Research advances in the role of gastric cancer‑derived mesenchymal stem cells in tumor progression (Review)
- Authors:
- Jiaqi Shen
- Wei Zhu
-
Affiliations: Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China - Published online on: December 4, 2020 https://doi.org/10.3892/ijmm.2020.4810
- Pages: 455-462
This article is mentioned in:
Abstract
 |
 |
|
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Suzuki H, Oda I, Abe S, Sekiguchi M, Mori G, Nonaka S, Yoshinaga S and Saito Y: High rate of 5-year survival among patients with early gastric cancer undergoing curative endoscopic submucosal dissection. Gastric Cancer. 19:198–205. 2016. View Article : Google Scholar | |
|
Hsu A, Chudasama R, Almhanna K and Raufi A: Targeted therapies for gastroesophageal cancers. Ann Transl Med. 8:11042020. View Article : Google Scholar : PubMed/NCBI | |
|
Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KE, Pritchard DM, Rugge M, et al: The stomach in health and disease. Gut. 64:1650–1668. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Dolcetti R, De Re V and Canzonieri V: Immunotherapy for Gastric Cancer: Time for a personalized approach? Int J Mol Sci. 19:16022018. View Article : Google Scholar : | |
|
Cheng HS, Lee JXT, Wahli W and Tan NS: Exploiting vulnerabilities of cancer by targeting nuclear receptors of stromal cells in tumor microenvironment. Mol Cancer. 18:512019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou ZX and Lu ZR: Molecular imaging of the tumor microen-vironment. Adv Drug Deliver Rev. 113:24–48. 2017. View Article : Google Scholar | |
|
Denton AE, Roberts EW and Fearon DT: Stromal Cells in the Tumor Microenvironment. Adv Exp Med Biol. 1060:99–114. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan HX, Zhou B, Cheng YG, Xu JW, Wang L, Zhang GY and Hu SY: Crosstalk between stromal cells and cancer cells in pancreatic cancer: New insights into stromal biology. Cancer Lett. 392:83–93. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen DX, Chen G, Jiang W, Fu M, Liu W, Sui J, Xu S, Liu Z, Zheng X, Chi L, et al: Association of the collagen signature in the tumor microenvironment with lymph node metastasis in early gastric cancer. JAMA Surg. 154:e1852492019. View Article : Google Scholar : PubMed/NCBI | |
|
Hodgson A, Xu B, Satkunasivam R and Downes MR: Tumour front inflammation and necrosis are independent prognostic predictors in high-grade urothelial carcinoma of the bladder. J Clin Pathol. 71:154–160. 2018. View Article : Google Scholar | |
|
Patil S and Singh N: Spatially controlled functional group grafting of silk films to induce osteogenic and chondrogenic differentiation of human mesenchymal stem cells. Mater Sci Eng C Mater Biol Appl. 91:796–805. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ghaneialvar H, Soltani L, Rahmani HR, Lotfi AS and Soleimani M: Characterization and classification of mesenchymal stem cells in several species using surface markers for cell therapy purposes. Indian J Clin Biochem. 33:46–52. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Schafer R and Bieback K: Characterization of mesenchymal stem or stromal cells: Tissue sources, heterogeneity, and function. Transfusion. 56:S2–S5. 2016. View Article : Google Scholar | |
|
Wang Y, Chen X, Cao W and Shi Y: Plasticity of mesenchymal stem cells in immunomodulation: Pathological and therapeutic implications. Nat Immunol. 15:1009–1016. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Zong C, Zhang HJ, Yang X, Gao L, Hou J, Ye F, Jiang J, Yang Y, Li R, Han Z and Wei L: The distinct roles of mesenchymal stem cells in the initial and progressive stage of hepatocarcinoma. Cell Death Dis. 9:3452018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Hu FY, Li G, Li G, Yang X, Liu L, Zhang R, Zhang B and Feng Y: Human colorectal cancer-derived mesenchymal stem cells promote colorectal cancer progression through IL-6/JAK2/STAT3 signaling. Cell Death Dis. 9:252018. View Article : Google Scholar : PubMed/NCBI | |
|
Dvorak HF: Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med. 315:1650–1659. 1986. View Article : Google Scholar : PubMed/NCBI | |
|
Chen J, Ma L, Zhang N, Zhu Y, Zhang K, Xu Z and Wang Q: Mesenchymal stem cells promote tumor progression via inducing stroma remodeling on rabbit VX2 bladder tumor model. Int J Biol Sci. 14:1012–1021. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Gao T, Yu Y, Cong Q, Wang Y, Sun M, Yao L, Xu C and Jiang W: Human mesenchymal stem cells in the tumour micro-environment promote ovarian cancer progression: The role of platelet-activating factor. BMC Cancer. 18:9992018. View Article : Google Scholar | |
|
Shojaei S, Hashemi SM, Ghanbarian H, Salehi M and Mohammadi-Yeganeh S: Effect of mesenchymal stem cells-derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression. J Cell Physiol. 234:3394–3409. 2019. View Article : Google Scholar | |
|
Worner PM, Schachtele DJ, Barabadi Z, Srivastav S, Chandrasekar B, Izadpanah R and Alt EU: Breast tumor micro-environment can transform naive mesenchymal stem cells into tumor-forming cells in nude mice. Stem Cells Dev. 28:341–352. 2019. View Article : Google Scholar | |
|
Shi Y, Du L, Lin L and Wang Y: Tumour-associated mesenchymal stem/stromal cells: Emerging therapeutic targets. Nat Rev Drug Discov. 16:35–52. 2017. View Article : Google Scholar | |
|
Friedenstein AJ, Chailakhjan RK and Lalykina KS: The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kine. 3:393–403. 1970. | |
|
Mushahary D, Spittler A, Kasper C, Weber V and Charwat V: Isolation, cultivation, and characterization of human mesen-chymal stem cells. Cytometry A. 93:19–31. 2018. View Article : Google Scholar | |
|
Xu X, Zhang X, Wang S, Qian H, Zhu W, Cao H, Wang M, Chen Y and Xu W: Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues. J Cancer Res Clin. 137:495–504. 2011. View Article : Google Scholar | |
|
Cao H, Xu W, Qian H, Zhu W, Yan Y, Zhou H, Zhang X and Xu X, Li J, Chen Z and Xu X: Mesenchymal stem cell-like cells derived from human gastric cancer tissues. Cancer Lett. 274:61–71. 2009. View Article : Google Scholar | |
|
Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang X, Zhu M, Li Z, Zhao X, Xu C, et al: Human gastric cancer mesenchymal stem cell-derived IL15 contributes to tumor cell epithelial-mesenchymal transition via upregulation tregs ratio and PD-1 expression in CD4 + T cell. Stem Cells Dev. 27:1203–1214. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu Q, Zhang X, Zhang L, Li W, Wu H, Yuan X, Mao F, Wang M, Zhu W, Qian H and Xu W: The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression. Cell Death Dis. 5:e12952014. View Article : Google Scholar : PubMed/NCBI | |
|
Li W, Zhou Y, Yang J, Zhang X, Zhang H, Zhang T, Zhao S, Zheng P, Huo J and Wu H: Gastric cancer-derived mesenchymal stem cells prompt gastric cancer progression through secretion of interleukin-8. J Exp Clin Cancer Res. 34:522015. View Article : Google Scholar : PubMed/NCBI | |
|
Cao M, Mao J, Duan X, Lu L, Zhang F, Lin B, Chen M, Zheng C, Zhang X and Shen J: In vivo tracking of the tropism of mesenchymal stem cells to malignant gliomas using reporter gene-based MR imaging. Int J Cancer. 142:1033–1046. 2018. View Article : Google Scholar | |
|
Chen Y, He Y, Wang X, Lu F and Gao J: Adiposederived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells. Oncol Rep. 41:2126–2136. 2019.PubMed/NCBI | |
|
Chaturvedi P, Gilkes DM, Takano N and Semenza GL: Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci USA. 111:E2120–E2129. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Jung YH, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, et al: Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun. 4:17952013. View Article : Google Scholar : PubMed/NCBI | |
|
Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L and Zannetti A: Inhibition of bone marrow-derived mesenchymal stem cells homing towards triple-negative breast cancer micro-environment using an Anti-PDGFRβ Aptamer. Theranostics. 7:3595–3607. 2017. View Article : Google Scholar : | |
|
Barcellos-de-Souza P, Comito G, Pons-Segura C, Taddei ML, Gori V, Becherucci V, Bambi F, Margheri F, Laurenzana A, Del Rosso M and Chiarugi P: Mesenchymal stem cells are recruited and activated into carcinoma-associated fibroblasts by prostate cancer microenvironment-derived TGF-β1. Stem Cells. 34:2536–2547. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Pavon LF, Sibov TT, de Souza AV, da Cruz EF, Malheiros SMF, Cabral FR, de Souza JG, Boufleur P, de Oliveira DM, de Toledo SRC, et al: Tropism of mesenchymal stem cell toward CD133+ stem cell of glioblastoma in vitro and promote tumor proliferation in vivo. Stem Cell Res Ther. 9:3102018. View Article : Google Scholar | |
|
Berger L, Shamai Y, Skorecki KL and Tzukerman M: Tumor specific recruitment and reprogramming of mesenchymal stem cells in tumorigenesis. Stem Cells. 34:1011–1026. 2016. View Article : Google Scholar | |
|
Shamai Y, Alperovich DC, Yakhini Z, Skorecki K and Tzukerman M: Reciprocal reprogramming of cancer cells and associated mesenchymal stem cells in gastric cancer. Stem Cells. 37:176–189. 2019. View Article : Google Scholar | |
|
Shen Y, Xue C, Li X, Ba L, Gu J, Sun Z, Han Q and Zhao RC: Effects of gastric cancer cell-derived exosomes on the immune regulation of mesenchymal stem cells by the NF-κB signaling pathway. Stem Cells Dev. 28:464–476. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu M, Wang M, Yang F, Tian Y, Cai J, Yang H, Fu H, Mao F, Zhu W, Qian H and Xu W: miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-κ B p65 activation. Oncotarget. 7:16567–16580. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ji RB, Zhang X, Qian H, Gu H, Sun Z, Mao F, Yan Y, Chen J, Liang Z and Xu W: miR-374 mediates the malignant transformation of gastric cancer-associated mesenchymal stem cells in an experimental rat model. Oncol Rep. 38:1473–1481. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sun Z, Chen J, Zhang J, Ji R, Xu W, Zhang X and Qian H: The role and mechanism of miR-374 regulating the malignant transformation of mesenchymal stem cells. Am J Transl Res. 10:3224–3232. 2018.PubMed/NCBI | |
|
Yang T, Zhang X, Wang M, Zhang J, Huang F, Cai J, Zhang Q, Mao F, Zhu W, Qian H and Xu W: Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-κ B pathway. PLoS One. 9:e975692014. View Article : Google Scholar | |
|
Xu R, Zhao X, Zhao Y, Chen B, Sun L, Xu C, Shen B, Wang M, Xu W and Zhu W: Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4+ T cells. Cell Prolif. 51:e123992018. View Article : Google Scholar | |
|
Zhang Q, Ding J, Liu J, Wang W, Zhang F, Wang J and Li Y: Helicobacter pylori-infected MSCs acquire a pro-inflammatory phenotype and induce human gastric cancer migration by promoting EMT in gastric cancer cells. Oncol Lett. 11:449–457. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Vafaei R, Nassiri SM and Siavashi V: 3-Adrenergic regulation of EPC features through manipulation of the bone marrow MSC niche. J Cell Biochem. 118:4753–4761. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Y, Bucan V, Baehre H, Von der Ohe J, Otte A and Hass R: Acquisition of new tumor cell properties by MSC-derived exosomes. Int J Oncol. 47:244–252. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Whiteside TL: Exosome and mesenchymal stem cell cross-talk in the tumor microenvironment. Semin Immunol. 35:69–79. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Huang F, Wang M, Yang T, Cai J, Zhang Q, Sun Z, Wu X, Zhang X, Zhu W, Qian H and Xu W: Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression. J Cancer Res Clin. 140:1835–1848. 2014. View Article : Google Scholar | |
|
Huang F, Yao Y, Wu J, Liu Q, Zhang J, Pu X, Zhang Q and Xia L: Curcumin inhibits gastric cancer-derived mesenchymal stem cells mediated angiogenesis by regulating NF-κB/VEGF signaling. Am J Transl Res. 9:5538–5547. 2017. | |
|
Sun J, Song Y, Wang Z, Chen X, Gao P, Xu Y, Zhou B and Xu H: Clinical significance of palliative gastrectomy on the survival of patients with incurable advanced gastric cancer: A systematic review and meta-analysis. BMC Cancer. 13:5772013. View Article : Google Scholar : PubMed/NCBI | |
|
Orditura M, Galizia G, Sforza V, Gambardella V, Fabozzi A, Laterza MM, Andreozzi F, Ventriglia J, Savastano B, Mabilia A, et al: Treatment of gastric cancer. World J Gastroenterol. 20:1635–1649. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Kwee RM and Kwee TC: Role of imaging in predicting response to neoadjuvant chemotherapy in gastric cancer. World J Gastroenterol. 20:1650–1656. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Shitara K: Chemotherapy for advanced gastric cancer: Future perspective in Japan. Gastric Cancer. 20:102–110. 2017. View Article : Google Scholar | |
|
Roberto M, Romiti A, Onesti CE, Zullo A, Falcone R and Marchetti P: Evolving treatments for advanced gastric cancer: Appraisal of the survival trend. Expert Rev Anticancer Ther. 16:717–729. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
McMillin DW, Negri JM and Mitsiades CS: The role of tumour-stromal interactions in modifying drug response: Challenges and opportunities. Nat Rev Drug Discov. 12:217–228. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zeng J, Chen S, Li C, Ye Z, Lin B, Liang Y, Wang B, Ma Y, Chai X, Zhang X, et al: Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression. J Cancer. 11:2068–2079. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Le Naour A, Prat M, Thibault B, Mével R, Lemaitre L, Leray H, Joubert MV, Coulson K, Golzio M, Lefevre L, et al: Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors. J Mol Cell Biol. 12:202–215. 2020. View Article : Google Scholar : | |
|
Pasquier J, Gosset M, Geyl C, Hoarau-Véchot J, Chevrot A, Pocard M, Mirshahi M, Lis R, Rafii A and Touboul C: CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 depen-dent chemoresistance in ovarian cancer. Mol Cancer. 17:472018. View Article : Google Scholar | |
|
Wang X: Stem cells in tissues, organoids, and cancers. Cell Mol Life Sci. 76:4043–4070. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Polejaeva IA, Chen SH, Vaught TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares DL, et al: Cloned pigs produced by nuclear transfer from adult somatic cells. Nature. 407:86–90. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K and Yamanaka S: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 131:861–872. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
He W, Liang B, Wang C, Li S, Zhao Y, Huang Q, Liu Z, Yao Z, Wu Q, Liao W, et al: MSC-regulated lncRNA MACC1-AS1 promotes stemness and chemoresistance through fatty acid oxidation in gastric cancer. Oncogene. 38:4637–4654. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Ji R, Zhang B, Zhang X, Xue J, Yuan X, Yan Y, Wang M, Zhu W, Qian H and Xu W: Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer. Cell Cycle. 14:2473–2483. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Chaudhary D, Trivedi RN, Kathuria A, Goswami TK, Khandia R and Munjal A: In vitro and in vivo immunomodulating properties of mesenchymal stem cells. Recent Pat Inflamm Allergy Drug Discov. 12:59–68. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Su CY, Fu XL, Duan W, Yu PW and Zhao YL: High density of CD68+ tumor-associated macrophages predicts a poor prognosis in gastric cancer mediated by IL-6 expression. Oncol Lett. 15:6217–6224. 2018.PubMed/NCBI | |
|
Li W, Zhang X, Wu F, Zhou Y, Bao Z, Li H, Zheng P and Zhao S: Gastric cancer-derived mesenchymal stromal cells trigger M2 macrophage polarization that promotes metastasis and EMT in gastric cancer. Cell Death Dis. 10:9182019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang M, Chen B, Sun XX, Zhao XD, Zhao YY, Sun L, Xu CG, Shen B, Su ZL, Xu WR and Zhu W: Gastric cancer tissue-derived mesenchymal stem cells impact peripheral blood mononuclear cells via disruption of Treg/Th17 balance to promote gastric cancer progression. Exp Cell Res. 361:19–29. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Schmid P, Cortes J, Pusztai L, McArthur H, Kümmel S, Bergh J, Denkert C, Park YH, Hui R, Harbeck N, et al: Pembrolizumab for early triple-negative breast cancer. N Engl J Med. 382:810–821. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Burtness B, Harrington KJ, Greil R, Soulières D, Tahara M, de Castro G Jr, Psyrri A, Basté N, Neupane P, Bratland Å, et al: Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): A randomised, open-label, phase 3 study. Lancet. 394:1915–1928. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kamath SD, Kalyan A and Benson A: Pembrolizumab for the treatment of gastric cancer. Expert Rev Anticancer Ther. 18:1177–1187. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Bang YJ, Kang YK, Catenacci DV, Muro K, Fuchs CS, Geva R, Hara H, Golan T, Garrido M, Jalal SI, et al: Pembrolizumab alone or in combination with chemotherapy as first-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma: Results from the phase II nonrandomized KEYNOTE-059 study. Gastric Cancer. 22:828–837. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Fukuoka S, Hara H, Takahashi N, Kojima T, Kawazoe A, Asayama M, Yoshii T, Kotani D, Tamura H, Mikamoto Y, et al: Regorafenib plus nivolumab in patients with advanced gastric or colorectal cancer: An open-label, dose-escalation, and dose-expansion phase Ib trial (REGONIVO, EPOC1603). J Clin Oncol. 38:2053–2061. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang H, Xu J, Zhu M, Zhao X, Xu C, et al: Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis. Cell Death Dis. 9:9282018. View Article : Google Scholar : PubMed/NCBI | |
|
Song Y, Du H, Dai C, Zhang L, Li S, Hunter DJ, Lu L and Bao C: Human adipose-derived mesenchymal stem cells for osteoarthritis: A pilot study with long-term follow-up and repeated injections. Regen Med. 13:295–307. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ahn SY, Chang YS, Sung SI and Park WS: Mesenchymal stem cells for severe intraventricular hemorrhage in preterm infants: Phase I dose-escalation clinical trial. Stem Cells Transl Med. 7:847–856. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lin W, Huang L, Li Y, Fang B, Li G, Chen L and Xu L: Mesenchymal stem cells and cancer: Clinical challenges and opportunities. Biomed Res Int. 2019:28208532019. View Article : Google Scholar : PubMed/NCBI | |
|
Pakravan K, Babashah S, Sadeghizadeh M, Mowla SJ, Mossahebi-Mohammadi M, Ataei F, Dana N and Javan M: MicroRNA-100 shuttled by mesenchymal stem cell-derived exosomes suppresses in vitro angiogenesis through modulating the mTOR/HIF-1α/VEGF signaling axis in breast cancer cells. Cell Oncol (Dordr). 40:457–470. 2017. View Article : Google Scholar | |
|
Zhang J, Hou L, Wu X, Zhao D, Wang Z, Hu H, Fu Y and He J: Inhibitory effect of genetically engineered mesenchymal stem cells with Apoptin on hepatoma cells in vitro and in vivo. Mol Cell Biochem. 416:193–203. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Shojaati G, Khandaker I, Funderburgh ML, Mann MM, Basu R, Stolz DB, Geary ML, Dos Santos A, Deng SX and Funderburgh JL: Mesenchymal stem cells reduce corneal fibrosis and inflammation via extracellular vesicle-mediated delivery of miRNA. Stem Cells Transl Med. 8:1192–1201. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang M, Zhao C, Shi H, Zhang B, Zhang L, Zhang X, Wang S, Wu X, Yang T, Huang F, et al: Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: Novel biomarkers and a mechanism for gastric cancer. Br J Cancer. 110:1199–1210. 2014. View Article : Google Scholar : PubMed/NCBI |
