Li S, Yan M, Li L and Zhang H: lncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer. Biomed Pharmacother. 102:749–757. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Heery R, Finn SP, Cuffe S and Gray SG: Long non-coding RNAs: Key regulators of epithelial-mesenchymal transition, tumour drug resistance and cancer stem cells. Cancers (Basel). 9. pp. 382017, View Article : Google Scholar

48 

Cao R, Shao J, Hu Y, Wang L, Li Z, Sun G and Gao X: MicroRNA-338-3p inhibits proliferation, migration, invasion, and EMT in osteosarcoma cells by targeting activator of 90 kDa heat shock protein ATPase homolog 1. Cancer Cell Int. 18:492018. View Article : Google Scholar

49 

Ding Z, Zhu J, Zeng Y, Du W, Zhang Y, Tang H, Zheng Y, Qin H, Liu Z and Huang JA: The regulation of Neuropilin 1 expression by miR-338-3p promotes non-small cell lung cancer via changes in EGFR signaling. Mol Carcinog. 58:1019–1032. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Liu S, Suo J, Wang C, Sun X, Wang D, He L, Zhang Y and Li W: Downregulation of tissue miR-338-3p predicts unfavorable prognosis of gastric cancer. Cancer Biomark. 21:117–122. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Liu F, Yang X, Geng M and Huang M: Targeting ERK, an Achilles' Heel of the MAPK pathway, in cancer therapy. Acta Pharm Sin B. 8:552–562. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Pollak MN, Schernhammer ES and Hankinson SE: Insulin-like growth factors and neoplasia. Nat Rev Cancer. 4:505–518. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Chen J, Deng T, Li X and Cai W: miR-193b inhibits the growth and metastasis of renal cell carcinoma by targeting IGF1R. Artif Cells Nanomed Biotechnol. 47:2058–2064. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song W, Wang K, Yang X, Dai W and Fan Z: Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p. Int J Mol Med 46: 1377-1388, 2020.
APA
Song, W., Wang, K., Yang, X., Dai, W., & Fan, Z. (2020). Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p. International Journal of Molecular Medicine, 46, 1377-1388. https://doi.org/10.3892/ijmm.2020.4687
MLA
Song, W., Wang, K., Yang, X., Dai, W., Fan, Z."Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p". International Journal of Molecular Medicine 46.4 (2020): 1377-1388.
Chicago
Song, W., Wang, K., Yang, X., Dai, W., Fan, Z."Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p". International Journal of Molecular Medicine 46, no. 4 (2020): 1377-1388. https://doi.org/10.3892/ijmm.2020.4687
Copy and paste a formatted citation
x
Spandidos Publications style
Song W, Wang K, Yang X, Dai W and Fan Z: Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p. Int J Mol Med 46: 1377-1388, 2020.
APA
Song, W., Wang, K., Yang, X., Dai, W., & Fan, Z. (2020). Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p. International Journal of Molecular Medicine, 46, 1377-1388. https://doi.org/10.3892/ijmm.2020.4687
MLA
Song, W., Wang, K., Yang, X., Dai, W., Fan, Z."Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p". International Journal of Molecular Medicine 46.4 (2020): 1377-1388.
Chicago
Song, W., Wang, K., Yang, X., Dai, W., Fan, Z."Long non‑coding RNA BANCR mediates esophageal squamous cell carcinoma progression by regulating the IGF1R/Raf/MEK/ERK pathway via miR‑338‑3p". International Journal of Molecular Medicine 46, no. 4 (2020): 1377-1388. https://doi.org/10.3892/ijmm.2020.4687
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