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Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1

  • Authors:
    • Yiwen Liu
    • Liuchi Chen
    • Qimei Gong
    • Hongwei Jiang
    • Yihua Huang
  • View Affiliations / Copyright

    Affiliations: Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat‑sen University, Guangzhou, Guangdong 510055, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 72
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    Published online on: March 31, 2022
       https://doi.org/10.3892/ijmm.2022.5128
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Abstract

FUN14 domain‑containing 1 (FUNDC1) is a receptor that has been previously reported to activate hypoxia‑induced mitophagy. However, the potential role of FUNDC1 in the pathophysiology of dental pulp diseases remains unknown. Therefore, present study first collected tissue specimens from patients with pulpitis and from healthy individuals. The results of reverse transcription‑quantitative PCR and immunohistochemical staining revealed markedly increased FUNDC1 and hypoxia‑inducible factor‑1α expression in pulpitis tissue specimens compared with those from healthy individuals. To provide a theoretical basis for the study of the occurrence, development and reparative mechanisms in the dental pulp after tissue injury, the present study then investigated the role of hypoxia‑induced mitophagy in the regulation of proliferation, migration and odontoblastic differentiation in human dental pulp cells (HDPCs), in addition, to the possible involvement of FUNDC1. The surface markers and multipotent differentiation capabilities of HDPCs were performed by flow cytometry (surface markers), alizarin red (osteogenic capabilities), alcian blue (chondrogenic capabilities) and oil red O (adipogenic capabilities). Following culture under hypoxia conditions (1% O2) for varying time periods, the proliferation, migration and odontoblastic differentiation of HDPCs were measured using Cell Counting Kit‑8, wound healing and Transwell migration assays, alkaline phosphatase staining and activity tests and western blotting (runt‑related transcription factor 2, collagen I, osterix and osteopontin), respectively. Immunofluorescence and western blotting were performed to measure the expression levels of hypoxia‑inducible factor‑1α, pro‑fission dynamin‑related protein 1, mitochondria‑related proteins translocase of inner mitochondrial membrane 23 and translocase of outer mitochondrial membrane 20, in addition to those of autophagy markers (p62, LC3II, Beclin‑1 and autophagy‑related 5). Transmission electron microscopy was also used to image the autophagosomes and mitochondrial morphology. In addition, to study the functional role of FUNDC1, its expression was silenced by liposome‑mediated transfection with small interfering RNA into HDPCs. Compared with those in HDPCs cultured under normoxic conditions (21% O2), the ability of autophagy in HDPCs cultured under hypoxic conditions for 18 h was markedly increased, whilst the proliferation, migration and odontoblastic differentiation were also enhanced. Increased numbers of autophagosomes could also be observed in the hypoxic group. However, FUNDC1 knockdown in HDPCs reversed the aforementioned effects. Overall, data from the present study suggest that hypoxia can promote the proliferation, migration and odontoblastic differentiation of HDPCs, where the underlying mechanism may be associated with the activation of mitophagy downstream of FUNDC1.
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View References

1 

Yin Z, Pascual C and Klionsky DJ: Autophagy: Machinery and regulation. Microb Cell. 3:588–596. 2016. View Article : Google Scholar

2 

Yang JW, Zhang YF, Wan CY, Sun ZY, Nie S, Jian SJ, Zhang L, Song GT and Chen Z: Autophagy in SDF-1a-mediated DPSC migration and pulp regeneration. Biomaterials. 44:11–23. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Pantovic A, Krstic A, Janjetovic K, Kocic J, Harhaji-Trajkovic L, Bugarski D and Trajkovic V: Coordinated time-dependent modulation of AMPK/Akt/mTOR signaling and autophagy controls osteogenic differentiation of human mesenchymal stem cells. Bone. 52:524–531. 2013. View Article : Google Scholar

4 

Pan Y, Li Z, Wang Y, Yan M, Wu J, Beharee RG and Yu J: Sodium fluoride regulates the osteo/odontogenic differentiation of stem cells from apical papilla by modulating autophagy. J Cell Physiol. Feb 14–2019.Epub ahead of print. View Article : Google Scholar

5 

Couve E, Osorio R and Schmachtenberg O: Mitochondrial autophagy and lipofuscin accumulation in aging odontoblasts. J Dent Res. 91:696–701. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Park SY, Sun EG, Lee Y, Kim MS, Kim JH, Kim WJ and Jung JY: Autophagy induction plays a protective role against hypoxic stress in human dental pulp cells. J Cell Biochem. 119:1992–2002. 2018. View Article : Google Scholar

7 

Roa-Mansergas X, Fado R, Atari M, Mir JF, Muley H, Serra D and Casals N: CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy. Sci Rep. 8:69972018. View Article : Google Scholar : PubMed/NCBI

8 

Zhuang H, Hu D, Singer D, Walker JV, Nisr RB, Tieu K, Ali K, Tredwin C, Luo S, Ardu S and Hu B: Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discov. 1:150242015. View Article : Google Scholar : PubMed/NCBI

9 

Huang Y, Li X, Liu Y, Gong Q, Tian J and Jiang H: LPS-induced autophagy in human dental pulp cells is associated with p38. J Mol Histol. 52:919–928. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Yang F, Li Y, Duan H, Wang H, Pei F, Chen Z and Zhang L: Activation of mitophagy in inflamed odontoblasts. Oral Dis. 25:1581–1588. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Wang Y, Liu N and Lu B: Mechanisms and roles of mitophagy in neurodegenerative diseases. CNS Neurosci Ther. 25:859–875. 2019.PubMed/NCBI

12 

Liu L, Feng D, Chen G, Chen M, Zheng Q, Song P, Ma Q, Zhu C, Wang R, Qi W, et al: Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. Nat Cell Biol. 14:177–185. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Zhang W, Siraj S, Zhang R and Chen Q: Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury. Autophagy. 13:1080–1081. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Yuan Q, Sun N, Zheng J, Wang Y, Yan X, Mai W, Liao Y and Chen X: Prognostic and Immunological role of FUN14 domain containing 1 in pan-cancer: Friend or foe? Front Oncol. 9:15022019. View Article : Google Scholar

15 

Yan M and Yu Y, Mao X, Feng J, Wang Y, Chen H, Xie K and Yu Y: Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immunopharmacol. 71:61–67. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Wu L, Zhang D, Zhou L, Pei Y, Zhuang Y, Cui W and Chen J: FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis. EBioMedicine. 41:384–394. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Veis A: The role of dental pulp-thoughts on the session on pulp repair processes. J Dent Res. 64:Spec No. 552–554. 1985. View Article : Google Scholar

18 

Kim SA, Choi HS and Ahn SG: Pin1 induces the ADP-induced migration of human dental pulp cells through P2Y1 stabilization. Oncotarget. 7:85381–85392. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Li C and Jiang H: Altered expression of circular RNA in human dental pulp cells during odontogenic differentiation. Mol Med Rep. 20:871–878. 2019.PubMed/NCBI

20 

Heyeraas KJ and Berggreen E: Interstitial fluid pressure in normal and inflamed pulp. Crit Rev Oral Biol Med. 10:328–336. 1999. View Article : Google Scholar

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

Gong Q, Jiang H, Wei X, Ling J and Wang J: Expression of erythropoietin and erythropoietin receptor in human dental pulp. J Endod. 36:1972–1977. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Luke AM, Patnaik R, Kuriadom S, Abu-Fanas S, Mathew S and Shetty KP: Human dental pulp stem cells differentiation to neural cells, osteocytes and adipocytes-An in vitro study. Heliyon. 6:e030542020. View Article : Google Scholar :

24 

Al Madhoun A, Sindhu S, Haddad D, Atari M, Ahmad R and Al-Mulla F: Dental pulp stem cells derived from adult human third molar tooth: A brief review. Front Cell Dev Biol. 9:7176242021. View Article : Google Scholar : PubMed/NCBI

25 

Chakraborty J, Caicci F, Roy M and Ziviani E: Investigating mitochondrial autophagy by routine transmission electron microscopy: Seeing is believing? Pharmacol Res. 160:1050972020. View Article : Google Scholar : PubMed/NCBI

26 

Sakdee JB, White RR, Pagonis TC and Hauschka PV: Hypoxia-amplified proliferation of human dental pulp cells. J Endod. 35:818–823. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Du R, Zhao J, Wen Y, Zhu Y and Jiang L: Deferoxamine enhances the migration of dental pulp cells via hypoxia-inducible factor 1alpha. Am J Transl Res. 13:4780–4787. 2021.

28 

Han Y, Chen Q, Zhang L and Dissanayaka WL: Indispensable role of HIF-1a signaling in post-implantation survival and angio-/vasculogenic properties of SHED. Front Cell Dev Biol. 9:6550732021. View Article : Google Scholar

29 

Chen Y, Zhao Q, Yang X, Yu X, Yu D and Zhao W: Effects of cobalt chloride on the stem cell marker expression and osteogenic differentiation of stem cells from human exfoliated deciduous teeth. Cell Stress Chaperones. 24:527–538. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Hu HM, Mao MH, Hu YH, Zhou XC, Li S, Chen CF, Li CN, Yuan QL and Li W: Artemisinin protects DPSC from hypoxia and TNF-alpha mediated osteogenesis impairments through CA9 and Wnt signaling pathway. Life Sci. 277:1194712021. View Article : Google Scholar

31 

Zhou Y, Fan W and Xiao Y: The effect of hypoxia on the stemness and differentiation capacity of PDLC and DPC. Biomed Res Int. 2014:8906752014. View Article : Google Scholar : PubMed/NCBI

32 

Vanacker J, Viswanath A, De Berdt P, Everard A, Cani PD, Bouzin C, Feron O, Diogenes A, Leprince JG and des Rieux A: Hypoxia modulates the differentiation potential of stem cells of the apical papilla. J Endod. 40:1410–1418. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Xu H, Xu F, Zhao J, Zhou C and Liu J: Platelet-rich plasma induces autophagy and promotes regeneration in human dental pulp cells. Front Bioeng Biotechnol. 9:6597422021. View Article : Google Scholar : PubMed/NCBI

34 

Li Y, Zhao X, He B, Wu W, Zhang H, Yang X and Cheng W: Autophagy activation by hypoxia regulates angiogenesis and apoptosis in oxidized low-density lipoprotein-induced preeclampsia. Front Mol Biosci. 8:7097512021. View Article : Google Scholar : PubMed/NCBI

35 

Pei F, Wang HS, Chen Z and Zhang L: Autophagy regulates odontoblast differentiation by suppressing NF-kappaB activation in an inflammatory environment. Cell Death Dis. 7:e21222016. View Article : Google Scholar

36 

Gong G, Hu L, Liu Y, Bai S, Dai X, Yin L, Sun Y, Wang X and Hou L: Upregulation of HIF-1alpha protein induces mitochondrial autophagy in primary cortical cell cultures through the inhibition of the mTOR pathway. Int J Mol Med. 34:1133–1140. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Song H, Chen X, Jiao Q, Qiu Z, Shen C, Zhang G, Sun Z, Zhang H and Luo QY: HIF-1alpha-mediated telomerase reverse transcriptase activation inducing autophagy through mammalian target of rapamycin promotes papillary thyroid carcinoma progression during hypoxia stress. Thyroid. 31:233–246. 2021. View Article : Google Scholar

38 

Zhang J, Zhang C, Jiang X, Li L, Zhang D, Tang D, Yan T, Zhang Q, Yuan H, Jia J, et al: Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration. Cell Death Dis. 10:2342019. View Article : Google Scholar : PubMed/NCBI

39 

Huang HY, Wang WC, Lin PY, Huang CP, Chen CY and Chen YK: The roles of autophagy and hypoxia in human inflammatory periapical lesions. Int Endod J. 51(Suppl 2): e125–e145. 2018. View Article : Google Scholar

40 

Ren C, Xu Y, Liu H, Wang Z, Ma T, Li Z, Sun L, Huang Q, Zhang K, Zhang C, et al: Effects of runt-related transcription factor 2 (RUNX2) on the autophagy of rapamycin-treated osteoblasts. Bioengineered. 13:5262–5276. 2022. View Article : Google Scholar : PubMed/NCBI

41 

Wang L, Wang P, Dong H, Wang S, Chu H, Yan W and Zhang X: Ulk1/FUNDC1 prevents nerve cells from hypoxia-induced apoptosis by promoting cell autophagy. Neurochem Res. 43:1539–1548. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Wu W, Li W, Chen H, Jiang L, Zhu R and Feng D: FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy. Autophagy. 12:1675–1676. 2016. View Article : Google Scholar : PubMed/NCBI

43 

De R, Mazumder S and Bandyopadhyay U: Mediators of mitophagy that regulate mitochondrial quality control play crucial role in diverse pathophysiology. Cell Biol Toxicol. 37:333–366. 2021. View Article : Google Scholar

44 

Wen W, Yu G, Liu W, Gu L, Chu J, Zhou X, Liu Y and Lai G: Silencing FUNDC1 alleviates chronic obstructive pulmonary disease by inhibiting mitochondrial autophagy and bronchial epithelium cell apoptosis under hypoxic environment. J Cell Biochem. 120:17602–17615. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Liu H, Zang C, Yuan F, Ju C, Shang M, Ning J, Yang Y, Ma J, Li G, Bao X and Zhang D: The role of FUNDC1 in mitophagy, mitochondrial dynamics and human diseases. Biochem Pharmacol. 197:1148912022. View Article : Google Scholar

46 

Zhang W: The mitophagy receptor FUN14 domain-containing 1 (FUNDC1): A promising biomarker and potential therapeutic target of human diseases. Genes Dis. 8:640–654. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, Zhuang H, Zhang X, Chen H, Li S, et al: FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 35:1368–1384. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Hou H, Er P, Cheng J, Chen X, Ding X, Wang Y, Chen X, Yuan Z, Pang Q, Wang P and Qian D: High expression of FUNDC1 predicts poor prognostic outcomes and is a promising target to improve chemoradiotherapy effects in patients with cervical cancer. Cancer Med. 6:1871–1881. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Lampert MA, Orogo AM, Najor RH, Hammerling BC, Leon LJ, Wang BJ, Kim T, Sussman MA and Gustafsson ÅB: BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation. Autophagy. 15:1182–1198. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Chen L, Gong Q, Jiang H and Huang Y: Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1. Int J Mol Med 49: 72, 2022.
APA
Liu, Y., Chen, L., Gong, Q., Jiang, H., & Huang, Y. (2022). Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1. International Journal of Molecular Medicine, 49, 72. https://doi.org/10.3892/ijmm.2022.5128
MLA
Liu, Y., Chen, L., Gong, Q., Jiang, H., Huang, Y."Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1". International Journal of Molecular Medicine 49.5 (2022): 72.
Chicago
Liu, Y., Chen, L., Gong, Q., Jiang, H., Huang, Y."Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1". International Journal of Molecular Medicine 49, no. 5 (2022): 72. https://doi.org/10.3892/ijmm.2022.5128
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Chen L, Gong Q, Jiang H and Huang Y: Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1. Int J Mol Med 49: 72, 2022.
APA
Liu, Y., Chen, L., Gong, Q., Jiang, H., & Huang, Y. (2022). Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1. International Journal of Molecular Medicine, 49, 72. https://doi.org/10.3892/ijmm.2022.5128
MLA
Liu, Y., Chen, L., Gong, Q., Jiang, H., Huang, Y."Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1". International Journal of Molecular Medicine 49.5 (2022): 72.
Chicago
Liu, Y., Chen, L., Gong, Q., Jiang, H., Huang, Y."Hypoxia‑induced mitophagy regulates proliferation, migration and odontoblastic differentiation of human dental pulp cells through FUN14 domain‑containing 1". International Journal of Molecular Medicine 49, no. 5 (2022): 72. https://doi.org/10.3892/ijmm.2022.5128
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