Open Access

GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression

  • Authors:
    • Yunlong Huang
    • Ran Ruan
    • Yanxin Fang
    • Kaiming Wu
    • Long Yao
    • Renquan Zhang
    • Wei He
  • View Affiliations

  • Published online on: August 3, 2021     https://doi.org/10.3892/ijmm.2021.5017
  • Article Number: 184
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Growth factor‑independent 1 (GFI1) has been reported to serve a vital role in hematopoietic development. However, the function and molecular mechanism of GFI1 in esophageal squamous cell carcinoma (ESCC) remains unknown. In the present study, the biological functions and the molecular mechanism of the effects of GFI1 in ESCC were analyzed. The results demonstrated that GFI1 expression levels were significantly upregulated in ESCC compared with those in normal esophageal tissues. Knockdown of GFI1 using small interfering RNA suppressed ESCC cell proliferation and migration. Furthermore, GFI1 enhanced STAT3 and NF‑κB signaling by inhibiting the expression of suppressor of cytokine signaling 1 (SOCS1) in ESCC cells. Taken together, the results of the present study demonstrated that GFI1 promoted the proliferation and migration of ESCC cells via inhibition of SOCS1 expression. These results suggested that GFI1 may be a valuable target for ESCC therapy.
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October-2021
Volume 48 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Huang Y, Ruan R, Fang Y, Wu K, Yao L, Zhang R and He W: GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression. Int J Mol Med 48: 184, 2021.
APA
Huang, Y., Ruan, R., Fang, Y., Wu, K., Yao, L., Zhang, R., & He, W. (2021). GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression. International Journal of Molecular Medicine, 48, 184. https://doi.org/10.3892/ijmm.2021.5017
MLA
Huang, Y., Ruan, R., Fang, Y., Wu, K., Yao, L., Zhang, R., He, W."GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression". International Journal of Molecular Medicine 48.4 (2021): 184.
Chicago
Huang, Y., Ruan, R., Fang, Y., Wu, K., Yao, L., Zhang, R., He, W."GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression". International Journal of Molecular Medicine 48, no. 4 (2021): 184. https://doi.org/10.3892/ijmm.2021.5017