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Article Open Access

Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation

  • Authors:
    • Jing Zhao
    • Juan Chen
    • Yuan-Yuan Li
    • Ling-Ling Xia
    • Yong-Gui Wu
  • View Affiliations / Copyright

    Affiliations: Department of Nephropathy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 177
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    Published online on: July 16, 2021
       https://doi.org/10.3892/ijmm.2021.5010
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Abstract

It has been previously reported that macrophages may be involved in diabetic nephropathy (DN) development. Furthermore, Bruton's tyrosine kinase (BTK) may participate in macrophage activation and lead to the release of inflammatory mediators. The main aim of the present study was to analyze the association between renal BTK expression and clinical indicators. Moreover, BTK knockout mice were used to establish a diabetic model for further research. The results demonstrated that BTK was activated in the kidneys of patients with DN and was associated with the progression of proteinuria, creatinine levels, estimated glomerular filtration rate and pathological changes in the kidneys of patients with DN. Furthermore, BTK knockout was observed to reduce urinary protein excretion, alleviate renal injury and decrease renal inflammation in diabetic mice. This protection may be attributed to BTK‑induced suppression of the activation of the Nod‑like receptor (NLR) family pyrin domain containing 3 inflammasome. Collectively, it has been demonstrated in the present study that BTK may be a potential target for DN treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Chen J, Li Y, Xia L and Wu Y: Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation. Int J Mol Med 48: 177, 2021.
APA
Zhao, J., Chen, J., Li, Y., Xia, L., & Wu, Y. (2021). Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation. International Journal of Molecular Medicine, 48, 177. https://doi.org/10.3892/ijmm.2021.5010
MLA
Zhao, J., Chen, J., Li, Y., Xia, L., Wu, Y."Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation". International Journal of Molecular Medicine 48.3 (2021): 177.
Chicago
Zhao, J., Chen, J., Li, Y., Xia, L., Wu, Y."Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation". International Journal of Molecular Medicine 48, no. 3 (2021): 177. https://doi.org/10.3892/ijmm.2021.5010
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Chen J, Li Y, Xia L and Wu Y: Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation. Int J Mol Med 48: 177, 2021.
APA
Zhao, J., Chen, J., Li, Y., Xia, L., & Wu, Y. (2021). Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation. International Journal of Molecular Medicine, 48, 177. https://doi.org/10.3892/ijmm.2021.5010
MLA
Zhao, J., Chen, J., Li, Y., Xia, L., Wu, Y."Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation". International Journal of Molecular Medicine 48.3 (2021): 177.
Chicago
Zhao, J., Chen, J., Li, Y., Xia, L., Wu, Y."Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation". International Journal of Molecular Medicine 48, no. 3 (2021): 177. https://doi.org/10.3892/ijmm.2021.5010
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