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Review Open Access

Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)

  • Authors:
    • Yinfeng Wang
    • Changchang Hu
    • Tao Fang
    • Yang Jin
    • Ruijin Wu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 150
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    Published online on: June 14, 2021
       https://doi.org/10.3892/ijmm.2021.4983
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Abstract

The developmental origins of health and disease concept illustrates that exposure in early life to various factors may affect the offspring's long‑term susceptibility to disease. During development, the nervous system is sensitive and vulnerable to the environmental insults. Polychlorinated biphenyls (PCBs), which are divided into dioxin‑like (DL‑PCBs) and non‑dioxin‑like PCBs (NDL‑PCBs), are synthetic persistent environmental endocrine‑disrupting chemicals. The toxicological mechanisms of DL‑PCBs have been associated with the activation of the aryl hydrocarbon receptor and NDL‑PCBs have been associated with ryanodine receptor‑mediated calcium ion channels, which affect neuronal migration, promote dendritic growth and alter neuronal connectivity. In addition, PCB accumulation in the placenta destroys the fetal placental unit and affects endocrine function, particularly thyroid hormones and the dopaminergic system, leading to neuroendocrine disorders. However, epidemiological investigations have not achieved a consistent result in different study cohorts. The present review summarizes the epidemiological differences and possible mechanisms of the effects of intrauterine PCB exposure on neurological development.
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Spandidos Publications style
Wang Y, Hu C, Fang T, Jin Y and Wu R: Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review). Int J Mol Med 48: 150, 2021.
APA
Wang, Y., Hu, C., Fang, T., Jin, Y., & Wu, R. (2021). Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review). International Journal of Molecular Medicine, 48, 150. https://doi.org/10.3892/ijmm.2021.4983
MLA
Wang, Y., Hu, C., Fang, T., Jin, Y., Wu, R."Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)". International Journal of Molecular Medicine 48.2 (2021): 150.
Chicago
Wang, Y., Hu, C., Fang, T., Jin, Y., Wu, R."Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)". International Journal of Molecular Medicine 48, no. 2 (2021): 150. https://doi.org/10.3892/ijmm.2021.4983
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Hu C, Fang T, Jin Y and Wu R: Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review). Int J Mol Med 48: 150, 2021.
APA
Wang, Y., Hu, C., Fang, T., Jin, Y., & Wu, R. (2021). Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review). International Journal of Molecular Medicine, 48, 150. https://doi.org/10.3892/ijmm.2021.4983
MLA
Wang, Y., Hu, C., Fang, T., Jin, Y., Wu, R."Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)". International Journal of Molecular Medicine 48.2 (2021): 150.
Chicago
Wang, Y., Hu, C., Fang, T., Jin, Y., Wu, R."Perspective on prenatal polychlorinated biphenyl exposure and the development of the progeny nervous system (Review)". International Journal of Molecular Medicine 48, no. 2 (2021): 150. https://doi.org/10.3892/ijmm.2021.4983
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