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Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure

  • Authors:
    • Peng Zhao
    • Yunkai Wang
    • Luping Zhang
    • Jinhua Zhang
    • Ning Liu
    • Hongqiang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology I, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Cardiac Surgery ICU, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Physical Examination, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China, Department of Cardiology II, Yantai Yuhuangding Hospital, Yantai, Shandong 264000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 5
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    Published online on: December 30, 2020
       https://doi.org/10.3892/ijmm.2020.4838
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Abstract

Heart failure (HF) is a serious threat to human health. Long noncoding RNAs (lncRNAs) are critical regulators of HF. The aim of the study was to investigate the molecular mechanism of MALAT1 in HF rats. MALAT1 expression was detected in serum of normal volunteers and HF patients, HF rats and isoproterenol (ISO)‑induced H9C2 cells, and its diagnostic value was evaluated in HF patients. Indexes related to cardiac functions and hemodynamics, myocardial injury, lipid metabolism, lipid oxidation, and inflammation were detected. Moreover, the downstream mechanism of MALAT1 was predicted and verified and in vivo experiments were further performed in ISO‑induced H9C2 cells to verify the effects of MALAT1 in HF. MALAT1 was highly expressed in serum of HF patients, HF rats and ISO‑induced H9C2 cells and was valuable in predicting HF. Inhibition of MALAT1 increased cardiac function and anti‑inflammation and alleviated myocardial injury, lipid metabolism, lipid oxidation and apoptosis rates. Inhibition of MALAT1 reduced H9C2 cell injury. MALAT1 competitively bound to microRNA (miR)‑532‑3p to upregulate LDLR protein. Inhibition of miR‑532‑3p weakened the protective effect of downregulated MALAT1 against H9C2 cell injury. We concluded that MALAT1 upregulated LDLR expression by competitively binding to miR‑532‑3p, thereby increasing pathological injury in HF.
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View References

1 

Snipelisky D, Chaudhry SP and Stewart GC: The many faces of heart failure. Card Electrophysiol Clin. 11:11–20. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Tomasoni D, Adamo M, Lombardi CM and Metra M: Highlights in heart failure. ESC Heart Fail. 6:1105–1127. 2019. View Article : Google Scholar

3 

Bozkurt B and Khalaf S: Heart failure in women. Methodist Debakey Cardiovasc J. 13:216–223. 2017.

4 

Melander S and Miller S: Heart failure: Overcoming the physiologic dilemma through evidence-based practice. Nurs Clin North Am. 51:13–27. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Ziaeian B and Fonarow GC: Epidemiology and aetiology of heart failure. Nat Rev Cardiol. 13:368–378. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Martinelli AEM, Maranhao RC, Carvalho PO, Freitas FR, Silva BMO, Curiati MNC, Kalil Filho R and Pereira-Barretto AC: Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure. Lipids Health Dis. 17:2422018. View Article : Google Scholar : PubMed/NCBI

7 

Bui AL, Horwich TB and Fonarow GC: Epidemiology and risk profile of heart failure. Nat Rev Cardiol. 8:30–41. 2011. View Article : Google Scholar :

8 

Rosik J, Szostak B, Machaj F and Pawlik A: Potential targets of gene therapy in the treatment of heart failure. Expert Opin Ther Targets. 22:811–816. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Fan Z, Gao S, Chen Y, Xu B, Yu C, Yue M and Tan X: Integrative analysis of competing endogenous RNA networks reveals the functional lncRNAs in heart failure. J Cell Mol Med. 22:4818–4829. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Turton N, Swan R, Mahenthiralingam T, Pitts D and Dykes IM: The functions of long non-coding RNA during embryonic cardiovascular development and its potential for diagnosis and treatment of congenital heart disease. J Cardiovasc Dev Dis. 6:212019. View Article : Google Scholar :

11 

Zhao Y, Wu J, Liangpunsakul S and Wang L: Long non-coding RNA in liver metabolism and disease: Current status. Liver Res. 1:163–167. 2017. View Article : Google Scholar

12 

Yan Y, Song D, Wu J and Wang J: Long non-coding RNAs link oxidized low-density lipoprotein with the inflammatory response of macrophages in atherogenesis. Front Immunol. 11:242020. View Article : Google Scholar : PubMed/NCBI

13 

Sirtori CR, Ruscica M, Calabresi L, Chiesa G, Giovannoni R and Badimon JJ: HDL therapy today: From atherosclerosis, to stent compatibility to heart failure. Ann Med. 51:345–359. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Wu Q and Yi X: Down-regulation of long noncoding RNA MALAT1 protects hippocampal neurons against excessive autophagy and apoptosis via the PI3K/Akt signaling pathway in rats with epilepsy. J Mol Neurosci. 65:234–245. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Liu L, Tan L, Yao J and Yang L: Long non-coding RNA MALAT1 regulates cholesterol accumulation in ox-LDL-induced macrophages via the microRNA-17-5p/ABCA1 axis. Mol Med Rep. 21:1761–1770. 2020.PubMed/NCBI

16 

Wang L, Qi Y, Wang Y, Tang H, Li Z, Wang Y, Tang S and Zhu H: LncRNA MALAT1 suppression protects endothelium against oxLDL-induced inflammation via inhibiting expression of MiR-181b target gene TOX. Oxid Med Cell Longev. 2019:82458102019. View Article : Google Scholar

17 

Huang Y: The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases. J Cell Mol Med. 22:5768–5775. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Shah P, Bristow MR and Port JD: MicroRNAs in heart failure, cardiac transplantation, and myocardial recovery: Biomarkers with therapeutic potential. Curr Heart Fail Rep. 14:454–464. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Bauersachs R, Zeymer U, Briere JB, Marre C, Bowrin K and Huelsebeck M: Burden of coronary artery disease and peripheral artery disease: A literature review. Cardiovasc Ther. 2019:82950542019. View Article : Google Scholar

20 

Huang R, Cao Y, Li H, Hu Z, Zhang H, Zhang L, Su W, Xu Y, Liang L, Melgiri ND, et al: miR-532-3p-CSF2RA axis as a key regulator of vulnerable atherosclerotic plaque formation. Can J Cardiol. 36:1782–1794. 2020. View Article : Google Scholar : PubMed/NCBI

21 

Arola-Arnal A and Blade C: Proanthocyanidins modulate microRNA expression in human HepG2 cells. PLoS One. 6:e259822011. View Article : Google Scholar : PubMed/NCBI

22 

Gao K, Zhang J, Gao P, Wang Q, Liu Y, Liu J, Zhang Y, Li Y, Chang H, Ren P, et al: Qishen granules exerts cardioprotective effects on rats with heart failure via regulating fatty acid and glucose metabolism. Chin Med. 15:212020. View Article : Google Scholar : PubMed/NCBI

23 

Zatroch KK, Knight CG, Reimer JN and Pang DS: Refinement of intraperitoneal injection of sodium pentobarbital for euthanasia in laboratory rats (Rattus norvegicus). BMC Vet Res. 13:602017. View Article : Google Scholar : PubMed/NCBI

24 

Fan C, Tang X, Ye M, Zhu G, Dai Y, Yao Z and Yao X: Qi-Li-Qiang-Xin alleviates isoproterenol-induced myocardial injury by inhibiting excessive autophagy via activating AKT/mTOR pathway. Front Pharmacol. 10:13292019. View Article : Google Scholar :

25 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Zhao W, Geng D, Li S, Chen Z and Sun M: LncRNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR-20a-5p/HMGA2 axis in breast cancer. Cancer Med. 7:842–855. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Zhou YX, Wang C, Mao LW, Wang YL, Xia LQ, Zhao W, Shen J and Chen J: Long noncoding RNA HOTAIR mediates the estrogen-induced metastasis of endometrial cancer cells via the miR-646/NPM1 axis. Am J Physiol Cell Physiol. 314:C690–C701. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Choi SS, Kim ES, Koh M, Lee SJ, Lim D, Yang YR, Jang HJ, Seo KA, Min SH, Lee IH, et al: A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity. J Biol Chem. 289:26618–26629. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Madej-Pilarczyk A, Niezgoda A, Janus M, Wojnicz R, Marchel M, Fidziańska A, Grajek S and Hausmanowa-Petrusewicz I: Limb-girdle muscular dystrophy with severe heart failure overlapping with lipodystrophy in a patient with LMNA mutation p.Ser334del. J Appl Genet. 58:87–91. 2017. View Article : Google Scholar :

30 

Cao Z, Pan X, Yang Y, Huang Y and Shen HB: The lncLocator: A subcellular localization predictor for long non-coding RNAs based on a stacked ensemble classifier. Bioinformatics. 34:2185–2194. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Rogers C and Bush N: Heart failure: Pathophysiology, diagnosis, medical treatment guidelines, and nursing management. Nurs Clin North Am. 50:787–799. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Scheuermann JC and Boyer LA: Getting to the heart of the matter: Long non-coding RNAs in cardiac development and disease. EMBO J. 32:1805–1816. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Toraih EA, El-Wazir A, Alghamdi SA, Alhazmi AS, El-Wazir M, Abdel-Daim MM and Fawzy MS: Association of long non-coding RNA MIAT and MALAT1 expression profiles in peripheral blood of coronary artery disease patients with previous cardiac events. Genet Mol Biol. 42:509–518. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Hartupee J and Mann DL: Neurohormonal activation in heart failure with reduced ejection fraction. Nat Rev Cardiol. 14:30–38. 2017. View Article : Google Scholar :

35 

Guo X, Wu X, Han Y, Tian E and Cheng J: LncRNA MALAT1 protects cardiomyocytes from isoproterenol-induced apoptosis through sponging miR-558 to enhance ULK1-mediated protective autophagy. J Cell Physiol. 234:10842–10854. 2019. View Article : Google Scholar

36 

Sadoh WE, Eregie CO, Nwaneri DU and Sadoh AE: The diagnostic value of both troponin T and creatinine kinase isoenzyme (CK-MB) in detecting combined renal and myocardial injuries in asphyxiated infants. PLoS One. 9:e913382014. View Article : Google Scholar : PubMed/NCBI

37 

Wang X, Wang J, Tu T, Iyan Z, Mungun D, Yang Z and Guo Y: Remote ischemic postconditioning protects against myocardial ischemia-reperfusion injury by inhibition of the RAGE-HMGB1 pathway. Biomed Res Int. 2018:45656302018.PubMed/NCBI

38 

Yan B, Liu S, Li X, Zhong Y, Tong F and Yang S: Preconditioning with endoplasmic reticulum stress alleviated heart ischemia/reperfusion injury via modulating IRE1/ATF6/RACK1/PERK and PGC-1α in diabetes mellitus. Biomed Pharmacother. 118:1094072019. View Article : Google Scholar

39 

Fan YZ, Huang H, Wang S, Tan GJ and Zhang QZ: Effect of lncRNA MALAT1 on rats with myocardial infarction through regulating ERK/MAPK signaling pathway. Eur Rev Med Pharmacol Sci. 23:9041–9049. 2019.PubMed/NCBI

40 

Abdalla S, Fu X, Elzahwy SS, Klaetschke K, Streichert T and Quitterer U: Up-regulation of the cardiac lipid metabolism at the onset of heart failure. Cardiovasc Hematol Agents Med Chem. 9:190–206. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Kurpińska AK, Jarosz A, Ożgo M and Skrzypczak WF: Changes in lipid metabolism during last month of pregnancy and first two months of lactation in primiparous cows-analysis of apolipoprotein expression pattern and changes in concentration of total cholesterol, HDL, LDL, triglycerides. Pol J Vet Sci. 18:291–298. 2015. View Article : Google Scholar

42 

Li J, Lei HT, Cao L, Mi YN, Li S and Cao YX: Crocin alleviates coronary atherosclerosis via inhibiting lipid synthesis and inducing M2 macrophage polarization. Int Immunopharmacol. 55:120–127. 2018. View Article : Google Scholar

43 

Yan C, Chen J and Chen N: Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability. Sci Rep. 6:226402016. View Article : Google Scholar : PubMed/NCBI

44 

Shirazi LF, Bissett J, Romeo F and Mehta JL: Role of inflammation in heart failure. Curr Atheroscler Rep. 19:272017. View Article : Google Scholar : PubMed/NCBI

45 

Zhang Y, Zhang H, Zhang Z, Li S, Jiang W, Li X and Lv J: LncRNA MALAT1 cessation antagonizes hypoxia/reoxygenation injury in hepatocytes by inhibiting apoptosis and inflammation via the HMGB1-TLR4 axis. Mol Immunol. 112:22–29. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Cao DW, Liu MM, Duan R, Tao YF, Zhou JS, Fang WR, Zhu JR, Niu L and Sun JG: The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation. Acta Pharmacol Sin. 41:22–33. 2020. View Article : Google Scholar :

47 

Fragasso G: Deranged cardiac metabolism and the pathogenesis of heart failure. Card Fail Rev. 2:8–13. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Yang L, Xu F, Zhang M, Shang XY, Xie X, Fu T, Li JP and Li HL: Role of LncRNA MALAT-1 in hypoxia-induced PC12 cell injury via regulating p38MAPK signaling pathway. Neurosci Lett. 670:41–47. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Li L, Wang Q, Yuan Z, Chen A, Liu Z, Wang Z and Li H: LncRNA-MALAT1 promotes CPC proliferation and migration in hypoxia by up-regulation of JMJD6 via sponging miR-125. Biochem Biophys Res Commun. 499:711–718. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Wang X, Song C, Zhou X, Han X, Li J, Wang Z, Shang H, Liu Y and Cao H: Mitochondria associated MicroRNA expression profiling of heart failure. Biomed Res Int. 2017:40425092017.PubMed/NCBI

51 

Bayoumi AS, Teoh JP, Aonuma T, Yuan Z, Ruan X, Tang Y, Su H, Weintraub NL and Kim IM: MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition. Cardiovasc Res. 113:1603–1614. 2017. View Article : Google Scholar : PubMed/NCBI

52 

Bayes-Genis A, Núñez J, Zannad F, Ferreira JP, Anker SD, Cleland JG, Dickstein K, Filippatos G, Lang CC, Ng LL, et al: The PCSK9-LDL receptor axis and outcomes in heart failure: BIOSTAT-CHF subanalysis. J Am Coll Cardiol. 70:2128–2136. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao P, Wang Y, Zhang L, Zhang J, Liu N and Wang H: Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure. Int J Mol Med 47: 5, 2021.
APA
Zhao, P., Wang, Y., Zhang, L., Zhang, J., Liu, N., & Wang, H. (2021). Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure. International Journal of Molecular Medicine, 47, 5. https://doi.org/10.3892/ijmm.2020.4838
MLA
Zhao, P., Wang, Y., Zhang, L., Zhang, J., Liu, N., Wang, H."Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure". International Journal of Molecular Medicine 47.3 (2021): 5.
Chicago
Zhao, P., Wang, Y., Zhang, L., Zhang, J., Liu, N., Wang, H."Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure". International Journal of Molecular Medicine 47, no. 3 (2021): 5. https://doi.org/10.3892/ijmm.2020.4838
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao P, Wang Y, Zhang L, Zhang J, Liu N and Wang H: Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure. Int J Mol Med 47: 5, 2021.
APA
Zhao, P., Wang, Y., Zhang, L., Zhang, J., Liu, N., & Wang, H. (2021). Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure. International Journal of Molecular Medicine, 47, 5. https://doi.org/10.3892/ijmm.2020.4838
MLA
Zhao, P., Wang, Y., Zhang, L., Zhang, J., Liu, N., Wang, H."Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure". International Journal of Molecular Medicine 47.3 (2021): 5.
Chicago
Zhao, P., Wang, Y., Zhang, L., Zhang, J., Liu, N., Wang, H."Mechanism of long non‑coding RNA metastasis‑associated lung adenocarcinoma transcript 1 in lipid metabolism and inflammation in heart failure". International Journal of Molecular Medicine 47, no. 3 (2021): 5. https://doi.org/10.3892/ijmm.2020.4838
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