Open Access

CAPN6 in disease: An emerging therapeutic target (Review)

  • Authors:
    • Lin Chen
    • Dongqiong Xiao
    • Fajuan Tang
    • Hu Gao
    • Xihong Li
  • View Affiliations

  • Published online on: September 21, 2020     https://doi.org/10.3892/ijmm.2020.4734
  • Pages: 1644-1652
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

As a member of the calpain protein family, calpain6 (CAPN6) is highly expressed mainly in the placenta and embryos. It plays a number of important roles in cellular processes, such as the stabilization of microtubules, the maintenance of cell stability, the control of cell movement and the inhibition of apoptosis. In recent years, various studies have found that CAPN6 is one of the contributing factors associated with the tumorigenesis of uterine tumors and osteosarcoma, and that CAPN6 participates in the development of tumors by promoting cell proliferation and angiogenesis, and by inhibiting apoptosis, which is mainly regulated by the phosphatidylinositol 3 kinase (PI3K)/protein kinase B (Akt) pathway. Due to its abnormal cellular expression, CAPN6 has also been found to be associated with a number of diseases, such as white matter damage and muscular dystrophy. Therefore, CAPN6 may be a novel therapeutic target for these diseases. In the present review, the role of CAPN6 in disease and its possible use as a target in various therapies are discussed.
View Figures
View References

Related Articles

Journal Cover

November-2020
Volume 46 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Xiao D, Tang F, Gao H and Li X: CAPN6 in disease: An emerging therapeutic target (Review). Int J Mol Med 46: 1644-1652, 2020
APA
Chen, L., Xiao, D., Tang, F., Gao, H., & Li, X. (2020). CAPN6 in disease: An emerging therapeutic target (Review). International Journal of Molecular Medicine, 46, 1644-1652. https://doi.org/10.3892/ijmm.2020.4734
MLA
Chen, L., Xiao, D., Tang, F., Gao, H., Li, X."CAPN6 in disease: An emerging therapeutic target (Review)". International Journal of Molecular Medicine 46.5 (2020): 1644-1652.
Chicago
Chen, L., Xiao, D., Tang, F., Gao, H., Li, X."CAPN6 in disease: An emerging therapeutic target (Review)". International Journal of Molecular Medicine 46, no. 5 (2020): 1644-1652. https://doi.org/10.3892/ijmm.2020.4734