|
1
|
Voelkel NF, Quaife RA, Leinwand LA, Barst
RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW,
et al: Right ventricular function and failure: Report of a national
heart, lung, and blood institute working group on cellular and
molecular mechanisms of right heart failure. Circulation.
114:1883–1891. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Tonelli AR, Arelli V, Minai OA, Newman J,
Bair N, Heresi GA and Dweik RA: Causes and circumstances of death
in pulmonary arterial hypertension. Am J Respir Crit Care Med.
188:365–369. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Frieler RA and Mortensen RM: Immune cell
and other noncardiomyocyte regulation of cardiac hypertrophy and
remodeling. Circulation. 131:1019–1030. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bishop SP and Altschuld RA: Increased
glycolytic metabolism in cardiac hypertrophy and congestive
failure. Am J Physiol. 218:153–159. 1970. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Partovian C, Adnot S, Eddahibi S, Teiger
E, Levame M, Dreyfus P, Raffestin B and Frelin C: Heart and lung
VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced
pulmonary hypertension. Am J Physiol. 275:H1948–H1956.
1998.PubMed/NCBI
|
|
6
|
Oikawa M, Kagaya Y, Otani H, Sakuma M,
Demachi J, Suzuki J, Takahashi T, Nawata J, Ido T, Watanabe J and
Shirato K: Increased [18F]fluorodeoxyglucose accumulation in right
ventricular free wall in patients with pulmonary hypertension and
the effect of epoprostenol. J Am Coll Cardiol. 45:1849–1855. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Panche AN, Diwan AD and Chandra SR:
Flavonoids: An overview. J Nutr Sci. 5:e472016. View Article : Google Scholar
|
|
8
|
García-Lafuente A, Guillamón E, Villares
A, Rostagno MA and Martínez JA: Flavonoids as anti-inflammatory
agents: Implications in cancer and cardiovascular disease. Inflamm
Res. 58:537–552. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Li XW, Wang XM, Li S and Yang JR: Effects
of chrysin (5,7-dihydroxyflavone) on vascular remodeling in
hypoxia-induced pulmonary hypertension in rats. Chin Med. 10:42015.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Yang M, Xiong J, Zou Q, Wang DD and Huang
CX: Chrysin attenuates interstitial fibrosis and improves cardiac
function in a rat model of acute myocardial infarction. J Mol
Histol. 49:555–565. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Kseibati MO, Sharawy MH and Salem HA:
Chrysin mitigates bleomycin-induced pulmonary fibrosis in rats
through regulating inflammation, oxidative stress, and hypoxia. Int
Immunopharmacol. 89:1070112020. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Abe K, Toba M, Alzoubi A, Ito M, Fagan KA,
Cool CD, Voelkel NF, McMurtry IF and Oka M: Formation of plexiform
lesions in experimental severe pulmonary arterial hypertension.
Circulation. 121:2747–2754. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Oka M, Homma N, Taraseviciene-Stewart L,
Morris KG, Kraskauskas D, Burns N, Voelkel NF and McMurtry IF: Rho
kinase-mediated vasoconstriction is important in severe occlusive
pulmonary arterial hypertension in rats. Circ Res. 100:923–929.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Toba M, Alzoubi A, O'Neill KD, Gairhe S,
Matsumoto Y, Oshima K, Abe K and Oka M: Temporal hemodynamic and
histological progression in Sugen5416/hypoxia/normoxia-exposed
pulmonary arterial hypertensive rats. Am J Physiol Heart Circ
Physiol. 306:H243–H250. 2014. View Article : Google Scholar :
|
|
15
|
Taraseviciene-Stewart L, Kasahara Y, Alger
L, Hirth P, Mc Mahon G, Waltenberger J, Voelkel NF and Tuder RM:
Inhibition of the VEGF receptor 2 combined with chronic hypoxia
causes cell death-dependent pulmonary endothelial cell
proliferation and severe pulmonary hypertension. FASEB J.
15:427–438. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Sanada TJ, Hosomi K, Shoji H, Park J,
Naito A, Ikubo Y, Yanagisawa A, Kobayashi T, Miwa H, Suda R, et al:
Gut microbiota modification suppresses the development of pulmonary
arterial hypertension in an SU5416/hypoxia rat model. Pulm Circ.
10:20458940209291472020. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Guidelines of the Animal Research
Committee of Laboratory Animal Center, Graduate School of Medicine,
Chiba University. https://www.chiba-u.ac.jp/general/JoureiV5HTMLContents/act/frame/frame110000180.htm.
Accessed March 3, 2022.
|
|
18
|
Kato F, Sakao S, Takeuchi T, Suzuki T,
Nishimura R, Yasuda T, Tanabe N and Tatsumi K: Endothelial
cell-related autophagic pathways in Sugen/hypoxia-exposed pulmonary
arterial hypertensive rats. Am J Physiol Lung Cell Mol Physiol.
313:L899–L915. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Takeuchi T, Sakao S, Kato F, Naito A, Jujo
T, Yasuda T, Tanabe N and Tatsumi K: Pulmonary haemodynamics are
correlated with intimal lesions in a rat model of severe PAH:
Attenuation of pulmonary vascular remodelling with ambrisentan.
Histol Histopathol. 31:1357–1365. 2016.PubMed/NCBI
|
|
20
|
Ge SX, Son EW and Yao R: iDEP: An
integrated web application for differential expression and pathway
analysis of RNA-Seq data. BMC Bioinformatics. 19:5342018.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Kuleshov MV, Jones MR, Rouillard AD,
Fernandez NF, Duan Q, Wang Z, Koplev S, Jenkins SL, Jagodnik KM,
Lachmann A, et al: Enrichr: A comprehensive gene set enrichment
analysis web server 2016 update. Nucleic Acids Res. 44:W90–W97.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Sakao S, Kawakami E, Shoji H, Naito A,
Miwa H, Suda R, Sanada TJ, Tanabe N and Tatsumi K: Metabolic
remodeling in the right ventricle of rats with severe pulmonary
arterial hypertension. Mol Med Rep. 23:2272021. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
24
|
Yeligar SM, Kang BY, Bijli KM, Kleinhenz
JM, Murphy TC, Torres G, San Martin A, Sutliff RL and Hart CM:
PPARγ regulates mitochondrial structure and function and human
pulmonary artery smooth muscle cell proliferation. Am J Respir Cell
Mol Biol. 58:648–657. 2018. View Article : Google Scholar :
|
|
25
|
Gomez-Arroyo J, Mizuno S, Szczepanek K,
Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L,
Kraskauskas D, Wijesinghe DS, et al: Metabolic gene remodeling and
mitochondrial dysfunction in failing right ventricular hypertrophy
secondary to pulmonary arterial hypertension. Circ Heart Fail.
6:136–144. 2013. View Article : Google Scholar
|
|
26
|
Vidal-Puig AJ, Considine RV, Jimenez-Liñan
M, Werman A, Pories WJ, Caro JF and Flier JS: Peroxisome
proliferator-activated receptor gene expression in human tissues.
Effects of obesity, weight loss, and regulation by insulin and
glucocorticoids. J Clin Invest. 99:2416–2422. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Qi HP, Wang Y, Zhang QH, Guo J, Li L, Cao
YG, Li SZ, Li XL, Shi MM, Xu W, et al: Activation of peroxisome
proliferator-activated receptor γ (PPARγ) through NF-κB/Brg1 and
TGF-β1 pathways attenuates cardiac remodeling in
pressure-overloaded rat hearts. Cell Physiol Biochem. 35:899–912.
2015. View Article : Google Scholar
|
|
28
|
Lee TW, Bai KJ, Lee TI, Chao TF, Kao YH
and Chen YJ: PPARs modulate cardiac metabolism and mitochondrial
function in diabetes. J Biomed Sci. 24:52017. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Dominy JE and Puigserver P: Mitochondrial
biogenesis through activation of nuclear signaling proteins. Cold
Spring Harb Perspect Biol. 5:a0150082013. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fan W and Evans R: PPARs and ERRs:
Molecular mediators of mitochondrial metabolism. Curr Opin Cell
Biol. 33:49–54. 2015. View Article : Google Scholar :
|
|
31
|
Ricote M and Glass CK: PPARs and molecular
mechanisms of transrepression. Biochim Biophys Acta. 1771:926–935.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Calnek DS, Mazzella L, Roser S, Roman J
and Hart CM: Peroxisome proliferator-activated receptor gamma
ligands increase release of nitric oxide from endothelial cells.
Arterioscler Thromb Vasc Biol. 23:52–57. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Pascual G, Fong AL, Ogawa S, Gamliel A, Li
AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG and Glass CK: A
SUMOylation-dependent pathway mediates transrepression of
inflammatory response genes by PPAR-gamma. Nature. 437:759–763.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Del Fabbro L, Rossito Goes A, Jesse CR, de
Gomes MG, Cattelan Souza L, Lobo Ladd FV, Lobo Ladd AAB, Nunes
Arantes RV, Reis Simionato A, Oliveira MS, et al: Chrysin protects
against behavioral, cognitive and neurochemical alterations in a
6-hydroxydopamine model of Parkinson's disease. Neurosci Lett.
706:158–163. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Jiang Y, Gong FL, Zhao GB and Li J:
Chrysin suppressed inflammatory responses and the inducible nitric
oxide synthase pathway after spinal cord injury in rats. Int J Mol
Sci. 15:12270–12279. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Tang H, Tao A, Song J, Liu Q, Wang H and
Rui T: Doxorubicin-induced cardiomyocyte apoptosis: Role of
mitofusin 2. Int J Biochem Cell Biol. 88:55–59. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Yamamoto Y: Effects of dietary chrysin
supplementation on blood pressure and oxidative status of rats fed
a high-fat high-sucrose diet. Food Sci Technol Res. 20:295–300.
2014. View Article : Google Scholar
|
|
38
|
Andrade N, Andrade S, Silva C, Rodrigues
I, Guardão L, Guimarães JT, Keating E and Martel F: Chronic
consumption of the dietary polyphenol chrysin attenuates metabolic
disease in fructose-fed rats. Eur J Nutr. 59:151–165. 2020.
View Article : Google Scholar
|
|
39
|
Fu B, Xue J, Li Z, Shi X, Jiang BH and
Fang J: Chrysin inhibits expression of hypoxia-inducible
factor-1alpha through reducing hypoxia-inducible factor-1alpha
stability and inhibiting its protein synthesis. Mol Cancer Ther.
6:220–226. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Liang YC, Tsai SH, Tsai DC, Lin-Shiau SY
and Lin JK: Suppression of inducible cyclooxygenase and nitric
oxide synthase through activation of peroxisome
proliferator-activated receptor-gamma by flavonoids in mouse
macrophages. FEBS Lett. 496:12–18. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Xu W, Janocha AJ and Erzurum SC:
Metabolism in pulmonary hypertension. Annu Rev Physiol. 83:551–576.
2021. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Randle PJ, Garland PB, Hales CN and
Newsholme EA: The glucose fatty-acid cycle. Its role in insulin
sensitivity and the metabolic disturbances of diabetes mellitus.
Lancet. 1:785–789. 1963. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Brittain EL, Talati M, Fessel JP, Zhu H,
Penner N, Calcutt MW, West JD, Funke M, Lewis GD, Gerszten RE, et
al: Fatty acid metabolic defects and right ventricular lipotoxicity
in human pulmonary arterial hypertension. Circulation.
133:1936–1944. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hemnes AR, Brittain EL, Trammell AW,
Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M,
Absi T, et al: Evidence for right ventricular lipotoxicity in
heritable pulmonary arterial hypertension. Am J Respir Crit Care
Med. 189:325–334. 2014. View Article : Google Scholar :
|
|
45
|
Kampf JP and Kleinfeld AM: Is membrane
transport of FFA mediated by lipid, protein, or both? An unknown
protein mediates free fatty acid transport across the adipocyte
plasma membrane. Physiology (Bethesda). 22:7–14. 2007.
|
|
46
|
McGarry JD and Brown NF: The mitochondrial
carnitine palmitoyltransferase system. From concept to molecular
analysis. Eur J Biochem. 244:1–14. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Vonk Noordegraaf A, Chin KM, Haddad F,
Hassoun PM, Hemnes AR, Hopkins SR, Kawut SM, Langleben D, Lumens J
and Naeije R: Pathophysiology of the right ventricle and of the
pulmonary circulation in pulmonary hypertension: An update. Eur
Respir J. 53:18019002019. View Article : Google Scholar
|
|
48
|
Ryan JJ and Archer SL: Emerging concepts
in the molecular basis of pulmonary arterial hypertension: Part I:
Metabolic plasticity and mitochondrial dynamics in the pulmonary
circulation and right ventricle in pulmonary arterial hypertension.
Circulation. 131:1691–1702. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Han S and Chandel NS: Lessons from cancer
metabolism for pulmonary arterial hypertension and fibrosis. Am J
Respir Cell Mol Biol. 65:134–145. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Laumanns IP, Fink L, Wilhelm J, Wolff JC,
Mitnacht-Kraus R, Graef-Hoechst S, Stein MM, Bohle RM, Klepetko W,
Hoda MA, et al: The noncanonical WNT pathway is operative in
idiopathic pulmonary arterial hypertension. Am J Respir Cell Mol
Biol. 40:683–691. 2009. View Article : Google Scholar
|
|
51
|
Kar UP, Dey H and Rahaman A: Regulation of
dynamin family proteins by post-translational modifications. J
Biosci. 42:333–344. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Naz S, Imran M, Rauf A, Orhan IE, Shariati
MA, Iahtisham-Ul-H, Yasmin Iqra, Shahbaz M, Qaisrani TB, Shah ZA,
et al: Chrysin: Pharmacological and therapeutic properties. Life
Sci. 235:1167972019. View Article : Google Scholar : PubMed/NCBI
|
