Open Access

Role of ceramides in diabetic foot ulcers (Review)

  • Authors:
    • Ying Wang
    • Zhen Sun
    • Guangyao Zang
    • Lili Zhang
    • Zhongqun Wang
  • View Affiliations

  • Published online on: February 6, 2023     https://doi.org/10.3892/ijmm.2023.5229
  • Article Number: 26
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diabetes mellitus (DM) is a metabolic disorder, which if not managed properly, can lead to serious health problems over time and impose significant financial burden on the patient, their family and society as a whole. The study of this disease and the underlying biological mechanism is gaining momentum. Multiple pieces of conclusive evidence show that ceramides are involved in the occurrence and development of diabetes. The present review focuses on the function of ceramides, a type of sphingolipid signaling molecule, to provide a brief description of ceramides and their metabolism, discuss the significant roles of ceramides in the healthy skin barrier, and speculate on the potential involvement of ceramides in the pathogenesis and development of diabetic foot ulcers (DFUs). Understanding these aspects of this disease more thoroughly is crucial to establish how ceramides contribute to the etiology of diabetic foot infections and identify possible therapeutic targets for the treatment of DFUs.
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March-2023
Volume 51 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Y, Sun Z, Zang G, Zhang L and Wang Z: Role of ceramides in diabetic foot ulcers (Review). Int J Mol Med 51: 26, 2023
APA
Wang, Y., Sun, Z., Zang, G., Zhang, L., & Wang, Z. (2023). Role of ceramides in diabetic foot ulcers (Review). International Journal of Molecular Medicine, 51, 26. https://doi.org/10.3892/ijmm.2023.5229
MLA
Wang, Y., Sun, Z., Zang, G., Zhang, L., Wang, Z."Role of ceramides in diabetic foot ulcers (Review)". International Journal of Molecular Medicine 51.3 (2023): 26.
Chicago
Wang, Y., Sun, Z., Zang, G., Zhang, L., Wang, Z."Role of ceramides in diabetic foot ulcers (Review)". International Journal of Molecular Medicine 51, no. 3 (2023): 26. https://doi.org/10.3892/ijmm.2023.5229