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Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses

  • Authors:
    • Yuan He
    • Xinlin Lu
    • Tao Chen
    • Yu Yang
    • Jing Zheng
    • Can Chen
    • Yuanqi Zhang
    • Wei Lei
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cardiovascular Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Cardiovascular Medicine Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Gerontology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Department of Obstetrics and Gynecology, University of Wisconsin‑Madison, Madison, WI 53715, USA, Department of Vascular, Thyroid and Breast Surgery, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
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    Published online on: January 28, 2021
       https://doi.org/10.3892/ijmm.2021.4862
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Abstract

Resveratrol (RES) is a natural phenol which possesses multiple pharmacological actions. The present study aimed to determine whether RES protects against myocardial ischemic injury in association with the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses in mice following acute myocardial infarction (AMI). Male C57/BL mice were randomly assigned to 3 groups as follows: The sham‑operated (sham) group, AMI + vehicle group and AMI + RES group. Rat H9C2 cells were also used to examine the effects of RES on hypoxia‑induced oxidative injury in vitro. Redox homeostasis in the mouse myocardium and rat H9C2 cells was determined post‑treatment. The mRNA and protein levels of phosphorylated (p‑)IκB kinase (p‑IKK), p‑nuclear factor (NF)‑κB p65, interleukin (IL)‑1β, IL‑6, nerve growth factor (NGF) and insulin‑like growth factor‑1 (IGF‑1) were measured by RT‑qPCR and western blot analysis. It was found that RES slightly protected the myocardium against ischemic injury in mice, while it prevented the hypoxia‑induced apoptosis of H9C2 cells. RES decreased the production of reactive oxygen species (ROS) and enhanced the activities of superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GPx). RES also downregulated the protein and/or mRNA levels of p‑IKK, p‑NF‑κB p65, IL‑1β, IL‑6, NGF and IGF‑1 at 7 and 28 days after infarction. On the whole, these data indicate that RES protects the myocardium against ischemic injury in association with the inhibition of oxidative stress and inflammatory responses. Thus, RES has the potential to be used as an adjunctive therapeutic drug for heart diseases.
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Copy and paste a formatted citation
Spandidos Publications style
He Y, Lu X, Chen T, Yang Y, Zheng J, Chen C, Zhang Y and Lei W: Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses. Int J Mol Med 47: 29, 2021.
APA
He, Y., Lu, X., Chen, T., Yang, Y., Zheng, J., Chen, C. ... Lei, W. (2021). Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses. International Journal of Molecular Medicine, 47, 29. https://doi.org/10.3892/ijmm.2021.4862
MLA
He, Y., Lu, X., Chen, T., Yang, Y., Zheng, J., Chen, C., Zhang, Y., Lei, W."Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses". International Journal of Molecular Medicine 47.3 (2021): 29.
Chicago
He, Y., Lu, X., Chen, T., Yang, Y., Zheng, J., Chen, C., Zhang, Y., Lei, W."Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses". International Journal of Molecular Medicine 47, no. 3 (2021): 29. https://doi.org/10.3892/ijmm.2021.4862
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Lu X, Chen T, Yang Y, Zheng J, Chen C, Zhang Y and Lei W: Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses. Int J Mol Med 47: 29, 2021.
APA
He, Y., Lu, X., Chen, T., Yang, Y., Zheng, J., Chen, C. ... Lei, W. (2021). Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses. International Journal of Molecular Medicine, 47, 29. https://doi.org/10.3892/ijmm.2021.4862
MLA
He, Y., Lu, X., Chen, T., Yang, Y., Zheng, J., Chen, C., Zhang, Y., Lei, W."Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses". International Journal of Molecular Medicine 47.3 (2021): 29.
Chicago
He, Y., Lu, X., Chen, T., Yang, Y., Zheng, J., Chen, C., Zhang, Y., Lei, W."Resveratrol protects against myocardial ischemic injury via the inhibition of NF‑κB‑dependent inflammation and the enhancement of antioxidant defenses". International Journal of Molecular Medicine 47, no. 3 (2021): 29. https://doi.org/10.3892/ijmm.2021.4862
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