Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2021 Volume 48 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 48 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice

  • Authors:
    • Lei Wang
    • Jiangwei Ding
    • Changliang Zhu
    • Baorui Guo
    • Wu Yang
    • Wenxin He
    • Xinxiao Li
    • Yangyang Wang
    • Wenchao Li
    • Feng Wang
    • Tao Sun
  • View Affiliations / Copyright

    Affiliations: Ningxia Key Laboratory of Cerebrocranial Disease, Incubation Base of National Key Laboratory, Ningxia Medical University, Yinchuan, Ningxia 750000, P.R. China, Department of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 219
    |
    Published online on: October 20, 2021
       https://doi.org/10.3892/ijmm.2021.5052
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epilepsy comorbidities and anti‑epileptic drugs (AEDs) are currently the main limitations of epilepsy treatment. Semaglutide is a glucagon like peptide‑1 analogue that has entered the market as a new once‑weekly drug for type II diabetes. The aim of the present study was to investigate the functions of semaglutide in epilepsy and inflammation models, in order to investigate its potential mechanism. In vitro, an inflammation model was established using lipopolysaccharide (LPS) and nigericin stimulation in BV2 cells. In vivo, chronic epilepsy model mice were generated using a pentylenetetrazole (PTZ) kindling method. BV2 cell proliferation was assessed using the Cell Counting Kit‑8. The effects of semaglutide on NLR family pyrin domain containing 3 (NLRP3) inflammasome activation and inflammatory cytokine secretion were determined using western blotting (WB) and ELISA. A lactate dehydrogenase (LDH) assay kit was used to detect the effect of semaglutide on LDH release. Electrocorticography and the modified Racine scale were used to assess seizure severity. Cognitive function was evaluated with behavioral assessment. Morphological changes in the hippocampus were observed with Nissl staining. Double immunofluorescence staining for NeuN and Iba‑1, WB and immunofluorescence analysis of apoptosis‑related proteins were used to evaluate neuronal apoptosis. The NLRP3 inflammasome was assessed by reverse transcription‑quantitative PCR, WB and immunofluorescence staining, and inflammatory cytokine release was evaluated by WB analysis in the hippocampus of C57/BL6J model mouse. Semaglutide attenuated the LPS‑ and nigericin‑induced inflammatory response and LDH release by blocking NLRP3 inflammasome activation in BV2 cells. Moreover, semaglutide decreased seizure severity, alleviated hippocampal neuronal apoptosis, ameliorated cognitive dysfunction, blocked NLRP3 inflammasome activation and decreased inflammatory cytokine secretion in PTZ‑kindled mice. These results indicated that semaglutide reduced seizure severity, exerted neuroprotective effects and ameliorated cognitive dysfunction, possibly via inhibition of NLRP3 inflammasome activation and inflammatory cytokine secretion. Semaglutide may therefore be a novel, promising adjuvant therapeutic for epilepsy and its associated comorbidities.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Rong S, Wan D, Fan Y, Liu S, Sun K, Huo J, Zhang P, Li X, Xie X, Wang F, et al: Amentoflavone affects epileptogenesis and exerts neuroprotective effects by inhibiting NLRP3 inflammasome. Front Pharmacol. 10:8562019. View Article : Google Scholar : PubMed/NCBI

2 

Juvale IIA and Che Has AT: Possible interplay between the theories of pharmacoresistant epilepsy. Eur J Neurosci. 53:1998–2026. 2021. View Article : Google Scholar

3 

Xiao D, Lv J, Zheng Z, Liu Y, Zhang Y, Luo C, Qi L, Qin B and Liu C: Mechanisms of microRNA 142 in mitochondrial autophagy and hippocampal damage in a rat model of epilepsy. Int J Mol Med. 47:982021. View Article : Google Scholar

4 

González-H G, Contreras-García IJ, Sánchez-Huerta K, Queiroz CM, Gallardo Gudiño LR, Mendoza-Torreblanca JG and Zamudio SR: Levetiracetam reduced the basal excitability of the dentate gyrus without restoring impaired synaptic plasticity in rats with temporal lobe epilepsy. Brain Sci. 10:E6342020. View Article : Google Scholar : PubMed/NCBI

5 

Guiard BP and Di Giovanni G: Central serotonin-2A (5-HT2A) receptor dysfunction in depression and epilepsy: The missing link? Front Pharmacol. 6:462015. View Article : Google Scholar :

6 

Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P and Engel J Jr: Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia. 46:470–472. 2005. View Article : Google Scholar

7 

Baroli G, Sanchez JR, Agostinelli E, Mariottini P and Cervelli M: Polyamines: The possible missing link between mental disorders and epilepsy (Review). Int J Mol Med. 45:3–9. 2020.

8 

Perucca E, Brodie MJ, Kwan P and Tomson T: 30 years of second-generation antiseizure medications: Impact and future perspectives. Lancet Neurol. 19:544–556. 2020. View Article : Google Scholar

9 

Wang Y and Chen Z: An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy. Pharmacol Ther. 201:77–93. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Löscher W, Potschka H, Sisodiya SM and Vezzani A: Drug resistance in epilepsy: Clinical impact, potential mechanisms, and new innovative treatment options. Pharmacol Rev. 72:606–638. 2020. View Article : Google Scholar : PubMed/NCBI

11 

West PJ, Saunders GW, Remigio GJ, Wilcox KS and White HS: Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice. Epilepsia. 55:214–223. 2014. View Article : Google Scholar :

12 

Vezzani A, Fujinami RS, White HS, Preux PM, Blümcke I, Sander JW and Löscher W: Infections, inflammation and epilepsy. Acta Neuropathol. 131:211–234. 2016. View Article : Google Scholar :

13 

Espinosa-Garcia C, Zeleke H and Rojas A: Impact of stress on epilepsy: Focus on neuroinflammation-A mini review. Int J Mol Sci. 22:40612021. View Article : Google Scholar : PubMed/NCBI

14 

Shao BZ, Xu ZQ, Han BZ, Su DF and Liu C: NLRP3 inflammasome and its inhibitors: A review. Front Pharmacol. 6:2622015. View Article : Google Scholar

15 

Wu C, Zhang G, Chen L, Kim S, Yu J, Hu G, Chen J, Huang Y, Zheng G and Huang S: The role of NLRP3 and IL-1β in refractory epilepsy brain injury. Front Neurol. 10:14182020. View Article : Google Scholar

16 

de Brito Toscano EC, Vieira ÉL, Dias BB, Caliari MV, Gonçalves AP, Giannetti AV, Siqueira JM, Suemoto CK, Leite RE, Nitrini R, et al: NLRP3 and NLRP1 inflammasomes are up-regulated in patients with mesial temporal lobe epilepsy and may contribute to overexpression of caspase-1 and IL-β in sclerotic hippocampi. Brain Res. 1752:1472302021. View Article : Google Scholar

17 

Kegler A, Caprara AL, Pascotini ET, Arend J, Gabbi P, Duarte MM, Furian AF, Oliveira MS, Royes LF and Fighera MR: Apoptotic markers are increased in epilepsy patients: A relation with manganese superoxide dismutase Ala16Val polymorphism and deizure type through IL-1β and IL-6 pathways. BioMed Res Int. 2020:62504292020. View Article : Google Scholar

18 

Liu R, Wu S, Guo C, Hu Z, Peng J, Guo K, Zhang X and Li J: Ibuprofen exerts antiepileptic and neuroprotective effects in the rat model of pentylenetetrazol-induced epilepsy via the COX-2/NLRP3/IL-18 pathway. Neurochem Res. 45:2516–2526. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Tran KL, Park YI, Pandya S, Muliyil NJ, Jensen BD, Huynh K and Nguyen QT: Overview of glucagon-like peptide-1 receptor agonists for the treatment of patients with type 2 diabetes. Am Health Drug Benefits. 10:178–188. 2017.

20 

Koshal P and Jamwal S: An insight review. Neuropharmacology. 136:271–279. 2018. View Article : Google Scholar

21 

Zhu W, Feng PP, He K, Li SW and Gong JP: Liraglutide protects non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in a mouse model induced by high-fat diet. Biochem Biophys Res Commun. 505:523–529. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Yu X, Hao M, Liu Y, Ma X, Lin W, Xu Q, Zhou H, Shao N and Kuang H: Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy. Eur J Pharmacol. 864:1727152019. View Article : Google Scholar : PubMed/NCBI

23 

Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F and Trapp S: Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. Mol Metab. 4:718–731. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Graham DL, Durai HH, Trammell TS, Noble BL, Mortlock DP, Galli A and Stanwood GD: A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain. J Comp Neurol. 528:2445–2470. 2020. View Article : Google Scholar :

25 

Liu S, Jin Z, Zhang Y, Rong S, He W, Sun K, Wan D, Huo J, Xiao L, Li X, et al: The glucagon-like peptide-1 analogue liraglutide reduces seizures susceptibility, cognition dysfunction and neuronal apoptosis in a mouse model of dravet syndrome. Front Pharmacol. 11:1362020. View Article : Google Scholar

26 

Dhillon S: Semaglutide: First global approval. Drugs. 78:275–284. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Yang X, Feng P, Zhang X, Li D, Wang R, Ji C, Li G and Hölscher C: The diabetes drug semaglutide reduces infarct size, inflammation, and apoptosis, and normalizes neurogenesis in a rat model of stroke. Neuropharmacology. 158:1077482019. View Article : Google Scholar : PubMed/NCBI

28 

Chang YF, Zhang D, Hu WM, Liu DX and Li L: Semaglutide-mediated protection against Aβ correlated with enhancement of autophagy and inhibition of apotosis. J Clin Neurosci. 81:234–239. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Zhang L, Zhang L, Li L and Hölscher C: Semaglutide is neuro-protective and reduces α-synuclein levels in the chronic MPTP mouse model of Parkinson's disease. J Parkinsons Dis. 9:157–171. 2019. View Article : Google Scholar

30 

Minkeviciene R, Rheims S, Dobszay MB, Zilberter M, Hartikainen J, Fülöp L, Penke B, Zilberter Y, Harkany T, Pitkänen A, et al: Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci. 29:3453–3462. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, Laferla FM, Cai H, Rose GM and Patrylo PR: Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3xTg-AD mice. PLoS One. 7:e487822012. View Article : Google Scholar

32 

Nam HY, Nam JH, Yoon G, Lee JY, Nam Y, Kang HJ, Cho HJ, Kim J and Hoe HS: Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice. J Neuroinflammation. 15:2712018. View Article : Google Scholar :

33 

Zeng QZ, Yang F, Li CG, Xu LH, He XH, Mai FY, Zeng CY, Zhang CC, Zha QB and Ouyang DY: Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages. Front Immunol. 10:722019. View Article : Google Scholar :

34 

Koshal P and Kumar P: Neurochemical modulation involved in the beneficial effect of liraglutide, GLP-1 agonist on PTZ kindling epilepsy-induced comorbidities in mice. Mol Cell Biochem. 415:77–87. 2016. View Article : Google Scholar

35 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

36 

Zheng Z, Liang P, Hou B, Lu X, Ma Q, Yu X, Han S, Peng B, Chen T, Liu W, et al: The effect of dipeptidyl peptidase IV on disease-associated microglia phenotypic transformation in epilepsy. J Neuroinflammation. 18:1122021. View Article : Google Scholar :

37 

Vezzani A, Balosso S and Ravizza T: Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy. Nat Rev Neurol. 15:459–472. 2019. View Article : Google Scholar

38 

Swanson KV, Deng M and Ting JP: The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol. 19:477–489. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Birnbaum Y, Tran D, Bajaj M and Ye Y: DPP-4 inhibition by linagliptin prevents cardiac dysfunction and inflammation by targeting the Nlrp3/ASC inflammasome. Basic Res Cardiol. 114:352019. View Article : Google Scholar

40 

Safar MM, Shahin NN, Mohamed AF and Abdelkader NF: Suppression of BACE1 and amyloidogenic/RAGE axis by sitagliptin ameliorates PTZ kindling-induced cognitive deficits in rats. Chem Biol Interact. 328:1091442020. View Article : Google Scholar : PubMed/NCBI

41 

Zhu L, Chen L, Xu P, Lu D, Dai S, Zhong L, Han Y, Zhang M, Xiao B, Chang L, et al: Genetic and molecular basis of epilepsy-related cognitive dysfunction. Epilepsy Behav. 104:1068482020. View Article : Google Scholar

42 

Lai MC, Lin KM, Yeh PS, Wu SN and Huang CW: The novel effect of immunomodulator-glatiramer acetate on epileptogenesis and epileptic seizures. Cell Physiol Biochem. 50:150–168. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Alomar SY, Gentili A, Zaibi MS, Kępczyńska MA and Trayhurn P: IL-1β (interleukin-1β) stimulates the production and release of multiple cytokines and chemokines by human preadipocytes. Arch Physiol Biochem. 122:117–122. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Chen A, Chen Z, Xia Y, Lu D, Yang X, Sun A, Zou Y, Qian J and Ge J: Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells. Biochem Biophys Res Commun. 499:267–272. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J and Chen X: Dulaglutide inhibits high glucose-induced endothelial dysfunction and NLRP3 inflammasome activation. Arch Biochem Biophys. 671:203–209. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Ma J, Shi M, Zhang X, Liu X, Chen J, Zhang R, Wang X and Zhang H: GLP 1R agonists ameliorate peripheral nerve dysfunction and inflammation via p38 MAPK/NF-κB signaling pathways in streptozotocin induced diabetic rats. Int J Mol Med. 41:2977–2985. 2018.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang L, Ding J, Zhu C, Guo B, Yang W, He W, Li X, Wang Y, Li W, Wang F, Wang F, et al: Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. Int J Mol Med 48: 219, 2021.
APA
Wang, L., Ding, J., Zhu, C., Guo, B., Yang, W., He, W. ... Sun, T. (2021). Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. International Journal of Molecular Medicine, 48, 219. https://doi.org/10.3892/ijmm.2021.5052
MLA
Wang, L., Ding, J., Zhu, C., Guo, B., Yang, W., He, W., Li, X., Wang, Y., Li, W., Wang, F., Sun, T."Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice". International Journal of Molecular Medicine 48.6 (2021): 219.
Chicago
Wang, L., Ding, J., Zhu, C., Guo, B., Yang, W., He, W., Li, X., Wang, Y., Li, W., Wang, F., Sun, T."Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice". International Journal of Molecular Medicine 48, no. 6 (2021): 219. https://doi.org/10.3892/ijmm.2021.5052
Copy and paste a formatted citation
x
Spandidos Publications style
Wang L, Ding J, Zhu C, Guo B, Yang W, He W, Li X, Wang Y, Li W, Wang F, Wang F, et al: Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. Int J Mol Med 48: 219, 2021.
APA
Wang, L., Ding, J., Zhu, C., Guo, B., Yang, W., He, W. ... Sun, T. (2021). Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. International Journal of Molecular Medicine, 48, 219. https://doi.org/10.3892/ijmm.2021.5052
MLA
Wang, L., Ding, J., Zhu, C., Guo, B., Yang, W., He, W., Li, X., Wang, Y., Li, W., Wang, F., Sun, T."Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice". International Journal of Molecular Medicine 48.6 (2021): 219.
Chicago
Wang, L., Ding, J., Zhu, C., Guo, B., Yang, W., He, W., Li, X., Wang, Y., Li, W., Wang, F., Sun, T."Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice". International Journal of Molecular Medicine 48, no. 6 (2021): 219. https://doi.org/10.3892/ijmm.2021.5052
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team