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lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184

  • Authors:
    • Qiang Xie
    • Shankun Zhao
    • Ran Kang
    • Xiaolan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Reproduction, Affiliated Dongguan Hospital, Southern Medical University, Dongguan, Guangdong 523059, P.R. China, Department of Urology, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, Taizhou 318000, P.R. China, Department of Urology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China, Reproductive Center of Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 182
    |
    Published online on: July 28, 2021
       https://doi.org/10.3892/ijmm.2021.5015
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Abstract

Long non‑coding RNA (lncRNA) small nucleolar RNA host gene 11 (SNHG11) has been shown to play an important role in the development and progression of numerous types of cancer. However, to the best of our knowledge, the role of SNHG11 in prostate cancer (PCa) development and metastasis remains unclear. Thus, the aim of the present study was to investigate the functional role and molecular mechanisms of SNHG11 in PCa progression. It was revealed that the SNHG11 expression levels were significantly upregulated in PCa tissues, in comparison with those in adjacent normal tissues. Functionally, SNHG11 knockdown significantly suppressed PCa cell proliferation, migration, invasion and metastasis in vitro and in vivo. Furthermore, SNHG11 was found to positively regulate insulin‑like growth factor 1 receptor (IGF‑1R) expression by sponging microRNA (miRNA/miR)‑184 in PCa cells. The results of rescue experiments demonstrated that IGF‑1R overexpression reversed the suppressive effects of SNHG11 knockdown on the proliferation, migration and invasion of PCa cells. On the whole, the findings of the present study suggest that SNHG11 expression is upregulated in PCa and that it facilitates PCa progression, at least in part, via the modulation of the miR‑184/IGF‑1R signaling axis.
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Copy and paste a formatted citation
Spandidos Publications style
Xie Q, Zhao S, Kang R and Wang X: lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184. Int J Mol Med 48: 182, 2021.
APA
Xie, Q., Zhao, S., Kang, R., & Wang, X. (2021). lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184. International Journal of Molecular Medicine, 48, 182. https://doi.org/10.3892/ijmm.2021.5015
MLA
Xie, Q., Zhao, S., Kang, R., Wang, X."lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184". International Journal of Molecular Medicine 48.3 (2021): 182.
Chicago
Xie, Q., Zhao, S., Kang, R., Wang, X."lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184". International Journal of Molecular Medicine 48, no. 3 (2021): 182. https://doi.org/10.3892/ijmm.2021.5015
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Q, Zhao S, Kang R and Wang X: lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184. Int J Mol Med 48: 182, 2021.
APA
Xie, Q., Zhao, S., Kang, R., & Wang, X. (2021). lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184. International Journal of Molecular Medicine, 48, 182. https://doi.org/10.3892/ijmm.2021.5015
MLA
Xie, Q., Zhao, S., Kang, R., Wang, X."lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184". International Journal of Molecular Medicine 48.3 (2021): 182.
Chicago
Xie, Q., Zhao, S., Kang, R., Wang, X."lncRNA SNHG11 facilitates prostate cancer progression through the upregulation of IGF‑1R expression and by sponging miR‑184". International Journal of Molecular Medicine 48, no. 3 (2021): 182. https://doi.org/10.3892/ijmm.2021.5015
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