Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October-2022 Volume 50 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2022 Volume 50 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway

  • Authors:
    • Wenmei Wang
    • Weite Shang
    • Jiang Zou
    • Ke Liu
    • Meidong Liu
    • Xiaoqin Qiu
    • Huali Zhang
    • Kangkai Wang
    • Nian Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, School of Basic Medical Science, Central South University, Changsha, Hunan 410008, P.R. China, Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 129
    |
    Published online on: August 30, 2022
       https://doi.org/10.3892/ijmm.2022.5185
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Zinc finger protein 667 (ZNF667, also referred as Mipu1), a widely expressed KRAB/C2H2‑type zinc finger transcription factor, can protect against hypoxic‑ischemic myocardial injury. Pro‑angiogenesis is regarded as a promising strategy for the treatment of acute myocardial infarction (AMI). However, whether ZNF667 is involved in the angiogenesis following AMI remains to be elucidated. The present study reported that the expression of ZNF667 in CD31‑positive endothelial cells (ECs) was upregulated in the heart of AMI mice. Hypoxic challenge (1% oxygen) promoted the mRNA and protein expression of ZNF667 in the human umbilical vein endothelial cells (HUVECs) in a time‑dependent manner. Moreover, ZNF667 promoted hypoxia‑induced invasion and tube formation of HUVECs. Mechanically, ZNF667 could directly bind to the promoter of anti‑angiogenic gene VASH1 and inhibit its expression. Consequently, VASH1 overexpression abolished hypoxic challenge or ZNF667 overexpression‑induced invasion and tube formation of HUVECs. Further bioinformatic analyses suggested that overexpression of ZNF667 or knockdown of VASH1‑induced differentially expressed genes in HUVECs were greatly enriched in the Wnt signaling pathway (DAAM1, LEF1, RAC2, FRAT1, NFATc2 and WNT5A). Together, these data suggested that ZNF667 facilitates myocardial ischemia‑driven angiogenesis through transcriptional repression of VASH1 and regulation of Wnt signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, de Ferranti SD, Floyd J, Fornage M, Gillespie C, et al: Heart disease and stroke statistics-2017 update: A report from the american heart association. Circulation. 135. pp. e146–e603. 2017, View Article : Google Scholar

2 

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, et al: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the global burden of disease study 2010. Lancet. 380:2095–2128. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Olivetti G, Capasso JM, Meggs LG, Sonnenblick EH and Anversa P: Cellular basis of chronic ventricular remodeling after myocardial infarction in rats. Circ Res. 68:856–869. 1991. View Article : Google Scholar : PubMed/NCBI

4 

Hori M and Nishida K: Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res. 81:457–464. 2009. View Article : Google Scholar

5 

Ware JA and Simons M: Angiogenesis in ischemic heart disease. Nat Med. 3:158–164. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Cho HM, Kim PH, Chang HK, Shen YM, Bonsra K, Kang BJ, Yum SY, Kim JH, Lee SY, Choi MC, et al: Targeted genome engineering to control VEGF expression in human umbilical cord blood-derived mesenchymal stem cells: Potential implications for the treatment of myocardial infarction. Stem Cells Transl Med. 6:1040–1051. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Tykhomyrov AA, Nedzvetsky VS, Bardachenko NI, Grinenko TV and Kuryata OV: Statin treatment decreases serum angiostatin levels in patients with ischemic heart disease. Life Sci. 134:22–29. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Chu H and Wang Y: Therapeutic angiogenesis: Controlled delivery of angiogenic factors. Ther Deliv. 3:693–714. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Ouma GO, Jonas RA, Usman MH and Mohler ER III: Targets and delivery methods for therapeutic angiogenesis in peripheral artery disease. Vasc Med. 17:174–192. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Lavu M, Gundewar S and Lefer DJ: Gene therapy for ischemic heart disease. J Mol Cell Cardiol. 50:742–750. 2011. View Article : Google Scholar

11 

Yamamoto N, Oyaizu T, Enomoto M, Horie M, Yuasa M, Okawa A and Yagishita K: VEGF and bFGF induction by nitric oxide is associated with hyperbaric oxygen-induced angiogenesis and muscle regeneration. Sci Rep. 10:27442020. View Article : Google Scholar : PubMed/NCBI

12 

Zaslavsky A, Baek KH, Lynch RC, Short S, Grillo J, Folkman J, Italiano JE Jr and Ryeom S: Platelet-derived thrombospondin-1 is a critical negative regulator and potential biomarker of angiogenesis. Blood. 115:4605–4613. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Matsunaga T, Weihrauch DW, Moniz MC, Tessmer J, Warltier DC and Chilian WM: Angiostatin inhibits coronary angiogenesis during impaired production of nitric oxide. Circulation. 105:2185–2191. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Idrisova KF, Zeinalova AK, Masgutova GA, Bogov AA, Allegrucci C, Syromiatnikova VY, Salafutdinov II, Garanina EE, Andreeva DI, Kadyrov AA, et al: Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury. Neural Regen Res. 17:1240–1247. 2022. View Article : Google Scholar

15 

Almeida I, Gomes AO, Lima M, Silva I and Vasconcelos C: Different contributions of angiostatin and endostatin in angiogenesis impairment in systemic sclerosis: A cohort study. Clin Exp Rheumatol. 100(Suppl): 37–42. 2016.

16 

Zhao G, Na R, Li L, Xiao H, Ding N, Sun Y and Han R: Vasohibin-1 inhibits angiogenesis and suppresses tumor growth in renal cell carcinoma. Oncol Rep. 38:1021–1028. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Tang X, Yang Y, Yuan H, You J, Burkatovskaya M and Amar S: Novel transcriptional regulation of VEGF in inflammatory processes. J Cell Mol Med. 17:386–397. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Matsakas A, Yadav V, Lorca S, Evans RM and Narkar VA: Revascularization of ischemic skeletal muscle by estrogen-related receptor-gamma. Circ Res. 110:1087–1096. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, et al: HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 451:1008–1012. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, et al: Regulation of tumor angiogenesis by EZH2. Cancer Cell. 18:185–197. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Yuan C, Zhang HL, Liu Y, Wang QP and Xiao XZ: Cloning and characterization of a new gene mip1 up-regulated during myocardial ishemia-reperfusion. Progress in Biochemistry and Biophysics. 2004:231–236. 2014.In Chinese.

22 

Wang G, Jiang L, Song J, Zhou SF, Zhang H, Wang K and Xiao X: Mipu1 protects H9c2 myogenic cells from hydrogen peroxide-induced apoptosis through inhibition of the expression of the death receptor Fas. Int J Mol Sci. 15:18206–18220. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Jiang L, Wang H, Shi C, Liu K, Liu M, Wang N, Wang K, Zhang H, Wang G and Xiao X: ZNF667/Mipu1 is a novel anti-apoptotic factor that directly regulates the expression of the rat Bax gene in H9c2 cells. PLoS One. 9:e1116532014. View Article : Google Scholar : PubMed/NCBI

24 

Wang G, Zuo X, Yuan C, Zheng Y, Jiang L, Song J, Liu Y, Zhang B and Xiao X: Mipu1, a novel rat zinc-finger protein, inhibits transcriptional activities of AP-1 and SRE in mitogen-activated protein kinase signaling pathway. Mol Cell Biochem. 322:93–102. 2009. View Article : Google Scholar

25 

Wang K, Lei J, Zou J, Xiao H, Chen A, Liu X, Liu Y, Jiang L, Xiao Z and Xiao X: Mipu1, a novel direct target gene, is involved in hypoxia inducible factor 1-mediated cytoprotection. PLoS One. 8:e828272013. View Article : Google Scholar : PubMed/NCBI

26 

Hashimoto T and Shibasaki F: Hypoxia-inducible factor as an angiogenic master switch. Front Pediatr. 3:332015. View Article : Google Scholar : PubMed/NCBI

27 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. National Academies Press; Washington, DC: 2011

28 

Zou J, Wang N, Liu M, Bai Y, Wang H, Liu K, Zhang H, Xiao X and Wang K: Nucleolin mediated pro-angiogenic role of Hydroxysafflor Yellow A in ischaemic cardiac dysfunction: Post-transcriptional regulation of VEGF-A and MMP-9. J Cell Mol Med. 22:2692–2705. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Zou J, Fei Q, Xiao H, Wang H, Liu K, Liu M, Zhang H, Xiao X, Wang K and Wang N: VEGF-A promotes angiogenesis after acute myocardial infarction through increasing ROS production and enhancing ER stress-mediated autophagy. J Cell Physiol. 234:17690–17703. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Jiang L, Tang D, Wang K, Zhang H, Yuan C, Duan D and Xiao X: Functional analysis of a novel KRAB/C2H2 zinc finger protein Mipu1. Biochem Biophys Res Commun. 356:829–835. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

32 

Cassandri M, Smirnov A, Novelli F, Pitolli C, Agostini M, Malewicz M, Melino G and Raschellà G: Zinc-finger proteins in health and disease. Cell Death Discov. 3:170712017. View Article : Google Scholar : PubMed/NCBI

33 

Laity JH, Lee BM and Wright PE: Zinc finger proteins: New insights into structural and functional diversity. Curr Opin Struct Biol. 11:39–46. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Pan L, Sheng M, Huang Z, Zhu Z, Xu C, Teng L, He L, Gu C, Yi C and Li J: Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis. PLoS One. 12:e01866352017. View Article : Google Scholar : PubMed/NCBI

35 

Shang J, Gao ZY, Zhang LY and Wang CY: Over-expression of JAZF1 promotes cardiac microvascular endothelial cell proliferation and angiogenesis via activation of the Akt signaling pathway in rats with myocardial ischemia-reperfusion. Cell Cycle. 18:1619–1634. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Wang G, Zuo X, Liu J, Jiang L, Liu Y, Zheng Y, Zhang B and Xiao X: Expression of Mipu1 in response to myocardial infarction in rats. Int J Mol Sci. 10:492–506. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Yuan D, Huang J, Yuan X, Zhao J and Jiang W: Zinc finger protein 667 expression is upregulated by cerebral ischemic preconditioning and protects cells from oxidative stress. Biomed Rep. 1:534–538. 2013. View Article : Google Scholar

38 

Qu SL, Fan WJ, Zhang C, Guo F, Pan WJ, Han D, Li W, Zhu YN and Jiang ZS: Mipu1 inhibits lipid accumulation through down-regulation of CD36 in RAW264.7 cells. Cell Physiol Biochem. 37:879–889. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Qu SL, Fan WJ, Zhang C, Guo F, Han D, Pan WJ, Li W, Feng DM and Jiang ZS: Mipu1 overexpression protects macrophages from oxLDL-induced foam cell formation and cell apoptosis. DNA Cell Biol. 33:839–846. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Watanabe K, Hasegawa Y, Yamashita H, Shimizu K, Ding Y, Abe M, Ohta H, Imagawa K, Hojo K, Maki H, et al: Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis. J Clin Invest. 114:898–907. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Kimura H, Miyashita H, Suzuki Y, Kobayashi M, Watanabe K, Sonoda H, Ohta H, Fujiwara T, Shimosegawa T and Sato Y: Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis. Blood. 113:4810–4818. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Takahashi Y, Saga Y, Koyanagi T, Takei Y, Machida S, Taneichi A, Mizukami H, Sato Y, Matsubara S and Fujiwara H: The angiogenesis regulator vasohibin-1 inhibits ovarian cancer growth and peritoneal dissemination and prolongs host survival. Int J Oncol. 47:2057–2063. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Miller JR: The wnts. Genome Biol. 3:REVIEWS30012002.PubMed/NCBI

44 

Tetsu O and McCormick F: Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 398:422–426. 1999. View Article : Google Scholar : PubMed/NCBI

45 

Zhang X, Gaspard JP and Chung DC: Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia. Cancer Res. 61:6050–6054. 2001.PubMed/NCBI

46 

Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J and Matsumoto K: The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 23:131–139. 2003. View Article : Google Scholar :

47 

Cheng CW, Yeh JC, Fan TP, Smith SK and Charnock-Jones DS: Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration. Biochem Biophys Res Commun. 365:285–290. 2008. View Article : Google Scholar

48 

Shi YN, Zhu N, Liu C, Wu HT, Gui Y, Liao DF and Qin L: Wnt5a and its signaling pathway in angiogenesis. Clin Chim Acta. 471:263–269. 2017. View Article : Google Scholar : PubMed/NCBI

49 

De P, Peng Q, Traktuev DO, Li W, Yoder MC, March KL and Durden DL: Expression of RAC2 in endothelial cells is required for the postnatal neovascular response. Exp Cell Res. 315:248–263. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Ju R, Cirone P, Lin S, Griesbach H, Slusarski DC and Crews CM: Activation of the planar cell polarity formin DAAM1 leads to inhibition of endothelial cell proliferation, migration, and angiogenesis. Proc Natl Acad Sci USA. 107:6906–6911. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Cai Y, Yao H, Sun Z, Wang Y, Zhao Y, Wang Z and Li L: Role of NFAT in the progression of diabetic atherosclerosis. Front Cardiovasc Med. 8:6351722021. View Article : Google Scholar : PubMed/NCBI

52 

Zaichuk TA, Shroff EH, Emmanuel R, Filleur S, Nelius T and Volpert OV: Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J Exp Med. 199:1513–1522. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Planutiene M, Planutis K and Holcombe RF: Lymphoid enhancer-binding factor 1, a representative of vertebrate-specific Lef1/Tcf1 sub-family, is a Wnt-beta-catenin pathway target gene in human endothelial cells which regulates matrix metalloproteinase-2 expression and promotes endothelial cell invasion. Vasc Cell. 3:282011. View Article : Google Scholar

54 

Guo G, Liu J, Ren Y, Mao X, Hao Y, Zhong C, Chen X, Wang X, Wu Y, Lian S, et al: FRAT1 enhances the proliferation and tumorigenesis of CD133(+)nestin(+) glioma stem cells in vitro and in vivo. J Cancer. 11:2421–2430. 2020. View Article : Google Scholar :

55 

Gao M, Wang H, Liu Y, Tu ZZ, Liu MD, Chen GW and Liu K: Changes of the expression of Mipu1 gene in tissues of mice in endotoxemia. Life Sci Res. 14:331–334. 2010.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang W, Shang W, Zou J, Liu K, Liu M, Qiu X, Zhang H, Wang K and Wang N: ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. Int J Mol Med 50: 129, 2022.
APA
Wang, W., Shang, W., Zou, J., Liu, K., Liu, M., Qiu, X. ... Wang, N. (2022). ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. International Journal of Molecular Medicine, 50, 129. https://doi.org/10.3892/ijmm.2022.5185
MLA
Wang, W., Shang, W., Zou, J., Liu, K., Liu, M., Qiu, X., Zhang, H., Wang, K., Wang, N."ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway". International Journal of Molecular Medicine 50.4 (2022): 129.
Chicago
Wang, W., Shang, W., Zou, J., Liu, K., Liu, M., Qiu, X., Zhang, H., Wang, K., Wang, N."ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway". International Journal of Molecular Medicine 50, no. 4 (2022): 129. https://doi.org/10.3892/ijmm.2022.5185
Copy and paste a formatted citation
x
Spandidos Publications style
Wang W, Shang W, Zou J, Liu K, Liu M, Qiu X, Zhang H, Wang K and Wang N: ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. Int J Mol Med 50: 129, 2022.
APA
Wang, W., Shang, W., Zou, J., Liu, K., Liu, M., Qiu, X. ... Wang, N. (2022). ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. International Journal of Molecular Medicine, 50, 129. https://doi.org/10.3892/ijmm.2022.5185
MLA
Wang, W., Shang, W., Zou, J., Liu, K., Liu, M., Qiu, X., Zhang, H., Wang, K., Wang, N."ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway". International Journal of Molecular Medicine 50.4 (2022): 129.
Chicago
Wang, W., Shang, W., Zou, J., Liu, K., Liu, M., Qiu, X., Zhang, H., Wang, K., Wang, N."ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway". International Journal of Molecular Medicine 50, no. 4 (2022): 129. https://doi.org/10.3892/ijmm.2022.5185
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team