Open Access

Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review)

  • Authors:
    • Niladri Ganguly
    • Subrata Chakrabarti
  • View Affiliations

  • Published online on: January 18, 2021     https://doi.org/10.3892/ijmm.2021.4856
  • Article Number: 23
  • Copyright: © Ganguly et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Liver fibrosis is one of the major liver pathologies affecting patients worldwide. It results from an improper tissue repair process following liver injury or inflammation. If left untreated, it ultimately leads to liver cirrhosis and liver failure. Long non‑coding RNAs (lncRNAs) have been implicated in a wide variety of diseases. They can regulate gene expression and modulate signaling. Some of the lncRNAs promote, while others inhibit liver fibrosis. Similarly, other epigenetic processes, such as methylation and acetylation regulate gene transcription and can modulate gene expression. Notably, there are several regulatory associations of lncRNAs with other epigenetic processes. A major mechanism of action of long non‑coding RNAs is to competitively bind to their target microRNAs (miRNAs or miRs), which in turn affects miRNA availability and bioactivity. In the present review, the role of lncRNAs and related epigenetic processes contributing to liver fibrosis is discussed. Finally, various potential therapeutic approaches targeting lncRNAs and related epigenetic processes, which are being considered as possible future treatment targets for liver fibrosis are identified.
View Figures
View References

Related Articles

Journal Cover

March-2021
Volume 47 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ganguly N and Ganguly N: Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review). Int J Mol Med 47: 23, 2021
APA
Ganguly, N., & Ganguly, N. (2021). Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review). International Journal of Molecular Medicine, 47, 23. https://doi.org/10.3892/ijmm.2021.4856
MLA
Ganguly, N., Chakrabarti, S."Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review)". International Journal of Molecular Medicine 47.3 (2021): 23.
Chicago
Ganguly, N., Chakrabarti, S."Role of long non‑coding RNAs and related epigenetic mechanisms in liver fibrosis (Review)". International Journal of Molecular Medicine 47, no. 3 (2021): 23. https://doi.org/10.3892/ijmm.2021.4856