Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
September-2021 Volume 48 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 48 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4

Retraction in: /10.3892/ijmm.2024.5353
  • Authors:
    • Jing-Meng Hu
    • Li-Jie He
    • Peng-Bo Wang
    • Yan Yu
    • Ya-Ping Ye
    • Li Liang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The Southern Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Nephrology, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 169
    |
    Published online on: July 9, 2021
       https://doi.org/10.3892/ijmm.2021.5002
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute renal injury (ARI) is a life‑threatening condition and a main contributor to end‑stage renal disease, which is mainly caused by ischemia‑reperfusion (I/R). miR‑106b‑5p is a kidney function‑related miRNA; however, whether miR‑106b‑5p regulates the progression of ARI remains unclear. The present study thus aimed to examine the effects of miR‑106b‑5p antagonist on the regulation of ARI progression. It was found that miR‑106b‑5p expression was upregulated in the renal tissue of rats with I/R‑induced ARI and in NRK‑52E rat renal proximal tubular epithelial cells subjected to hypoxia‑reoxygenation (H/R). In vitro, H/R induction suppressed the proliferation, and promoted the apoptosis and autophagy of NRK‑52E cells, whereas miR‑106b‑5p antagonist (inhibition of miR‑106b‑5p) promoted the proliferation, and attenuated the apoptosis and autophagy of NRK‑52E cells under the H/R condition. Dual luciferase reporter gene assay validated that transcription factor 4 (TCF4) was a target of miR‑106b‑5p. It was further found that TCF4 overexpression promoted the proliferation, and inhibited the apoptosis and autophagy of NRK‑52E cells subjected to H/R. Moreover, the effects of miR‑106b‑5p antagonist on NRK‑52E cell proliferation, apoptosis and autophagy were mediated through the regulation of TCF4. In vivo, miR‑106b‑5p antagonist reduced the severity of renal injury, decreased cell proliferation in renal tissues and lowered the serum creatinine (Scr) and blood urea nitrogen (BUN) levels in the blood samples from rats with I/R‑induced ARI. On the whole, the findings presented herein demonstrate that miR‑106b‑5p antagonist attenuates ARI by promoting the proliferation, and suppressing the apoptosis and autophagy of renal cells via upregulating TCF4.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Fortrie G, de Geus HR and Betjes MG: The aftermath of acute kidney injury: A narrative review of long-term mortality and renal function. Crit Care. 23:242019. View Article : Google Scholar : PubMed/NCBI

2 

Kölling M, Genschel C, Kaucsar T, Hübner A, Rong S, Schmitt R, Sörensen-Zender I, Haddad G, Kistler A, Seeger H, et al: Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury. Sci Rep. 8:34382018. View Article : Google Scholar : PubMed/NCBI

3 

Diao C, Wang L, Liu H, Du Y and Liu X: Aged kidneys are refractory to autophagy activation in a rat model of renal ischemia-reperfusion injury. Clin Interv Aging. 14:525–534. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Wang M, Deng J, Lai H, Lai Y, Meng G, Wang Z, Zhou Z, Chen H, Yu Z, Li S and Jiang H: Vagus nerve stimulation ameliorates renal ischemia-reperfusion injury through inhibiting NF-κB activation and iNOS protein expression. Oxid Med Cell Longev. 2020:71065252020.

5 

Liu H, Wang L, Weng X, Chen H, Du Y, Diao C, Chen Z and Liu X: Inhibition of Brd4 alleviates renal ischemia/reperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress. Redox Biol. 24:1011952019. View Article : Google Scholar : PubMed/NCBI

6 

Xi X, Zou C, Ye Z, Huang Y, Chen T and Hu H: Pioglitazone protects tubular cells against hypoxia/reoxygenation injury through enhancing autophagy via AMPK-mTOR signaling pathway. Eur J Pharmacol. 863:1726952019. View Article : Google Scholar : PubMed/NCBI

7 

Prieto-Moure B, Lloris-Carsí JM, Belda-Antolí M, Toledo-Pereyra LH and Cejalvo-Lapeña D: Allopurinol protective effect of renal ischemia by downregulating TNF-α, IL-1β, and IL-6 response. J Invest Surg. 30:143–151. 2017. View Article : Google Scholar

8 

Yingjie K, Haihong Y, Lingwei C, Sen Z, Yuanting D, Shasha C, Liutong P, Ying W and Min Z: Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling. Biomed Pharmacother. 112:1086812019. View Article : Google Scholar : PubMed/NCBI

9 

Gu H, Gu S, Zhang X, Zhang S, Zhang D, Lin J, Hasengbayi S and Han W: MiR-106b-5p promotes aggressive progression of hepatocellular carcinoma via targeting RUNX3. Cancer Med. 8:6756–6767. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Sun K, Jia Z, Duan R, Yan Z, Jin Z, Yan L, Li Q and Yang J: Long non-coding RNA XIST regulates miR-106b-5p/P21 axis to suppress tumor progression in renal cell carcinoma. Biochem Biophys Res Commun. 510:416–420. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Tsukita S, Yamada T, Takahashi K, Munakata Y, Hosaka S, Takahashi H, Gao J, Shirai Y, Kodama S, Asai Y, et al: MicroRNAs 106b and 222 improve hyperglycemia in a mouse model of insulin-deficient diabetes via pancreatic β-Cell proliferation. EBioMedicine. 15:163–172. 2017. View Article : Google Scholar

12 

Liu F, Gong J, Huang W, Wang Z, Wang M, Yang J, Wu C, Wu Z and Han B: MicroRNA-106b-5p boosts glioma tumorigensis by targeting multiple tumor suppressor genes. Oncogene. 33:4813–4822. 2014. View Article : Google Scholar

13 

Zeng T, Wang X, Wang W, Feng Q, Lao G, Liang Y, Wang C, Zhou J, Chen Y, Liu J, et al: Endothelial cell-derived small extracellular vesicles suppress cutaneous wound healing through regulating fibroblasts autophagy. Clin Sci (Lond). 133:CS201900082019. View Article : Google Scholar

14 

Muendlein A, Geiger K, Leiherer A, Saely CH, Fraunberger P and Drexel H: Evaluation of the associations between circulating microRNAs and kidney function in coronary angiography patients. Am J Physiol Renal Physiol. 318:F315–F321. 2020. View Article : Google Scholar

15 

In't Hout FEM, Gerritsen M, Bullinger L, Van der Reijden BA, Huls G, Vellenga E and Jansen JH: Transcription factor 4 (TCF4) expression predicts clinical outcome in RUNX1 mutated and translocated acute myeloid leukemia. Haematologica. 105:e454–e457. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Wang Y, Lu Z, Zhang Y, Cai Y, Yun D, Tang T, Cai Z, Wang C, Zhang Y, Fang F, et al: Transcription factor 4 safeguards hippocampal dentate gyrus development by regulating neural progenitor migration. Cereb Cortex. 30:3102–3115. 2020. View Article : Google Scholar

17 

Young RM, Ewan KB, Ferrer VP, Allende ML, Godovac-Zimmermann J, Dale TC and Wilson S: Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation. Elife. 8:e514472019. View Article : Google Scholar :

18 

Menon MC, Chuang PY, Li Z, Wei C, Zhang W, Luan Y, Yi Z, Xiong H, Woytovich C, Greene I, et al: Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. J Clin Invest. 125:208–221. 2015. View Article : Google Scholar :

19 

Al-bataineh MM, Kinlough CL, Poland PA, Pastor-Soler NM, Sutton TA, Mang HE, Bastacky SI, Gendler SJ, Madsen CS, Singh S, et al: Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 310:F569–F579. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Li H, Ma Y, Chen B and Shi J: MiR-182 enhances acute kidney injury by promoting apoptosis involving the targeting and regulation of TCF7L2/Wnt/β-catenins pathway. Eur J Pharmacol. 831:20–27. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Xu Z, Hong Z, Ma M, Liu X, Chen L, Zheng C, Xi X and Shao J: Rock2 promotes RCC proliferation by decreasing SCARA5 expression through β-catenin/TCF4 signaling. Biochem Biophys Res Commun. 480:586–593. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Nàger M, Sallán MC, Visa A, Pushparaj C, Santacana M, Macià A, Yeramian A, Cantí C and Herreros J: Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers. Autophagy. 14:619–636. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Wei H, Qu H, Wang H, Ji B, Ding Y, Liu D, Duan Y, Liang H, Peng C, Xiao X and Deng H: 1,25-Dihydroxyvitamin-D3 prevents the development of diabetic cardiomyopathy in type 1 diabetic rats by enhancing autophagy via inhibiting the beta-catenin/TCF4/GSK-3beta/mTOR pathway. J Steroid Biochem Mol Biol. 168:71–90. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Zhang XB, Chen X, Li DJ, Qi GN, Dai YQ, Gu J, Chen MQ, Hu S, Liu ZY and Yang ZM: Inhibition of miR-155 ameliorates acute kidney injury by apoptosis involving the regulation on TCF4/Wnt/β-Catenin pathway. Nephron. 143:135–147. 2019. View Article : Google Scholar

25 

Shen B, Mei M, Pu Y, Zhang H, Liu H, Tang M, Pan Q, He Y, Wu X and Zhao H: Necrostatin-1 attenuates renal ischemia and reperfusion injury via meditation of HIF-1α/mir-26a/TRPC6/PARP1 Signaling. Mol Ther Nucleic Acids. 17:701–713. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

27 

Hu Y, Yang C, Yang S, Cheng F, Rao J and Wang X: MiR-665 promotes hepatocellular carcinoma cell migration, invasion, and proliferation by decreasing Hippo signaling through targeting PTPRB. Cell Death Dis. 9:9542018. View Article : Google Scholar : PubMed/NCBI

28 

Wang X, Liu J, Yin W, Abdi F, Pang PD, Fucci QA, Abbott M, Chang SL, Steele G, Patel A, et al: MiR-218 expressed in endothelial progenitor cells contributes to the development and repair of the kidney microvasculature. Am J Pathol. 190:642–659. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Jia P, Wu X, Dai Y, Teng J, Fang Y, Hu J, Zou J, Liang M and Ding X: MicroRNA-21 is required for local and remote ischemic preconditioning in multiple organ protection against sepsis. Crit Care Med. 45:e703–e710. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Amrouche L, Desbuissons G, Rabant M, Sauvaget V, Nguyen C, Benon A, Barre P, Rabaté C, Lebreton X, Gallazzini M, et al: MicroRNA-146a in human and experimental ischemic AKI: CXCL8-dependent mechanism of action. J Am Soc Nephrol. 28:479–493. 2017. View Article : Google Scholar :

31 

Hao J, Wei Q, Mei S, Li L, Su Y, Mei C and Dong Z: Induction of microRNA-175p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. Kidney Int. 91:106–118. 2017. View Article : Google Scholar

32 

Wei Q, Liu Y, Liu P, Hao J, Liang M, Mi QS, Chen JK and Dong Z: MicroRNA-489 induction by hypoxia-inducible factor-1 protects against ischemic kidney injury. J Am Soc Nephrol. 27:2784–2796. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Xu Z, Li Z, Wang W, Xia Y, He Z, Li B, Wang S, Huang X, Sun G, Xu J, et al: MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. Cancer Lett. 449:226–236. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Ma L, Li Z, Li W, Ai J and Chen X: MicroRNA-142-3p suppresses endometriosis by regulating KLF9-mediated autophagy in vitro and in vivo. RNA Biol. 16:1733–1748. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Zheng GH, Wen X, Wang YJ, Han XR, Shan Q, Li W, Zhao T, Wu DM, Lu J and Zheng YL: MicroRNA-381-induced down-regulation of CXCR4 promotes the proliferation of renal tubular epithelial cells in rat models of renal ischemia reperfusion injury. J Cell Biochem. 119:3149–3161. 2018. View Article : Google Scholar

36 

Chen S, Yao Y, Lin F, Bian F, Zhu C and Jiang G: MiR-424 is over-expressed and attenuates ischemia-reperfusion kidney injury via p53 and death receptor 6 pathway. Am J Transl Res. 11:1965–1979. 2019.PubMed/NCBI

37 

Liu XJ, Hong Q, Wang Z, Yu YY, Zou X and Xu LH: MicroRNA-34a suppresses autophagy in tubular epithelial cells in acute kidney injury. Am J Nephrol. 42:168–175. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Yan Y, Ma Z, Zhu J, Zeng M, Liu H and Dong Z: MiR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury. Am J Physiol Renal Physiol. 318:F878–887. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Liu B, Chai Y, Guo W, Lin K, Chen S, Liu J, Sun G, Chen G, Song F, He Y, et al: MicroRNA-188 aggravates contrast-induced apoptosis by targeting SRSF7 in novel isotonic contrast-induced acute kidney injury rat models and renal tubular epithelial cells. Ann Transl Med. 7:3782019. View Article : Google Scholar : PubMed/NCBI

40 

Xu X, Song N, Zhang X, Jiao X, Hu J, Liang M, Teng J and Ding X: Renal protection mediated by hypoxia inducible factor-1α depends on proangiogenesis function of miR-21 by targeting thrombospondin 1. Transplantation. 101:1811–1819. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Wu XQ, Tian XY, Wang ZW, Wu X, Wang JP and Yan TZ: MiR-191 secreted by platelet-derived microvesicles induced apoptosis of renal tubular epithelial cells and participated in renal ischemia-reperfusion injury via inhibiting CBS. Cell Cycle. 18:119–129. 2019. View Article : Google Scholar :

42 

Chen SJ, Wu P, Sun LJ, Zhou B, Niu W, Liu S, Lin FJ and Jiang GR: MiR-204 regulates epithelial-mesenchymal transition by targeting SP1 in the tubular epithelial cells after acute kidney injury induced by ischemia-reperfusion. Oncol Rep. 37:1148–1158. 2017. View Article : Google Scholar

43 

Chen HH, Lan YF, Li HF, Cheng CF, Lai PF, Li WH and Lin H: Urinary miR-16 transactivated by C/EBPβ reduces kidney function after ischemia/reperfusion-induced injury. Sci Rep. 6:279452016. View Article : Google Scholar

44 

Luo X, Wang J, Wei X, Wang S and Wang A: Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccharide-induced osteoarthritis progression by miR-130a-3p/TCF4. Life Sci. 240:1170192020. View Article : Google Scholar

45 

Yin C, Tian Y, Yu Y, Yang C, Su P, Zhao Y, Wang X, Zhang K, Pei J, Li D, et al: MiR-129-5p inhibits bone formation through TCF4. Front Cell Dev Biol. 8:6006412020. View Article : Google Scholar : PubMed/NCBI

46 

Xu J, Cao D, Zhang D, Zhang Y and Yue Y: MicroRNA-1 facilitates hypoxia-induced injury by targeting NOTCH3. J Cell Biochem. 121:4458–4469. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Li N, Guo X, Liu L, Wang L and Cheng R: Molecular mechanism of miR-204 regulates proliferation, apoptosis and autophagy of cervical cancer cells by targeting ATF2. Artif Cells Nanomed Biotechnol. 47:2529–2535. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Shen Y, Zhao Y, Wang L, Zhang W, Liu C and Yin A: MicroRNA-194 overexpression protects against hypoxia/reperfusion-induced HK-2 cell injury through direct targeting Rheb. J Cell Biochem. Nov 28–2018.Epub ahead of print.

49 

Guo Y, Ni J, Chen S, Bai M, Lin J, Ding G, Zhang Y, Sun P, Jia Z, Huang S, et al: MicroRNA-709 mediates acute tubular injury through effects on mitochondrial function. J Am Soc Nephrol. 29:449–461. 2018. View Article : Google Scholar :

50 

Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hübner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, et al: MicroRNA-24 antagonism prevents renal ischemia reperfusion injury. J Am Soc Nephrol. 25:2717–2729. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hu J, He L, Wang P, Yu Y, Ye Y and Liang L: Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353. Int J Mol Med 48: 169, 2021.
APA
Hu, J., He, L., Wang, P., Yu, Y., Ye, Y., & Liang, L. (2021). Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353. International Journal of Molecular Medicine, 48, 169. https://doi.org/10.3892/ijmm.2021.5002
MLA
Hu, J., He, L., Wang, P., Yu, Y., Ye, Y., Liang, L."Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353". International Journal of Molecular Medicine 48.3 (2021): 169.
Chicago
Hu, J., He, L., Wang, P., Yu, Y., Ye, Y., Liang, L."Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353". International Journal of Molecular Medicine 48, no. 3 (2021): 169. https://doi.org/10.3892/ijmm.2021.5002
Copy and paste a formatted citation
x
Spandidos Publications style
Hu J, He L, Wang P, Yu Y, Ye Y and Liang L: Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353. Int J Mol Med 48: 169, 2021.
APA
Hu, J., He, L., Wang, P., Yu, Y., Ye, Y., & Liang, L. (2021). Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353. International Journal of Molecular Medicine, 48, 169. https://doi.org/10.3892/ijmm.2021.5002
MLA
Hu, J., He, L., Wang, P., Yu, Y., Ye, Y., Liang, L."Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353". International Journal of Molecular Medicine 48.3 (2021): 169.
Chicago
Hu, J., He, L., Wang, P., Yu, Y., Ye, Y., Liang, L."Antagonist targeting miR‑106b‑5p attenuates acute renal injury by regulating renal function, apoptosis and autophagy via the upregulation of TCF4 Retraction in /10.3892/ijmm.2024.5353". International Journal of Molecular Medicine 48, no. 3 (2021): 169. https://doi.org/10.3892/ijmm.2021.5002
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team