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2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling

  • Authors:
    • Yu-Hsuan Wen
    • Hui-Yi Lin
    • Jia-Ni Lin
    • Guo-Fang Tseng
    • Chung-Feng Hwang
    • Chung-Ching Lin
    • Chuan-Jen Hsu
    • Hung-Pin Wu
  • View Affiliations / Copyright

    Affiliations: Institute of Medical Sciences, Tzu Chi University, Hualien 970374, Taiwan, R.O.C., School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404328, Taiwan, R.O.C., Department of Otolaryngology, Head and Neck Surgery, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 427213, Taiwan, R.O.C., Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833401, Taiwan, R.O.C.
    Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 71
    |
    Published online on: March 29, 2022
       https://doi.org/10.3892/ijmm.2022.5127
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Abstract

Gentamicin is an important aminoglycoside antibiotic used in the treatment of gram‑negative bacterial infections, but nephrotoxicity and ototoxicity reduce its utility. The autophagy pathway is involved in damage of auditory hair cells. With the aim of developing new strategies for attenuating gentamicin ototoxicity, the present study investigated the otoprotective mechanism of 2,3,4',5‑tetrahydroxystilbene‑2‑O‑β‑D-glucoside (THSG) in vitro using the mouse cochlear cell line UB/OC‑2. MTT assay demonstrated that gentamicin reduced UB/OC‑2 cell viability and western blotting showed that gentamicin upregulated autophagy‑related proteins, such as Beclin, autophagy related 5 and LC3‑II. THSG significantly attenuated gentamicin‑induced cytotoxicity, clearly reduced LDH release observed by LDH assay and decreased the expression of autophagy‑related proteins. Reverse‑transcription‑quantitative (RT‑q) PCR and western blotting showed that THSG against gentamicin‑induced autophagy via suppressing the expression of Sesn2, at both the mRNA and protein level and a possible involvement of AMP‑activated protein kinase (AMPK)/mTOR signaling response. Collectively, the present study demonstrated that THSG decreased gentamicin‑induced ototoxicity in UB/OC‑2 cochlear cells via the autophagic signaling in regulating Sesn2/AMPK/mTOR pathway. These results suggested that THSG might be a new therapeutic agent with the potential to attenuate gentamicin ototoxicity.
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View References

1 

Jiang M, Karasawa T and Steyger PS: Aminoglycoside-induced cochleotoxicity: A review. Front Cell Neurosci. 11:3082017. View Article : Google Scholar : PubMed/NCBI

2 

Chen KS, Bach A, Shoup A and Winick NJ: Hearing loss and vestibular dysfunction among children with cancer after receiving aminoglycosides. Pediatr Blood Cancer. 60:1772–1777. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Vu AA, Nadaraja GS, Huth ME, Luk L, Kim J, Chai R, Ricci AJ and Cheng AG: Integrity and regeneration of mechanotransduction machinery regulate aminoglycoside entry and sensory cell death. PLoS One. 8:e547942013. View Article : Google Scholar : PubMed/NCBI

4 

Ylikoski J, Xing-Qun L, Virkkala J and Pirvola U: Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death. Hear Res. 166:33–43. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Jensen-Smith HC, Hallworth R and Nichols MG: Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cells. PLoS One. 7:e384712012. View Article : Google Scholar : PubMed/NCBI

6 

Wen YH, Lin JN, Wu RS, Yu SH, Hsu CJ, Tseng GF and Wu HP: Otoprotective Effect of 2,3,4′,5-Tetrahydroxystilbene-2-O-β-d-glucoside on gentamicin-induced apoptosis in mouse cochlear UB/OC-2 cells. Molecules. 25:30702020. View Article : Google Scholar

7 

Parzych KR and Klionsky DJ: An overview of autophagy: Morphology, mechanism, and regulation. Antioxid Redox Signal. 20:460–473. 2014. View Article : Google Scholar :

8 

Denton D and Kumar S: Autophagy-dependent cell death. Cell Death Differ. 26:605–616. 2019. View Article : Google Scholar :

9 

Nikoletopoulou V, Markaki M, Palikaras K and Tavernarakis N: Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 1833:3448–3459. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhou H, Qian X, Xu N, Zhang S, Zhu G, Zhang Y, Liu D, Cheng C, Zhu X, Liu Y, et al: Disruption of Atg7-dependent autophagy causes electromotility disturbances, outer hair cell loss, and deafness in mice. Cell Death Dis. 11:9132020. View Article : Google Scholar : PubMed/NCBI

11 

Fujimoto C, Iwasaki S, Urata S, Morishita H, Sakamaki Y, Fujioka M, Kondo K, Mizushima N and Yamasoba T: Autophagy is essential for hearing in mice. Cell Death Dis. 8:e27802017. View Article : Google Scholar : PubMed/NCBI

12 

Li H, Song Y, He Z, Chen X, Wu X, Li X, Bai X, Liu W, Li B, Wang S, et al: Meclofenamic acid reduces reactive oxygen species accumulation and apoptosis, inhibits excessive autophagy, and protects hair cell-like HEI-OC1 cells from cisplatin-induced damage. Front Cell Neurosci. 12:1392018. View Article : Google Scholar : PubMed/NCBI

13 

Mazure NM and Pouyssegur J: Hypoxia-induced autophagy: Cell death or cell survival? Curr Opin Cell Biol. 22:177–180. 2010. View Article : Google Scholar

14 

Antikainen H, Driscoll M, Haspel G and Dobrowolski R: TOR-mediated regulation of metabolism in aging. Aging Cell. 16:1219–1233. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Fu X, Sun X, Zhang L, Jin Y, Chai R, Yang L, Zhang A, Liu X, Bai X, Li J, et al: Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss. J Clin Invest. 128:4938–4955. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Vilimanovich U and Jevremovic SA: Dihydroquercetin: A novel potent flavonoid antioxidant as an adjuvant for effective cancer treatment. EC Nutr. 14:660–674. 2019.

17 

Kim YC and Guan KL: mTOR: A pharmacologic target for autophagy regulation. J Clin Invest. 125:25–32. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Rhee SG and Bae SH: The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1. Free Radic Biol Med. 88:205–211. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Ebnoether E, Ramseier A, Cortada M, Bodmer D and Levano-Huaman S: Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling. Cell Death Discov. 3:170242017. View Article : Google Scholar : PubMed/NCBI

20 

Lin L, Ni B, Lin H, Zhang M, Li X, Yin X, Qu C and Ni J: Traditional usages, botany, phytochemistry, pharmacology and toxicology of Polygonum multiflorum Thunb: A review. J Ethnopharmacol. 159:158–183. 2015. View Article : Google Scholar

21 

Ling S and Xu JW: Biological activities of 2,3,5,4′-Tetrahydrox ystilbene-2-O-β-D-Glucoside in antiaging and antiaging-related disease treatments. Oxid Med Cell Longev. 2016:49732392016. View Article : Google Scholar

22 

Xu S, Liu J, Shi J, Wang Z and Ji L: 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2. Sci Rep. 7:165112017. View Article : Google Scholar

23 

Park SY, Jin ML, Wang Z, Park G and Choi YW: 2,3,4′,5-tetrahyd roxystilbene-2-O-β-d-glucoside exerts anti-inflammatory effects on lipopolysaccharide-stimulated microglia by inhibiting NF-κB and activating AMPK/Nrf2 pathways. Food Chem Toxicol. 97:159–167. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Lin EY, Bayarsengee U, Wang CC, Chiang YH and Cheng CW: The natural compound 2,3,5,4′-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway. Environ Toxicol. 33:72–82. 2018. View Article : Google Scholar

25 

Wu TY, Lin JN, Luo ZY, Hsu CJ, Wang JS and Wu HP: 2,3,4′,5-Tetrahydroxystilbene-2-O-β-D-Glucoside (THSG) activates the Nrf2 antioxidant pathway and attenuates oxidative stress-induced cell death in mouse cochlear UB/OC-2 cells. Biomolecules. 10:4652020. View Article : Google Scholar

26 

Rivolta MN, Grix N, Lawlor P, Ashmore JF, Jagger DJ and Holley MC: Auditory hair cell precursors immortalized from the mammalian inner ear. Proc Biol Sci. 265:1595–1603. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Lin HY, Lin JN, Ma JW, Yang NS, Ho CT, Kuo SC and Way TD: Demethoxycurcumin induces autophagic and apoptotic responses on breast cancer cells in photodynamic therapy. J Funct Foods. 12:439–449. 2015. View Article : Google Scholar

28 

Lin JN, Lin VC, Rau KM, Shieh PC, Kuo DH, Shieh JC, Chen WJ, Tsai SC and Way TD: Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. J Agric Food Chem. 58:1584–1592. 2010. View Article : Google Scholar

29 

Graham L and Orenstein JM: Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research. Nat Protoc. 2:2439–2450. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Trierweiler C, Hockenjos B, Zatloukal K, Thimme R, Blum HE, Wagner EF and Hasselblatt P: The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice. Cell Death Differ. 23:576–582. 2016. View Article : Google Scholar :

31 

Delbridge GJ and Khachigian LM: FGF-1-induced platelet-derived growth factor-A chain gene expression in endothelial cells involves transcriptional activation by early growth response factor-1. Circ Res. 81:282–288. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Lin JF, Lin YC, Tsai TF, Chen HE, Chou KY and Hwang TI: Cisplatin induces protective autophagy through activation of BECN1 in human bladder cancer cells. Drug Des Devel Ther. 11:1517–1533. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Fischel-Ghodsian N: Genetic factors in aminoglycoside toxicity. Pharmacogenomics. 6:27–36. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Matsui JI, Gale JE and Warchol ME: Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro. J Neurobiol. 61:250–266. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Akinwumi BC, Bordun KM and Anderson HD: Biological activities of stilbenoids. Int J Mol Sci. 19:7922018. View Article : Google Scholar :

36 

Treml J, Leláková V, Šmejkal K, Paulíčková T, Labuda Š, Granica S, Havlík J, Jankovská D, Padrtová T and Hošek J: Antioxidant activity of selected stilbenoid derivatives in a cellular model system. biomolecules. Biomolecules. 9:4682019. View Article : Google Scholar

37 

Storniolo CE, Quifer-Rada P, Lamuela-Raventos RM and Moreno JJ: Piceid presents antiproliferative effects in intestinal epithelial Caco-2 cells, effects unrelated to resveratrol release. Food Funct. 5:2137–2144. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Storniolo CE and Moreno JJ: Resveratrol metabolites have an antiproliferative effect on intestinal epithelial cancer cells. Food Chem. 134:1385–1391. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Fang B and Xiao H: Rapamycin alleviates cisplatin-induced ototoxicity in vivo. Biochem Biophys Res Commun. 448:443–447. 2014. View Article : Google Scholar : PubMed/NCBI

40 

de Iriarte Rodríguez R, Pulido S, Rodríguez-de la Rosa L, Magariños M and Varela-Nieto I: Age-regulated function of autophagy in the mouse inner ear. Hear Res. 330:39–50. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Yuan H, Wang X, Hill K, Chen J, Lemasters J, Yang SM and Sha SH: Autophagy attenuates noise-induced hearing loss by reducing oxidative stress. Antioxid Redox Signal. 22:1308–1324. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Wei JL, Fang M, Fu ZX, Zhang SR, Guo JB, Wang R, Lv ZB and Xiong YF: Sestrin 2 suppresses cells proliferation through AMPK/mTORC1 pathway activation in colorectal cancer. Oncotarget. 8:49318–49328. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Li DK, Chen J, Ge ZZ and Sun ZX: Hepatotoxicity in rats induced by aqueous extract of polygoni multiflori radix, root of Polygonum multiflorum related to the activity inhibition of CYP1A2 or CYP2E1. Evid Based Complement Alternat Med. 2017:94567852017.

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Copy and paste a formatted citation
Spandidos Publications style
Wen Y, Lin H, Lin J, Tseng G, Hwang C, Lin C, Hsu C and Wu H: 2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling. Int J Mol Med 49: 71, 2022.
APA
Wen, Y., Lin, H., Lin, J., Tseng, G., Hwang, C., Lin, C. ... Wu, H. (2022). 2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling. International Journal of Molecular Medicine, 49, 71. https://doi.org/10.3892/ijmm.2022.5127
MLA
Wen, Y., Lin, H., Lin, J., Tseng, G., Hwang, C., Lin, C., Hsu, C., Wu, H."2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling". International Journal of Molecular Medicine 49.5 (2022): 71.
Chicago
Wen, Y., Lin, H., Lin, J., Tseng, G., Hwang, C., Lin, C., Hsu, C., Wu, H."2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling". International Journal of Molecular Medicine 49, no. 5 (2022): 71. https://doi.org/10.3892/ijmm.2022.5127
Copy and paste a formatted citation
x
Spandidos Publications style
Wen Y, Lin H, Lin J, Tseng G, Hwang C, Lin C, Hsu C and Wu H: 2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling. Int J Mol Med 49: 71, 2022.
APA
Wen, Y., Lin, H., Lin, J., Tseng, G., Hwang, C., Lin, C. ... Wu, H. (2022). 2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling. International Journal of Molecular Medicine, 49, 71. https://doi.org/10.3892/ijmm.2022.5127
MLA
Wen, Y., Lin, H., Lin, J., Tseng, G., Hwang, C., Lin, C., Hsu, C., Wu, H."2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling". International Journal of Molecular Medicine 49.5 (2022): 71.
Chicago
Wen, Y., Lin, H., Lin, J., Tseng, G., Hwang, C., Lin, C., Hsu, C., Wu, H."2,3,4',5‑Tetrahydroxystilbene‑2‑O‑β‑D‑glucoside ameliorates gentamicin‑induced ototoxicity by modulating autophagy via Sesn2/AMPK/mTOR signaling". International Journal of Molecular Medicine 49, no. 5 (2022): 71. https://doi.org/10.3892/ijmm.2022.5127
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