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Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation

  • Authors:
    • Ying Lan
    • Lvlin Chen
    • Juncheng Zhu
    • Hui Li
    • Zhimei Lin
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P.R. China, Department of Hematology, The Affiliated Hospital of Chengdu University, Chengdu, Sichuan 610081, P.R. China
    Copyright: © Lan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 55
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    Published online on: May 17, 2023
       https://doi.org/10.3892/ijmm.2023.5258
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Abstract

The side effects of chemotherapy drugs have been hindering the progress of tumor treatment. The liver is the metabolic site of most drugs, which leads to the frequent occurrence of liver injury. Classical chemotherapy drugs such as pirarubicin (THP) can also cause dose‑dependent hepatotoxicity, and the related mechanism is closely related to liver inflammation. Scutellarein (Sc) is a potential Chinese herbal monomer exhibiting liver protection activity, which can effectively alleviate the liver inflammation caused by obesity. In the present study, THP was used to establish a rat model of hepatotoxicity, and Sc was used for treatment. The experimental methods used included measuring body weight, detecting serum biomarkers, observing liver morphology with H&E staining, observing cell apoptosis with TUNEL staining, and detecting the expression of PTEN/AKT/NFκB signaling pathways and inflammatory genes with PCR and western blotting. However, whether Sc can inhibit the liver inflammation induced by THP has not been reported. The experimental results showed that THP led to the upregulation of PTEN and the increase of inflammatory factors in rat liver, while Sc effectively alleviated the aforementioned changes. It was further identified in primary hepatocytes that Sc can effectively inhabited PTEN, regulate AKT/NFκB signaling pathway, inhibit liver inflammation and ultimately protect the liver.
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Copy and paste a formatted citation
Spandidos Publications style
Lan Y, Chen L, Zhu J, Li H and Lin Z: Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation. Int J Mol Med 52: 55, 2023.
APA
Lan, Y., Chen, L., Zhu, J., Li, H., & Lin, Z. (2023). Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation. International Journal of Molecular Medicine, 52, 55. https://doi.org/10.3892/ijmm.2023.5258
MLA
Lan, Y., Chen, L., Zhu, J., Li, H., Lin, Z."Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation". International Journal of Molecular Medicine 52.1 (2023): 55.
Chicago
Lan, Y., Chen, L., Zhu, J., Li, H., Lin, Z."Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation". International Journal of Molecular Medicine 52, no. 1 (2023): 55. https://doi.org/10.3892/ijmm.2023.5258
Copy and paste a formatted citation
x
Spandidos Publications style
Lan Y, Chen L, Zhu J, Li H and Lin Z: Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation. Int J Mol Med 52: 55, 2023.
APA
Lan, Y., Chen, L., Zhu, J., Li, H., & Lin, Z. (2023). Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation. International Journal of Molecular Medicine, 52, 55. https://doi.org/10.3892/ijmm.2023.5258
MLA
Lan, Y., Chen, L., Zhu, J., Li, H., Lin, Z."Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation". International Journal of Molecular Medicine 52.1 (2023): 55.
Chicago
Lan, Y., Chen, L., Zhu, J., Li, H., Lin, Z."Scutellarein regulates the PTEN/AKT/NFκB signaling pathway to reduce pirarubicin related liver inflammation". International Journal of Molecular Medicine 52, no. 1 (2023): 55. https://doi.org/10.3892/ijmm.2023.5258
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