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CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)

  • Authors:
    • Lin Chen
    • Fajuan Tang
    • Hu Gao
    • Xiaoyan Zhang
    • Xihong Li
    • Dongqiong Xiao
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 203
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    Published online on: September 21, 2021
       https://doi.org/10.3892/ijmm.2021.5036
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Abstract

Calpains are a family of Ca2+‑dependent cysteine proteases that participate in various cellular processes. Calpain 3 (CAPN3) is a classical calpain with unique N‑terminus and insertion sequence 1 and 2 domains that confer characteristics such as rapid autolysis, Ca2+‑independent activation and Na+ activation of the protease. CAPN3 is the only muscle‑specific calpain that has important roles in the promotion of calcium release from skeletal muscle fibers, calcium uptake of sarcoplasmic reticulum, muscle formation and muscle remodeling. Studies have indicated that recessive mutations in CAPN3 cause limb‑girdle muscular dystrophy (MD) type 2A and other types of MD; eosinophilic myositis, melanoma and epilepsy are also closely related to CAPN3. In the present review, the characteristics of CAPN3, its biological functions and roles in the pathogenesis of a number of disorders are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Chen L, Tang F, Gao H, Zhang X, Li X and Xiao D: CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review). Int J Mol Med 48: 203, 2021.
APA
Chen, L., Tang, F., Gao, H., Zhang, X., Li, X., & Xiao, D. (2021). CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review). International Journal of Molecular Medicine, 48, 203. https://doi.org/10.3892/ijmm.2021.5036
MLA
Chen, L., Tang, F., Gao, H., Zhang, X., Li, X., Xiao, D."CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)". International Journal of Molecular Medicine 48.5 (2021): 203.
Chicago
Chen, L., Tang, F., Gao, H., Zhang, X., Li, X., Xiao, D."CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)". International Journal of Molecular Medicine 48, no. 5 (2021): 203. https://doi.org/10.3892/ijmm.2021.5036
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Tang F, Gao H, Zhang X, Li X and Xiao D: CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review). Int J Mol Med 48: 203, 2021.
APA
Chen, L., Tang, F., Gao, H., Zhang, X., Li, X., & Xiao, D. (2021). CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review). International Journal of Molecular Medicine, 48, 203. https://doi.org/10.3892/ijmm.2021.5036
MLA
Chen, L., Tang, F., Gao, H., Zhang, X., Li, X., Xiao, D."CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)". International Journal of Molecular Medicine 48.5 (2021): 203.
Chicago
Chen, L., Tang, F., Gao, H., Zhang, X., Li, X., Xiao, D."CAPN3: A muscle‑specific calpain with an important role in the pathogenesis of diseases (Review)". International Journal of Molecular Medicine 48, no. 5 (2021): 203. https://doi.org/10.3892/ijmm.2021.5036
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