Open Access

‘Psoriasis 1’ reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation

  • Authors:
    • Yang Gao
    • Wen Sun
    • Xushan Cha
    • Hailong Wang
  • View Affiliations

  • Published online on: August 6, 2020     https://doi.org/10.3892/ijmm.2020.4695
  • Pages: 1538-1550
  • Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Psoriasis is an immune‑mediated dermatosis characterized by T‑lymphocyte‑mediated epidermal hyperplasia, for which there are currently no effective clinical treatments. ‘Psoriasis 1’ is a Chinese herbal medicine formulation that has been recently used extensively in China for treating patients with psoriasis. However, the molecular mechanism of action of this potent formulation has not yet been fully elucidated. In the present study, the effects of ‘Psoriasis 1’ on T ymphocytes in patients with psoriasis were investigated and the underlying molecular mechanism was discussed. Blood samples were collected from 40 patients with psoriasis. ELISA was employed to assess the levels of tumour necrosis factor‑α, interferon‑γ, interleukin (IL)‑2, IL‑6, transforming growth factor‑β, IL‑4, IL‑12, IL‑23 and vitamin D (VD). Western blot and quantitative PCR analyses were used to investigate the expression levels of VD receptor (VDR) and signal transducer and activator of transcription (STAT)4 in T lymphocytes. ‘Psoriasis 1’ was observed to significantly increase CD4+ T cells. It also notably upregulated the mRNA and protein expression of VDR, and downregulated the mRNA and protein expression of STAT4. Moreover, the suppression of VDR was found to aggravate the inflammatory response, which was reversed by ‘Psoriasis 1.’ Thus, this formulation reportedly decreased the inflammation mediated by T lymphocytes in patients with psoriasis through inhibiting VDR‑mediated STAT4 inactivation.
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October-2020
Volume 46 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Gao Y, Sun W, Cha X and Wang H: ‘Psoriasis 1’ reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation. Int J Mol Med 46: 1538-1550, 2020
APA
Gao, Y., Sun, W., Cha, X., & Wang, H. (2020). ‘Psoriasis 1’ reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation. International Journal of Molecular Medicine, 46, 1538-1550. https://doi.org/10.3892/ijmm.2020.4695
MLA
Gao, Y., Sun, W., Cha, X., Wang, H."‘Psoriasis 1’ reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation". International Journal of Molecular Medicine 46.4 (2020): 1538-1550.
Chicago
Gao, Y., Sun, W., Cha, X., Wang, H."‘Psoriasis 1’ reduces T‑lymphocyte‑mediated inflammation in patients with psoriasis by inhibiting vitamin D receptor‑mediated STAT4 inactivation". International Journal of Molecular Medicine 46, no. 4 (2020): 1538-1550. https://doi.org/10.3892/ijmm.2020.4695