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Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis

  • Authors:
    • Hui Jiang
    • Chang Fan
    • Yunqi Lu
    • Xiaoya Cui
    • Jian Liu
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    Affiliations: Experimental Center of Clinical Research, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230031, P.R. China, Department of Biochemistry, Drew University, Madison, NJ 07940, USA
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 130
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    Published online on: May 17, 2021
       https://doi.org/10.3892/ijmm.2021.4963
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Abstract

Previous studies have confirmed that astragaloside (AST) exerts a positive effect on alleviating synovial and joint injury in rheumatoid arthritis (RA). However, the precise mechanisms through which AST acts in the treatment of RA remain unclear. Long non‑coding RNA (lncRNA) LOC100912373 was identified as a key gene related to RA and has been proven to interact with miR‑17‑5p, in order to regulate the pyruvate dehydrogenase kinase 1 and protein kinase B axis (PDK1/AKT axis). The present study aimed to determine whether AST may treat RA through the interaction between lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis. MTT assays and flow cytometry were used to detect the proliferation and cell cycle progression of AST‑treated fibroblast‑like synoviocytes (FLSs). The expression of lncRNA LOC100912373 and miR‑17‑5p, as well as relative the mRNA expression of the PDK1 and AKT genes following AST intervention was detected by reverse transcription‑quantitative PCR (RT‑qPCR), immunofluorescence and western blot analysis. The results revealed that AST inhibited FLS proliferation, reduced lncRNA LOC100912373 expression levels, increased miR‑17‑5p expression levels, and decreased the PDK1 and p‑AKT expression levels. Additionally, consecutive rescue experiments revealed that AST counteracted the effects of lncRNA LOC100912373 overexpression on FLS proliferation and cell cycle progression. On the whole, the present study demonstrates that AST inhibits FLS proliferation by regulating the expression of lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis.
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View References

1 

Smolen JS, Aletaha D and McInnes IB: Rheumatoid arthritis. Lancet. 388:2023–2038. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Ham S, Bae JB, Lee S, Kim BJ, Han BG, Kwok SK and Roh TY: Epigenetic analysis in rheumatoid arthritis synoviocytes. Exp Mol Med. 51:1–13. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Li X, Yuan K, Zhu Q, Lu Q, Jiang H, Zhu M, Huang G and Xu A: Andrographolide ameliorates rheumatoid arthritis by regulating the apoptosis-NETosis balance of neutrophils. Int J Mol Sci. 20:50352019. View Article : Google Scholar

4 

Blunk I, Thomsen H, Reinsch N, Mayer M, Försti A, Sundquist J, Sundquist K and Hemminki K: Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis. Sci Rep. 10:115622020. View Article : Google Scholar : PubMed/NCBI

5 

Mameli G, Erre GL, Caggiu E, Mura S, Cossu D, Bo M, Cadoni ML, Piras A, Mundula N, Colombo E, et al: Identification of a HERV-K env surface peptide highly recognized in rheumatoid arthritis (RA) patients: A cross-sectional case-control study. Clin Exp Immunol. 189:127–131. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Muschter D, Schäfer N, Stangl H, Straub RH and Grässel S: Sympathetic neurotransmitters modulate osteoclastogenesis and osteoclast activity in the context of collagen-induced arthritis. PLoS One. 10:e01397262015. View Article : Google Scholar : PubMed/NCBI

7 

Lowin T, Anssar TM, Bäuml M, Classen T, Schneider M and Pongratz G: Positive and negative cooperativity of TNF and Interferon-γ in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures. Sci Rep. 10:7802020. View Article : Google Scholar

8 

Zhao J, Chen B, Peng X, Wang C, Wang K, Han F and Xu J: Quercetin suppresses migration and invasion by targeting miR-146a/GATA6 axis in fibroblast-like synoviocytes of rheumatoid arthritis. Immunopharmacol Immunotoxicol. 42:221–227. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Lucchino B, Spinelli FR, Iannuccelli C, Guzzo MP, Conti F and Di Franco M: Mucosa-environment interactions in the pathogenesis of rheumatoid arthritis. Cells. 8:7002019. View Article : Google Scholar

10 

Cappelli LC, Thomas MA, Bingham CO III, Shah AA and Darrah E: Immune checkpoint inhibitor-induced inflammatory arthritis as a model of autoimmune arthritis. Immunol Rev. 294:106–123. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Matta R, Wang X, Ge H, Ray W, Nelin LD and Liu Y: Triptolide induces anti-inflammatory cellular responses. Am J Transl Res. 1:267–282. 2009.PubMed/NCBI

12 

Guo Q, Mao X, Zhang Y, Meng S, Xi Y, Ding Y, Zhang X, Dai Y, Liu X, Wang C, et al: Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance. J Transl Med. 14:1652016. View Article : Google Scholar : PubMed/NCBI

13 

Liu XY, Xu L, Wang Y, Li JX, Zhang Y, Zhang C, Wang SS and Zhang XM: Protective effects of total flavonoids of astragalus against adjuvant-induced arthritis in rats by regulating OPG/RANKL/NF-κB pathway. Int Immunopharmacol. 44:105–114. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Pu X, Ma X, Liu L, Ren J, Li H, Li X, Yu S, Zhang W and Fan W: Structural characterization and antioxidant activity in vitro of polysaccharides from angelica and astragalus. Carbohydr Polym. 137:154–164. 2016. View Article : Google Scholar

15 

Dong Z, Zhao P, Xu M, Zhang C, Guo W, Chen H, Tian J, Wei H, Lu R and Cao T: Astragaloside IV alleviates heart failure via activating PPARα to switch glycolysis to fatty acid β-oxidation. Sci Rep. 7:26912017. View Article : Google Scholar

16 

Chen L, Xie ZY, Liu L, Zhu L, Wang F, Fan P, Sinkemani A, Zhang C, Hong X and Wu XT: Nuclear factor-kappa B-dependent X-box binding protein 1 signalling promotes the proliferation of nucleus pulposus cells under tumour necrosis factor alpha stimulation. Cell Prolif. 52:e125422019. View Article : Google Scholar

17 

Chen X, Chen X, Gao J, Yang H, Duan Y, Feng Y, He X, Gong X, Wang H, Wu X and Chang J: Astragaloside III enhances anti-tumor response of NK cells by elevating NKG2D and IFN-γ. Front Pharmacol. 10:8982019. View Article : Google Scholar

18 

Jiang H, Wu FR, Liu J, Qin XJ, Jiang NN and Li WP: Effect of astragalosides on long non-coding RNA expression profiles in rats with adjuvant-induced arthritis. Int J Mol Med. 44:1344–1356. 2019.PubMed/NCBI

19 

Xu F, Jin L, Jin Y, Nie Z and Zheng H: Long noncoding RNAs in autoimmune diseases. J Biomed Mater Res A. 107:468–475. 2019. View Article : Google Scholar

20 

Zhang TP, Zhu BQ, Tao SS, Fan YG, Li XM, Pan HF and Ye DQ: Long non-coding RNAs genes polymorphisms and their expression levels in patients with rheumatoid arthritis. Front Immunol. 10:25292019. View Article : Google Scholar : PubMed/NCBI

21 

Jiang H, Liu J, Fan C, Wang J and Li W: lncRNAS56464.1 as a ceRNA promotes the proliferation of fibroblast-like synoviocytes in experimental arthritis via the Wnt signaling pathway and sponges miR-152-3p. Int J Mol Med. 47:172021. View Article : Google Scholar :

22 

Bi X, Guo XH, Mo BY, Wang ML, Luo XQ, Chen YX, Liu F, Olsen N, Pan YF and Zheng SG: LncRNA PICSAR promotes cell proliferation, migration and invasion of fibroblast-like synoviocytes by sponging miRNA-4701-5p in rheumatoid arthritis. EBioMedicine. 50:408–420. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Jiang H, Qin XJ, Li WP, Ma R, Wang T and Li ZQ: LncRNAs expression in adjuvant-induced arthritis rats reveals the potential role of LncRNAs contributing to rheumatoid arthritis pathogenesis. Gene. 593:131–142. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Fan C, Cui X, Chen S, Huang S and Jiang H: LncRNA LOC100912373 modulates PDK1 expression by sponging miR-17-5p to promote the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Am J Transl Res. 12:7709–7723. 2020.

25 

Jiang H, Liu J, Wang T, Gao JR, Sun Y, Huang CB, Meng M and Qin XJ: Urinary metabolite profiling provides potential differentiation to explore the mechanisms of adjuvant-induced arthritis in rats. Biomed Chromatogr. 30:1397–1405. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Zhu L, Li J, Guo L, Yu X, Wu D, Luo L, Zhu L, Chen W, Chen C, Ye C and Zhang D: Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis. Br J Pharmacol. 172:3446–3459. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Luo C, Liang JS, Gong J, Zhang HL, Feng ZJ, Yang HT, Zhang HB and Kong QH: miRNA-31 over-expression improve synovial cells apoptosis induced by RA. Bratisl Lek Listy. 119:355–360. 2018.PubMed/NCBI

28 

Chen L, Feng L, Wang X, Du J, Chen Y, Yang W, Zhou C, Cheng L, Shen Y, Fang S, et al: Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway. Sci Rep. 5:81332015. View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

30 

Yang Y, Dong Q and Li R: Matrine induces the apoptosis of fibroblast-like synoviocytes derived from rats with collagen-induced arthritis by suppressing the activation of the JAK/STAT signaling pathway. Int J Mol Med. 39:307–316. 2017. View Article : Google Scholar :

31 

Siu MKY, Jiang YX, Wang JJ, Leung THY, Ngu SF, Cheung ANY, Ngan HYS and Chan KKL: PDK1 promotes ovarian cancer metastasis by modulating tumor-mesothelial adhesion, invasion, and angiogenesis via α5β1 integrin and JNK/IL-8 signaling. Oncogenesis. 9:242020. View Article : Google Scholar

32 

He J, Wang Y, Liu T, Liu G, Chen S, Li Q, Quan Y, Yang H, Feng J, Wang S, et al: Stage-specific requirement of kinase PDK1 for NK cells development and activation. Cell Death Differ. 26:1918–1928. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Song X, Wang Z, Liang H, Zhang W, Ye Y, Li H, Hu Y, Zhang Y, Weng H, Lu J, et al: Dioscin induces gallbladder cancer apoptosis by inhibiting ROS-mediated PI3K/AKT signalling. Int J Biol Sci. 13:782–793. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Saji M, Kim CS, Wang C, Zhang X, Khanal T, Coombes K, La Perle K, Cheng SY, Tsichlis PN and Ringel MD: Akt isoform-specific effects on thyroid cancer development and progression in a murine thyroid cancer model. Sci Rep. 10:183162020. View Article : Google Scholar : PubMed/NCBI

35 

Bunte K and Beikler T: Th17 cells and the IL-23/IL-17 axis in the pathogenesis of periodontitis and immune-mediated inflammatory diseases. Int J Mol Sci. 20:33942019. View Article : Google Scholar :

36 

Bodkhe R, Balakrishnan B and Taneja V: The role of microbiome in rheumatoid arthritis treatment. Ther Adv Musculoskelet Dis. 11:1759720X198446322019. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Zhou J, Tang C, Yu J, Zhu W, Guo J and Wang Y: Positive effect of astragaloside IV on neurite outgrowth via talin-dependent integrin signaling and microfilament force. J Cell Physiol. 236:2156–2168. 2021. View Article : Google Scholar

38 

Li N, Wu K, Feng F, Wang L, Zhou X and Wang W: Astragaloside IV alleviates silica-induced pulmonary fibrosis via inactivation of the TGF-β1/Smad2/3 signaling pathway. Int J Mol Med. 47:162021. View Article : Google Scholar

39 

Wang B and Chen MZ: Astragaloside IV possesses antiarthritic effect by preventing interleukin 1β-induced joint inflammation and cartilage damage. Arch Pharm Res. 37:793–802. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Wang S, Zuo S, Liu Z, Ji X, Yao Z and Wang X: Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis. Biomed Pharmacother. 106:813–820. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Xie YF, Feng WW, Liu MC, Xie J, Yu L, Gong XH, Li YX and Peng C: Investigation of efficacy enhancing and toxicity reducing mechanism of combination of aconiti lateralis radix praeparata and paeoniae radix alba in adjuvant-induced arthritis rats by metabolomics. Evid Based Complement Alternat Med. 2019:98648412019. View Article : Google Scholar : PubMed/NCBI

42 

Jia Q, Wang T, Wang X, Xu H, Liu Y, Wang Y, Shi Q and Liang Q: Astragalin suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis and in human fibroblast-like synoviocytes. Front Pharmacol. 10:942019. View Article : Google Scholar : PubMed/NCBI

43 

Yan MM, Chen CY, Zhao BS, Zu YG, Fu YJ, Liu W and Efferth T: Enhanced extraction of astragalosides from radix astragali by negative pressure cavitation-accelerated enzyme pretreatment. Bioresour Technol. 101:7462–7471. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Salmena L, Poliseno L, Tay Y, Kats L and Pandolfi PP: A ceRNA hypothesis: The rosetta stone of a hidden RNA language? Cell. 146:353–358. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Zhao CC, Jiao Y, Zhang YY, Ning J, Zhang YR, Xu J, Wei W and Kang-Sheng G: Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC. Cell Death Dis. 10:2522019. View Article : Google Scholar

46 

Mo BY, Guo XH, Yang MR, Liu F, Bi X, Liu Y, Fang LK, Luo XQ, Wang J, Bellanti JA, et al: Long non-coding RNA GAPLINC promotes tumor-like biologic behaviors of fibroblast-like synoviocytes as MicroRNA sponging in rheumatoid arthritis patients. Front Immunol. 9:7022018. View Article : Google Scholar : PubMed/NCBI

47 

Yan S, Wang P, Wang J, Yang J, Lu H, Jin C, Cheng M and Xu D: Long non-coding RNA HIX003209 promotes inflammation by sponging miR-6089 via TLR4/NF-κB signaling pathway in rheumatoid arthritis. Front Immunol. 10:22182019. View Article : Google Scholar

48 

Li G, Liu Y, Meng F, Xia Z, Wu X, Fang Y, Zhang C, Zhang Y and Liu D: LncRNA MEG3 inhibits rheumatoid arthritis through miR-141 and inactivation of AKT/mTOR signalling pathway. J Cell Mol Med. 23:7116–7120. 2019. View Article : Google Scholar : PubMed/NCBI

49 

Sun L, Tu J, Liu C, Pan A, Xia X and Chen X: Analysis of lncRNA expression profiles by sequencing reveals that lnc-AL928768.3 and lnc-AC091493.1 are novel biomarkers for disease risk and activity of rheumatoid arthritis. Inflammopharmacology. 28:437–450. 2020. View Article : Google Scholar

50 

Sun C, Sun Y, Jiang D, Bao G, Zhu X, Xu D, Wang Y and Cui Z: PDK1 promotes the inflammatory progress of fibroblast-like synoviocytes by phosphorylating RSK2. Cell Immunol. 315:27–33. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, Yang X, Lian F and Sun L: Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes. Rheumatology (Oxford). 46:920–926. 2007. View Article : Google Scholar

52 

Ichikawa R, Kawasaki R, Iwata A, Otani S, Nishio E, Nomura H and Fujii T: MicroRNA-126-3p suppresses HeLa cell proliferation, migration and invasion, and increases apoptosis via the PI3K/PDK1/AKT pathway. Oncol Rep. 43:1300–1308. 2020.PubMed/NCBI

53 

Shen X, Yu Y, Ma P, Luo Z, Hu Y, Li M, He Y, Zhang Y, Peng Z, Song G and Cai K: Titania nanotubes promote osteogenesis via mediating crosstalk between macrophages and MSCs under oxidative stress. Colloids Surf B Biointerfaces. 180:39–48. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Chen D, Zeng S, Huang M, Xu H, Liang L and Yang X: Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. J Cell Mol Med. 21:781–790. 2017. View Article : Google Scholar

55 

Fu H, Zhang W, Yuan Q, Niu M, Zhou F, Qiu Q, Mao G, Wang H, Wen L, Sun M, et al: PAK1 promotes the proliferation and inhibits apoptosis of human spermatogonial stem cells via PDK1/KDR/ZNF367 and ERK1/2 and AKT pathways. Mol Ther Nucleic Acids. 12:769–786. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang H, Fan C, Lu Y, Cui X and Liu J: Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis. Int J Mol Med 48: 130, 2021.
APA
Jiang, H., Fan, C., Lu, Y., Cui, X., & Liu, J. (2021). Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis. International Journal of Molecular Medicine, 48, 130. https://doi.org/10.3892/ijmm.2021.4963
MLA
Jiang, H., Fan, C., Lu, Y., Cui, X., Liu, J."Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis". International Journal of Molecular Medicine 48.1 (2021): 130.
Chicago
Jiang, H., Fan, C., Lu, Y., Cui, X., Liu, J."Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis". International Journal of Molecular Medicine 48, no. 1 (2021): 130. https://doi.org/10.3892/ijmm.2021.4963
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang H, Fan C, Lu Y, Cui X and Liu J: Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis. Int J Mol Med 48: 130, 2021.
APA
Jiang, H., Fan, C., Lu, Y., Cui, X., & Liu, J. (2021). Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis. International Journal of Molecular Medicine, 48, 130. https://doi.org/10.3892/ijmm.2021.4963
MLA
Jiang, H., Fan, C., Lu, Y., Cui, X., Liu, J."Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis". International Journal of Molecular Medicine 48.1 (2021): 130.
Chicago
Jiang, H., Fan, C., Lu, Y., Cui, X., Liu, J."Astragaloside regulates lncRNA LOC100912373 and the miR‑17‑5p/PDK1 axis to inhibit the proliferation of fibroblast‑like synoviocytes in rats with rheumatoid arthritis". International Journal of Molecular Medicine 48, no. 1 (2021): 130. https://doi.org/10.3892/ijmm.2021.4963
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