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Article Open Access

Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages

  • Authors:
    • Zhuoxiao Han
    • Jiao Ma
    • Ying Han
    • Guanli Yuan
    • Rui Jiao
    • Aihong Meng
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Neurosurgery, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P.R. China, Department of Respiratory and Critical Care Medicine, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 32
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    Published online on: March 7, 2023
       https://doi.org/10.3892/ijmm.2023.5235
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Abstract

Irisin is a hormone‑like myokine that regulates cell signaling pathways and exerts anti‑inflammatory effects. However, the specific molecular mechanisms involved in this process are currently unknown. The present study explored the role and mechanisms underlying the functions of irisin in alleviating acute lung injury (ALI). The present study used MH‑S, an established murine alveolar macrophage‑derived cell line, and a mouse model of lipopolysaccharide (LPS)‑induced‑ALI to examine the efficacy of irisin against ALI in vitro and in vivo, respectively. Fibronectin type III repeat‑containing protein/irisin was expressed in the inflamed lung tissue, but not in normal lung tissue. Exogenous irisin reduced alveolar inflammatory cell infiltration and pro‑inflammatory factor secretion in mice following LPS stimulation. It also inhibited the polarization of M1‑type macrophages and promoted the repolarization of M2‑type macrophages, thus reducing the LPS‑induced production and secretion of interleukin (IL)‑1β, IL‑18 and tumor necrosis factor‑α. In addition, irisin reduced the release of the molecular chaperone heat shock protein 90 (HSP90), inhibited the formation of nucleotide‑binding and oligomerization domain‑like receptor protein 3 (NLRP3) inflammasome complexes, and decreased the expression of caspase‑1 and the cleavage of gasdermin D (GSDMD), leading to reduced pyroptosis and the accompanying inflammation. On the whole, the findings of the present study demonstrate that irisin attenuates ALI by inhibiting the HSP90/NLRP3/caspase‑1/GSDMD signaling pathway, reversing macrophage polarization and reducing the pyroptosis of macrophages. These findings provide a theoretical basis for understanding the role of irisin in the treatment of ALI and acute respiratory distress syndrome.
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Copy and paste a formatted citation
Spandidos Publications style
Han Z, Ma J, Han Y, Yuan G, Jiao R and Meng A: Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. Int J Mol Med 51: 32, 2023.
APA
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., & Meng, A. (2023). Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. International Journal of Molecular Medicine, 51, 32. https://doi.org/10.3892/ijmm.2023.5235
MLA
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., Meng, A."Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages". International Journal of Molecular Medicine 51.4 (2023): 32.
Chicago
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., Meng, A."Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages". International Journal of Molecular Medicine 51, no. 4 (2023): 32. https://doi.org/10.3892/ijmm.2023.5235
Copy and paste a formatted citation
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Spandidos Publications style
Han Z, Ma J, Han Y, Yuan G, Jiao R and Meng A: Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. Int J Mol Med 51: 32, 2023.
APA
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., & Meng, A. (2023). Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. International Journal of Molecular Medicine, 51, 32. https://doi.org/10.3892/ijmm.2023.5235
MLA
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., Meng, A."Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages". International Journal of Molecular Medicine 51.4 (2023): 32.
Chicago
Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., Meng, A."Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages". International Journal of Molecular Medicine 51, no. 4 (2023): 32. https://doi.org/10.3892/ijmm.2023.5235
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