Open Access

Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)

  • Authors:
    • Zhenwang Ma
    • Hao Liang
    • Bingcheng Hu
    • Shaojie Cai
    • Dong Yan
  • View Affiliations

  • Published online on: May 2, 2023     https://doi.org/10.3892/ijmm.2023.5253
  • Article Number: 50
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Parkinson's disease (PD) is a neurodegenerative disorder that has a high incidence during the aging process and is characterized by the loss of dopaminergic neurons in the substantia nigra, leading to motor dysfunctions and non‑motor symptoms. Impaired clearance and excessive accumulation of aberrantly modified proteins or damaged organelles, such as aggregated α‑synuclein and dysfunctional mitochondria, are regarded as the main causes of nigrostriatal neurodegeneration. As one of the major degradation pathways, autophagy can recycle these useless or toxic substances to maintain cellular homeostasis and it plays a crucial role in PD progression. MicroRNAs (miRNAs) are a group of small non‑coding RNA molecules that regulate gene expression by silencing targeted mRNAs. Recent studies have illustrated that autophagy‑regulating miRNA has been implicated in pathological processes of PD, including α‑synuclein accumulation, mitochondrial damage, neuroinflammation and neuronal apoptosis, which suggests that targeting autophagy‑regulating miRNAs may provide novel therapeutic strategies for this disease. The present review summarizes the role of autophagy in PD and emphasizes the role of miRNA‑mediated autophagy in PD, for the development of promising interventions in this disease.
View Figures
View References

Related Articles

Journal Cover

June-2023
Volume 51 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Ma Z, Liang H, Hu B, Cai S and Yan D: Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review). Int J Mol Med 51: 50, 2023
APA
Ma, Z., Liang, H., Hu, B., Cai, S., & Yan, D. (2023). Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review). International Journal of Molecular Medicine, 51, 50. https://doi.org/10.3892/ijmm.2023.5253
MLA
Ma, Z., Liang, H., Hu, B., Cai, S., Yan, D."Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)". International Journal of Molecular Medicine 51.6 (2023): 50.
Chicago
Ma, Z., Liang, H., Hu, B., Cai, S., Yan, D."Autophagy‑regulating miRNAs: Novel therapeutic targets for Parkinson's disease (Review)". International Journal of Molecular Medicine 51, no. 6 (2023): 50. https://doi.org/10.3892/ijmm.2023.5253