Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
July-2021 Volume 48 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 48 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Protective effects of Lycium barbarum polysaccharide on ovariectomy‑induced cognition reduction in aging mice

  • Authors:
    • Xiaomin Zheng
    • Junyan Wang
    • Fengchen Bi
    • Yilu Li
    • Jingjing Xiao
    • Zhi Chai
    • Yunhong Li
    • Zhenhua Miao
    • Yin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China, Department of Physiology and Neurobiology, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 121
    |
    Published online on: May 6, 2021
       https://doi.org/10.3892/ijmm.2021.4954
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Women experience cognitive decline as they age due to the decrease in estrogen levels following menopause. Currently, effective pharmaceutical treatments for age‑related cognitive decline are lacking; however, several Traditional Chinese medicines have shown promising effects. Lycium barbarum polysaccharides (LBPs) were found to exert a wide variety of biological activities, including anti‑inflammatory, antioxidant and anti‑aging effects. However, to the best of our knowledge, the neuroprotective actions of LBP on cognitive impairment induced by decreased levels of estrogen have not yet been determined. To evaluate the effects of LBP on learning and memory impairment in an animal model of menopause, 45 female ICR mice were randomly divided into the following three groups: i) Sham; ii) ovariectomy (OVX); and iii) OVX + LBP treatment. The results of open‑field and novel object recognition tests revealed that mice in the OVX group had learning and memory impairments, and lacked the ability to recognize and remember new objects. Notably, these deficits were attenuated following LBP treatment. Immunohistochemical staining confirmed the protective effects of LBP on hippocampal neurons following OVX. To further investigate the underlying mechanism of OVX in mice, mRNA sequencing of the hippocampal tissue was performed, which revealed that the Toll‑like receptor 4 (TLR4) inflammatory signaling pathway was significantly upregulated in the OVX group. Moreover, reverse transcription‑quantitative PCR and immunohistochemical staining demonstrated that OVX induced hippocampal injury, upregulated the expression levels of TLR4, myeloid differentiation factor 88 and NF‑κB, and increased the expression of TNF‑α, IL‑6 and IL‑1β inflammatory factors. Conversely, LBP treatment downregulated the expression levels of mRNAs and proteins associated with the TLR4/NF‑κB signaling pathway, decreased the inflammatory response and reduced neuronal injury in mice that underwent OVX. In conclusion, the findings of the present study indicated that oral LBP treatment may alleviate OVX‑induced cognitive impairments by downregulating the expression levels of mRNAs and proteins associated with the TLR4/NF‑κB signaling pathway, thereby reducing neuroinflammation and damage to the hippocampal neurons. Thus, LBP may represent a potential agent for the prevention of learning and memory impairments in patients with accelerated aging caused by estrogen deficiency.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Kumar A: Editorial: Neuroinflammation and cognition. Front Aging Neurosci. 10:4132018. View Article : Google Scholar

2 

Russell JK, Jones CK and Newhouse PA: The role of estrogen in brain and cognitive aging. Neurotherapeutics. 16:649–665. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Chen Z, Tang Y, Liu A, Jin X, Zhu J and Lu X: Oral administration of Grifola Frondosa polysaccharides improves memory impairment in aged rats via antioxidant action. Mol Nutr Food Res. 61:17003132017. View Article : Google Scholar

4 

Ryan J, Carriere I, Scali J, Ritchie K and Ancelin ML: Life-time estrogen exposure and cognitive functioning in later life. Psychoneuroendocrino. 34:287–298. 2009. View Article : Google Scholar

5 

Lamar M, Resnick SM and Zonderman AB: Longitudinal changes in verbal memory in older adults: Distinguishing the effects of age from repeat testing. Neurology. 60:82–86. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Hohman TJ, Beason-Held LL, Lamar M and Resnick SM: Subjective cognitive complaints and longitudinal changes in memory and brain function. Neuropsychology. 25:125–130. 2011. View Article : Google Scholar :

7 

Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC and Verdin E: From discoveries in ageing research to therapeutics for healthy ageing. Nature. 571:183–192. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Garbers C, Kuck F, Aparicio-Siegmund S, Konzak K, Kessenbrock M, Sommerfeld A, Häussinger D, Lang PA, Brenner D, Mak TW, et al: Cellular senescence Or EGFR signaling induces interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle. 12:3421–3432. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Franceschi C, Garagnani P, Parini P, Giuliani C and Santoro A: Inflammaging: A new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 14:576–590. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Renz H, Holt PG, Inouye M, Logan AC, Prescott SL and Sly PD: An exposome perspective: Early-life events and immune development in a changing world. J Allergy Clin Immunol. 140:24–40. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Sly PD, Carpenter DO, Van den Berg M, Stein RT, Landrigan PJ, Brune-Drisse MN and Suk W: Health consequences of environmental exposures: Causal thinking in global environmental epidemiology. Ann Glob Health. 82:3–9. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Floreani A, Leung PS and Gershwin ME: Environmental basis of autoimmunity. Clin Rev Allergy Immunol. 50:287–300. 2016. View Article : Google Scholar

13 

Ferrucci L and Fabbri E: Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 15:505–522. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Liberale L, Montecucco F, Tardif JC, Libby P and Camici GG: Inflamm-ageing: The role of inflammation in age-dependent cardiovascular disease. Eur Heart J. 41:2974–2982. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Franceschi C and Campisi J: Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 69(Suppl 1): S4–S9. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Wang RP, Ho YS, Leung WK, Goto T and Chang RC: Systemic inflammation linking chronic periodontitis to cognitive decline. Brain Behav Immun. 81:63–73. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Baulch JE, Acharya MM, Allen BD, Ru N, Chmielewski NN, Martirosian V, Giedzinski E, Syage A, Park AL, Benke SN, et al: Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. Proc Natl Acad Sci USA. 113:4836–4841. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Lee JY, Joo B, Nam JH, Nam HY, Lee W, Nam Y, Seo Y, Kang HJ, Cho HJ, Jang YP, et al: An aqueous extract of herbal medicine ALWPs enhances cognitive performance and inhibits LPS-induced neuroinflammation via FAK/NF-kappaB signaling pathways. Front Aging Neurosci. 10:2692018. View Article : Google Scholar

19 

Jacobs AH and Tavitian B: Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab. 32:1393–1415. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Chandrasekaran A, Idelchik M and Melendez JA: Redox control of senescence and age-related disease. Redox Biol. 11:91–102. 2017. View Article : Google Scholar

21 

Zeng P, Li J, Chen Y and Zhang L: The structures and biological functions of polysaccharides from traditional chinese herbs. Prog Mol Biol Transl Sci. 163:423–444. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Li S, Liu H, Wang W, Wang X, Zhang C, Zhang J, Jing H, Ren Z, Gao Z, Song X and Jia L: Antioxidant and anti-aging effects of acidic-extractable polysaccharides by agaricus bisporus. Int J Biol Macromol. 106:1297–1306. 2018. View Article : Google Scholar

23 

Zhang R, Zhang X, Tang Y and Mao J: Composition, isolation, purification and biological activities of Sargassum Fusiforme Polysaccharides: A review. Carbohydr Polym. 228:1153812020. View Article : Google Scholar

24 

Zhu Y, Yu X, Ge Q, Li J, Wang D, Wei Y and Ouyang Z: Antioxidant and anti-aging activities of polysaccharides from Cordyceps cicadae. Int J Biol Macromol. 157:394–400. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Li H, Li Z, Peng L, Jiang N, Liu Q, Zhang E, Liang B, Li R and Zhu H: Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage. Free Radic Res. 51:200–210. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Tian X, Liang T, Liu Y, Ding G, Zhang F and Ma Z: Extraction, structural characterization, and biological functions of Lycium Barbarum Polysaccharides: A Review. Biomolecules. 9:3892019. View Article : Google Scholar :

27 

Chang RC and So KF: Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell Mol Neurobiol. 28:643–652. 2008. View Article : Google Scholar

28 

Zhang Z, Zhou Y, Fan H, Billy KJ, Zhao Y, Zhan X, Yang L and Jia Y: Effects of Lycium barbarum polysaccharides on health and aging of C. Elegans depend On Daf-12/Daf-16. Oxid Med Cell Longev. 2019:63794932019.

29 

Blair JA, Bhatta S and Casadesus G: CNS luteinizing hormone receptor activation rescues ovariectomy-related loss of spatial memory and neuronal plasticity. Neurobiol Aging. 78:111–120. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Bohm-Levine N, Goldberg AR, Mariani M, Frankfurt M and Thornton J: Reducing luteinizing hormone levels after ovariectomy improves spatial memory: Possible role of brain-derived neurotrophic factor. Horm Behav. 118:1045902020. View Article : Google Scholar

31 

Monthakantirat O, Sukano W, Umehara K, Noguchi H, Chulikhit Y and Matsumoto K: Effect of miroestrol on ovariectomy-induced cognitive impairment and lipid peroxidation in mouse brain. Phytomedicine. 21:1249–1255. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Sbisa AM, Gogos A and van den Buuse M: Spatial working memory in the touchscreen operant platform is disrupted in female rats by ovariectomy but not estrous cycle. Neurobiol Learn Mem. 144:147–154. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Robinson MD, McCarthy DJ and Smyth GK: EdgeR: A bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar

34 

Pertea M, Pertea GM, Antonescu CM, Chang TC, Mendell JT and Salzberg SL: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol. 33:290–295. 2015. View Article : Google Scholar : PubMed/NCBI

35 

The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res. 47:D330–D338. 2019. View Article : Google Scholar :

36 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar :

37 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

38 

Shi Z, Zhu L, Li T, Tang X, Xiang Y, Han X, Xia L, Zeng L, Nie J, Huang Y, et al: Neuroprotective mechanisms of Lycium barbarum polysaccharides against ischemic insults by regulating NR2B and NR2A containing NMDA receptor signaling pathways. Front Cell Neurosci. 11:2882017. View Article : Google Scholar :

39 

Fjell AM, McEvoy L, Holland D, Dale AM and Walhovd KB: What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Prog Neurobiol. 117:20–40. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Stanojlovic M, Pallais JP, Lee MK and Kotz CM: Pharmacological and chemogenetic orexin/hypocretin intervention ameliorates hipp-dependent memory impairment in the A53T mice model of Parkinson's disease. Mol Brain. 12:872019. View Article : Google Scholar : PubMed/NCBI

41 

No authors listed. 2020 Alzheimer's disease facts and figures. Alzheimers Dement. Mar 10–2020.Epub ahead of print.

42 

Boyle PA, Yu L, Wilson RS, Leurgans SE, Schneider JA and Bennett DA: Person-specific contribution of neuropathologies to cognitive loss in old age. Ann Neurol. 83:74–83. 2018. View Article : Google Scholar :

43 

Nascimento C, Di Lorenzo Alho AT, Bazan Conceição Amaral C, Leite REP, Nitrini R, Jacob-Filho W, Pasqualucci CA, Hokkanen SRK, Hunter S, Keage H, et al: Prevalence of transactive response DNA-binding Protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis. Neuropathol Appl Neurobiol. 44:286–297. 2018. View Article : Google Scholar

44 

Morgan KN, Derby CA and Gleason CE: Cognitive changes with reproductive aging, perimenopause, and menopause. Obstet Gynecol Clin North Am. 45:751–763. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Bettio L, Rajendran L and Gil-Mohapel J: The effects of aging in the hippocampus and cognitive decline. Neurosci Biobehav Rev. 79:66–86. 2017. View Article : Google Scholar : PubMed/NCBI

46 

Rehman SU, Shah SA, Ali T, Chung JI and Kim MO: Anthocyanins reversed D-galactose-induced oxidative stress and neuroinflammation mediated cognitive impairment in adult rats. Mol Neurobiol. 54:255–271. 2017. View Article : Google Scholar

47 

Huang C, Irwin MG, Wong G and Chang R: Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. J Neuroinflammation. 15:1472018. View Article : Google Scholar : PubMed/NCBI

48 

Liang J, Wu Y, Yuan H, Yang Y, Xiong Q, Liang C, Li Z, Li C, Zhang G, Lai X, et al: Dendrobium officinale polysaccharides attenuate learning and memory disabilities via anti-oxidant and anti-inflammatory actions. Int J Biol Macromol. 126:414–426. 2019. View Article : Google Scholar

49 

Zhang X, Bai L, Zhang S, Zhou X, Li Y and Bai J: Trx-1 ameliorates learning and memory deficits in MPTP-induced Parkinson's disease model in mice. Free Radic Biol Med. 124:380–387. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Arroyo-García LE, Tendilla-Beltrán H, Vázquez-Roque RA, Jurado-Tapia EE, Díaz A, Aguilar-Alonso P, Brambila E, Monjaraz E, De La Cruz F, Rodríguez-Moreno A and Flores G: Amphetamine sensitization alters hippocampal neuronal morphology and memory and learning behaviors. Mol Psychiatry. Jun 17–2020.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

51 

Ramani M, Kumar R, Halloran B, Lal CV, Ambalavanan N and McMahon LL: Supraphysiological levels of oxygen exposure during the neonatal period impairs signaling pathways required for learning and memory. Sci Rep. 8:99142018. View Article : Google Scholar : PubMed/NCBI

52 

Lu J, Xu Y, Hu W, Gao Y, Ni X, Sheng H and Liu Y: Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats. Neurosci Lett. 573:13–18. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Kouhestani S, Jafari A and Babaei P: Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia. Neural Regen Res. 13:1827–1832. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Saied NM, Georgy GS, Hussien RM and Hassan WA: Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats. Clin Exp Pharmacol Physiol. 48:337–346. 2021. View Article : Google Scholar

55 

Lu SM, Gui B, Dong HQ, Zhang X, Zhang SS, Hu LQ, Liu HL, Sun J and Qian YN: Prophylactic lithium alleviates splenectomy-induced cognitive dysfunction Possibly by inhibiting hippocampal TLR4 activation in aged rats. Brain Res Bull. 114:31–41. 2015. View Article : Google Scholar : PubMed/NCBI

56 

Zhong Q, Zou Y, Liu H, Chen T, Zheng F, Huang Y, Chen C and Zhang Z: Toll-like receptor 4 deficiency ameliorates β2-microglobulin induced age-related cognition decline due to neuroinflammation in mice. Mol Brain. 13:202020. View Article : Google Scholar

57 

Wang S, Zhang X, Zhai L, Sheng X, Zheng W, Chu H and Zhang G: Atorvastatin attenuates cognitive deficits and neuroinflammation induced by Aβ1-42 involving modulation of TLR4/TRAF6/NF-κB pathway. J Mol Neurosci. 64:363–373. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Zhang Q, Wu HH, Wang Y, Gu GJ, Zhang W and Xia R: Neural stem cell transplantation decreases neuroinflammation in a transgenic mouse model of Alzheimer's disease. J Neurochem. 136:815–825. 2016. View Article : Google Scholar

59 

He P, Yan S, Zheng J, Gao Y, Zhang S, Liu Z, Liu X and Xiao C: Eriodictyol attenuates LPS-induced neuroinflammation, amyloidogenesis, and cognitive impairments via the inhibition of NF-κB in male C57BL/6J mice and BV2 microglial cells. J Agric Food Chem. 66:10205–10214. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Xu Y, Sheng H, Bao Q, Wang Y, Lu J and Ni X: NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice. Brain Behav Immun. 56:175–186. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Peng Q, Liu H, Shi S and Li M: Lycium ruthenicum polysaccharide attenuates inflammation through inhibiting TLR4/NF-κB signaling pathway. Int J Biol Macromol. 67:330–335. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Gan F, Liu Q, Liu Y, Huang D, Pan C, Song S and Huang K: Lycium barbarum polysaccharides improve CCl4-induced liver fibrosis, inflammatory response and TLRs/NF-kB signaling pathway expression in wistar rats. Life Sci. 192:205–212. 2018. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng X, Wang J, Bi F, Li Y, Xiao J, Chai Z, Li Y, Miao Z and Wang Y: Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice. Int J Mol Med 48: 121, 2021.
APA
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z. ... Wang, Y. (2021). Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice. International Journal of Molecular Medicine, 48, 121. https://doi.org/10.3892/ijmm.2021.4954
MLA
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z., Li, Y., Miao, Z., Wang, Y."Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice". International Journal of Molecular Medicine 48.1 (2021): 121.
Chicago
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z., Li, Y., Miao, Z., Wang, Y."Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice". International Journal of Molecular Medicine 48, no. 1 (2021): 121. https://doi.org/10.3892/ijmm.2021.4954
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng X, Wang J, Bi F, Li Y, Xiao J, Chai Z, Li Y, Miao Z and Wang Y: Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice. Int J Mol Med 48: 121, 2021.
APA
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z. ... Wang, Y. (2021). Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice. International Journal of Molecular Medicine, 48, 121. https://doi.org/10.3892/ijmm.2021.4954
MLA
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z., Li, Y., Miao, Z., Wang, Y."Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice". International Journal of Molecular Medicine 48.1 (2021): 121.
Chicago
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z., Li, Y., Miao, Z., Wang, Y."Protective effects of <em>Lycium barbarum</em> polysaccharide on ovariectomy‑induced cognition reduction in aging mice". International Journal of Molecular Medicine 48, no. 1 (2021): 121. https://doi.org/10.3892/ijmm.2021.4954
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team