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Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer

  • Authors:
    • Yu He
    • Yuchuan Shi
    • Yang Yang
    • Huanhuan Huang
    • Yifan Feng
    • Yunmeng Wang
    • Lei Zhan
    • Bing Wei
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China, Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 172
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    Published online on: July 13, 2021
       https://doi.org/10.3892/ijmm.2021.5005
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Abstract

Endometrial cancer (EC) is widely known as an aggressive malignancy. Due to the limited therapeutic options and poor prognosis of patients with advanced‑stage EC, there is a need to identify effective alternative treatments. Chrysin is a naturally active flavonoid (5,7‑dihydroxyflavone), which has been demonstrated to exert anticancer effects and may present a novel strategy for EC treatment. However, the role of chrysin in EC remains largely unclear. The aim of the present study was to examine the anticancer effects of chrysin on EC. The results revealed that, in addition to apoptosis, chrysin increased the LC3II expression levels and markedly accelerated the autophagic flux, suggesting that chrysin induced both the autophagy and apoptosis of EC cells. Furthermore, the inhibition of autophagy by chloroquine enhanced the inhibitory effect on cell proliferation and the promotion of the chrysin‑induced apoptosis of EC cells, indicating that chrysin‑induced autophagy was a cytoprotective mechanism. Additionally, chrysin led to the production of intracellular reactive oxygen species (ROS). N‑acetylcysteine (NAC) pretreatment significantly inhibited chrysin‑induced autophagy, suggesting that ROS activated autophagy induced by chrysin in EC cells. Furthermore, the phosphorylated (p‑)Akt and p‑mTOR levels were significantly decreased in a concentration‑dependent manner following treatment with chrysin, while NAC blocked these effects. Taken together, these findings demonstrated that chrysin‑induced autophagy via the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in EC cells.
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View References

1 

Urick ME and Bell DW: Clinical actionability of molecular targets in endometrial cancer. Nat Rev Cancer. 19:510–521. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Troisi J, Raffone A, Travaglino A, Belli G, Belli C, Anand S, Giugliano L, Cavallo P, Scala G, Symes S, et al: Development and validation of a serum metabolomic signature for endometrial cancer screening in postmenopausal women. JAMA Netw Open. 3:e20183272020. View Article : Google Scholar : PubMed/NCBI

3 

Clarke MA, Long BJ, Del Mar Morillo A, Arbyn M, Bakkum-Gamez JN and Wentzensen N: Association of endometrial cancer risk with postmenopausal bleeding in women: A systematic review and meta-analysis. JAMA Intern Med. 178:1210–1222. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Korets SB, Czok S, Blank SV, Curtin JP and Schneider RJ: Targeting the mTOR/4E-BP pathway in endometrial cancer. Clin Cancer Res. 17:7518–7528. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Rai R, Essel KG, Benbrook DM, Garland J, Zhao YD and Chandra V: Preclinical efficacy and involvement of AKT, mTOR, and ERK kinases in the mechanism of sulforaphane against endometrial cancer. Cancers (Basel). 12:12732020. View Article : Google Scholar

6 

Ma L, Zhang M, Zhao R, Wang D, Ma Y and Li A: Plant natural products: Promising resources for cancer chemoprevention. Molecules. 26:9332021. View Article : Google Scholar : PubMed/NCBI

7 

Sauter ER: Cancer prevention and treatment using combination therapy with natural compounds. Expert Rev Clin Pharmacol. 13:265–285. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Song S, Gao K, Niu R, Wang J, Zhang J, Gao C, Yang B and Liao X: Inclusion complexes between chrysin and amino-appended β-cyclodextrins (ACDs): Binding behavior, water solubility, in vitro antioxidant activity and cytotoxicity. Mater Sci Eng C Mater Biol Appl. 106:1101612020. View Article : Google Scholar

9 

Mani R and Natesan V: Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action. Phytochemistry. 145:187–196. 2018. View Article : Google Scholar

10 

Kasala ER, Bodduluru LN, Madana RM, Athira KV, Gogoi R and Barua CC: Chemopreventive and therapeutic potential of chrysin in cancer: Mechanistic perspectives. Toxicol Lett. 233:214–225. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Moghadam ER, Ang HL, Asnaf SE, Zabolian A, Saleki H, Yavari M, Esmaeili H, Zarrabi A, Ashrafizadeh M and Kumar AP: Broad-spectrum preclinical antitumor activity of chrysin: Current trends and future perspectives. Biomolecules. 10:13742020. View Article : Google Scholar :

12 

Roy S, Sil A and Chakraborty T: Potentiating apoptosis and modulation of p53, Bcl2, and Bax by a novel chrysin ruthenium complex for effective chemotherapeutic efficacy against breast cancer. J Cell Physiol. 234:4888–4909. 2019. View Article : Google Scholar

13 

Brechbuhl HM, Kachadourian R, Min E, Chan D and Day BJ: Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of glutathione. Toxicol Appl Pharmacol. 258:1–9. 2012. View Article : Google Scholar :

14 

Zhang T, Chen X, Qu L, Wu J, Cui R and Zhao Y: Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in hela cells. Bioorg Med Chem. 12:6097–6105. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Lima APB, Almeida TC, Barros TMB, Rocha LCM, Garcia CCM and da Silva GN: Toxicogenetic and antiproliferative effects of chrysin in urinary bladder cancer cells. Mutagenesis. 13:geaa0212020.

16 

Koff JL, Ramachandiran S and Bernal-Mizrachi L: A time to kill: Targeting apoptosis in cancer. Int J Mol Sci. 16:2942–2955. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Pang X, Zhang X, Jiang Y, Su Q, Li Q and Li Z: Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer. Biomolecules. 11:1352021. View Article : Google Scholar : PubMed/NCBI

18 

Crawley O, Opperman KJ, Desbois M, Adrados I, Borgen MA, Giles AC, Duckett DR and Grill B: Autophagy is inhibited by ubiquitin ligase activity in the nervous system. Nat Commun. 10:50172019. View Article : Google Scholar : PubMed/NCBI

19 

Ranieri R, Ciaglia E, Amodio G, Picardi P, Proto MC, Gazzerro P, Laezza C, Remondelli P, Bifulco M and Pisanti S: N6-isopentenyladenosine dual targeting of AMPK and rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux. Cell Death Differ. 25:353–367. 2018. View Article : Google Scholar :

20 

Lin YM, Chen CI, Hsiang YP, Hsu YC, Cheng KC, Chien PH, Pan HL, Lu CC and Chen YJ: Chrysin attenuates cell viability of human colorectal cancer cells through autophagy induction unlike 5-fluorouracil/oxaliplatin. Int J Mol Sci. 19:17632018. View Article : Google Scholar :

21 

Garcia-Martinez T, Vendrell-Flotats M, Martinez-Rodero I, Ordóñez-León EA, Álvarez-Rodríguez M, López-Béjar M, Yeste M and Mogas T: Glutathione ethyl ester protects in vitro-maturing bovine oocytes against oxidative stress induced by subsequent vitrification/warming. Int J Mol Sci. 21:75472020. View Article : Google Scholar :

22 

An Z, Tassa A, Thomas C, Zhong R, Xiao G, Fotedar R, Tu BP, Klionsky DJ and Levine B: Autophagy is required for G1/G0 quiescence in response to nitrogen starvation in Saccharomyces cerevisiae. Autophagy. 10:1702–1711. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Nunez-Olvera SI, Gallardo-Rincon D, Puente-Rivera J, Salinas-Vera YM, Marchat LA, Morales-Villegas R and López-Camarillo C: Autophagy machinery as a promising therapeutic target in endometrial cancer. Front Oncol. 9:13262019. View Article : Google Scholar : PubMed/NCBI

24 

Guo F, Zhang H, Jia Z, Cui M and Tian J: Chemoresistance and targeting of growth factors/cytokines signalling pathways: Towards the development of effective therapeutic strategy for endometrial cancer. Am J Cancer Res. 8:1317–1331. 2018.PubMed/NCBI

25 

Sharom FJ: ABC multidrug transporters: Structure, function and role in chemoresistance. Pharmacogenomics. 9:105–127. 2008. View Article : Google Scholar

26 

Crommentuijn MH, Maguire CA, Niers JM, Vandertop WP, Badr CE, Würdinger T and Tannous BA: Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 10:625–634. 2016. View Article : Google Scholar

27 

Bronikowska J, Szliszka E, Kostrzewa-Susłow E, Jaworska D, Czuba ZP, Bednarski P and Król W: Novel structurally related flavones augment cell death induced by rhsTRAIL. Int J Mol Sci. 18:12112017. View Article : Google Scholar :

28 

Rybstein MD, Bravo-San Pedro JM, Kroemer G and Galluzzi L: The autophagic network and cancer. Nat Cell Biol. 20:243–251. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Dou QH, Chen HN, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, et al: Ivermectin induces cytostatic autophagy by blocking the PAK1/akt axis in breast cancer. Cancer Res. 76:4457–4469. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Yao C, Liu BB, Qian XD, Li LQ, Cao HB, Guo QS and Zhou GF: Crocin induces autophagic apoptosis in hepatocellular carcinoma by inhibiting Akt/mTOR activity. Onco Targets Ther. 11:2017–2028. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Amaravadi RK, Lippincott-Schwartz J, Yin XM, Weiss WA, Takebe N, Timmer W, DiPaola RS, Lotze MT and White E: Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res. 17:654–666. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Ohnishi K, Yano S, Fujimoto M, Sakai M, Harumoto E, Furuichi A, Masuda M, Ohminami H, Yamanaka-Okumura H, Hara T and Taketani Y: Identification of dietary phytochemicals capable of enhancing the autophagy flux in HeLa and Caco-2 human cell lines. Antioxidants (Basel). 9:11932020. View Article : Google Scholar

33 

Lu Y, Xiao L, Liu Y, Wang H, Li H, Zhou Q, Pan J, Lei B, Huang A and Qi S: MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. Autophagy. 11:2213–2232. 2016. View Article : Google Scholar :

34 

Kim K, Dayem AA, Gil M, Yang GM, Lee SB, Kwon OH, Choi S, Kang GH, Lim KM, Kim D and Cho SG: 3,2′-Dihydroxyflavone improves the proliferation and survival of human pluripotent stem cells and their differentiation into hematopoietic progenitor cells. J Clin Med. 9:6692020. View Article : Google Scholar

35 

Lewinska A, Adamczyk-Grochala J, Deregowska A and Wnuk M: Sulforaphane-induced cell cycle arrest and senescence are accompanied by DNA hypomethylation and changes in microRNA profile in breast cancer cells. Theranostics. 7:3461–3477. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Ye S, Zhao T, Zhang W, Tang Z, Gao C, Ma Z, Xiong JW, Peng J, Tan WQ and Chen J: p53 isoform Δ113p53 promotes zebrafish heart regeneration by maintaining redox homeostasis. Cell Death Dis. 11:5682020. View Article : Google Scholar

37 

Deng L, Gao X, Liu B, He X, Xu J, Qiang J, Wu Q and Liu S: NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway. Cell Death Dis. 9:11432018. View Article : Google Scholar : PubMed/NCBI

38 

Yang CC, Tsai MH, Li KY, Hou CH and Lin FH: Carbon-doped TiO2 activated by X-ray irradiation for the generation of reactive oxygen species to enhance photodynamic therapy in tumor treatment. Int J Mol Sci. 20:20722019. View Article : Google Scholar

39 

Lim W, Ryu S, Bazer FW, Kim SM and Song G: Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction. J Cell Physiol. 233:3129–3140. 2018. View Article : Google Scholar

40 

Ru JY and Wang YF: Osteocyte apoptosis: The roles and key molecular mechanisms in resorption-related bone diseases. Cell Death Dis. 11:8462020. View Article : Google Scholar : PubMed/NCBI

41 

Guglielmelli P, Barosi G, Rambaldi A, Marchioli R, Masciulli A, Tozzi L, Biamonte F, Bartalucci N, Gattoni E, Lupo ML, et al: Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis. Blood. 118:2069–2076. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Zhou Y, Chen X, Qu N, Zhang B and Xia C: Chondroprotection of PPARα activation by WY14643 via autophagy involving akt and ERK in LPS-treated mouse chondrocytes and osteoarthritis model. J Cell Mol Med. 23:2782–2793. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Wang YX, Yang L, Wang HQ, Zhao XQ, Liu T, Li YH, Zeng QX, Li YH and Song DQ: Synthesis and evolution of berberine derivatives as a new class of antiviral agents against enterovirus 71 through the MEK/ERK pathway and autophagy. Molecules. 23:20842018. View Article : Google Scholar :

44 

Ives A, Nomura J, Martinon F, Roger T, LeRoy D, Miner JN, Simon G, Busso N and So A: Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation. Nat Commun. 6:65552015. View Article : Google Scholar

45 

Su Z, Burchfield JG, Yang P, Humphrey SJ, Yang G, Francis D, Yasmin S, Shin SY, Norris DM, Kearney AL, et al: Global redox proteome and phosphoproteome analysis reveals redox switch in akt. Nat Commun. 10:54862019. View Article : Google Scholar : PubMed/NCBI

46 

Huang CR, Chang TW, Lee CT, Shen CJ, Chang WC and Chen BK: ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis. Oncogenesis. 10:112021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He Y, Shi Y, Yang Y, Huang H, Feng Y, Wang Y, Zhan L and Wei B: Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer. Int J Mol Med 48: 172, 2021.
APA
He, Y., Shi, Y., Yang, Y., Huang, H., Feng, Y., Wang, Y. ... Wei, B. (2021). Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer. International Journal of Molecular Medicine, 48, 172. https://doi.org/10.3892/ijmm.2021.5005
MLA
He, Y., Shi, Y., Yang, Y., Huang, H., Feng, Y., Wang, Y., Zhan, L., Wei, B."Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer". International Journal of Molecular Medicine 48.3 (2021): 172.
Chicago
He, Y., Shi, Y., Yang, Y., Huang, H., Feng, Y., Wang, Y., Zhan, L., Wei, B."Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer". International Journal of Molecular Medicine 48, no. 3 (2021): 172. https://doi.org/10.3892/ijmm.2021.5005
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Shi Y, Yang Y, Huang H, Feng Y, Wang Y, Zhan L and Wei B: Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer. Int J Mol Med 48: 172, 2021.
APA
He, Y., Shi, Y., Yang, Y., Huang, H., Feng, Y., Wang, Y. ... Wei, B. (2021). Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer. International Journal of Molecular Medicine, 48, 172. https://doi.org/10.3892/ijmm.2021.5005
MLA
He, Y., Shi, Y., Yang, Y., Huang, H., Feng, Y., Wang, Y., Zhan, L., Wei, B."Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer". International Journal of Molecular Medicine 48.3 (2021): 172.
Chicago
He, Y., Shi, Y., Yang, Y., Huang, H., Feng, Y., Wang, Y., Zhan, L., Wei, B."Chrysin induces autophagy through the inactivation of the ROS‑mediated Akt/mTOR signaling pathway in endometrial cancer". International Journal of Molecular Medicine 48, no. 3 (2021): 172. https://doi.org/10.3892/ijmm.2021.5005
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