Open Access

Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)

  • Authors:
    • Xiaorui Zhao
    • Yue Wang
    • Qiongfang Yu
    • Pei Yu
    • Qiaoyu Zheng
    • Xue Yang
    • Dian Gao
  • View Affiliations

  • Published online on: September 16, 2020     https://doi.org/10.3892/ijmm.2020.4731
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are a type of endogenous non‑coding RNAs that are connected at the 3' and 5' ends by exon or intron cyclization, which forms a covalently closed loop. They are stable, well conserved, exhibit specific expression in mammalian cells and can function as microRNA (miRNA or miR) sponges to regulate the target genes of miRNAs, which influences biological processes. Such as tumor proliferation, invasion, metastasis, apoptosis and tumor stage. circRNAs represent promising candidates for clinical diagnosis and treatment. In the present review, the biogenesis, classification and functions of circRNAs in tumors are briefly summarized and discussed. In addition, the participation of circRNAs in signal transduction pathways regulating gastrointestinal cancer cellular functions is highlighted.

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Copy and paste a formatted citation
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Spandidos Publications style
Zhao X, Wang Y, Yu Q, Yu P, Zheng Q, Yang X and Gao D: Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review). Int J Mol Med 0: 0-0, 1899
APA
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., & Gao, D. (1899). Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review). International Journal of Molecular Medicine, 0, 0-0. https://doi.org/10.3892/ijmm.2020.4731
MLA
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., Gao, D."Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)". International Journal of Molecular Medicine 0.0 (1899): 0-0.
Chicago
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., Gao, D."Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)". International Journal of Molecular Medicine 0, no. 0 (1899): 0-0. https://doi.org/10.3892/ijmm.2020.4731