Open Access

CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review)

  • Authors:
    • Jinyao Huang
    • Liang Zheng
    • Zicheng Sun
    • Jie Li
  • View Affiliations

  • Published online on: August 30, 2022     https://doi.org/10.3892/ijmm.2022.5184
  • Article Number: 128
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent years, the incidence rate of breast cancer has increased year by year, and it has become a major threat to the health of women globally. Among all breast cancer subtypes, the hormone receptor (HR)+/human epidermal growth factor receptor 2 (HER2) luminal subtype breast cancer is the most common form of breast cancer. Cyclin‑dependent kinase 4 and 6 (CDK4/6) inhibitors, the hotspots in the field of targeted therapy for breast cancer, have proved to exhibit a good effect on patients with HR+/HER2 breast cancer in a number of clinical trials, but the problem of drug resistance is inevitable. At present, three specific CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have been approved by the USA Food and Drug Administration for the first‑line treatment of HR+/HER2 breast cancer. The drug resistance mechanisms of CDK4/6 inhibitors can be divided into cell cycle‑specific resistance and cell cycle non‑specific resistance. With the discovery of the drug resistance mechanism of CDK4/6 inhibitors, various targeted strategies have been proposed. The present review mainly discusses the mechanism of CDK4/6 inhibitors, drug resistance mechanisms and treatment strategies after resistance.
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October-2022
Volume 50 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Huang J, Zheng L, Sun Z and Li J: CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review). Int J Mol Med 50: 128, 2022
APA
Huang, J., Zheng, L., Sun, Z., & Li, J. (2022). CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review). International Journal of Molecular Medicine, 50, 128. https://doi.org/10.3892/ijmm.2022.5184
MLA
Huang, J., Zheng, L., Sun, Z., Li, J."CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review)". International Journal of Molecular Medicine 50.4 (2022): 128.
Chicago
Huang, J., Zheng, L., Sun, Z., Li, J."CDK4/6 inhibitor resistance mechanisms and treatment strategies (Review)". International Journal of Molecular Medicine 50, no. 4 (2022): 128. https://doi.org/10.3892/ijmm.2022.5184