Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as helpful biomarkers for patients hospitalized for deep vein thrombosis

Selvaggio,Stefano; Brugaletta,Giuseppe; Abate,Angela; Musso,Cinzia; Romano,Marcello; Di Raimondo,Domenico; Pirera,Edoardo; Dattilo,Giuseppe; Signorelli,Salvatore Santo

doi:10.3892/ijmm.2023.5255

Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as helpful biomarkers for patients hospitalized for deep vein thrombosis

Authors:
- Stefano Selvaggio
- Giuseppe Brugaletta
- Angela Abate
- Cinzia Musso
- Marcello Romano
- Domenico Di Raimondo
- Edoardo Pirera
- Giuseppe Dattilo
- Salvatore Santo Signorelli
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Affiliations: Geriatric Unit, ‘Maggiore’ Hospital, I‑97015 Modica, Italy, Geriatric Unit, General Hospital ‘Garibaldi’ Nesima, I‑95123 Catania, Italy, Internal Medicine Unit, General Hospital ‘G. Di Maria’, I‑96012 Avola, Italy, Infectious Disease Unit, Umberto I Hospital, I‑96100 Siracusa, Italy, Division of Internal Medicine and Stroke Care, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise) ‘G. D'Alessandro’, University of Palermo, I‑90127 Palermo, Italy, Division of Internal Medicine and Stroke Care, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (Promise) ‘G. D'Alessandro’, University of Palermo, I‑90127 Palermo, Italy, Department of Biomedical and Dental Science and Morphofunctional Imaging, University of Messina, I‑98122 Messina, Italy, Department of Clinical and Experimental Medicine, University of Catania, Internal Medicine Unit, University Hospital ‘G. Rodolico’, I‑95123 Catania, Italy
Published online on: May 9, 2023 https://doi.org/10.3892/ijmm.2023.5255
Article Number: 52

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Abstract

There is an increased interest for novel biomarkers in order to improve the diagnostic accuracy for deep vein thrombosis (DVT). Moreover, the link between inflammation and venous thromboembolism has attracted increasing research interests. The present study aimed to evaluate the role of the platelet‑to‑lymphocyte ratio (PLR), neutrophil‑to‑lymphocyte ratio (NLR) and monocyte‑to‑high‑density lipoprotein cholesterol ratio (MHR) as biomarkers for acute DVT. For this purpose, 300 consecutive patients who were hospitalized were considered; 33 patients out of the 300 were admitted for acute DVT of the lower limbs. The PLR, NLR and MHR, as well as the acute phase inflammation markers (leukocytes, neutrophils, C‑reactive protein and fibrinogen) were measured. The patients with DVT exhibited significantly higher levels of PLR, NLR and MHR compared to those without DVT (P<0.001). Simple binary linear regression analysis (without confounding factors) between the NLR, PLR and MHR highest quartile and DVT revealed an odds ratio of 3.149 (P=0.01) for PLR, and an odds ratio of 4.191 (P=0.001) for MHR. Following the correction for the main confounding factors, PLR maintained a significant association with DVT (odds ratio, 3.379; P=0.007) and MHR maintained a stronger significant association with DVT (odds ratio, 4.378; P=0.001). It was thus hypothesized that the assessment of PLR and MHR, but not of NLR may help clinicians to improve the laboratory evaluation in elderly hospitalized patients with suspected DVT.

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