Open Access

Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3

  • Authors:
    • Junpeng Ji
    • Huibing Li
    • Jing Chen
    • Wenjun Wang
  • View Affiliations

  • Published online on: June 29, 2022     https://doi.org/10.3892/ijmm.2022.5168
  • Article Number: 111
  • Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Bladder cancer is the most common malignant tumor of the urinary system, and in China it is first among urogenital system tumors. More therapeutic targets are still urgently required to combat this disease. Lamin B2 (LMNB2) is a type of nuclear lamina filament protein, which is involved in multiple cellular processes, and known as an oncogene affecting the progression of multiple types of cancers. Although the multiple effects of LMNB2 on cancer progression have been elucidated, its possible role in bladder cancer remains unclear. In the present study, it was determined that LMNB2 expression was upregulated in human bladder cancer tissues, and its expression was correlated with the prognosis and the clinical features, including tumor stage (P=0.001) and recurrence (P=0.006) of patients with bladder cancer. In addition, it was further revealed that LMNB2 depletion inhibited bladder cancer cell proliferation, stimulated cell cycle arrest and apoptosis in vitro, and suppressed tumor growth of bladder cancer cells in mice. Furthermore, the present data revealed that LMNB2 promoted the proliferation of bladder cancer cells via transcriptional activation of CDCA3 expression. Therefore, the role of LMNB2 in bladder cancer progression was demonstrated, and may serve as a promising therapeutic target for bladder cancer treatment.
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September-2022
Volume 50 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Ji J, Li H, Chen J and Wang W: Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3. Int J Mol Med 50: 111, 2022.
APA
Ji, J., Li, H., Chen, J., & Wang, W. (2022). Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3. International Journal of Molecular Medicine, 50, 111. https://doi.org/10.3892/ijmm.2022.5168
MLA
Ji, J., Li, H., Chen, J., Wang, W."Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3". International Journal of Molecular Medicine 50.3 (2022): 111.
Chicago
Ji, J., Li, H., Chen, J., Wang, W."Lamin B2 contributes to the proliferation of bladder cancer cells via activating the expression of cell division cycle‑associated protein 3". International Journal of Molecular Medicine 50, no. 3 (2022): 111. https://doi.org/10.3892/ijmm.2022.5168