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Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells

  • Authors:
    • Zizhan Li
    • Qin Zhou
    • Xianguang Liu
    • Yaohua Li
    • Xinli Fan
    • Gangli Liu
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250012, P.R. China, Vip Center, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250012, P.R. China, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250012, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 145
    |
    Published online on: November 9, 2022
       https://doi.org/10.3892/ijmm.2022.5201
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Abstract

Although there are numerous treatment strategies, including surgery and chemotherapy, the prognosis of cervical cancer remains far from satisfactory. There is an urgent need to develop more effective, more tolerable and safer therapeutics for the treatment of cervical cancer. Lycorine is a natural plantextract that has been previously found to confer anti‑tumor activities. Therefore, in the present study, the effects of lycorine and its possible mechanism of action in cervical cancer were investigated. Cell Counting Kit‑8, wound healing and Transwell assays were used to verify the proliferation and migration of HeLa cells following lycorine intervention. The results demonstrated that lycorine significantly inhibited the proliferation and migration of HeLa cells. RNA binding motif 10 (RBM10) is a protein associated with apoptosis. It has been suggested that lycorine can affect the expression of RBM10. Flow cytometry demonstrated that lycorine may inhibit the initiation and progression of cervical cancer by promoting apoptosis, which may be mediated through the upregulation of RBM10 expression and increasing TNF‑α levels. Xenograft mouse experiments indicated that when lycorine was injected through the tail vein, HeLa tumor growth was inhibited. Mechanistically, western blotting demonstrated that lycorine significantly inhibited the activation of the Akt signaling pathway and potentially reversed epithelial‑mesenchymal transition, which was also mediated by RBM10. Furthermore, following RBM10 knockdown with small interfering‑RNA, the inhibitory effects of lycorine on cervical cancer was significantly abrogated. Overall, results of the present study suggest that lycorine can upregulate the expression of RBM10 and inhibit the proliferation and migration of cervical cancer cells.
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1 

Moga MA, Dima L, Balan A, Blidaru A, Dimienescu OG, Podasca C and Toma S: Are bioactive molecules from seaweeds a novel and challenging option for the prevention of HPV infection and cervical cancer therapy?-A review. Int J Mol Sci. 22:6292021. View Article : Google Scholar

2 

Davies-Oliveira JC, Smith MA, Grover S, Canfell K and Crosbie EJ: Eliminating cervical cancer: Progress and challenges for high-income countries. Clin Oncol (R Coll Radiol). 33:550–559. 2021. View Article : Google Scholar

3 

Buskwofie A, David-West G and Clare CA: A review of cervical cancer: Incidence and disparities. J Natl Med Assoc. 112:229–232. 2020.PubMed/NCBI

4 

Li H, Wu X and Cheng X: Advances in diagnosis and treatment of metastatic cervical cancer. J Gynecol Oncol. 27:e432016. View Article : Google Scholar : PubMed/NCBI

5 

Hill EK: Updates in cervical cancer treatment. Clin Obstet Gynecol. 63:3–11. 2020. View Article : Google Scholar

6 

Liontos M, Kyriazoglou A, Dimitriadis I, Dimopoulos MA and Bamias A: Systemic therapy in cervical cancer: 30 Years in review. Crit Rev Oncol Hematol. 137:9–17. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Cao Z, Yang P and Zhou Q: Multiple biological functions and pharmacological effects of lycorine. Sci China Chem. 56:1382–1391. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Xiang Y, Guo Z, Zhu P, Chen J and Huang Y: Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science. Cancer Med. 8:1958–1975. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Zhai B, Zhang N, Han X, Li Q, Zhang M, Chen X, Li G, Zhang R, Chen P, Wang W, et al: Molecular targets of β-elemene, a herbal extract used in traditional Chinese medicine, and its potential role in cancer therapy: A review. Biomed Pharmacother. 114:1088122019. View Article : Google Scholar

10 

Zhang P, Yuan X, Yu T, Huang H, Yang C, Zhang L, Yang S, Luo X and Luo J: Lycorine inhibits cell proliferation, migration and invasion, and primarily exerts in vitro cytostatic effects in human colorectal cancer via activating the ROS/p38 and PI3K/AKT signaling pathways. Oncol Rep. 45:192021. View Article : Google Scholar

11 

Shang H, Jang X, Shi L and Ma Y: Lycorine inhibits cell proliferation and induced oxidative stress-mediated apoptosis via regulation of the JAK/STAT3 signaling pathway in HT-3 cells. J Biochem Mol Toxicol. 35:e228822021. View Article : Google Scholar : PubMed/NCBI

12 

Shi J, Zhao H, Lian H, Ke L, Zhao L, Wang C and Han Q: CD276 (B7H3) improve cancer stem cells formation in cervical carcinoma cell lines. Transl Cancer Res. 10:65–72. 2021. View Article : Google Scholar

13 

Xu Y, Wu H, Huang C and Lu L: Clinical value of traditional laparotomy, extensive vaginal hysterectomy, and laparoscope-assisted vaginal hysterectomy in the treatment of patients with cervical intraepithelial neoplasia III. Transl Cancer Res. 10:2409–2415. 2021. View Article : Google Scholar

14 

Wang W, Gao X, Zhu Y, Qi Y and Wang Y: Diagnostic significance of a color Doppler ultrasound combined with serum CXCL16 and E-cad in cervical cancer. Transl Cancer Res. 10:1492–1499. 2021. View Article : Google Scholar

15 

Li Z, Wang S, Fang S, Li X, Li Y and Liu G: Adipose-derived stem cells promote the proliferation, migration, and invasion of oral squamous cell carcinoma cells by activating the Wnt/planar cell polarity signaling pathway. Transl Cancer Res. 11:306–315. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

17 

National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the care and use of laboratory animals. 8th edition: Washington (DC): National Academies Press (US); 2011

18 

Li Z, Fan X, Xu X, Zhou Q, Xing G and Liu G: Adipose-derived stem cells postpone the progression of Sjögren's syndrome by upregulating the Hippo signaling pathway. Exp Ther Med. 24:5872022. View Article : Google Scholar

19 

Hu M, Tan J, Liu Z, Li L, Zhang H, Zhao D, Li B, Gao X, Che N and Zhang T: Comprehensive comparative molecular characterization of young and old lung cancer patients. Front Oncol. 11:8068452022. View Article : Google Scholar : PubMed/NCBI

20 

Jung JH, Lee H, Zeng SX and Lu H: RBM10, a new regulator of p53. Cells. 9:21072020. View Article : Google Scholar :

21 

Witkiewicz AK, McMillan EA, Balaji U, Baek G, Lin WC, Mansour J, Mollaee M, Wagner KU, Koduru P, Yopp A, et al: Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets. Nat Commun. 6:67442015. View Article : Google Scholar : PubMed/NCBI

22 

Wang K, Bacon ML, Tessier JJ, Rintala-Maki ND, Tang V and Sutherland LC: RBM10 modulates apoptosis and influences TNF-α gene expression. J Cell Death. 5:1–19. 2012. View Article : Google Scholar

23 

Jung JH, Lee H, Cao B, Liao P, Zeng SX and Lu H: RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53. Oncogene. 39:1031–1040. 2020. View Article : Google Scholar :

24 

Han LP, Wang CP and Han SL: Overexpression of RBM10 induces osteosarcoma cell apoptosis and inhibits cell proliferation and migration. Med Sci (Paris). 34:81–86. 2018. View Article : Google Scholar

25 

Stratos I, Behrendt AK, Anselm C, Gonzalez A, Mittlmeier T and Vollmar B: Inhibition of TNF-α restores muscle force, inhibits inflammation, and reduces apoptosis of traumatized skeletal muscles. Cells. 11:23972022. View Article : Google Scholar

26 

Ji Y, Xie S, Jiang L, Liu L, Li L, Luo L, Chen Y, Zhang J, Yu L, Zhang Y, et al: Increased cell apoptosis in human lung adenocarcinoma and in vivo tumor growth inhibition by RBM10, a tumor suppressor gene. Oncol Lett. 14:4663–4669. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Cao Y, Di X, Zhang Q, Li R and Wang K: RBM10 regulates tumor apoptosis, proliferation, and metastasis. Front Oncol. 11:6039322021. View Article : Google Scholar : PubMed/NCBI

28 

Zhao J, Zhang P and Wang X: YBX1 promotes tumor progression via the PI3K/AKT signaling pathway in laryngeal squamous cell carcinoma. Transl Cancer Res. 10:4859–4869. 2021. View Article : Google Scholar

29 

Tateishi K, Nakamura T, Juratli TA, Williams EA, Matsushita Y, Miyake S, Nishi M, Miller JJ, Tummala SS, Fink AL, et al: PI3K/AKT/mTOR pathway alterations promote malignant progression and xenograft formation in oligodendroglial tumors. Clin Cancer Res. 25:4375–4387. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Zheng M, Zhou Q, Liu X, Wang C and Liu G: CTHRC1 overexpression promotes cervical carcinoma progression by activating the Wnt/PCP signaling pathway. Oncol Rep. 41:1531–1538. 2019.PubMed/NCBI

31 

Castillo Ferrer C, Berthenet K and Ichim G: Apoptosis-fueling the oncogenic fire. FEBS J. 288:4445–4463. 2021. View Article : Google Scholar

32 

Obeng E: Apoptosis (programmed cell death) and its signals-a review. Braz J Biol. 81:1133–1143. 2021. View Article : Google Scholar

33 

Inoue A: RBM10: Structure, functions, and associated diseases. Gene. 783:1454632021. View Article : Google Scholar : PubMed/NCBI

34 

He Y, Wang W, Xu X, Yang B, Yu X, Wu Y and Wang J: Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m6A modification. Bone. 154:1161822022. View Article : Google Scholar

35 

Song M, Bode AM, Dong Z and Lee MH: AKT as a therapeutic target for cancer. Cancer Res. 79:1019–1031. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Revathidevi S and Munirajan AK: Akt in cancer: Mediator and more. Semin Cancer Biol. 59:80–91. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Zhou Q, Liu X, Li Y, Fan X and Liu G: Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. Int J Mol Med 50: 145, 2022.
APA
Li, Z., Zhou, Q., Liu, X., Li, Y., Fan, X., & Liu, G. (2022). Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. International Journal of Molecular Medicine, 50, 145. https://doi.org/10.3892/ijmm.2022.5201
MLA
Li, Z., Zhou, Q., Liu, X., Li, Y., Fan, X., Liu, G."Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells". International Journal of Molecular Medicine 50.6 (2022): 145.
Chicago
Li, Z., Zhou, Q., Liu, X., Li, Y., Fan, X., Liu, G."Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells". International Journal of Molecular Medicine 50, no. 6 (2022): 145. https://doi.org/10.3892/ijmm.2022.5201
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Zhou Q, Liu X, Li Y, Fan X and Liu G: Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. Int J Mol Med 50: 145, 2022.
APA
Li, Z., Zhou, Q., Liu, X., Li, Y., Fan, X., & Liu, G. (2022). Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. International Journal of Molecular Medicine, 50, 145. https://doi.org/10.3892/ijmm.2022.5201
MLA
Li, Z., Zhou, Q., Liu, X., Li, Y., Fan, X., Liu, G."Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells". International Journal of Molecular Medicine 50.6 (2022): 145.
Chicago
Li, Z., Zhou, Q., Liu, X., Li, Y., Fan, X., Liu, G."Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells". International Journal of Molecular Medicine 50, no. 6 (2022): 145. https://doi.org/10.3892/ijmm.2022.5201
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