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Article

A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia

  • Authors:
    • Weimin Meng
    • Xiuting Cao
    • Wengqing Sun
    • Liheng Zheng
    • Bingdong Fan
    • Shengjing Zhou
    • Hongjuan Liu
    • Hua Wang
    • Wenxin Wang
    • Xiang Liu
  • View Affiliations / Copyright

    Affiliations: Intensive Care Unit, The Fourth People's Hospital of Qinghai Province, Xining, Qinghai 810000, P.R. China, Intensive Care Unit, The Fourth People's Hospital of Qinghai Province, Xining, Qinghai 810000, P.R. China, Intensive Care Unit, Shandong Chest Hospital, Jinan, Shandong 250000, P.R. China, Clinical Laboratory, Shijiazhuang Fifth People's Hospital, Shijiazhuang, Hebei 050000, P.R. China, Emergency Department, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, P.R. China, Emergency Intensive Care Unit, Qinghai Red Cross Hospital, Xining, Qinghai 810000, P.R. China
  • Article Number: 217
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    Published online on: October 18, 2021
       https://doi.org/10.3892/ijmm.2021.5050
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Abstract

Matrix metalloproteinase (MMP)‑9 is associated with the severity of ventilator‑associated pneumonia (VAP), while an rs1056629 SNP located in the 3'‑untranslated region (UTR) of MMP‑9 affects the microRNA (miRNA/miR)‑491‑mediated regulation of MMP‑9 expression. In the present study, the effect of rs1056629 on the development of VAP in patients with chronic obstructive pulmonary disease (COPD) was investigated. Patients with COPD were enrolled in the study and their genotypes of rs1056629 (CC, CA or AA) were determined. ELISA was used to analyze the levels of TNF‑α and IL‑6 in the monocytes of patients with COPD carrying differential genotypes of rs1056629. Reverse transcription‑quantitative PCR was carried out to evaluate the expression of miR‑491 and MMP‑9 mRNA in the different groups of patients with COPD. Luciferase assay was used to confirm the inhibitory role of miR‑491 in MMP‑9 expression. Western blot analysis was carried out to assess the expression of MMP‑9 protein in A549 and H1299 cells transfected with miR‑491 mimics. The risk and severity of VAP were significantly elevated in patients with COPD carrying the CC and AC genotypes of rs1056629. Although there was no difference in the expression of miR‑491 in patients carrying different genotypes of rs1056629, the expression levels of TNF‑α, IL‑6 and MMP‑9 were increased in patients with COPD carrying the CC and AC genotypes of rs1056629. The results of luciferase assay revealed that miR‑491 inhibited the expression of MMP‑9 through direct binding to the 3'UTR of MMP‑9. Transfection of miR‑491 mimics into A549 and H1299 cells markedly suppressed the expression of MMP‑9 in a concentration‑dependent manner. On the whole, the findings of the present study confirm that the CC and AC genotypes of rs1056629 increase the risk of developing VAP in patients with COPD by increasing the expression of MMP‑9.
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View References

1 

Hunter J, Annadurai S and Rothwell M: Diagnosis, management and prevention of ventilator-associated pneumonia in the UK. Eur J Anaesthesiol. 24:971–977. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Vincent JL: Ventilator-associated pneumonia. J Hosp Infect. 57:272–280. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Namath A and Patterson AJ: Genetic polymorphisms in sepsis. Crit Care Clin. 25835–856. (x)2009. View Article : Google Scholar : PubMed/NCBI

4 

Zhang B, Pan X, Cobb GP and Anderson TA: microRNAs as oncogenes and tumor suppressors. Dev Biol. 302:1–12. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS and Krichevsky AM: MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 28:5369–5380. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Fan G, He Z, Cao L, Shi X, Wu S and Zhou G: miR-139 inhibits osteosarcoma cell proliferation and invasion by targeting ROCK1. Front Biosci (Landmark Ed). 24:1167–1177. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS and Johnson JM: Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 433:769–773. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Deveci M, Catalyürek UV and Toland AE: mrSNP: Software to detect SNP effects on microRNA binding. BMC Bioinformatics. 15:732014. View Article : Google Scholar : PubMed/NCBI

9 

Tian X and Zhang X: A Single nucleotide polymorphism (rs1056629) in 3′-UTR of MMP-9 is responsible for a decreased risk of metastatic osteosarcoma by compromising its interaction with microRNA-491-5p. Cell Physiol Biochem. 38:1415–1424. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Yuan M, Zhan Q, Duan X, Song B, Zeng S, Chen X, Yang Q and Xia J: A functional polymorphism at miR-491-5p binding site in the 3′-UTR of MMP-9 gene confers increased risk for atherosclerotic cerebral infarction in a Chinese population. Atherosclerosis. 226:447–452. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Li YT, Wang YC, Lee HL, Lu MC and Yang SF: Elevated plasma matrix metalloproteinase-9 and its correlations with severity of disease in patients with ventilator-associated pneumonia. Int J Med Sci. 13:638–645. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Vandooren J, Van den Steen PE and Opdenakker G: Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade. Crit Rev Biochem Mol Biol. 48:222–272. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Atkinson JJ and Senior RM: Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol. 28:12–24. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Chiang TY, Tsao SM, Yeh CB and Yang SF: Matrix metalloproteinases in pneumonia. Clin Chim Acta. 433:272–277. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Brown GM, Brown DM, Donaldson K, Drost E and MacNee W: Neutrophil sequestration in rat lungs. Thorax. 50:661–667. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Chen Z, Shao X, Dou X, Zhang X, Wang Y, Zhu C, Hao C, Fan M, Ji W and Yan Y: Role of the mycoplasma pneumoniae/interleukin-8/neutrophil axis in the pathogenesis of pneumonia. PLoS One. 11:e01463772016. View Article : Google Scholar : PubMed/NCBI

17 

Zhou XY, Ben SQ, Chen HL and Ni SS: A comparison of APACHE II and CPIS scores for the prediction of 30-day mortality in patients with ventilator-associated pneumonia. Int J Infect Dis. 30:144–147. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Fan Y, Gao F, Wu Y, Zhang J, Zhu M and Xiong L: Does ventilator-associated event surveillance detect ventilator-associated pneumonia in intensive care units? A systematic review and meta-analysis. Crit Care. 20:3382016. View Article : Google Scholar : PubMed/NCBI

20 

Craven DE, Hudcova J and Lei Y: Diagnosis of ventilator-associated respiratory infections (VARI): Microbiologic clues for tracheobronchitis (VAT) and pneumonia (VAP). Clin Chest Med. 32:547–557. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Rosell A, Cuadrado E, Ortega-Aznar A, Hernández-Guillamon M, Lo EH and Montaner J: MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke. 39:1121–1126. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lakhan SE, Kirchgessner A, Tepper D and Leonard A: Matrix metalloproteinases and blood-brain barrier disruption in acute ischemic stroke. Front Neurol. 4:322013. View Article : Google Scholar : PubMed/NCBI

23 

Boroujerdi A, Welser-Alves JV and Milner R: Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5. Angiogenesis. 18:255–264. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Chen F, Eriksson P, Hansson GK, Herzfeld I, Klein M, Hansson LO and Valen G: Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque. Int J Mol Med. 15:57–65. 2005.PubMed/NCBI

25 

Hu J, Van den Steen PE, Sang QX and Opdenakker G: Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. Nat Rev Drug Discov. 6:480–498. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Ram M, Sherer Y and Shoenfeld Y: Matrix metalloproteinase-9 and autoimmune diseases. J Clin Immunol. 26:299–307. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Ahrens D, Koch AE, Pope RM, Stein-Picarella M and Niedbala MJ: Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis. Arthritis Rheum. 39:1576–1587. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Chang YH, Lin IL, Tsay GJ, Yang SC, Yang TP, Ho KT, Hsu TC and Shiau MY: Elevated circulatory MMP-2 and MMP-9 levels and activities in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Biochem. 41:955–959. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Lakatos G, Sipos F, Miheller P, Hritz I, Varga MZ, Juhasz M, Molnar B, Tulassay Z and Herszenyi L: The behavior of matrix metalloproteinase-9 in lymphocytic colitis, collagenous colitis and ulcerative colitis. Pathol Oncol Res. 18:85–91. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Peterson JT: The importance of estimating the therapeutic index in the development of matrix metalloproteinase inhibitors. Cardiovasc Res. 69:677–687. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Ben David D, Reznick AZ, Srouji S and Livne E: Exposure to pro-inflammatory cytokines upregulates MMP-9 synthesis by mesenchymal stem cells-derived osteoprogenitors. Histochem Cell Biol. 129:589–597. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Ben-David D, Livne E and Reznick AZ: The involvement of oxidants and NF-kB in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Inflamm Res. 61:673–688. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ordas I, Eckmann L, Talamini M, Baumgart DC and Sandborn WJ: Ulcerative colitis. Lancet. 380:1606–1619. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Schaaf B, Liebau C, Kurowski V, Droemann D and Dalhoff K: Hospital acquired pneumonia with high-risk bacteria is associated with increased pulmonary matrix metalloproteinase activity. BMC Pulm Med. 8:122008. View Article : Google Scholar : PubMed/NCBI

35 

El Solh AA, Akinnusi ME, Wiener-Kronish JP, Lynch SV, Pineda LA and Szarpa K: Persistent infection with pseudomonas aeruginosa in ventilator-associated pneumonia. Am J Respir Crit Care Med. 178:513–519. 2008. View Article : Google Scholar : PubMed/NCBI

36 

El-Solh AA, Amsterdam D, Alhajhusain A, Akinnusi ME, Saliba RG, Lynch SV and Wiener-Kronish JP: Matrix metalloproteases in bronchoalveolar lavage fluid of patients with type III Pseudomonas aeruginosa pneumonia. J Infect. 59:49–55. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Ito A, Mukaiyama A, Itoh Y, Nagase H, Thogersen IB, Enghild JJ, Sasaguri Y and Mori Y: Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem. 271:14657–14660. 1996. View Article : Google Scholar : PubMed/NCBI

38 

Schönbeck U, Mach F and Libby P: Generation of biologically active IL-1 beta by matrix metalloproteinases: A novel caspase-1-independent pathway of IL-1 beta processing. J Immunol. 161:3340–3346. 1998.PubMed/NCBI

39 

Amantea D, Russo R, Certo M, Rombola L, Adornetto A, Morrone LA, Corasaniti MT and Bagetta G: Caspase-1-independent maturation of IL-1β in ischemic brain injury: Is there a role for gelatinases? Mini Rev Med Chem. 16:729–737. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Wittmann M, Kingsbury SR and McDermott MF: Is caspase 1 central to activation of interleukin-1? Joint Bone Spine. 78:327–330. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Saren P, Welgus HG and Kovanen PT: TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol. 157:4159–4165. 1996.PubMed/NCBI

42 

Gearing AJ, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL, et al: Processing of tumour necrosis factor-alpha precursor by metalloproteinases. Nature. 370:555–557. 1994. View Article : Google Scholar : PubMed/NCBI

43 

Yu Q and Stamenkovic I: Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes Dev. 14:163–176. 2000.PubMed/NCBI

44 

Rainer PP, Hao S, Vanhoutte D, Lee DI, Koitabashi N, Molkentin JD and Kass DA: Cardiomyocyte-specific transforming growth factor β suppression blocks neutrophil infiltration, augments multiple cytoprotective cascades, and reduces early mortality after myocardial infarction. Circ Res. 114:1246–1257. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Dayer C and Stamenkovic I: Recruitment of matrix metalloproteinase-9 (MMP-9) to the fibroblast cell surface by lysyl hydroxylase 3 (LH3) triggers transforming growth factor-β (TGF-β) activation and fibroblast differentiation. J Biol Chem. 290:13763–13778. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Meng W, Cao X, Sun W, Zheng L, Fan B, Zhou S, Liu H, Wang H, Wang W, Liu X, Liu X, et al: A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia. Int J Mol Med 48: 217, 2021.
APA
Meng, W., Cao, X., Sun, W., Zheng, L., Fan, B., Zhou, S. ... Liu, X. (2021). A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia. International Journal of Molecular Medicine, 48, 217. https://doi.org/10.3892/ijmm.2021.5050
MLA
Meng, W., Cao, X., Sun, W., Zheng, L., Fan, B., Zhou, S., Liu, H., Wang, H., Wang, W., Liu, X."A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia". International Journal of Molecular Medicine 48.6 (2021): 217.
Chicago
Meng, W., Cao, X., Sun, W., Zheng, L., Fan, B., Zhou, S., Liu, H., Wang, H., Wang, W., Liu, X."A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia". International Journal of Molecular Medicine 48, no. 6 (2021): 217. https://doi.org/10.3892/ijmm.2021.5050
Copy and paste a formatted citation
x
Spandidos Publications style
Meng W, Cao X, Sun W, Zheng L, Fan B, Zhou S, Liu H, Wang H, Wang W, Liu X, Liu X, et al: A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia. Int J Mol Med 48: 217, 2021.
APA
Meng, W., Cao, X., Sun, W., Zheng, L., Fan, B., Zhou, S. ... Liu, X. (2021). A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia. International Journal of Molecular Medicine, 48, 217. https://doi.org/10.3892/ijmm.2021.5050
MLA
Meng, W., Cao, X., Sun, W., Zheng, L., Fan, B., Zhou, S., Liu, H., Wang, H., Wang, W., Liu, X."A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia". International Journal of Molecular Medicine 48.6 (2021): 217.
Chicago
Meng, W., Cao, X., Sun, W., Zheng, L., Fan, B., Zhou, S., Liu, H., Wang, H., Wang, W., Liu, X."A functional polymorphism at the miR‑491‑5p binding site in the 3'‑untranslated region of the MMP‑9 gene increases the risk of developing ventilator‑associated pneumonia". International Journal of Molecular Medicine 48, no. 6 (2021): 217. https://doi.org/10.3892/ijmm.2021.5050
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