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Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state

  • Authors:
    • Egle Zalyte
    • Jonas Cicenas
  • View Affiliations / Copyright

    Affiliations: Proteomics Centre, Institute of Biochemistry, Vilnius University Life Sciences Centre, LT‑10257 Vilnius, Lithuania
    Copyright: © Zalyte et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 84
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    Published online on: May 4, 2022
       https://doi.org/10.3892/ijmm.2022.5140
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Abstract

Pancreatic cancer is a highly metastatic and therapy‑resistant disease. In the present study, the prospects of a novel approach to kill pancreatic cancer cells were examined: Starvation combined with ferroptosis induction. Established pancreatic cancer cell lines (Miapaca2, Panc‑1, Su.86.86 and T3M4), as well as a unique cell line, Capan‑26, which was originally derived in the authors' laboratory, were used. Cells were deprived from growth factors, amino acids and pseudo‑starved using treatment with mTOR inhibitors; erastin was used to induce ferroptosis. Cell viability and lipid peroxidation measurements using flow cytometry revealed that the starved pancreatic cancer cells reacted differently to ferroptosis induction: The Panc‑1, Su.86.86 and T3M4 cells gained sensitivity, while the Miapaca2 cells acquired resistance. Fluorescence microscopy revealed that ERK1/2 translocated to the nucleus of the starved pancreatic cancer cells. Moreover, ERK1/2 pharmacological inhibition with SCH772984 prevented erastin‑induced ferroptosis in the starved Panc‑1, Su.86.86 and T3M4 cells. Confocal microscopy also indicated JNK activation. However, the inhibition of this kinase revealed its unexpected role in oxidative stress management: Treatment with the JNK inhibitor, SP600125, increased the viability of pseudo‑starved cells following erastin treatment. In addition, the FBS‑starved Miapaca2 and Capan‑26 cells transitioned between epithelial and mesenchymal cell states. The results were further confirmed using wound healing assays, western blot analysis and microscopic analysis of epithelial‑to‑mesenchymal transition (EMT) markers. Mesenchymal properties were associated with a higher sensitivity to erastin, whereas epithelial‑like cells were more resistant. Finally, it was demonstrated that compounds targeting EMT‑related signaling pathways increased cell sensitivity to erastin. On the whole, these results confirm that in starved pancreatic cancer cells, ERK1/2 and JNK signaling, as well as switching between epithelial and mesenchymal states mediates sensitivity to erastin and reveal novel therapeutic prospects of the combination of starvation with ferroptosis induction.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Spadi R, Brusa F, Ponzetti A, Chiappino I, Birocco N, Ciuffreda L and Satolli MA: Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians. World J Clin Oncol. 7:27–43. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Petrillo A, Pappalardo A, Calabrese F, Tirino G, Pompella L, Ventriglia J, Laterza MM, Caterino M, Sforza V, Iranzo V, et al: First line nab-paclitaxel plus gemcitabine in elderly metastatic pancreatic patients: A good choice beyond age. J Gastroint Oncol. 10:910–917. 2019. View Article : Google Scholar

4 

Sarabi M, Mais L, Oussaid N, Desseigne F, Guibert P and De La Fouchardiere C: Use of gemcitabine as a second-line treatment following chemotherapy with folfirinox for metastatic pancreatic adenocarcinoma. Oncol Lett. 13:4917–4924. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Ferlay J, Partensky C and Bray F: More deaths from pancreatic cancer than breast cancer in the EU by 2017. Acta Oncol. 55:1158–1160. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Han C, Liu Y, Dai R, Ismail N, Su W and Li B: Ferroptosis and its potential role in human diseases. Front Pharmacol. 11:2392020. View Article : Google Scholar : PubMed/NCBI

8 

Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, Mckeon F, Lynch M, Crum CP, et al: Iron addiction: A novel therapeutic target in ovarian cancer. Oncogene. 36:4089–4099. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Eling N, Reuter L, Hazin J, Hamacher-Brady A and Brady NR: Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells. Oncoscience. 2:517–532. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Li B, Yang L, Peng X, Fan Q, Wei S, Yang S, Li X, Jin H, Wu B, Huang M, et al: Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers. Biomed Pharmacother. 130:1107102020. View Article : Google Scholar

11 

Gagliardi M, Saverio V, Monzani R, Ferrari E, Piacentini M and Corazzari M: Ferroptosis: A new unexpected chance to treat metastatic melanoma? Cell Cycle. 19:2411–2425. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Liu H, Schreiber SL and Stockwell BR: Targeting dependency on the GPX4 lipid peroxide repair pathway for cancer therapy. Biochemistry. 57:2059–2060. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, et al: Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. 547:453–457. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Koppula P, Zhuang L and Gan B: Cystine transporter SLC7A11/xCT in cancer: Ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 12:599–620. 2021. View Article : Google Scholar :

15 

Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, et al: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496:101–105. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Liu Q, Zhang H, Jiang X, Qian C, Liu Z and Luo D: Factors involved in cancer metastasis: A better understanding to 'seed and soil' hypothesis. Mol Cancer. 16:1762017. View Article : Google Scholar

17 

Ni B, Ghosh B, Paldy FS, Colin R, Heimerl T and Sourjik V: Evolutionary remodeling of bacterial motility checkpoint control. Cell Rep. 18:866–877. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Gancedo JM: Control of pseudohyphae formation in Saccharomyces cerevisiae. FEMS Microbiol Rev. 25:107–123. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Keenan MM and Chi JT: Alternative fuels for cancer cells. Cancer J. 21:49–55. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB, et al: Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature. 497:633–637. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Martinez-Outschoorn UE, Lisanti MP and Sotgia F: Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol. 25:47–60. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, et al: Pancreatic cancers require autophagy for tumor growth. Genes Devel. 25:717–729. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Lugano R, Ramachandran M and Dimberg A: Tumor angiogenesis: Causes, consequences, challenges and opportunities. Cell Mol Life Sci. 77:1745–1770. 2020. View Article : Google Scholar :

24 

Prabhakar NR and Semenza GL: Adaptive and maladaptive cardiorespiratory responses to continuous and intermittent hypoxia mediated by hypoxia-inducible factors 1-2. Physiol Rev. 92:967–1003. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Kuczynski EA, Vermeulen PB, Pezzella F, Kerbel RS and Reynolds AR: Vessel co-option in cancer. Nat Rev Clin Oncol. 16:469–493. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Neophytou CM, Panagi M, Stylianopoulos T and Papageorgis P: The role of tumor microenvironment in cancer metastasis: Molecular mechanisms and therapeutic opportunities. Cancers (Basel). 13:20532021. View Article : Google Scholar

27 

Janssen LME, Ramsay EE, Logsdon CD and Overwijk WW: The immune system in cancer metastasis: Friend or foe? J Immunotherapy Cancer. 5:792017. View Article : Google Scholar

28 

Wang RA, Lu YY and Fan DM: Reasons for cancer metastasis: A holistic perspective. Mol Clin Oncol. 3:1199–1202. 2015. View Article : Google Scholar

29 

Trauzold A, Siegmund D, Schniewind B, Sipos B, Egberts J, Zorenkov D, Emme D, Röder C, Kalthoff H and Wajant H: TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma. Oncogene. 25:7434–7439. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Jiao D, Cai Z, Choksi S, Ma D, Choe M, Kwon HN, Baik JY, Rowan BG, Liu C and Liu ZG: Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis. Cell Res. 28:868–870. 2018. View Article : Google Scholar : PubMed/NCBI

31 

Zalyte E, Dedonyte V, Kurlinkus B, Sileikis A, Schemmer P and Valius M: Establishment and characterization of a new pancreatic ductal adenocarcinoma cell line capan-26. Anticancer Res. 41:1401–1406. 2021. View Article : Google Scholar : PubMed/NCBI

32 

Ger M, Žalytė E, Kaupinis A, Kurlinkus B, Petrulionis M, Šileikis A, Strupas K and Valius M: Primary pancreatic ductal adenocarcinoma cell cultures represent the features of native tumours. Biologija. 65:20–33. 2019. View Article : Google Scholar

33 

Rabanal-Ruiz Y, Otten EG and Korolchuk VI: mTORC1 as the main gateway to autophagy. Essays Biochem. 61:565–584. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J and Rozengurt E: Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells. PLoS One. 8:e572892013. View Article : Google Scholar : PubMed/NCBI

35 

Liou GY, Döppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP and Storz P: Mutant kras-induced mitochondrial oxidative stress in acinar cells upregulates EGFR signaling to drive formation of pancreatic precancerous lesions. Cell Rep. 14:2325–2336. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Palmieri VO, Grattagliano I and Palasciano G: Ethanol induces secretion of oxidized proteins by pancreatic acinar cells. Cell Biol Toxicol. 23:459–464. 2007. View Article : Google Scholar : PubMed/NCBI

37 

Zhu S, Zhang Q, Sun X, Zeh HJ III, Lotze MT, Kang R and Tang D: HSPA5 regulates ferroptotic cell death in cancer cells. Cancer Res. 77:2064–2077. 2017. View Article : Google Scholar : PubMed/NCBI

38 

White EZ, Pennant NM, Carter JR, Hawsawi O, Odero-Marah V and Hinton CV: Serum deprivation initiates adaptation and survival to oxidative stress in prostate cancer cells. Sci Rep. 10:125052020. View Article : Google Scholar : PubMed/NCBI

39 

Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, et al: Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 22:225–234. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Wu CA, Chao Y, Shiah SG and Lin WW: Nutrient deprivation induces the warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase. Biochimica et biophysica Acta. 1833:1147–1156. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Sato H, Nomura S, Maebara K, Sato K, Tamba M and Bannai S: Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation. Biochem Biophysical Res Communicati. 325:109–116. 2004. View Article : Google Scholar

42 

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, et al: mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT. Mol Cell. 67:128–138 e127. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D and Kaplowitz N: Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem. 283:13565–13577. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Win S, Than TA, Le BH, Garcia-Ruiz C, Fernandez-Checa JC and Kaplowitz N: Sab (Sh3bp5) dependence of JNK mediated inhibition of mitochondrial respiration in palmitic acid induced hepatocyte lipotoxicity. J Hepatol. 62:1367–1374. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Lee YH, Govinda B, Kim JC, Kim TI, Lee NH, Lee JC, Yi HK and Jhee EC: Oxidative stress resistance through blocking Hsp60 translocation followed by SAPK/JNK inhibition in aged human diploid fibroblasts. Cell Biochem Funct. 27:35–39. 2009. View Article : Google Scholar

46 

Li XY and Leung PS: Erastin-induced ferroptosis is a regulator for the growth and function of human pancreatic islet-like cell clusters. Cell Regen. 9:162020. View Article : Google Scholar : PubMed/NCBI

47 

Yang Y, Lin Z, Han Z, Wu Z, Hua J, Zhong R, Zhao R, Ran H, Qu K, Huang H, et al: miR-539 activates the SAPK/JNK signaling pathway to promote ferropotosis in colorectal cancer by directly targeting TIPE. Cell Death Dis. 7:2722021. View Article : Google Scholar

48 

Kamphorst JJ, Nofal M, Commisso C, Hackett SR, Lu W, Grabocka E, Vander Heiden MG, Miller G, Drebin JA, Bar-Sagi D, et al: Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein. Cancer Res. 75:544–553. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Tong H, Yin H, Hossain MA, Wang Y, Wu F, Dong X, Gao S, Zhan K and He W: Starvation-induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF-β1/Smad3-mediated epithelial-mesenchymal transition activation. J Cell Biochem. 120:5118–5127. 2019. View Article : Google Scholar

50 

Stone TW: Dependence and guidance receptors-DCC and Neogenin-in partial EMT and the actions of serine proteases. Front Oncol. 10:942020. View Article : Google Scholar : PubMed/NCBI

51 

Kim WK, Kwon Y, Jang M, Park M, Kim J, Cho S, Jang DG, Lee WB, Jung SH, Choi HJ, et al: β-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers. Sci Rep. 9:184402019. View Article : Google Scholar

52 

Coppock JD, Vermeer PD, Vermeer DW, Lee KM, Miskimins WK, Spanos WC and Lee JH: mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC. Oncotarget. 7:24228–24241. 2016. View Article : Google Scholar : PubMed/NCBI

53 

Chan DLH, Segelov E, Wong RS, Smith A, Herbertson RA, Li BT, Tebbutt N, Price T and Pavlakis N: Epidermal growth factor receptor (EGFR) inhibitors for metastatic colorectal cancer. Cochrane Database Syst Rev. 6:CD0070472017.PubMed/NCBI

54 

Demkova L and Kucerova L: Role of the HGF/c-MET tyrosine kinase inhibitors in metastasic melanoma. Mol Cancer. 17:262018. View Article : Google Scholar : PubMed/NCBI

55 

Yu S, Chen Z, Zeng X, Chen X and Gu Z: Advances in nanomedicine for cancer starvation therapy. Theranostics. 9:8026–8047. 2019. View Article : Google Scholar : PubMed/NCBI

56 

D'Aronzo M, Vinciguerra M, Mazza T, Panebianco C, Saracino C, Pereira SP, Graziano P and Pazienza V: Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models. Oncotarget. 6:18545–18557. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zalyte E and Cicenas J: Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state. Int J Mol Med 49: 84, 2022.
APA
Zalyte, E., & Cicenas, J. (2022). Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state. International Journal of Molecular Medicine, 49, 84. https://doi.org/10.3892/ijmm.2022.5140
MLA
Zalyte, E., Cicenas, J."Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state". International Journal of Molecular Medicine 49.6 (2022): 84.
Chicago
Zalyte, E., Cicenas, J."Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state". International Journal of Molecular Medicine 49, no. 6 (2022): 84. https://doi.org/10.3892/ijmm.2022.5140
Copy and paste a formatted citation
x
Spandidos Publications style
Zalyte E and Cicenas J: Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state. Int J Mol Med 49: 84, 2022.
APA
Zalyte, E., & Cicenas, J. (2022). Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state. International Journal of Molecular Medicine, 49, 84. https://doi.org/10.3892/ijmm.2022.5140
MLA
Zalyte, E., Cicenas, J."Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state". International Journal of Molecular Medicine 49.6 (2022): 84.
Chicago
Zalyte, E., Cicenas, J."Starvation mediates pancreatic cancer cell sensitivity to ferroptosis via ERK1/2, JNK and changes in the cell mesenchymal state". International Journal of Molecular Medicine 49, no. 6 (2022): 84. https://doi.org/10.3892/ijmm.2022.5140
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