Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2020 Volume 46 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2020 Volume 46 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)

  • Authors:
    • Xiaorui Zhao
    • Yue Wang
    • Qiongfang Yu
    • Pei Yu
    • Qiaoyu Zheng
    • Xue Yang
    • Dian Gao
  • View Affiliations / Copyright

    Affiliations: Department of Pathogen Biology and Immunology, Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1611-1632
    |
    Published online on: September 16, 2020
       https://doi.org/10.3892/ijmm.2020.4731
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Circular RNAs (circRNAs) are a type of endogenous non‑coding RNAs that are connected at the 3' and 5' ends by exon or intron cyclization, which forms a covalently closed loop. They are stable, well conserved, exhibit specific expression in mammalian cells and can function as microRNA (miRNA or miR) sponges to regulate the target genes of miRNAs, which influences biological processes. Such as tumor proliferation, invasion, metastasis, apoptosis and tumor stage. circRNAs represent promising candidates for clinical diagnosis and treatment. In the present review, the biogenesis, classification and functions of circRNAs in tumors are briefly summarized and discussed. In addition, the participation of circRNAs in signal transduction pathways regulating gastrointestinal cancer cellular functions is highlighted.
View Figures

Figure 1

Figure 2

View References

1 

Wang Y, Mo Y, Gong Z, Yang X, Yang M, Zhang S, Xiong F, Xiang B, Zhou M, Liao Q, et al: Circular RNAs in human cancer. Mol Cancer. 16:252017. View Article : Google Scholar : PubMed/NCBI

2 

Zhang Y, Liang W, Zhang P, Chen J, Qian H, Zhang X and Xu W: Circular RNAs: Emerging cancer biomarkers and targets. J Exp Clin Cancer Res. 36:1522017. View Article : Google Scholar : PubMed/NCBI

3 

Sanger HL, Klotz G, Riesner D, Gross HJ and Kleinschmidt AK: Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci USA. 73:3852–3856. 1976. View Article : Google Scholar : PubMed/NCBI

4 

Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, et al: Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 7:112152016. View Article : Google Scholar : PubMed/NCBI

5 

Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS, Libby RT, Howell GR and John SWM: Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective. Proc Natl Acad Sci USA. 114:E3839–E3848. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Benitez-Herreros J, Lopez-Guajardo L, Camara-Gonzalez C, Vazquez-Blanco M and Castro-Rebollo M: Association between macular perfusion and photoreceptor layer status in diabetic macular edema. Retina. 35:288–293. 2015. View Article : Google Scholar

7 

Zhao ZJ and Shen J: Circular RNA participates in the carcinogenesis and the malignant behavior of cancer. RNA Biol. 14:514–521. 2017. View Article : Google Scholar :

8 

Ren X, Du Y, You L and Zhao Y: Potential functions and implications of circular RNA in gastrointestinal cancer. Oncol Lett. 14:7016–7020. 2017.

9 

Ying X, Hanmin C, Wenqi Y, Zhichang L and Zhengming Z: Research progress on the role of circRNA in gastrointestinal tumor. China J Clin Oncol. 44:778–781. 2017.

10 

Li B and Huang C: Regulation of EMT by STAT3 in gastrointestinal cancer (Review). Int J Oncol. 50:753–767. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Zhang XO, Wang HB, Zhang Y, Lu X, Chen LL and Yang L: Complementary sequence-mediated exon circularization. Cell. 159:134–147. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Z, Yang T and Xiao J: Circular RNAs: Promising biomarkers for human diseases. EBioMedicine. 34:267–274. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Jeck WR and Sharpless NE: Detecting and characterizing circular RNAs. Nat Biotechnol. 32:453–461. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chen LL and Yang L: Regulation of circRNA biogenesis. RNA Biol. 12:381–388. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L and Chen LL: Circular intronic long noncoding RNAs. Mol Cell. 51:792–806. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wang Q, Qu L, Chen X, Zhao YH and Luo Q: Progress in understanding the relationship between circular RNAs and neurological disorders. J Mol Neurosci. 65:546–556. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Chen LL: The biogenesis and emerging roles of circular RNAs. Nat Rev Mol Cell Biol. 17:205–211. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar :

20 

Wei CC, Luo Z, Song YF, Pan YX, Wu K and You WJ: Identification of autophagy related genes LC3 and ATG4 from yellow catfish Pelteobagrus fulvidraco and their transcriptional responses to waterborne and dietborne zinc exposure. Chemosphere. 175:228–238. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Ebbesen KK, Kjems J and Hansen TB: Circular RNAs: Identification, biogenesis and function. Biochim Biophys Acta. 1859:163–168. 2016. View Article : Google Scholar

22 

Li X, Yang L and Chen LL: The biogenesis, functions, and challenges of circular RNAs. Mol Cell. 71:428–442. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Kulcheski FR, Christoff AP and Margis R: Circular RNAs are miRNA sponges and can be used as a new class of biomarker. J Biotechnol. 238:42–51. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Qian L, Yu S, Chen Z, Meng Z, Huang S and Wang P: The emerging role of circRNAs and their clinical significance in human cancers. Biochim Biophys Acta Rev Cancer. 1870:247–260. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Fang L, Du WW, Lyu J, Dong J, Zhang C, Yang W, He A, Kwok YSS, Ma J, Wu N, et al: Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1. Cell Death Differ. 25:2195–2208. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Du WW, Yang W, Liu E, Yang Z, Dhaliwal P and Yang BB: Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 44:2846–2858. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Wilusz JE: A 360° view of circular RNAs: From biogenesis to functions. Wiley Interdiscip Rev RNA. 9:e14782018. View Article : Google Scholar

28 

Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21.e7. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, et al: Circ-ZNF609 Is a circular RNA that can be translated and functions in myogenesis. Mol Cell. 66:22–37.e9. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Zhang M, Huang N, Yang X, Luo J, Yan S, Xiao F, Chen W, Gao X, Zhao K, Zhou H, et al: A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigen-esis. Oncogene. 37:1805–1814. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, et al: Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 110:304–315. 2018. View Article : Google Scholar :

32 

Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Abdelmohsen K, Panda AC, Munk R, Grammatikakis I, Dudekula DB, De S, Kim J, Noh JH, Kim KM, Martindale JL and Gorospe M: Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1. RNA Biol. 14:361–369. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Li HM, Ma XL and Li HG: Intriguing circles: Conflicts and controversies in circular RNA research. Wiley Interdiscip Rev RNA. 10:e15382019. View Article : Google Scholar : PubMed/NCBI

35 

Li J, Li H, Lv X, Yang Z, Gao M, Bi Y, Zhang Z, Wang S, Cui Z, Zhou B and Yin Z: Diagnostic performance of circular RNAs in human cancers: A systematic review and meta-analysis. Mol Genet Genomic Med. 7:e007492019.PubMed/NCBI

36 

Lin G, Sheng H, Xie H, Zheng Q, Shen Y, Shi G and Ye D: circLPAR1 is a novel biomarker of prognosis for muscle-invasive bladder cancer with invasion and metastasis by miR-762. Oncol Lett. 17:3537–3547. 2019.PubMed/NCBI

37 

Li Z, Zhou Y, Yang G, He S, Qiu X, Zhang L, Deng Q and Zheng F: Using circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma. Clin Chim Acta. 492:37–44. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Mao W, Huang X, Wang L, Zhang Z, Liu M, Li Y, Luo M, Yao X, Fan J and Geng J: Circular RNA hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 by targeting miR-181a-5p to promote bladder cancer progression. J Exp Clin Cancer Res. 38:1692019. View Article : Google Scholar : PubMed/NCBI

39 

Hou LD and Zhang J: Circular RNAs: An emerging type of RNA in cancer. Int J Immunopathol Pharmacol. 30:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Yuan Y, Liu W, Zhang Y, Zhang Y and Sun S: CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. Biochem Biophys Res Commun. 503:870–875. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Zhang XL, Xu LL and Wang F: Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1. Cell Biol Int. 41:1056–1064. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Xie H, Ren X, Xin S, Lan X, Lu G, Lin Y, Yang S, Zeng Z, Liao W, Ding YQ and Liang L: Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer. Oncotarget. 7:26680–26691. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Tang W, Ji M, He G, Yang L, Niu Z, Jian M, Wei Y, Ren L and Xu J: Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. Onco Targets Ther. 10:2045–2056. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Zhang Z, Fu C, Xu Q and Wei X: Long non-coding RNA CASC7 inhibits the proliferation and migration of colon cancer cells via inhibiting microRNA-21. Biomed Pharmacother. 95:1644–1653. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Wang CJ, Stratmann J, Zhou ZG and Sun XF: Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells. BMC Cancer. 10:6162010. View Article : Google Scholar : PubMed/NCBI

47 

Chen S, Zhang L, Su Y and Zhang X: Screening potential biomarkers for colorectal cancer based on circular RNA chips. Oncol Rep. 39:2499–2512. 2018.PubMed/NCBI

48 

Bian L, Zhi X, Ma L, Zhang J, Chen P, Sun S, Li J, Sun Y and Qin J: Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p/FOXO4 axis. Biochem Biophys Res Commun. 505:346–352. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Yong W, Zhuoqi X, Baocheng W, Dongsheng Z, Chuan Z and Yueming S: Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer. Biomed Pharmacother. 102:1188–1194. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Weng W, Wei Q, Toden S, Yoshida K, Nagasaka T, Fujiwara T, Cai S, Qin H, Ma Y and Goel A: Circular RNA ciRS-7-A promising prognostic biomarker and a potential therapeutic target in colorectal cancer. Clin Cancer Res. 23:3918–3928. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Peng L, Chen G, Zhu Z, Shen Z, Du C, Zang R, Su Y, Xie H, Li H, Xu X, et al: Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease. Oncotarget. 8:808–818. 2017. View Article : Google Scholar :

52 

Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, Sun H, Pan Y, He B and Wang S: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7. Cell Death Dis. 9:4172018. View Article : Google Scholar : PubMed/NCBI

53 

Xu XW, Zheng BA, Hu ZM, Qian ZY, Huang CJ, Liu XQ and Wu WD: Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b. Oncotarget. 8:91674–91683. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Shen T, Cheng X, Liu X, Xia C, Zhang H, Pan D, Zhang X and Li Y: Circ_0026344 restrains metastasis of human colorectal cancer cells via miR-183. Artif Cells Nanomed Biotechnol. 47:4038–4045. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Fang G, Ye BL, Hu BR, Ruan XJ and Shi YX: CircRNA_100290 promotes colorectal cancer progression th rough miR-516b-induced downregulation of FZD4 expression and Wnt/β-catenin signaling. Biochem Biophys Res Commun. 504:184–189. 2018. View Article : Google Scholar : PubMed/NCBI

56 

He JH, Li YG, Han ZP, Zhou JB, Chen WM, Lv YB, He ML, Zuo JD and Zheng L: The CircRNA-ACAP2/Hsa-miR-21-5p/Tiam1 regulatory feedback circuit affects the proliferation, migration, and invasion of colon cancer SW480 cells. Cell Physiol Biochem. 49:1539–1550. 2018. View Article : Google Scholar

57 

Li X, Wang J, Zhang C, Lin C, Zhang J, Zhang W, Zhang W, Lu Y, Zheng L and Li X: Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7. J Pathol. 246:166–179. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Huang G, Zhu H, Shi Y, Wu W, Cai H and Chen X: cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/β-catenin pathway. PLoS One. 10:e01312252015. View Article : Google Scholar

59 

Zhu M, Xu Y, Chen Y and Yan F: Circular BANP, an upregu-lated circular RNA that modulates cell proliferation in colorectal cancer. Biomed Pharmacother. 88:138–144. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Xiong W, Ai YQ and Li YF, Ye Q, Chen ZT, Qin JY, Liu QY, Wang H, Ju YH, Li WH and Li YF: Microarray analysis of circular RNA expression profile associated with 5-fluorouracil-based chemo-radiation resistance in colorectal cancer cells. Biomed Res Int. 2017:84216142017. View Article : Google Scholar

61 

Zeng Y, Xu Y, Shu R, Sun L, Tian Y, Shi C, Zheng Z, Wang K and Luo H: Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis. Int J Mol Med. 40:1818–1828. 2017.PubMed/NCBI

62 

Hsiao KY, Lin YC, Gupta SK, Chang N, Yen L, Sun HS and Tsai SJ: Noncoding effects of circular RNA CCDC66 promote colon cancer growth and metastasis. Cancer Res. 77:2339–2350. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Zhong D, Li P and Gong PY: Hsa_circ_0005075 promotes the proliferation and invasion of colorectal cancer cells. Int J Biol Markers. 34:284–291. 2019. View Article : Google Scholar : PubMed/NCBI

64 

Jin YD, Ren YR, Gao YX, Zhang L and Ding Z: Hsa_ circ_0005075 predicts a poor prognosis and acts as an oncogene in colorectal cancer via activating Wnt/β-catenin pathway. Eur Rev Med Pharmacol Sci. 23:3311–3319. 2019.PubMed/NCBI

65 

Zhang Q, Zhang C, Ma JX, Ren H, Sun Y and Xu JZ: Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a. World J Gastroenterol. 25:5300–5309. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Pei FL, Cao MZ and Li YF: Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis. J Biochem. 167:55–65. 2020. View Article : Google Scholar

67 

Lu X, Yu Y, Liao F and Tan S: Homo sapiens circular RNA 0079993 (hsa_circ_0079993) of the POLR2J4 gene acts as an oncogene in colorectal cancer through the microRNA-203a-3p1 and CREB1 axis. Med Sci Monit. 25:6872–6883. 2019. View Article : Google Scholar : PubMed/NCBI

68 

Lu C, Jiang W, Hui B, Rong D, Fu K, Dong C, Tang W and Cao H: The circ_0021977/miR-10b-5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer. J Cell Physiol. 235:2273–2285. 2020. View Article : Google Scholar

69 

Zhang J, Liu H, Zhao P, Zhou H and Mao T: Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p. J Cell Biochem. 120:3027–3037. 2019. View Article : Google Scholar

70 

Li H, Jin X, Liu B, Zhang P, Chen W and Li Q: CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer. BMC Cancer. 19:8262019. View Article : Google Scholar : PubMed/NCBI

71 

Ren TJ, Liu C, Hou JF and Shan FX: CircDDX17 reduces 5-fluorouracil resistance and hinders tumorigenesis in colorectal cancer by regulating miR-31-5p/KANK1 axis. Eur Rev Med Pharmacol Sci. 24:1743–1754. 2020.PubMed/NCBI

72 

Zhang ZJ, Zhang YH, Qin XJ, Wang YX and Fu J: Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis. Eur Rev Med Pharmacol Sci. 24:2387–2400. 2020.PubMed/NCBI

73 

Ding DY, Wang D and Shu ZB: Hsa_circ_0007534 knockdown represses the development of colorectal cancer cells through regulating miR-613/SLC25A22 axis. Eur Rev Med Pharmacol Sci. 24:3004–3022. 2020.PubMed/NCBI

74 

Zheng X, Ma YF, Zhang XR, Li Y, Zhao HH and Han SG: Circ_0056618 promoted cell proliferation, migration and angiogenesis through sponging with miR-206 and upregulating CXCR4 and VEGF-A in colorectal cancer. Eur Rev Med Pharmacol Sci. 24:4190–4202. 2020.PubMed/NCBI

75 

Tu FL, Guo XQ, Wu HX, He ZY, Wang F, Sun AJ and Dai XD: Circ-0001313/miRNA-510-5p/AKT2 axis promotes the development and progression of colon cancer. Am J Transl Res. 12:281–291. 2020.PubMed/NCBI

76 

Wu HB, Huang SS, Lu CG, Tian SD and Chen M: CircAPLP2 regulates the proliferation and metastasis of colorectal cancer by targeting miR-101-3p to activate the Notch signalling pathway. Am J Transl Res. 12:2554–2569. 2020.PubMed/NCBI

77 

Chen C, Huang Z, Mo X, Song Y, Li X, Li X and Zhang M: The circular RNA 001971/miR-29c-3p axis modulates colorectal cancer growth, metastasis, and angiogenesis through VEGFA. J Exp Clin Cancer Res. 39:912020. View Article : Google Scholar : PubMed/NCBI

78 

Chen H, Pei L, Xie P and Guo G: Circ-PRKDC contributes to 5-fluorouracil resistance of colorectal cancer cells by regulating miR-375/FOXM1 axis and Wnt/β-catenin pathway. Onco Targets Ther. 13:5939–5953. 2020. View Article : Google Scholar :

79 

Chen HY, Li XN, Ye CX, Chen ZL and Wang ZJ: Circular RNA circHUWE1 is upregulated and promotes cell proliferation, migration and invasion in colorectal cancer by sponging miR-486. Onco Targets Ther. 13:423–434. 2020. View Article : Google Scholar : PubMed/NCBI

80 

Chen MS, Lin CH, Huang LY and Qiu XM: CircRNA SMARCC1 sponges MiR-1403p to regulate cell progression in colorectal cancer. Cancer Manag Res. 12:4899–4910. 2020. View Article : Google Scholar :

81 

Chen P, Yao Y, Yang N, Gong L, Kong Y and Wu A: Circular RNA circCTNNA1 promotes colorectal cancer progression by sponging miR-149-5p and regulating FOXM1 expression. Cell Death Dis. 11:5572020. View Article : Google Scholar : PubMed/NCBI

82 

Chen ZL, Li XN, Ye CX, Chen HY and Wang ZJ: Elevated levels of circRUNX1 in colorectal cancer promote cell growth and metastasis via miR-145-5p/IGF1 signalling. Onco Targets Ther. 13:4035–4048. 2020. View Article : Google Scholar : PubMed/NCBI

83 

Deng Z, Li X, Wang H, Geng Y, Cai Y, Tang Y, Wang Y, Yu X, Li L and Li R: Dysregulation of circRNA_0001946 contributes to the proliferation and metastasis of colorectal cancer cells by targeting MicroRNA-135a-5p. Front Genet. 11:3572020. View Article : Google Scholar : PubMed/NCBI

84 

Du H, He Z, Feng F, Chen D, Zhang L, Bai J, Wu H, Han E and Zhang J: Hsa_circ_0038646 promotes cell proliferation and migration in colorectal cancer via miR-331-3p/GRIK3. Oncol Lett. 20:266–274. 2020.PubMed/NCBI

85 

Feng W, Gong H, Wang Y, Zhu G, Xue T, Wang Y and Cui G: circIFT80 Functions as a ceRNA of miR-1236-3p to promote colorectal cancer progression. Mol Ther Nucleic Acids. 18:375–387. 2019. View Article : Google Scholar : PubMed/NCBI

86 

Hu B, Xian Z, Zou Q, Zhang D, Su D, Yao J and Ren D: CircFAT1 suppresses colorectal cancer development through regulating miR-520b/UHRF1 axis or miR-302c-3p/UHRF1 axis. Cancer Biother Radiopharm. May 5–2020.Epub ahead of print. View Article : Google Scholar

87 

Jian X, He H, Zhu J, Zhang Q, Zheng Z, Liang X, Chen L, Yang M, Peng K, Zhang Z, et al: Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemore-sistance by regulating BMI1 through miR-340. Mol Cancer. 19:202020. View Article : Google Scholar

88 

Li C and Zhou H: Circular RNA hsa_circRNA_102209 promotes the growth and metastasis of colorectal cancer through miR-761-mediated Ras and Rab interactor 1 signaling. Cancer Med. Jul 24–2020.Epub ahead of print). :101002/cam4.3332.

89 

Li W, Xu Y, Wang X, Cao G, Bu W, Wang X, Fang Z, Xu Y, Dong M and Tao Q: circCCT3 modulates vascular endothelial growth factor A and Wnt signaling to enhance colorectal cancer metastasis through sponging miR-613. DNA Cell Biol. 39:118–125. 2020. View Article : Google Scholar

90 

Lu C, Fu L, Qian X, Dou L and Cang S: Knockdown of circular RNA circ-FARSA restricts colorectal cancer cell growth through regulation of miR-330-5p/LASP1 axis. Arch Biochem Biophys. 689:1084342020. View Article : Google Scholar : PubMed/NCBI

91 

Ma Z, Han C, Xia W, Wang S, Li X, Fang P, Yin R, Xu L and Yang L: circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS. Cell Death Dis. 11:3562020. View Article : Google Scholar : PubMed/NCBI

92 

Ren C, Zhang Z, Wang S, Zhu W, Zheng P and Wang W: Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs. Biol Chem. 401:487–496. 2020. View Article : Google Scholar

93 

Shang A, Gu C, Wang W, Wang X, Sun J, Zeng B, Chen C, Chang W, Ping Y, Ji P, et al: Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis. Mol Cancer. 19:1172020. View Article : Google Scholar

94 

Sun J, Liu J, Zhu Q, Xu F, Kang L and Shi X: Hsa_circ_0001806 Acts as a ceRNA to facilitate the stemness of colorectal cancer cells by increasing COL1A1. Onco Targets Ther. 13:6315–6327. 2020. View Article : Google Scholar : PubMed/NCBI

95 

Wang J, Luo J, Liu G and Li X: Circular RNA hsa_circ_0008285 inhibits colorectal cancer cell proliferation and migration via the miR-382-5p/PTEN axis. Biochem Biophys Res Commun. 527:503–510. 2020. View Article : Google Scholar : PubMed/NCBI

96 

Wang X, Chen Y, Liu W, Liu T and Sun D: Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling. J Cell Mol Med. Jul 18–2020.Epub ahead of print. View Article : Google Scholar

97 

Wang X, Ren Y, Ma S and Wang S: Circular RNA 0060745, a novel circRNA, promotes colorectal cancer cell proliferation and metastasis through miR-4736 sponging. Onco Targets Ther. 13:1941–1951. 2020. View Article : Google Scholar : PubMed/NCBI

98 

Wang X, Zhang H, Yang H, Bai M, Ning T, Deng T, Liu R, Fan Q, Zhu K, Li J, et al: Exosome-delivered circRNA promotes glycol-ysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer. Mol Oncol. 14:539–555. 2020. View Article : Google Scholar : PubMed/NCBI

99 

Xiao H and Liu M: Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR-2467-3p sequestration. J Cell Physiol. 235:2881–2890. 2020. View Article : Google Scholar

100 

Yan Y, Su M and Qin B: CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal. Biochem Biophys Res Commun. 524:839–846. 2020. View Article : Google Scholar : PubMed/NCBI

101 

Yang B, Du K, Yang C, Xiang L, Xu Y, Cao C, Zhang J and Liu W: CircPRMT5 circular RNA promotes proliferation of colorectal cancer through sponging miR-377 to induce E2F3 expression. J Cell Mol Med. 24:3431–3437. 2020. View Article : Google Scholar : PubMed/NCBI

102 

Yang L, Sun H, Liu X, Chen J, Tian Z, Xu J, Xiang B and Qin B: Circular RNA hsa_circ_0004277 contributes to malignant phenotype of colorectal cancer by sponging miR-512-5p to upregulate the expression of PTMA. J Cell Physiol. Jan 21–2020.Epub ahead of print. View Article : Google Scholar

103 

Yang Z, Zhang J, Lu D, Sun Y, Zhao X, Wang X, Zhou W, He Q and Jiang Z: Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge. Cancer Cell Int. 20:672020. View Article : Google Scholar : PubMed/NCBI

104 

Yin W, Xu J, Li C, Dai X, Wu T and Wen J: Circular RNA circ_0007142 facilitates colorectal cancer progression by modulating CDC25A expression via miR-122-5p. Onco Targets Ther. 13:3689–3701. 2020. View Article : Google Scholar : PubMed/NCBI

105 

Zhang J, Wang H, Wu K, Zhan F and Zeng H: Dysregulated circRNA_100876 contributes to proliferation and metastasis of colorectal cancer by targeting microRNA-516b (miR-516b). Cancer Biol Ther. 21:733–740. 2020. View Article : Google Scholar : PubMed/NCBI

106 

Zhang L, Dong X, Yan B, Yu W and Shan L: CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1. Cell Death Dis. 11:5422020. View Article : Google Scholar : PubMed/NCBI

107 

Zhang X, Xu Y, Yamaguchi K, Hu J, Zhang L, Wang J, Tian J and Chen W: Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis. Cancer Cell Int. 20:1032020. View Article : Google Scholar : PubMed/NCBI

108 

Zhang Y, Zhang Z, Yi Y, Wang Y and Fu J: CircNOL10 acts as a sponge of miR-135a/b-5p in suppressing colorectal cancer progression via regulating KLF9. Onco Targets Ther. 13:5165–5176. 2020. View Article : Google Scholar : PubMed/NCBI

109 

Zhou C, Liu HS, Wang FW, Hu T, Liang ZX, Lan N, He XW, Zheng XB, Wu XJ, Xie D, et al: circCAMSAP1 promotes tumor growth in colorectal cancer via the miR-328-5p/E2F1 axis. Mol Ther. 28:914–928. 2020. View Article : Google Scholar : PubMed/NCBI

110 

Sun HD, Xu ZP, Sun ZQ, Zhu B, Wang Q, Zhou J, Jin H, Zhao A, Tang WW and Cao XF: Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep. 8:101112018. View Article : Google Scholar : PubMed/NCBI

111 

Cheng J, Zhuo H, Xu M, Wang L, Xu H, Peng J, Hou J, Lin L and Cai J: Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med. 16:2162018. View Article : Google Scholar : PubMed/NCBI

112 

Li H, Yao G, Feng B, Lu X and Fan Y: Circ_0056618 and CXCR4 act as competing endogenous in gastric cancer by regulating miR-206. J Cell Biochem. 119:9543–9551. 2018. View Article : Google Scholar : PubMed/NCBI

113 

Zhang J, Liu H, Hou L, Wang G, Zhang R, Huang Y, Chen X and Zhu J: Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression. Mol Cancer. 16:1512017. View Article : Google Scholar : PubMed/NCBI

114 

Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, et al: PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 275:1943–1947. 1997. View Article : Google Scholar : PubMed/NCBI

115 

Namløs HM, Meza-Zepeda LA, Barøy T, Østensen IH, Kresse SH, Kuijjer ML, Serra M, Bürger H, Cleton-Jansen AM and Myklebost O: Modulation of the osteosarcoma expression phenotype by microRNAs. PLoS One. 7:e480862012. View Article : Google Scholar : PubMed/NCBI

116 

Lee KH, Lotterman C, Karikari C, Omura N, Feldmann G, Habbe N, Goggins MG, Mendell JT and Maitra A: Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology. 9:293–301. 2009. View Article : Google Scholar : PubMed/NCBI

117 

Liu T, Liu S, Xu Y, Shu R, Wang F, Chen C, Zeng Y and Luo H: Circular RNA-ZFR inhibited cell proliferation and promoted apoptosis in gastric cancer by sponging miR-130a/miR-107 and modulating PTEN. Cancer Res Treat. 50:1396–1417. 2018. View Article : Google Scholar : PubMed/NCBI

118 

Liu R, Lu Z, Gu J, Liu J, Huang E, Liu X, Wang L, Yang J, Deng Y, Qian J, et al: MicroRNAs 15A and 161 activate signaling pathways that mediate chemotaxis of immune regulatory B cells to colorectal tumors. Gastroenterology. 154:637–651.e7. 2018. View Article : Google Scholar

119 

Hu ZY, Chen B, Zhang JP and Ma YY: Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease. J Biol Chem. 292:18062–18074. 2017. View Article : Google Scholar : PubMed/NCBI

120 

Shang X, Li G, Liu H, Li T, Liu J, Zhao Q and Wang C: Comprehensive circular RNA profiling reveals that hsa_ circ_0005075, a new circular RNA biomarker, is involved in hepatocellular crcinoma development. Medicine (Baltimore). 95:e38112016. View Article : Google Scholar

121 

Liu Z, Huang S, Cao Y, Yao Y, Li J, Chen J, Jiang B, Yuan X, Xiang X, Xiong J and Deng J: YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106. Biochem Biophys Res Commun. 503:2370–2375. 2018. View Article : Google Scholar : PubMed/NCBI

122 

Li G, Xue M, Yang F, Jin Y, Fan Y and Li W: CircRBMS3 promotes gastric cancer tumorigenesis by regulating miR-153-SNAI1 axis. J Cell Physiol. 234:3020–3028. 2018. View Article : Google Scholar : PubMed/NCBI

123 

Chang P, Wang F and Li Y: Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p. Biosci Rep. 38:BSR201805382018. View Article : Google Scholar : PubMed/NCBI

124 

Zhong S, Wang J, Hou J, Zhang Q, Xu H, Hu J, Zhao J and Feng J: Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells. Epigenomics. 10:1301–1313. 2018. View Article : Google Scholar : PubMed/NCBI

125 

Li P, Chen H, Chen S, Mo X, Li T, Xiao B, Yu R and Guo J: Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer. 116:626–633. 2017. View Article : Google Scholar : PubMed/NCBI

126 

Huang YS, Jie N, Zou KJ and Weng Y: Expression profile of circular RNAs in human gastric cancer tissues. Mol Med Rep. 16:2469–2476. 2017. View Article : Google Scholar : PubMed/NCBI

127 

Li J, Zhen L, Zhang Y, Zhao L, Liu H, Cai D, Chen H, Yu J, Qi X and Li G: Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells. Onco Targets Ther. 10:3521–3529. 2017. View Article : Google Scholar : PubMed/NCBI

128 

Sun H, Tang W, Rong D, Jin H, Fu K, Zhang W, Liu Z, Cao H and Cao X: Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark. 21:299–306. 2018. View Article : Google Scholar

129 

Li X, He M, Guo J and Cao T: Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling. Biochem Biophys Res Commun. 511:926–930. 2019. View Article : Google Scholar : PubMed/NCBI

130 

Lu J, Zhang PY, Li P, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, Huang CM and Zheng CH: Circular RNA hsa_ circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506-5p/FOXO3 axis. Biochem Biophys Res Commun. 512:29–33. 2019. View Article : Google Scholar : PubMed/NCBI

131 

Kong S, Yang Q, Tang C, Wang T, Shen X and Ju S: Identification of hsa_circ_0001821 as a novel diagnostic biomarker in gastric cancer via comprehensive circular RNA profiling. Front Genet. 10:8782019. View Article : Google Scholar :

132 

Liu Z, Pan HM, Xin L, Zhang Y, Zhang WM, Cao P and Xu HW: Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression. Eur Rev Med Pharmacol Sci. 23:9411–9417. 2019.PubMed/NCBI

133 

Dai X, Guo X, Liu J, Cheng A, Peng X, Zha L and Wang Z: Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression. Aging (Albany NY). 11:9689–9708. 2019. View Article : Google Scholar

134 

Guan E, Xu X and Xue F: circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth. Biochem Cell Biol. 98:164–170. 2020. View Article : Google Scholar

135 

Cao C, Han S, Yuan Y, Wu Y, Lian W, Zhang X, Pan L and Li M: Downregulated circular RNA hsa_circ_0000291 suppresses migration and proliferation of gastric cancer via targeting the miR-183/ITGB1 axis. Cancer Manag Res. 11:9675–9683. 2019. View Article : Google Scholar : PubMed/NCBI

136 

Chen LH, Wang LP and Ma XQ: Circ_SPECC1 enhances the inhibition of miR-526b on downstream KDM4A/YAP1 pathway to regulate the growth and invasion of gastric cancer cells. Biochem Biophys Res Commun. 517:253–259. 2019. View Article : Google Scholar : PubMed/NCBI

137 

Chen Z, Ju H, Zhao T, Yu S, Li P, Jia J, Li N, Jing X, Tan B and Li Y: hsa_circ_0092306 targeting miR-197-3p promotes gastric cancer development by regulating PRKCB in MKN-45 cells. Mol Ther Nucleic Acids. 18:617–626. 2019. View Article : Google Scholar : PubMed/NCBI

138 

Du W, Li D, Guo X, Li P, Li X, Tong S, Tong J, Kuang L and Liang D: Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC. Artif Cells Nanomed Biotechnol. 47:4120–4130. 2019. View Article : Google Scholar : PubMed/NCBI

139 

Liang M, Huang G, Liu Z, Wang Q, Yu Z, Liu Z, Lin H, Li M, Zhou X and Zheng Y: Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195/GPRC5A signalling. Cell Prolif. 52:e126612019. View Article : Google Scholar : PubMed/NCBI

140 

Wang Q, Wang T, Hu Y, Jiang W, Lu C, Zheng W, Zhang W, Chen Z and Cao H: Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335. Pathol Res Pract. 215:1525072019. View Article : Google Scholar : PubMed/NCBI

141 

Wang S, Tang D, Wang W, Yang Y, Wu X, Wang L and Wang D: circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer. Mol Cancer. 18:1622019. View Article : Google Scholar : PubMed/NCBI

142 

Wu L, Liu D and Yang Y: Enhanced expression of circular RNA circ-DCAF6 predicts adverse prognosis and promotes cell progression via sponging miR-1231 and miR-1256 in gastric cancer. Exp Mol Pathol. 110:1042732019. View Article : Google Scholar : PubMed/NCBI

143 

Zhang H, Wang X, Huang H, Wang Y, Zhang F and Wang S: Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP). Artif Cells Nanomed Biotechnol. 47:308–318. 2019. View Article : Google Scholar : PubMed/NCBI

144 

Zhu Z, Rong Z, Luo Z, Yu Z, Zhang J, Qiu Z and Huang C: Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis. Mol Cancer. 18:1262019. View Article : Google Scholar : PubMed/NCBI

145 

Cai X, Nie J, Chen L and Yu F: Circ_0000267 promotes gastric cancer progression via sponging MiR-503-5p and regulating HMGA2 expression. Mol Genet Genomic Med. 8:e10932020. View Article : Google Scholar

146 

Deng G, Mou T, He J, Chen D, Lv D, Liu H, Yu J, Wang S and Li G: Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth. J Exp Clin Cancer Res. 39:12020. View Article : Google Scholar : PubMed/NCBI

147 

Guo X, Dai X, Liu J, Cheng A, Qin C and Wang Z: Circular RNA circREPS2 acts as a sponge of miR-558 to suppress gastric cancer progression by regulating RUNX3/β-catenin signaling. Mol Ther Nucleic Acids. 21:577–591. 2020. View Article : Google Scholar : PubMed/NCBI

148 

He Y, Wang Y, Liu L, Liu S, Liang L, Chen Y and Zhu Z: Circular RNA circ_0006282 contributes to the progression of gastric cancer by sponging miR-155 to upregulate the expression of FBXO22. Onco Targets Ther. 13:1001–1010. 2020. View Article : Google Scholar : PubMed/NCBI

149 

Hu K, Qin X, Shao Y, Zhou Y, Ye G and Xu S: Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1. Mol Cell Probes. 52:1015622020. View Article : Google Scholar : PubMed/NCBI

150 

Li B, Jin M, Cao F, Li J, Wu J, Xu L, Liu X, Shi Y and Chen W: Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3. Gene. 750:1447532020. View Article : Google Scholar : PubMed/NCBI

151 

Li C, Tian Y, Liang Y and Li Q: Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis. Cancer Cell Int. 20:842020. View Article : Google Scholar : PubMed/NCBI

152 

Li H, Shan C, Wang J and Hu C: CircRNA hsa_circ_0001017 inhibited gastric cancer progression via acting as a sponge of miR-197. Dig Dis Sci. Aug 1–2020.Epub ahead of print. View Article : Google Scholar

153 

Li Y, Gong Y, Ma J and Gong X: Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway. Biomed Pharmacother. 127:1102192020. View Article : Google Scholar : PubMed/NCBI

154 

Liang L and Li L: Down-regulation of circNRIP1 promotes the apoptosis and inhibits the migration and invasion of gastric cancer cells by miR-182/ROCK1 axis. Onco Targets Ther. 13:6279–6288. 2020. View Article : Google Scholar : PubMed/NCBI

155 

Lin J, Liao S, Li E, Liu Z, Zheng R, Wu X and Zeng W: circ-CYFIP2 acts as a sponge of miR-1205 and affects the expression of its target gene E2F1 to regulate gastric cancer metastasis. Mol Ther Nucleic Acids. 21:121–132. 2020. View Article : Google Scholar : PubMed/NCBI

156 

Lin S, Song S, Sun R, Zhang M, Du Y, Zhang D, Xu W and Wang H: Oncogenic circular RNA Hsa-circ-000684 interacts with microRNA-186 to upregulate ZEB1 in gastric cancer. FASEB J. 34:8187–8203. 2020. View Article : Google Scholar : PubMed/NCBI

157 

Liu J, Dai X, Guo X, Cheng A, Mac SM and Wang Z: Circ-OXCT1 suppresses gastric cancer EMT and metastasis by attenuating TGF-β pathway through the circ-OXCT1/miR-136/SMAD4 axis. Onco Targets Ther. 13:3987–3998. 2020. View Article : Google Scholar :

158 

Liu J, Liu H, Zeng Q, Xu P, Liu M and Yang N: Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1α axis. Cancer Cell Int. 20:1712020. View Article : Google Scholar

159 

Liu P, Cai S and Li N: Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis. Exp Cell Res. 394:1121412020. View Article : Google Scholar : PubMed/NCBI

160 

Lu J, Wang YH, Huang XY, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, Huang CM, Zheng CH and Li P: circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p. J Cell Physiol. 235:6287–6299. 2020. View Article : Google Scholar : PubMed/NCBI

161 

Lu J, Wang YH, Yoon C, Huang XY, Xu Y, Xie JW, Wang JB, Lin JX, Chen QY, Cao LL, et al: Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis. Cancer Lett. 471:38–48. 2020. View Article : Google Scholar

162 

Luo Z, Rong Z, Zhang J, Zhu Z, Yu Z, Li T, Fu Z, Qiu Z and Huang C: Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression. Mol Cancer. 19:862020. View Article : Google Scholar : PubMed/NCBI

163 

Ma Y, Cong X, Zhang Y, Yin X, Zhu Z and Xue Y: CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis. Cancer Cell Int. 20:812020. View Article : Google Scholar : PubMed/NCBI

164 

Song H, Xu Y, Xu T, Fan R, Jiang T, Cao M, Shi L and Song J: CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p. Biomed Pharmacother. 126:1099412020. View Article : Google Scholar : PubMed/NCBI

165 

Mo WL, Jiang JT, Zhang L, Lu QC, Li J, Gu WD, Cheng Y and Wang HT: Circular RNA hsa_circ_0000467 promotes the development of gastric cancer by competitively binding to MicroRNA miR-326-3p. Biomed Res Int. 2020:40308262020. View Article : Google Scholar : PubMed/NCBI

166 

Quan J, Dong D, Lun Y, Sun B, Sun H, Wang Q and Yuan G: Circular RNA circHIAT1 inhibits proliferation and epithelial-mesenchymal transition of gastric cancer cell lines through downregulation of miR-21. J Biochem Mol Toxicol. 34:e224582020. View Article : Google Scholar : PubMed/NCBI

167 

Sun B, Sun H, Wang Q, Wang X, Quan J, Dong D and Lun Y: Circular RNA circMAN2B2 promotes growth and migration of gastric cancer cells by down-regulation of miR-145. J Clin Lab Anal. 34:e232152020. View Article : Google Scholar : PubMed/NCBI

168 

Wang GJ, Yu TY, Li YR, Liu YJ and Deng BB: Circ_0000190 suppresses gastric cancer progression potentially via inhibiting miR-1252/PAK3 pathway. Cancer Cell Int. 20:3512020. View Article : Google Scholar : PubMed/NCBI

169 

Wang J, Lv W, Lin Z, Wang X, Bu J and Su Y: Hsa_ circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis. Cancer Cell Int. 20:572020. View Article : Google Scholar

170 

Wang N, Lu K, Qu H, Wang H, Chen Y, Shan T, Ge X, Wei Y, Zhou P and Xia J: CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149. Biomed Pharmacother. 125:1098762020. View Article : Google Scholar : PubMed/NCBI

171 

Wang Y, Zhang J, Chen X and Gao L: Circ_0001023 promotes proliferation and metastasis of gastric cancer cells through miR-409-3p/PHF10 axis. Onco Targets Ther. 13:4533–4544. 2020. View Article : Google Scholar :

172 

Wei W, Mo X, Yan L, Huang M, Yang Y, Jin Q, Zhong H, Cao W, Wu K, Wu L, et al: Circular RNA profiling reveals that circRNA_104433 regulates cell growth by targeting miR-497-5p in gastric cancer. Cancer Manag Res. 12:15–30. 2020. View Article : Google Scholar : PubMed/NCBI

173 

Wu J, Chen Z, Song Y, Zhu Y, Dou G, Shen X, Zhou Y, Jiang H, Li J and Peng Y: CircRNA_0005075 suppresses carcinogenesis via regulating miR-431/p53/epithelial-mesenchymal transition axis in gastric cancer. Cell Biochem Funct. Mar 4–2020.Epub ahead of print. View Article : Google Scholar

174 

Wu Q, Wang H, Liu L, Zhu K, Yu W and Guo J: Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway. Biochem Biophys Res Commun. 521:303–309. 2020. View Article : Google Scholar

175 

Xia T, Pan Z and Zhang J: CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis. Cancer Med. 9:4299–4309. 2020. View Article : Google Scholar : PubMed/NCBI

176 

Xie M, Yu T, Jing X, Ma L, Fan Y, Yang F, Ma P, Jiang H, Wu X, Shu Y and Xu T: Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation. Mol Cancer. 19:1122020. View Article : Google Scholar : PubMed/NCBI

177 

Xu W, Zhou B, Wu J, Jiang P, Chen H and Yan F: Circular RNA hsa-circ-0007766 modulates the progression of gastric carcinoma via miR-1233-3p/GDF15 axis. Int J Med Sci. 17:1569–1583. 2020. View Article : Google Scholar :

178 

Yu X, Xiao W, Song H, Jin Y, Xu J and Liu X: CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression. Gene. 748:1446782020. View Article : Google Scholar : PubMed/NCBI

179 

Zhang L, Chang X, Zhai T, Yu J, Wang W, Du A and Liu N: A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis. Biochem Biophys Res Commun. 525:841–849. 2020. View Article : Google Scholar : PubMed/NCBI

180 

Zhang Y, Xia L, Wu J, Xu X and Li G: Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA-223. J Clin Lab Anal. Jun 19–2020.Epub ahead of print. View Article : Google Scholar

181 

Zhang Z, Wang C, Zhang Y, Yu S, Zhao G and Xu J: CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p. Gastric Cancer. 23:437–448. 2020. View Article : Google Scholar :

182 

Zhang Z, Wu H, Chen Z, Li G and Liu B: Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4. Cancer Cell Int. 20:252020. View Article : Google Scholar : PubMed/NCBI

183 

Li RC, Ke S, Meng FK, Lu J, Zou XJ, He ZG, Wang WF and Fang MH: CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell Death Dis. 9:8382018. View Article : Google Scholar : PubMed/NCBI

184 

Aliahmad P and Kaye J: Development of all CD4 T lineages requires nuclear factor TOX. J Exp Med. 205:245–256. 2008. View Article : Google Scholar : PubMed/NCBI

185 

Piwecka M, Glažar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, et al: Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science. 357:eaam85262017. View Article : Google Scholar : PubMed/NCBI

186 

Geng HH, Li R, Su YM, Xiao J, Pan M, Cai XX and Ji XP: The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression. PLoS One. 11:e01517532016. View Article : Google Scholar : PubMed/NCBI

187 

Sang M, Meng L, Sang Y, Liu S, Ding P, Ju Y, Liu F, Gu L, Lian Y, Li J, et al: Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression. Cancer Lett. 426:37–46. 2018. View Article : Google Scholar : PubMed/NCBI

188 

Li F, Zhang L, Li W, Deng J, Zheng J, An M, Lu J and Zhou Y: Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway. Oncotarget. 6:6001–6013. 2015. View Article : Google Scholar : PubMed/NCBI

189 

Su H, Lin F, Deng X, Shen L, Fang Y, Fei Z, Zhao L, Zhang X, Pan H, Xie D, et al: Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells. J Transl Med. 14:2252016. View Article : Google Scholar : PubMed/NCBI

190 

Zheng B, Wu Z, Xue S, Chen H, Zhang S, Zeng T, Xu G, Wu W, Zheng W and Chen C: hsa_circRNA_100873 upregulation is associated with increased lymphatic metastasis of esophageal squamous cell carcinoma. Oncol Lett. 18:6836–6844. 2018.

191 

Pan Z, Lin J, Wu D, He X, Wang W, Hu X, Zhang L and Wang M: Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma. Aging (Albany NY). 11:11937–11954. 2019. View Article : Google Scholar

192 

Liu J, Xue N, Guo Y, Niu K, Gao L, Zhang S, Gu H, Wang X, Zhao D and Fan R: CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217/Wnt3 pathway. Aging (Albany NY). 11:12412–12427. 2019. View Article : Google Scholar

193 

Huang E, Fu J, Yu Q, Xie P, Yang Z, Ji H, Wang L, Luo G, Zhang Y and Li K: CircRNA hsa circ 0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC 25A axis. Epigenomics. 12:587–603. 2020. View Article : Google Scholar : PubMed/NCBI

194 

Hou Y, Liu H and Pan W: Knockdown of circ_0003340 induces cell apoptosis, inhibits invasion and proliferation through miR-564/TPX2 in esophageal cancer cells. Exp Cell Res. 394:1121422020. View Article : Google Scholar : PubMed/NCBI

195 

Lan X, Liu X, Sun J, Yuan Q and Li J: CircRAD23B facilitates proliferation and invasion of esophageal cancer cells by sponging miR-5095. Biochem Biophys Res Commun. 516:357–364. 2019. View Article : Google Scholar : PubMed/NCBI

196 

Liu Z, Hu G, Zhao Y, Xiao Z, Yan M and Ren M: Silence of cZNF292 suppresses the growth, migration, and invasion of human esophageal cancer Eca-109 cells via upregulating miR-206. J Cell Biochem. 121:2354–2362. 2019. View Article : Google Scholar : PubMed/NCBI

197 

Ma Y, Zhang D, Wu H, Li P, Zhao W, Yang X, Xing X, Li S and Li J: Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p/PARP9 axis. Life Sci. 259:1181682020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

198 

Shi Y, Guo Z, Fang N, Jiang W, Fan Y, He Y, Ma Z and Chen Y: hsa_circ_0006168 sponges miR-100 and regulates mTOR to promote the proliferation, migration and invasion of esophageal squamous cell carcinoma. Biomed Pharmacother. 117:1091512019. View Article : Google Scholar : PubMed/NCBI

199 

Wu Y, Zhi L, Zhao Y, Yang L and Cai F: Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA-422a/Rab10 axis. Clin Exp Pharmacol Physiol. 47:1283–1290. 2020. View Article : Google Scholar : PubMed/NCBI

200 

Xu Z, Tie X, Li N, Yi Z, Shen F and Zhang Y: Circular RNA hsa_circ_0000654 promotes esophageal squamous cell carcinoma progression by regulating the miR-149-5p/IL-6/STAT3 pathway. IUBMB Life. 72:426–439. 2020. View Article : Google Scholar

201 

Chen Z, Yao N, Gu H, Song Y, Ye Z, Li L, Lu P and Shao Q: Circular RNA_LARP4 sponges miR-1323 and hampers progression of esophageal squamous cell carcinoma through modulating PTEN/PI3K/AKT pathway. Dig Dis Sci. 65:2272–2283. 2020. View Article : Google Scholar : PubMed/NCBI

202 

Xu L, Zhang M, Zheng X, Yi P, Lan C and Xu M: The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma. J Cancer Res Clin Oncol. 143:17–27. 2017. View Article : Google Scholar

203 

Yu J, Xu QG, Wang ZG, Yang Y, Zhang L, Ma JZ, Sun SH, Yang F and Zhou WP: Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. J Hepatol. 68:1214–1227. 2018. View Article : Google Scholar : PubMed/NCBI

204 

Lin X and Chen Y: Identification of potentially functional circRNA-miRNA-mRNA regulatory network in hepatocellular carcinoma by integrated microarray analysis. Med Sci Monit Basic Res. 24:70–78. 2018. View Article : Google Scholar : PubMed/NCBI

205 

Zhang X, Hu S, Zhang X, Wang L, Zhang X, Yan B, Zhao J, Yang A and Zhang R: MicroRNA-7 arrests cell cycle in G1 phase by directly targeting CCNE1 in human hepatocellular carcinoma cells. Biochem Biophys Res Commun. 443:1078–1084. 2014. View Article : Google Scholar

206 

Yu L, Gong X, Sun L, Zhou Q, Lu B and Zhu L: The circular RNA Cdr1as Act as an oncogene in hepatocellular carcinoma through targeting miR-7 expression. PLoS One. 11:e01583472016. View Article : Google Scholar : PubMed/NCBI

207 

Qin M, Liu G, Huo X, Tao X, Sun X, Ge Z, Yang J, Fan J, Liu L and Qin W: Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomark. 16:161–169. 2016. View Article : Google Scholar

208 

Han D, Li J, Wang H, Su X, Hou J, Gu Y, Qian C, Lin Y, Liu X, Huang M, et al: Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology. 66:1151–1164. 2017. View Article : Google Scholar : PubMed/NCBI

209 

Meng J, Chen S, Han JX, Qian B, Wang XR, Zhong WL, Qin Y, Zhang H, Gao WF, Lei YY, et al: Twist1 regulates vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma. Cancer Res. 78:4150–4162. 2018. View Article : Google Scholar : PubMed/NCBI

210 

Li X and Shen M: Circular RNA hsa_circ_103809 suppresses hepatocellular carcinoma proliferation and invasion by sponging miR-620. Eur Rev Med Pharmacol Sci. 23:555–566. 2019.PubMed/NCBI

211 

Wei Y, Chen X, Liang C, Ling Y, Yang X, Ye X, Zhang H, Yang P, Cui X, Ren Y, et al: A noncoding regulatory RNAs network driven by Circ-CDYL acts specifically in the early stages hepatocellular carcinoma. Hepatology. 71:130–147. 2020. View Article : Google Scholar

212 

Fu L, Chen Q, Yao T, Li T, Ying S, Hu Y and Guo J: Hsa_ circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma. Oncotarget. 8:43878–43888. 2017. View Article : Google Scholar : PubMed/NCBI

213 

Fu L, Yao T, Chen Q, Mo X, Hu Y and Guo J: Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma. Oncotarget. 8:58405–58416. 2017. View Article : Google Scholar : PubMed/NCBI

214 

Su Y, Xu C, Liu Y, Hu Y and Wu H: Circular RNA hsa_ circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge. Aging (Albany NY). 11:3362–3375. 2019. View Article : Google Scholar

215 

Cao S, Wang G, Wang J, Li C and Zhang L: Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR-375/JAK2. Immunol Cell Biol. 97:218–228. 2019. View Article : Google Scholar

216 

Guan Z, Tan J, Gao W, Li X, Yang Y, Li X, Li Y and Wang Q: Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR-486/CDK4 pathway. J Cell Physiol. 234:500–508. 2018. View Article : Google Scholar : PubMed/NCBI

217 

Guo J, Duan H, Li Y, Yang L and Yuan L: A novel circular RNA circ-ZNF652 promotes hepatocellular carcinoma metastasis through inducing snail-mediated epithelial-mesenchymal transition by sponging miR-203/miR-502-5p. Biochem Biophys Res Commun. 513:812–819. 2019. View Article : Google Scholar : PubMed/NCBI

218 

Jiang W, Wen D, Gong L, Wang Y, Liu Z and Yin F: Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET. Biochem Biophys Res Commun. 500:211–216. 2018. View Article : Google Scholar : PubMed/NCBI

219 

Li MF, Li YH, He YH, Wang Q, Zhang Y, Li XF, Meng XM, Huang C and Li J: Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC. Biomed Pharmacother. 99:848–858. 2018. View Article : Google Scholar : PubMed/NCBI

220 

Liu H, Xue L, Song C, Liu F, Jiang T and Yang X: Overexpression of circular RNA circ_001569 indicates poor prognosis in hepa-tocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p. Biochem Biophys Res Commun. 503:2659–2665. 2018. View Article : Google Scholar : PubMed/NCBI

221 

Liu L, Qi X, Gui Y, Huo H, Yang X and Yang L: Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma. Gene. 714:1439922019. View Article : Google Scholar : PubMed/NCBI

222 

Pan H, Tang L, Jiang H, Li X, Wang R, Gao J and Li Q: Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646. J Cell Biochem. Feb 5–2019.Epub ahead of print. View Article : Google Scholar

223 

Qi SX, Sun H, Liu H, Yu J, Jiang ZY and Yan P: Role and mechanism of circ-PRKCI in hepatocellular carcinoma. World J Gastroenterol. 25:1964–1974. 2019. View Article : Google Scholar : PubMed/NCBI

224 

Wang YG, Wang T, Ding M, Xiang SH, Shi M and Zhai B: hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307. Cancer Lett. 460:128–138. 2019. View Article : Google Scholar : PubMed/NCBI

225 

Xu L, Feng X, Hao X, Wang P, Zhang Y, Zheng X, Li L, Ren S, Zhang M and Xu M: CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth. J Exp Clin Cancer Res. 38:982019. View Article : Google Scholar : PubMed/NCBI

226 

Zhang J, Chang Y, Xu L and Qin L: Elevated expression of circular RNA circ_0008450 predicts dismal prognosis in hepa-tocellular carcinoma and regulates cell proliferation, apoptosis, and invasion via sponging miR-548p. J Cell Biochem. 120:9487–9494. 2019. View Article : Google Scholar

227 

Zheng H, Chen T, Li C, Xu C, Ding C, Chen J, Ju S, Zhang Z, Liang Z, Cui Z and Zhao J: A circular RNA hsa_circ_0079929 inhibits tumor growth in hepatocellular carcinoma. Cancer Manag Res. 11:443–454. 2019. View Article : Google Scholar : PubMed/NCBI

228 

Song C, Li D, Liu H, Sun H, Liu Z, Zhang L and Hu Y: The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1. J Cell Physiol. 234:2460–2470. 2019. View Article : Google Scholar

229 

Zhang PF, Wei CY, Huang XY, Peng R, Yang X, Lu JC, Zhang C, Gao C, Cai JB, Gao PT, et al: Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression. Mol Cancer. 18:1052019. View Article : Google Scholar : PubMed/NCBI

230 

Song H, Bian ZX, Li HY, Zhang Y, Ma J, Chen SH, Zhu JB, Zhang X, Wang J, Gu S, et al: Characterization of hsa_circ_0000594 as a new biomarker and therapeutic target for hepatoblastoma. Eur Rev Med Pharmacol Sci. 23:8274–8286. 2019.PubMed/NCBI

231 

Ding Y, Fang A, Yan J, Duan J, Wang N, Yi Y and Shen C: Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma. Oncol Lett. 18:5255–5268. 2019.PubMed/NCBI

232 

Zhu Q, Lu G, Luo Z, Gui F, Wu J, Zhang D and Ni Y: CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis. Biochem Biophys Res Commun. 497:626–632. 2018. View Article : Google Scholar : PubMed/NCBI

233 

Liu C, Zhong X, Li J and Xu F: Circular RNA circVAPA promotes cell proliferation in hepatocellular carcinoma. Hum Gene Ther Clin Dev. 30:152–159. 2019. View Article : Google Scholar : PubMed/NCBI

234 

Tan A, Li Q and Chen L: CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/β-catenin pathway. Arch Biochem Biophys. 661:196–202. 2019. View Article : Google Scholar

235 

Zhang X, Luo P, Jing W, Zhou H, Liang C and Tu J: circSMAD2 inhibits the epithelial-mesenchymal transition by targeting miR-629 in hepatocellular carcinoma. Onco Targets Ther. 11:2853–2863. 2018. View Article : Google Scholar : PubMed/NCBI

236 

Yang W, Ju HY and Tian XF: Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p. Eur Rev Med Pharmacol Sci. 24:2347–2357. 2020.PubMed/NCBI

237 

Li Z, Liu Y, Yan J, Zeng Q, Hu Y, Wang H, Li H, Li J and Yu Z: Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis. Aging (Albany NY). 12:2485–2497. 2020. View Article : Google Scholar

238 

Wang Y, Gao R, Li J, Tang S, Li S, Tong Q and Mao Y: Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis. Aging (Albany NY). 12:9793–9806. 2020. View Article : Google Scholar

239 

Jin J, Liu H, Jin M, Li W, Xu H and Wei F: Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis. Aging (Albany NY). 12:11623–11635. 2020. View Article : Google Scholar

240 

Li Z, Hu Y, Zeng Q, Wang H, Yan J, Li H and Yu Z: Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p. Cancer Cell Int. 19:2112019. View Article : Google Scholar : PubMed/NCBI

241 

Lin T, Dai Y, Guo X, Chen W, Zhao J, Cao L and Wu Z: Silencing of hsa_circ_0008450 represses hepatocellular carcinoma progression through regulation of microRNA-214-3p/EZH2 axis. Cancer Manag Res. 11:9133–9143. 2019. View Article : Google Scholar : PubMed/NCBI

242 

Liu L, Yang X, Li NF, Lin L and Luo H: Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma. Cell Cycle. 18:2939–2953. 2019. View Article : Google Scholar : PubMed/NCBI

243 

Liu Z, Yu Y, Huang Z, Kong Y, Hu X, Xiao W, Quan J and Fan X: CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression. Cell Death Dis. 10:9002019. View Article : Google Scholar : PubMed/NCBI

244 

Tian F, Yu C, Wu M, Wu X, Wan L and Zhu X: MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_ circ_0000204/miR-191/KLF6 axis. Cell Prolif. 52:e126352019. View Article : Google Scholar

245 

Yang X, Liu L, Zou H, Zheng YW and Wang KP: circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma. Dig Liver Dis. 51:1446–1455. 2019. View Article : Google Scholar : PubMed/NCBI

246 

Yang X, Song H, Zi Z, Kou J, Chen S, Dai Y, Wang J, Yuan L and Gao K: Circ_0005075 promotes hepatocellular carcinoma progression by suppression of microRNA-335. J Cell Physiol. 234:21937–21946. 2019. View Article : Google Scholar : PubMed/NCBI

247 

Yao Z, Xu R, Yuan L, Xu M, Zhuang H, Li Y, Zhang Y and Lin N: Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11. Cell Death Dis. 10:9452019. View Article : Google Scholar : PubMed/NCBI

248 

Zhu Y, Liu Y, Xiao B, Cai H, Liu M, Ma L, Yin H and Wang F: The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma. Biol Open. 8:bio0436872019. View Article : Google Scholar : PubMed/NCBI

249 

Zou H, Xu X, Luo L, Zhang Y, Luo L, Yao Y, Xiang G, Huang X and Wang G: Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622. Cell Cycle. 18:2398–2413. 2019. View Article : Google Scholar : PubMed/NCBI

250 

Cao Y, Tao Q, Kao X and Zhu X: Hsa-circRNA-103809 promotes hepatocellular carcinoma development via MicroRNA-1270/PLAG1 like zinc finger 2 axis. Dig Dis Sci. Jul 18–2020.Epub ahead of print. View Article : Google Scholar

251 

Ding Z, Guo L, Deng Z and Li P: Circ-PRMT5 enhances the proliferation, migration and glycolysis of hepatoma cells by targeting miR-188-5p/HK2 axis. Ann Hepatol. 19:269–279. 2020. View Article : Google Scholar : PubMed/NCBI

252 

Fu X, Zhang J, He X, Yan X, Wei J, Huang M, Liu Y, Lin J, Hu H and Liu L: Circular RNA MAN2B2 promotes cell proliferation of hepatocellular carcinoma cells via the miRNA-217/MAPK1 axis. J Cancer. 11:3318–3326. 2020. View Article : Google Scholar : PubMed/NCBI

253 

Gao J, Dai C, Yu X, Yin XB and Zhou F: Circ-TCF4.85 silencing inhibits cancer progression through microRNA-486-5p-targeted inhibition of ABCF2 in hepatocellular carcinoma. Mol Oncol. 14:447–461. 2020. View Article : Google Scholar :

254 

Gao S, Hu W, Huang X, Huang X, Chen W, Hao L, Chen Z, Wang J and Wei H: Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression. Cell Signal. 72:1096212020. View Article : Google Scholar : PubMed/NCBI

255 

He Y, Huang H, Jin L, Zhang F, Zeng M, Wei L, Tang S, Chen D and Wang W: CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions. Cell Death Dis. 11:3582020. View Article : Google Scholar : PubMed/NCBI

256 

Huang XY, Zhang PF, Wei CY, Peng R, Lu JC, Gao C, Cai JB, Yang X, Fan J, Ke AW, et al: Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepa-tocellular carcinoma via the miR-30-5p/snail/DPP4 axis. Mol Cancer. 19:922020. View Article : Google Scholar

257 

Jia B, Yin X, Wang Y, Qian J, He Y, Yang C, Yu G, Guo B and Meng X: CircRNA-PTN sponges miR-326 to promote proliferation in hepatocellular carcinoma. Onco Targets Ther. 13:4893–4903. 2020. View Article : Google Scholar : PubMed/NCBI

258 

Jia C, Yao Z, Lin Z, Zhao L, Cai X, Chen S, Deng M and Zhang Q: circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression. J Cell Physiol. Jul 15–2020.Epub ahead of print. View Article : Google Scholar

259 

Li J, Qin X, Wu R, Wan L, Zhang L and Liu R: Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis. J Cell Mol Med. 24:5152–5161. 2020. View Article : Google Scholar : PubMed/NCBI

260 

Li S, Weng J, Song F, Li L, Xiao C, Yang W and Xu J: Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression. Cell Death Dis. 11:4522020. View Article : Google Scholar : PubMed/NCBI

261 

Li Y, Shi H, Yuan J, Qiao L, Dong L and Wang Y: Downregulation of circular RNA circPVT1 restricts cell growth of hepatocel-lular carcinoma through downregulation of Sirtuin 7 via microRNA-3666. Clin Exp Pharmacol Physiol. 47:1291–1300. 2020. View Article : Google Scholar : PubMed/NCBI

262 

Lin Y, Huang G, Jin H and Jian Z: Circular RNA Gprc5a promotes HCC progression by activating YAP1/TEAD1 signalling pathway by sponging miR-1283. Onco Targets Ther. 13:4509–4521. 2020. View Article : Google Scholar : PubMed/NCBI

263 

Liu W, Yin C and Liu Y: Circular RNA circ_0091579 promotes hepatocellular carcinoma proliferation, migration, invasion, and glycolysis through miR-490-5p/CASC3 axis. Cancer Biother Radiopharm. Jul 14–2020.Epub ahead of print. View Article : Google Scholar

264 

Liu X, Yang L, Jiang D, Lu W and Zhang Y: Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/β-catenin signal pathway. Cancer Cell Int. 20:2952020. View Article : Google Scholar

265 

Pu J, Wang J, Li W, Lu Y, Wu X, Long X, Luo C and Wei H: hsa_circ_0000092 promotes hepatocellular carcinoma progression through up-regulating HN1 expression by binding to microRNA-338-3p. J Cell Mol Med. Feb 20–2020.Epub ahead of print. View Article : Google Scholar

266 

Song LN, Qiao GL, Yu J, Yang CM, Chen Y, Deng ZF, Song LH, Ma LJ and Yan HL: Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1. J Exp Clin Cancer Res. 39:1142020. View Article : Google Scholar : PubMed/NCBI

267 

Sun Q, Yu R, Wang C, Yao J and Zhang L: Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577. Cancer Cell Int. 20:2022020. View Article : Google Scholar : PubMed/NCBI

268 

Wang W, Li Y, Li X, Liu B, Han S, Li X, Zhang B, Li J and Sun S: Circular RNA circ-FOXP1 induced by SOX9 promotes hepatocellular carcinoma progression via sponging miR-875-3p and miR-421. Biomed Pharmacother. 121:1095172020. View Article : Google Scholar

269 

Wei X, Zheng W, Tian P, He Y, Liu H, Peng M, Li X and Liu X: Oncogenic hsa_circ_0091581 promotes the malignancy of HCC cell through blocking miR-526b from degrading c-MYC mRNA. Cell Cycle. 19:817–824. 2020. View Article : Google Scholar : PubMed/NCBI

270 

Yang J, Li Y, Yu Z, Zhou Y, Tu J, Lou J and Wang Y: Circular RNA Circ100084 functions as sponge of miR23a5p to regulate IGF2 expression in hepatocellular carcinoma. Mol Med Rep. 21:2395–2404. 2020.PubMed/NCBI

271 

Yu X, Sheng P, Sun J, Zhao X, Zhang J, Li Y, Zhang Y, Zhang W, Wang J, Liu K, et al: The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression. Cell Death Dis. 11:3402020. View Article : Google Scholar : PubMed/NCBI

272 

Zang H, Li Y, Zhang X and Huang G: Circ_0000517 contributes to hepatocellular carcinoma progression by upregulating TXNDC5 via sponging miR-1296-5p. Cancer Manag Res. 12:3457–3468. 2020. View Article : Google Scholar : PubMed/NCBI

273 

Zhang W, Zhu L, Yang G, Zhou B, Wang J, Qu X, Yan Z, Qian S and Liu R: Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p. Biosci Rep. 40:BSR201914182020. View Article : Google Scholar : PubMed/NCBI

274 

Zhao M, Dong G, Meng Q, Lin S and Li X: Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma cells. J Cell Biochem. Feb 9–2020.Epub ahead of print.

275 

Kim Y, Bang SS, Jee S, Park S, Shin SJ and Jang K: Prevalence and clinicopathological significance of MET overexpression and gene amplification in patients with gallbladder carcinoma. Cancer Res Treat. 52:481–491. 2020. View Article : Google Scholar :

276 

McNamara MG, Metran-Nascente C and Knox JJ: State-of-the-art in the management of locally advanced and metastatic gallbladder cancer. Curr Opin Oncol. 25:425–431. 2013. View Article : Google Scholar : PubMed/NCBI

277 

Sung YN, Song M, Lee JH, Song KB, Hwang DW, Ahn CS, Hwang S and Hong SM: Validation of the 8th edition of the American joint committee on cancer staging system for gallbladder cancer and implications for the follow-up of patients without node dissection. Cancer Res Treat. 52:455–468. 2020. View Article : Google Scholar :

278 

Kakaei F, Beheshtirouy S, Nejatollahi SM, Zarrintan S and Mafi MR: Surgical treatment of gallbladder carcinoma: A critical review. Updates Surg. 67:339–351. 2015. View Article : Google Scholar : PubMed/NCBI

279 

Kai D, Yannian L, Yitian C, Dinghao G, Xin Z and Wu J: Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124. Biochem Biophys Res Commun. 503:863–869. 2018. View Article : Google Scholar : PubMed/NCBI

280 

Wang S, Zhang Y, Cai Q, Ma M, Jin LY, Weng M, Zhou D, Tang Z, Wang JD and Quan Z: Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression. Mol Cancer. 18:1452019. View Article : Google Scholar : PubMed/NCBI

281 

Huang X, He M, Huang S, Lin R, Zhan M, Yang D, Shen H, Xu S, Cheng W, Yu J, et al: Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription. Mol Cancer. 18:1662019. View Article : Google Scholar : PubMed/NCBI

282 

Li T, Shao Y, Fu L, Xie Y, Zhu L, Sun W, Yu R, Xiao B and Guo J: Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl). 96:85–96. 2018. View Article : Google Scholar

283 

Su BB, Shi H and Wan J: Role of serum carcinoembryonic antigen in the detection of colorectal cancer before and after surgical resection. World J Gastroenterol. 18:2121–2126. 2012. View Article : Google Scholar : PubMed/NCBI

284 

Lee WS, Baek JH, Kim KK and Park YH: The prognostic significant of percentage drop in serum CEA post curative resection for colon cancer. Surg Oncol. 21:45–51. 2012. View Article : Google Scholar

285 

Shao Y, Li J, Lu R, Li T, Yang Y, Xiao B and Guo J: Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med. 6:1173–1180. 2017. View Article : Google Scholar : PubMed/NCBI

286 

Wang T, Shigdar S, Shamaileh HA, Gantier MP, Yin W, Xiang D, Wang L, Zhou SF, Hou Y, Wang P, et al: Challenges and opportunities for siRNA-based cancer treatment. Cancer Lett. 387:77–83. 2017. View Article : Google Scholar

287 

Zhang M and Xin Y: Circular RNAs: A new frontier for cancer diagnosis and therapy. J Hematol Oncol. 11:212018. View Article : Google Scholar : PubMed/NCBI

288 

Ebert MS and Sharp PA: MicroRNA sponges: Progress and possibilities. RNA. 16:2043–2050. 2010. View Article : Google Scholar : PubMed/NCBI

289 

Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15:4092014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Wang Y, Yu Q, Yu P, Zheng Q, Yang X and Gao D: Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review). Int J Mol Med 46: 1611-1632, 2020.
APA
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., & Gao, D. (2020). Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review). International Journal of Molecular Medicine, 46, 1611-1632. https://doi.org/10.3892/ijmm.2020.4731
MLA
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., Gao, D."Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)". International Journal of Molecular Medicine 46.5 (2020): 1611-1632.
Chicago
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., Gao, D."Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)". International Journal of Molecular Medicine 46, no. 5 (2020): 1611-1632. https://doi.org/10.3892/ijmm.2020.4731
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Wang Y, Yu Q, Yu P, Zheng Q, Yang X and Gao D: Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review). Int J Mol Med 46: 1611-1632, 2020.
APA
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., & Gao, D. (2020). Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review). International Journal of Molecular Medicine, 46, 1611-1632. https://doi.org/10.3892/ijmm.2020.4731
MLA
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., Gao, D."Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)". International Journal of Molecular Medicine 46.5 (2020): 1611-1632.
Chicago
Zhao, X., Wang, Y., Yu, Q., Yu, P., Zheng, Q., Yang, X., Gao, D."Circular RNAs in gastrointestinal cancer: Current knowledge, biomarkers and targeted therapy (Review)". International Journal of Molecular Medicine 46, no. 5 (2020): 1611-1632. https://doi.org/10.3892/ijmm.2020.4731
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team