Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
January-2023 Volume 51 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2023 Volume 51 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms

  • Authors:
    • Pengran Liu
    • Dan Zhang
    • Guixiong Huang
    • Mingdi Xue
    • Ying Fang
    • Lin Lu
    • Jiayao Zhang
    • Mao Xie
    • Zhewei Ye
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China, Department of Pharmacy, Wuhan No. 1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 2
    |
    Published online on: November 16, 2022
       https://doi.org/10.3892/ijmm.2022.5205
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Excessive proliferation and migration of fibroblasts in the lumbar laminectomy area can lead to epidural fibrosis, eventually resulting in failed back surgery syndrome. It has been reported that laminin α1, a significant biofunctional glycoprotein in the extracellular matrix, is involved in several fibrosis‑related diseases, such as pulmonary, liver and keloid fibrosis. However, the underlying mechanism of laminin α1 in epidural fibrosis remains unknown. The present study aimed to explore the effect and mechanism of laminin α1 in fibroblast proliferation, apoptosis and migration, and epidural fibrosis. Following the establishment of a laminectomy model, hematoxylin and eosin, Masson's trichrome and immunohistochemical staining were performed to determine the degree of epidural fibrosis, the number of fibroblasts, collagen content and the epidural expression levels of laminin α1, respectively. Furthermore, a stable small interfering RNA system was used to knock down the expression of laminin α1 in fibroblasts. The transfection efficiency was confirmed by reverse transcription‑quantitative PCR and immunofluorescence staining. Western blot analysis, scratch wound assay, EdU incorporation assay, flow cytometric analysis and Cell Counting Kit 8 assay were performed to assess the proliferation, apoptosis, migration and viability of fibroblasts, as well as the expression levels of the AKT/mechanistic target of rapamycin (mTOR) signaling‑related proteins. In vivo experiments revealed that laminin α1 was positively and time‑dependently associated with epidural fibrosis. In addition, laminin α1 knockdown attenuated cell proliferation, viability and migration, and promoted apoptosis. Furthermore, the results revealed that the activation of the AKT/mTOR signaling pathway was involved in the aforementioned processes. Overall, the current study illustrated the positive association between laminin α1 and epidural fibrosis, and also verified the effect of laminin α1 on fibroblast proliferation, apoptosis and migration. Furthermore, the results suggested that the AKT/mTOR signaling pathway may serve a significant role in regulating the behavior of laminin α1‑induced fibroblasts.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Kong L, Shang XF, Zhang WZ, Duan LQ, Yu Y, Ni WJ and Huang Y: Percutaneous endoscopic lumbar discectomy and microsurgical laminotomy: A prospective, randomized controlled trial of patients with lumbar disc herniation and lateral recess stenosis. Orthopade. 48:157–164. 2019. View Article : Google Scholar

2 

Sun F, Liang Q, Yan M, Wang H, Liu Z, Li F, Dong J and Liu T: Unilateral laminectomy by endoscopy in central lumbar canal spinal stenosis: Technical note and early outcomes. Spine (Phila Pa 1976). 45:E871–E877. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Liu P, Chen H, Yan L and Sun Y: Laminin α5 modulates fibroblast proliferation in epidural fibrosis through the PI3K/AKT/mTOR signaling pathway. Mol Med Rep. 21:1491–1500. 2020.PubMed/NCBI

4 

Guyer RD, Patterson M and Ohnmeiss DD: Failed back surgery syndrome: Diagnostic evaluation. J Am Acad Orthop Surg. 14:534–543. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Avellanal M, Diaz-Reganon G, Orts A, Gonzalez-Montero L and Riquelme I: Transforaminal epiduroscopy in patients with failed back surgery syndrome. Pain Physician. 22:89–95. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Rogerson A, Aidlen J and Jenis LG: Persistent radiculopathy after surgical treatment for lumbar disc herniation: Causes and treatment options. Int Orthop. 43:969–973. 2019. View Article : Google Scholar

7 

Sun Y, Zhao S, Li X, Yan L, Wang J, Wang D, Chen H, Dai J and He J: Local application of rapamycin reduces epidural fibrosis after laminectomy via inhibiting fibroblast proliferation and prompting apoptosis. J Orthop Surg Res. 11:582016. View Article : Google Scholar : PubMed/NCBI

8 

Dai J, Li X, Yan L, Chen H, He J, Wang S, Wang J and Sun Y: The effect of suramin on inhibiting fibroblast proliferation and preventing epidural fibrosis after laminectomy in rats. J Orthop Surg Res. 11:1082016. View Article : Google Scholar : PubMed/NCBI

9 

Wan Q, Chen H, Xiong G, Jiao R, Liu Y, Li X, Sun Y, Wang J and Yan L: Artesunate protects against surgery-induced knee arthrofibrosis by activating beclin-1-mediated autophagy via inhibition of mTOR signaling. Eur J Pharmacol. 854:149–158. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, et al: Application of a novel anti-adhesive membrane, E8002, in a rat laminectomy model. Int J Mol Sci. 19:15132018. View Article : Google Scholar : PubMed/NCBI

11 

Chen H, Yan L, Wang J, Sun Y, Li X, Zhao S, Wang D, Zhu G and Liang Y: Methotrexate prevents epidural fibrosis through endoplasmic reticulum stress signalling pathway. Eur J Pharmacol. 796:131–138. 2017. View Article : Google Scholar

12 

Zeng L, Sun Y, Li X, Wang J and Yan L: 10-Hydroxycamptothecin induces apoptosis in human fibroblasts by regulating miRNA-23b-3p expression. Mol Med Rep. 19:2680–2686. 2019.PubMed/NCBI

13 

Aumailley M, Bruckner-Tuderman L, Carter WG, Deutzmann R, Edgar D, Ekblom P, Engel J, Engvall E, Hohenester E, Jones JC, et al: A simplified laminin nomenclature. Matrix Biol. 24:326–332. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Durbeej M: Laminins. Cell Tissue Res. 339:259–268. 2010. View Article : Google Scholar

15 

Atsuta I, Yamaza T, Yoshinari M, Goto T, Kido MA, Kagiya T, Mino S, Shimono M and Tanaka T: Ultrastructural localization of laminin-5 (gamma2 chain) in the rat peri-implant oral mucosa around a titanium-dental implant by immuno-electron microscopy. Biomaterials. 26:6280–6287. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Sun Y, Wang TL, Toh WS and Pei M: The role of laminins in cartilaginous tissues: From development to regeneration. Eur Cell Mater. 34:40–54. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Yurchenco PD: Basement membranes: Cell scaffoldings and signaling platforms. Cold Spring Harb Perspect Biol. 3:a0049112011. View Article : Google Scholar : PubMed/NCBI

18 

Petz M, Them NC, Huber H and Mikulits W: PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res. 40:9738–9749. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Petz M, Them NC, Huber H, Beug H and Mikulits W: La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition. Nucleic Acids Res. 40:290–302. 2012. View Article : Google Scholar :

20 

Domogatskaya A, Rodin S and Tryggvason K: Functional diversity of laminins. Annu Rev Cell Dev Biol. 28:523–553. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Nishiuchi R, Takagi J, Hayashi M, Ido H, Yagi Y, Sanzen N, Tsuji T, Yamada M and Sekiguchi K: Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins. Matrix Biol. 25:189–197. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Savino W, Mendes-da-Cruz DA, Golbert DC, Riederer I and Cotta-de-Almeida V: Laminin-mediated interactions in thymocyte migration and development. Front Immunol. 6:5792015. View Article : Google Scholar : PubMed/NCBI

23 

Laperle A, Hsiao C, Lampe M, Mortier J, Saha K, Palecek SP and Masters KS: α-5 Laminin synthesized by human pluripotent stem cells promotes self-renewal. Stem Cell Reports. 5:195–206. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Department of Science and Technology of Hubei Province: Regulations of Laboratory Animals of Hubei Province. pp. 1–9. 2005, https://kjt.hubei.gov.cn/kjdt/ztzl/fzxczl/pfxcc/kjlflfg/202008/t20200826_2837541.shtml. Accessed January 1, 2021.

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

26 

Han G, Nguyen LN, Macherla C, Chi Y, Friedman JM, Nosanchuk JD and Martinez LR: Nitric oxide-releasing nanoparticles accelerate wound healing by promoting fibroblast migration and collagen deposition. Am J Pathol. 180:1465–1473. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Wang M, Li J, Zhang S, You Y, Zhu X, Xiang H, Yan L, Zhao F and Li Y: Effects of titanium dioxide nanoparticles on cell growth and migration of A549 cells under simulated microgravity. Nanomaterials (Basel). 12:18792022. View Article : Google Scholar : PubMed/NCBI

28 

Yan C and Boyd DD: Regulation of matrix metalloproteinase gene expression. J Cell Physiol. 211:19–26. 2007. View Article : Google Scholar

29 

Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acuña JM, Perez-Romero BA, Guerrero-Rodriguez JF, Martinez-Avila N and Martinez-Fierro ML: The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 21:97392020. View Article : Google Scholar :

30 

Atkinson JJ and Senior RM: Matrix metalloproteinase-9 in lung remodeling. Am J Respir Cell Mol Biol. 28:12–24. 2003. View Article : Google Scholar

31 

Felsen CN, Savariar EN, Whitney M and Tsien RY: Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma. Am J Physiol Lung Cell Mol Physiol. 306:L764–L774. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Engelman JA, Luo J and Cantley LC: The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet. 7:606–619. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Lam L, Hu X, Aktary Z, Andrews DW and Pasdar M: Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha. Breast Cancer Res Treat. 118:605–621. 2009. View Article : Google Scholar

34 

Wang S, Li X, Yan L, Nie Q, Dai J, Chen H, Wang J and Sun Y: Tamoxifen inhibits fibroblast proliferation and prevents epidural fibrosis by regulating the AKT pathway in rats. Biochem Biophys Res Commun. 497:937–942. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Zheng W, Qian Y, Chen S, Ruan H and Fan C: Rapamycin protects against peritendinous fibrosis through activation of autophagy. Front Pharmacol. 9:4022018. View Article : Google Scholar : PubMed/NCBI

36 

Aumailley M: The laminin family. Cell Adh Migr. 7:48–55. 2013. View Article : Google Scholar :

37 

Simon-Assmann P: The laminin family: Founding members of the basement membrane. Cell Adh Migr. 7:44–47. 2013. View Article : Google Scholar :

38 

Pozzi A, Yurchenco PD and Iozzo RV: The nature and biology of basement membranes. Matrix Biol. 57-58:1–11. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Hynes RO: The evolution of metazoan extracellular matrix. J Cell Biol. 196:671–679. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Kurek M, Åkesson E, Yoshihara M, Oliver E, Cui Y, Becker M, Alves-Lopes JP, Bjarnason R, Romerius P, Sundin M, et al: Spermatogonia loss correlates with LAMA 1 expression in human prepubertal testes stored for fertility preservation. Cells. 10:2412021. View Article : Google Scholar : PubMed/NCBI

41 

Hayashi H, Horinokita I, Yamada Y, Hamada K, Takagi N and Nomizu M: Effects of laminin-111 peptide coatings on rat neural stem/progenitor cell culture. Exp Cell Res. 400:1124402021. View Article : Google Scholar

42 

Truong AT, Hamada K, Yamada Y, Guo H, Kikkawa Y, Okamoto CT, MacKay JA and Nomizu M: Evaluation of extracellular matrix mimetic laminin bioactive peptide and elastin-like polypeptide. FASEB J. 34:6729–6740. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Carney KR, Bryan CD, Gordon HB and Kwan KM: LongAxis: A MATLAB-based program for 3D quantitative analysis of epithelial cell shape and orientation. Dev Biol. 458:1–11. 2020. View Article : Google Scholar :

44 

Lee CM, Cho SJ, Cho WK, Park JW, Lee JH, Choi AM, Rosas IO, Zheng M, Peltz G, Lee CG and Elias JA: Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis. JCI Insight. 3:e995742018. View Article : Google Scholar

45 

Limandjaja GC, van den Broek LJ, Breetveld M, Waaijman T, Monstrey S, de Boer EM, Scheper RJ, Niessen FB and Gibbs S: Characterization of in vitro reconstructed human normotrophic, hypertrophic, and keloid scar models. Tissue Eng Part C Methods. 24:242–253. 2018. View Article : Google Scholar : PubMed/NCBI

46 

Nieto N and Cederbaum AI: Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1. J Biol Chem. 278:15360–15372. 2003. View Article : Google Scholar : PubMed/NCBI

47 

Della TE, Rigamonti E, Perugino C, Baghai-Sain S, Sun N, Kaneko N, Maehara T, Rovati L, Ponzoni M, Milani R, et al: B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease. J Allergy Clin Immunol. 145:968–981 e14. 2020. View Article : Google Scholar

48 

Adusei KM, Ngo TB and Sadtler K: T lymphocytes as critical mediators in tissue regeneration, fibrosis, and the foreign body response. Acta Biomater. 133:17–33. 2021. View Article : Google Scholar : PubMed/NCBI

49 

Giannandrea M and Parks WC: Diverse functions of matrix metalloproteinases during fibrosis. Dis Model Mech. 7:193–203. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Webb AH, Gao BT, Goldsmith ZK, Irvine AS, Saleh N, Lee RP, Lendermon JB, Bheemreddy R, Zhang Q, Brennan RC, et al: Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma. BMC Cancer. 17:4342017. View Article : Google Scholar : PubMed/NCBI

51 

Zhou PL, Wu Z, Zhang W, Xu M, Ren J, Zhang Q, Sun Z and Han X: Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression. Cell Death Dis. 12:6762021. View Article : Google Scholar : PubMed/NCBI

52 

Chen J, Wu F, Shi Y, Yang D, Xu M, Lai Y and Liu Y: Identification of key candidate genes involved in melanoma metastasis. Mol Med Rep. 20:903–914. 2019.PubMed/NCBI

53 

Mammadova-Bach E, Rupp T, Spenlé C, Jivkov I, Shankaranarayanan P, Klein A, Pisarsky L, Méchine-Neuville A, Cremel G, Kedinger M, et al: Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biol Cell. 110:178–195. 2018. View Article : Google Scholar

54 

Heng C, Lefebvre O, Klein A, Edwards MM, Simon-Assmann P, Orend G and Bagnard D: Functional role of laminin α1 chain during cerebellum development. Cell Adh Migr. 5:480–489. 2011. View Article : Google Scholar

55 

Edwards MM, McLeod DS, Grebe R, Heng C, Lefebvre O and Lutty GA: Lama1 mutations lead to vitreoretinal blood vessel formation, persistence of fetal vasculature, and epiretinal membrane formation in mice. BMC Dev Biol. 11:602011. View Article : Google Scholar : PubMed/NCBI

56 

Yang L, Cao N, Miao Y, Dai Y and Wei Z: Morin acts as a USP7 inhibitor to hold back the migration of rheumatoid arthritis fibroblast-like synoviocytes in a 'prickle1-mTORC2' dependent manner. Mol Nutr Food Res. 65:e21003672021. View Article : Google Scholar

57 

Wang L, Wu T, Si C, Wang H, Yue K, Shang S, Li X, Chen Y and Guan H: Danlou tablet activates autophagy of vascular adventitial fibroblasts through PI3K/Akt/mTOR to protect cells from damage caused by atherosclerosis. Front Pharmacol. 12:7305252021. View Article : Google Scholar : PubMed/NCBI

58 

Lu Y, Zhong W, Liu Y, Chen W, Zhang J, Zeng Z, Huang H, Qiao Y, Wan X, Meng X, et al: Anti-PD-L1 antibody alleviates pulmonary fibrosis by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway. Int Immunopharmacol. 104:1085042022. View Article : Google Scholar : PubMed/NCBI

59 

Wang S, Li X, Yan L, Chen H, Wang J and Sun Y: Upregulation of P27Kip1 by mitomycin C induces fibroblast apoptosis and reduces epidural fibrosis. Int J Clin Exp Pathol. 10:11779–11788. 2017.

60 

Dai J, Sun Y, Yan L, Wang J, Li X and He J: Upregulation of NOXA by 10-Hydroxycamptothecin plays a key role in inducing fibroblasts apoptosis and reducing epidural fibrosis. PeerJ. 5:e28582017. View Article : Google Scholar : PubMed/NCBI

61 

Tang J, Xu XY, Luo BL, Yang L, Zhang XL, Sun YD, Hou ZQ and Yao G: Potential role of lnc-PTGS2 in fibrosis progression after laminectomy via targeting EGR1. J Biol Regul Homeost Agents. 34:2237–2244. 2020.PubMed/NCBI

62 

Shi R, Huang Y, Zhang J, Wu C, Gong M, Tian W and Zhang L: Effective delivery of mitomycin-C and meloxicam by double-layer electrospun membranes for the prevention of epidural adhesions. J Biomed Mater Res B Appl Biomater. 108:353–366. 2020. View Article : Google Scholar

63 

Song Z, Wu T, Sun J, Wang H, Hua F, Nicolas YSM, Kc R, Chen K, Jin Z, Liu J and Zhang M: Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways. J Cell Mol Med. 25:3272–3283. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu P, Zhang D, Huang G, Xue M, Fang Y, Lu L, Zhang J, Xie M and Ye Z: Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms. Int J Mol Med 51: 2, 2023.
APA
Liu, P., Zhang, D., Huang, G., Xue, M., Fang, Y., Lu, L. ... Ye, Z. (2023). Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms. International Journal of Molecular Medicine, 51, 2. https://doi.org/10.3892/ijmm.2022.5205
MLA
Liu, P., Zhang, D., Huang, G., Xue, M., Fang, Y., Lu, L., Zhang, J., Xie, M., Ye, Z."Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms". International Journal of Molecular Medicine 51.1 (2023): 2.
Chicago
Liu, P., Zhang, D., Huang, G., Xue, M., Fang, Y., Lu, L., Zhang, J., Xie, M., Ye, Z."Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms". International Journal of Molecular Medicine 51, no. 1 (2023): 2. https://doi.org/10.3892/ijmm.2022.5205
Copy and paste a formatted citation
x
Spandidos Publications style
Liu P, Zhang D, Huang G, Xue M, Fang Y, Lu L, Zhang J, Xie M and Ye Z: Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms. Int J Mol Med 51: 2, 2023.
APA
Liu, P., Zhang, D., Huang, G., Xue, M., Fang, Y., Lu, L. ... Ye, Z. (2023). Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms. International Journal of Molecular Medicine, 51, 2. https://doi.org/10.3892/ijmm.2022.5205
MLA
Liu, P., Zhang, D., Huang, G., Xue, M., Fang, Y., Lu, L., Zhang, J., Xie, M., Ye, Z."Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms". International Journal of Molecular Medicine 51.1 (2023): 2.
Chicago
Liu, P., Zhang, D., Huang, G., Xue, M., Fang, Y., Lu, L., Zhang, J., Xie, M., Ye, Z."Laminin α1 as a target for the treatment of epidural fibrosis by regulating fibrotic mechanisms". International Journal of Molecular Medicine 51, no. 1 (2023): 2. https://doi.org/10.3892/ijmm.2022.5205
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team