Open Access

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)

  • Authors:
    • Yong Ji
    • Jian Lv
    • Di Sun
    • Yufeng Huang
  • View Affiliations

  • Published online on: October 27, 2021     https://doi.org/10.3892/ijmm.2021.5056
  • Article Number: 1
  • Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress has been made in recent years, CRC survival remains unsatisfactory due to high metastasis and recurrence. Understanding the underlying molecular mechanisms of CRC tumorigenesis and metastasis has become increasingly important. Recently, aberrant Wnt/β‑catenin signaling has been reported to be strongly associated with CRC tumorigenesis, metastasis and recurrence. Therefore, the Wnt/β‑catenin signaling pathway has potential value as a therapeutic target for CRC. In the present review, the dysregulation of this pathway in CRC and the promoting or suppressing function of therapeutic targets on CRC were explored. In addition, the interaction between this pathway and epithelial‑mesenchymal transition (EMT), cell stemness, mutations, metastasis‑related genes and tumor angiogenesis in CRC cells were also investigated. Numerous studies on this pathway may help identify the potential diagnostic and prognostic markers and therapeutic targets for CRC.
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January-2022
Volume 49 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Ji Y, Lv J, Sun D and Huang Y: Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review). Int J Mol Med 49: 1, 2022
APA
Ji, Y., Lv, J., Sun, D., & Huang, Y. (2022). Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review). International Journal of Molecular Medicine, 49, 1. https://doi.org/10.3892/ijmm.2021.5056
MLA
Ji, Y., Lv, J., Sun, D., Huang, Y."Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)". International Journal of Molecular Medicine 49.1 (2022): 1.
Chicago
Ji, Y., Lv, J., Sun, D., Huang, Y."Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)". International Journal of Molecular Medicine 49, no. 1 (2022): 1. https://doi.org/10.3892/ijmm.2021.5056