Interaction between apical periodontitis and systemic disease (Review)
- Authors:
- Lanxiang Ye
- Li Cao
- Wencheng Song
- Chen Yang
- Qingming Tang
- Zhenglin Yuan
-
Affiliations: Department of Stomatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China - Published online on: May 30, 2023 https://doi.org/10.3892/ijmm.2023.5263
- Article Number: 60
-
Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Yamasaki M, Kumazawa M, Kohsaka T, Nakamura H and Kameyama Y: Pulpal and periapical tissue reactions after experimental pulpal exposure in rats. J Endod. 20:13–17. 1994. View Article : Google Scholar : PubMed/NCBI | |
Kakehashi S, Stanley HR and Fitzgerald RJ: The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol. 20:340–349. 1965. View Article : Google Scholar : PubMed/NCBI | |
Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA and Bier CA: The global prevalence of apical periodontitis: A systematic review and meta-analysis. Int Endod J. 54:712–735. 2021. View Article : Google Scholar | |
Bahrami G, Vaeth M, Kirkevang LL, Wenzel A and Isidor F: Risk factors for tooth loss in an adult population: A radiographic study. J Clin Periodontol. 35:1059–1065. 2008. View Article : Google Scholar : PubMed/NCBI | |
Gomes MS, Hugo FN, Hilgert JB, Sant'Ana Filho M, Padilha DM, Simonsick EM, Ferrucci L and Reynolds MA: Apical periodontitis and incident cardiovascular events in the baltimore longitudinal study of ageing. Int Endod J. 49:334–342. 2016. View Article : Google Scholar | |
Kierdorf U, Olsen MT, Kahle P, Ludolphy C and Kierdorf H: Dental pulp exposure, periapical inflammation and suppurative osteomyelitis of the jaws in juvenile Baltic grey seals (Halichoerus grypus grypus) from the late 19th century. PLoS One. 14:e02154012019. View Article : Google Scholar : PubMed/NCBI | |
Cintra LTA, Gomes MS, da Silva CC, Faria FD, Benetti F, Cosme-Silva L, Samuel RO, Pinheiro TN, Estrela C, González AC and Segura-Egea JJ: Evolution of endodontic medicine: A critical narrative review of the interrelationship between endodontics and systemic pathological conditions. Odontology. 109:741–769. 2021. View Article : Google Scholar : PubMed/NCBI | |
Li X, Kolltveit KM, Tronstad L and Olsen I: Systemic diseases caused by oral infection. Clin Microbiol Rev. 13:547–558. 2000. View Article : Google Scholar : PubMed/NCBI | |
Savarrio L, Mackenzie D, Riggio M, Saunders WP and Bagg J: Detection of bacteraemias during non-surgicalroot canal treatment. J Dent. 33:293–303. 2005. View Article : Google Scholar : PubMed/NCBI | |
Baumgartner JC, Heggers JP and Harrison JW: The incidence of bacteremias related to endodontic procedures. I. Nonsurgical endodontics. J Endod. 2:135–140. 1976. View Article : Google Scholar : PubMed/NCBI | |
Debelian GJ, Olsen I and Tronstad L: Bacteremia in conjunction with endodontic therapy. Endod Dent Traumatol. 11:142–149. 1995. View Article : Google Scholar : PubMed/NCBI | |
Gomes MS, Blattner TC, Sant'Ana Filho M, Grecca FS, Hugo FN, Fouad AF and Reynolds MA: Can apical periodontitis modify systemic levels of inflammatory markers? A systematic review and meta-analysis. J Endod. 39:1205–1217. 2013. View Article : Google Scholar : PubMed/NCBI | |
Samuel RO, Gomes-Filho JE, Azuma MM, Sumida DH, de Oliveira SHP, Chiba FY, Bomfim SRM, Ciarlini PC, Narciso LG and Cintra LTA: Endodontic infections increase leukocyte and lymphocyte levels in the blood. Clin Oral Investig. 22:1395–1401. 2018. View Article : Google Scholar | |
Poornima L, Ravishankar P, Abbott PV, Subbiya A and PradeepKumar AR: Impact of root canal treatment on high-sensitivity C-reactive protein levels in systemically healthy adults with apical periodontitis-a preliminary prospective, longitudinal interventional study. Int Endod J. 54:501–508. 2021. View Article : Google Scholar | |
Chen Y, Liu S and Leng SX: Chronic low-grade inflammatory phenotype (CLIP) and senescent immune dysregulation. Clin Ther. 41:400–409. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chan LT, Zhong S, Naqvi AR, Self-Fordham J, Nares S, Bair E and Khan AA: MicroRNAs: New insights into the pathogenesis of endodontic periapical disease. J Endod. 39:1498–1503. 2013. View Article : Google Scholar : PubMed/NCBI | |
Sasaki H, Hirai K, Martins CM, Furusho H, Battaglino R and Hashimoto K: Interrelationship between periapical lesion and systemic metabolic disorders. Curr Pharm Des. 22:2204–2215. 2016. View Article : Google Scholar : PubMed/NCBI | |
Segura-Egea JJ, Martín-González J and Castellanos-Cosano L: Endodontic medicine: Connections between apical periodontitis and systemic diseases. Int Endod J. 48:933–951. 2015. View Article : Google Scholar : PubMed/NCBI | |
Khalighinejad N, Aminoshariae MR, Aminoshariae A, Kulild JC, Mickel A and Fouad AF: Association between systemic diseases and apical periodontitis. J Endod. 42:1427–1434. 2016. View Article : Google Scholar : PubMed/NCBI | |
Cotti E and Mercuro G: Apical periodontitis and cardiovascular diseases: Previous findings and ongoing research. Int Endod J. 48:926–932. 2015. View Article : Google Scholar : PubMed/NCBI | |
American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care. 36(Suppl 1): S67–S74. 2013. View Article : Google Scholar : PubMed/NCBI | |
Wild S, Roglic G, Green A, Sicree R and King H: Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care. 27:1047–1053. 2004. View Article : Google Scholar : PubMed/NCBI | |
Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW and Malanda B: IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 138:271–281. 2018. View Article : Google Scholar : PubMed/NCBI | |
Velasco-Ortega E, Delgado-Ruiz RA and López-López J: Dentistry and diabetes: The influence of diabetes in oral diseases and dental treatments. J Diabetes Res. 2016:60731902016. View Article : Google Scholar | |
Haag DG, Peres KG, Balasubramanian M and Brennan DS: Oral conditions and health-related quality of life: A systematic review. J Dent Res. 96:864–874. 2017. View Article : Google Scholar : PubMed/NCBI | |
Rohani B: Oral manifestations in patients with diabetes mellitus. World J Diabetes. 10:485–489. 2019. View Article : Google Scholar : PubMed/NCBI | |
Segura-Egea JJ, Cabanillas-Balsera D, Jiménez-Sánchez MC and Martín-González J: Endodontics and diabetes: Association versus causation. Int Endod J. 52:790–802. 2019. View Article : Google Scholar : PubMed/NCBI | |
Tibúrcio-Machado CDS, Bello MDC, Maier J, Wolle CFB and Bier CAS: Influence of diabetes in the development of apical periodontitis: A critical literature review of human studies. J Endod. 43:370–376. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yip N, Liu C, Wu D and Fouad AF: The association of apical periodontitis and type 2 diabetes mellitus: A large hospital network cross-sectional case-controlled study. J Am Dent Assoc. 152:434–443. 2021. View Article : Google Scholar : PubMed/NCBI | |
Pérez-Losada FDL, Estrugo-Devesa A, Castellanos-Cosano L, Segura-Egea JJ, López-López J and Velasco-Ortega E: Apical periodontitis and diabetes mellitus type 2: A systematic review and meta-analysis. J Clin Med. 9:5402020. View Article : Google Scholar : PubMed/NCBI | |
Segura-Egea JJ, Jiménez-Pinzón A, Ríos-Santos JV, Velasco-Ortega E, Cisneros-Cabello R and Poyato-Ferrera M: High prevalence of apical periodontitis amongst type 2 diabetic patients. Int Endod J. 38:564–569. 2005. View Article : Google Scholar : PubMed/NCBI | |
Smadi L: Apical periodontitis and endodontic treatment in patients with type II diabetes mellitus: Comparative cross-sectional survey. J Contemp Dent Pract. 18:358–362. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sánchez-Domínguez B, López-López J, Jané-Salas E, Castellanos-Cosano L, Velasco-Ortega E and Segura-Egea JJ: Glycated hemoglobin levels and prevalence of apical periodontitis in type 2 diabetic patients. J Endod. 41:601–606. 2015. View Article : Google Scholar : PubMed/NCBI | |
Saleh W, Xue W and Katz J: Diabetes mellitus and periapical abscess: A cross-sectional study. J Endod. 46:1605–1609. 2020. View Article : Google Scholar : PubMed/NCBI | |
Sisli SN: Evaluation of the relationship between type II diabetes mellitus and the prevalence of apical periodontitis in root-filled teeth using cone beam computed tomography: An observational cross-sectional study. Med Princ Pract. 28:533–538. 2019. View Article : Google Scholar : PubMed/NCBI | |
Mesgarani A, Haghanifar S, Eshkevari N, Ehsani M, Khafri S, Nafarzade S and Damankesh Z: Frequency of odontogenic periradicular lesions in diabetic patients. Caspian J Intern Med. 5:22–25. 2014.PubMed/NCBI | |
Kohsaka T, Kumazawa M, Yamasaki M and Nakamura H: Periapical lesions in rats with streptozotocin-induced diabetes. J Endod. 22:418–421. 1996. View Article : Google Scholar : PubMed/NCBI | |
Al-Nazhan SA, Alsaeed SA, Al-Attas HA, Dohaithem AJ, Al-Serhan MS and Al-Maflehi NS: Prevalence of apical periodontitis and quality of root canal treatment in an adult Saudi population. Saudi Med J. 38:413–421. 2017. View Article : Google Scholar : PubMed/NCBI | |
Falk H, Hugoson A and Thorstensson H: Number of teeth, prevalence of caries and periapical lesions in insulin-dependent diabetics. Scand J Dent Res. 97:198–206. 1989.PubMed/NCBI | |
Alghofaily M, Tordik P, Romberg E, Martinho F and Fouad AF: Healing of apical periodontitis after nonsurgical root canal treatment: The role of statin intake. J Endod. 44:1355–1360. 2018. View Article : Google Scholar : PubMed/NCBI | |
De la Torre-Luna R, Domínguez-Pérez RA, Guillén-Nepita AL, Ayala-Herrera JL, Martínez-Martínez RE, Romero-Ayala ME, Pérez-Serrano RM and Vázquez-Garcidueñas MS: Prevalence of Candida albicans in primary endodontic infections associated with a higher frequency of apical periodontitis in type two diabetes mellitus patients. Eur J Clin Microbiol Infect Dis. 39:131–138. 2020. View Article : Google Scholar | |
Graves DT, Corrêa JD and Silva TA: The oral microbiota is modified by systemic diseases. J Dent Res. 98:148–156. 2019. View Article : Google Scholar : | |
Samuel RO, Ervolino E, de Azevedo Queiroz ÍO, Azuma MM, Ferreira GT and Cintra LTA: Th1/Th2/Th17/Treg balance in apical periodontitis of normoglycemic and diabetic rats. J Endod. 45:1009–1015. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cintra LTA, da Silva Facundo AC, Prieto AKC, Sumida DH, Narciso LG, Mogami Bomfim SR, Oliveira e Silva C, Dezan-Júnior E and Gomes-Filho JE: Blood profile and histology in oral infections associated with diabetes. J Endod. 40:1139–1144. 2014. View Article : Google Scholar : PubMed/NCBI | |
Azuma MM, Gomes-Filho JE, Prieto AKC, Samuel RO, de Lima VMF, Sumida DH, Ervolino E and Cintra LTA: Diabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in rats. Arch Oral Biol. 83:230–235. 2017. View Article : Google Scholar : PubMed/NCBI | |
Hasiakos S, Gwack Y, Kang M and Nishimura I: Calcium signaling in T cells and chronic inflammatory disorders of the oral cavity. J Dent Res. 100:693–699. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wu Y, Yang Y, Wang L, Chen Y, Han X, Sun L, Chen H and Chen Q: Effect of Bifidobacterium on osteoclasts: TNF-α/NF-κB inflammatory signal pathway-mediated mechanism. Front Endocrinol (Lausanne). 14:11092962023. View Article : Google Scholar | |
Iwama A, Nishigaki N, Nakamura K, Imaizumi I, Shibata N, Yamasaki M, Nakamura H, Kameyama Y and Kapila Y: The effect of high sugar intake on the development of periradicular lesions in rats with type 2 diabetes. J Dent Res. 82:322–325. 2003. View Article : Google Scholar : PubMed/NCBI | |
Cintra LTA, Samuel RO, Azuma MM, Ribeiro CP, Narciso LG, de Lima VM, Sumida DH, Coclete GA, Dezan-Júnior E and Gomes-Filho JE: Apical periodontitis and periodontal disease increase serum IL-17 levels in normoglycemic and diabetic rats. Clin Oral Investig. 18:2123–2128. 2014. View Article : Google Scholar : PubMed/NCBI | |
Bahrambeigi S, Yousefi B, Rahimi M and Shafiei-Irannejad V: Metformin; an old antidiabetic drug with new potentials in bone disorders. Biomed Pharmacother. 109:1593–1601. 2019. View Article : Google Scholar | |
Zhu M, Zhao Z, Xu HHK, Dai Z, Yu K, Xiao L, Schneider A, Weir MD, Oates TW, Bai Y and Zhang K: Effects of metformin delivery via biomaterials on bone and dental tissue engineering. Int J Mol Sci. 23:159052022. View Article : Google Scholar : PubMed/NCBI | |
Wang S, Xia Y, Ma T, Weir MD, Ren K, Reynolds MA, Shu Y, Cheng L, Schneider A and Xu HHK: Novel metformin-containing resin promotes odontogenic differentiation and mineral synthesis of dental pulp stem cells. Drug Deliv Transl Res. 9:85–96. 2019. View Article : Google Scholar | |
Zhang R, Liang Q, Kang W and Ge S: Metformin facilitates the proliferation, migration, and osteogenic differentiation of periodontal ligament stem cells in vitro. Cell Biol Int. 44:70–79. 2020. View Article : Google Scholar | |
Liu L, Zhang C, Hu Y and Peng B: Protective effect of metformin on periapical lesions in rats by decreasing the ratio of receptor activator of nuclear factor kappa B ligand/osteoprotegerin. J Endod. 38:943–947. 2012. View Article : Google Scholar : PubMed/NCBI | |
Lai EHH, Yang CN, Lin SK, Wang HW, Kok SH, Hong CY, Su IH, Yang H and Chang JZC: Metformin ameliorates periapical lesions through suppression of hypoxia-induced apoptosis of osteoblasts. J Endod. 44:1817–1825. 2018. View Article : Google Scholar : PubMed/NCBI | |
Wang HW, Lai EHH, Yang CN, Lin SK, Hong CY, Yang H, Chang JZC and Kok SH: Intracanal metformin promotes healing of apical periodontitis via suppressing inducible nitric oxide synthase expression and monocyte recruitment. J Endod. 46:65–73. 2020. View Article : Google Scholar | |
Sarmento EB, Gomes CC, Pires FR, Pinto LC, Antunes LAA and Armada L: Immunoexpression of bone resorption biomarkers in apical periodontitis in diabetics and normoglycaemics. Int Endod J. 53:1025–1032. 2020. View Article : Google Scholar : PubMed/NCBI | |
Wang CH, Chueh LH, Chen SC, Feng YC, Hsiao CK and Chiang CP: Impact of diabetes mellitus, hypertension, and coronary artery disease on tooth extraction after nonsurgical endodontic treatment. J Endod. 37:1–5. 2011. View Article : Google Scholar | |
Mindiola MJ, Mickel AK, Sami C, Jones JJ, Lalumandier JA and Nelson SS: Endodontic treatment in an American Indian population: A 10-year retrospective study. J Endod. 32:828–832. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lima SMF, Grisi DC, Kogawa EM, Franco OL, Peixoto VC, Gonçalves-Júnior JF, Arruda MP and Rezende TM: Diabetes mellitus and inflammatory pulpal and periapical disease: A review. Int Endod J. 46:700–709. 2013. View Article : Google Scholar : PubMed/NCBI | |
Uğur Aydın Z, Ocak MG, Bayrak S, Göller Bulut D and Orhan K: The effect of type 2 diabetes mellitus on changes in the fractal dimension of periapical lesion in teeth after root canal treatment: A fractal analysis study. Int Endod J. 54:181–189. 2021. View Article : Google Scholar | |
Rudranaik S, Nayak M and Babshet M: Periapical healing outcome following single visit endodontic treatment in patients with type 2 diabetes mellitus. J Clin Exp Dent. 8:e498–e504. 2016.PubMed/NCBI | |
Martinho JP, Coelho A, Oliveiros B, Pires S, Abrantes AM, Paulo S, Carvalho AC, Carrilho E, Paula A, Carvalho L, et al: Impairment of the angiogenic process may contribute to lower success rate of root canal treatments in diabetes mellitus. Int Endod J. 54:1687–1698. 2021. View Article : Google Scholar : PubMed/NCBI | |
Britto LR, Katz J, Guelmann M and Heft M: Periradicular radiographic assessment in diabetic and control individuals. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 96:449–452. 2003. View Article : Google Scholar : PubMed/NCBI | |
Fouad AF and Burleson J: The effect of diabetes mellitus on endodontic treatment outcome: Data from an electronic patient record. J Am Dent Assoc. 134(43-51): 117–118. 2003. View Article : Google Scholar | |
Laukkanen E, Vehkalahti MM and Kotiranta AK: Impact of systemic diseases and tooth-based factors on outcome of root canal treatment. Int Endod J. 52:1417–1426. 2019. View Article : Google Scholar : PubMed/NCBI | |
Arya S, Duhan J, Tewari S, Sangwan P, Ghalaut V and Aggarwal S: Healing of apical periodontitis after nonsurgical treatment in patients with type 2 diabetes. J Endod. 43:1623–1627. 2017. View Article : Google Scholar : PubMed/NCBI | |
Limeira FIR, Arantes DC, de Souza Oliveira C, de Melo DP, Magalhães CS and Bento PM: Root canal treatment and apical periodontitis in a brazilian population with type 1 diabetes mellitus: A cross-sectional paired study. J Endod. 46:756–762. 2020. View Article : Google Scholar : PubMed/NCBI | |
Doyle SL, Hodges JS, Pesun IJ, Baisden MK and Bowles WR: Factors affecting outcomes for single-tooth implants and endodontic restorations. J Endod. 33:399–402. 2007. View Article : Google Scholar : PubMed/NCBI | |
Marotta PS, Fontes TV, Armada L, Lima KC, Rôças IN and Siqueira JF Jr: Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population. J Endod. 38:297–300. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ng YL, Mann V and Gulabivala K: A prospective study of the factors affecting outcomes of nonsurgical root canal treatment: Part 1: Periapical health. Int Endod J. 44:583–609. 2011. View Article : Google Scholar : PubMed/NCBI | |
Bloomgarden ZT: Inflammation and insulin resistance. Diabetes Care. 26:1619–1623. 2003. View Article : Google Scholar : PubMed/NCBI | |
Cintra LTA, Samuel RO, Facundo ACS, Prieto AK, Sumida DH, Bomfim SR, Souza JC, Dezan-Júnior E and Gomes-Filho JE: Relationships between oral infections and blood glucose concentrations or HbA1c levels in normal and diabetic rats. Int Endod J. 47:228–237. 2014. View Article : Google Scholar | |
Astolphi RD, Curbete MM, Colombo NH, Shirakashi DJ, Chiba FY, Prieto AK, Cintra LT, Bomfim SR, Ervolino E and Sumida DH: Periapical lesions decrease insulin signal and cause insulin resistance. J Endod. 39:648–652. 2013. View Article : Google Scholar : PubMed/NCBI | |
Astolphi RD, Curbete MM, Chiba FY, Cintra LT, Ervolino E, da Mota MS, Antoniali C, Garbin CA and Sumida DH: Periapical lesions decrease insulin signaling in rat skeletal muscle. J Endod. 41:1305–1310. 2015. View Article : Google Scholar : PubMed/NCBI | |
Pereira RF, de Oliveira da Mota MS, de Lima Coutinho Mattera MS, Tsosura TV, Chiba FY, Garbin CA, Ervolino E, Cintra LT, Okamoto MM, Machado UF and Sumida DH: Periapical lesions decrease Akt serine phosphorylation and plasma membrane GLUT4 content in rat skeletal muscle. Clin Oral Investig. 20:1625–1630. 2016. View Article : Google Scholar | |
Felipe Pereira R, Willian Lattari Tessarin G, Yamamoto Chiba F, Sara de Lima Coutinho Mattera M, Gomes Pereira A, Verônica Saori Tsosura T, Gustavo Balera Brito V, Akira Fujii, de Oliveira R, Ervolino E, Helena Penha, de Oliveira S, et al: Apical periodontitis promotes insulin resistance and alters adaptive immunity markers in rats. Saudi Dent J. 33:979–986. 2021. View Article : Google Scholar : PubMed/NCBI | |
Tsosura TVS, Chiba FY, Mattera MSLC, Pereira RF, Cintra LTA, Conti LC, Santos RMD, Mateus JHP, Garbin CAS and Sumida DH: Maternal apical periodontitis is associated with insulin resistance in adult offspring. Int Endod J. 52:1040–1050. 2019. View Article : Google Scholar : PubMed/NCBI | |
Ferreira LL: Diabetic rats present high mean platelet count in the presence of oral infections. Braz Dent J. 28:548–551. 2017. View Article : Google Scholar : PubMed/NCBI | |
Prieto AKC, Gomes-Filho JE, Azuma MM, Sivieri-Araújo G, Narciso LG, Souza JC, Ciarlini PC and Cintra LTA: Influence of apical periodontitis on stress oxidative parameters in diabetic rats. J Endod. 43:1651–1656. 2017. View Article : Google Scholar : PubMed/NCBI | |
Barcelos RCS, Rosa HZ, Roversi K, Tibúrcio-Machado CDS, Inchaki PT, Burger ME and Bier CAS: Apical periodontitis induces changes on oxidative stress parameters and increases Na+/K+-ATPase activity in adult rats. Arch Oral Biol. 118:1048492020. View Article : Google Scholar | |
Schulze A, Schönauer M and Busse M: Sudden improvement of insulin sensitivity related to an endodontic treatment. J Periodontol. 78:2380–2384. 2007. View Article : Google Scholar : PubMed/NCBI | |
Stys LPA, Böttcher DE, Scarparo RK, Gonçalves Waltrick SB, de Figueiredo JAP, Gomes MS and Campos MM: Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: Preliminary findings. Aust Endod J. 48:105–115. 2022. View Article : Google Scholar | |
No authors listed. Consensus development conference: Diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med. 94:646–650. 1993. View Article : Google Scholar : PubMed/NCBI | |
NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy: Osteoporosis prevention, diagnosis, and therapy. JAMA. 285:785–795. 2001. View Article : Google Scholar | |
Gilles JA, Carnes DL, Dallas MR, Holt SC and Bonewald LF: Oral bone loss is increased in ovariectomized rats. J Endod. 23:419–422. 1997. View Article : Google Scholar : PubMed/NCBI | |
López-López J, Castellanos-Cosano L, Estrugo-Devesa A, Gómez-Vaquero C, Velasco-Ortega E and Segura-Egea JJ: Radiolucent periapical lesions and bone mineral density in post-menopausal women. Gerodontology. 32:195–201. 2015. View Article : Google Scholar | |
Tounta TS: Diagnosis of osteoporosis in dental patients. J Frailty Sarcopenia Falls. 2:21–27. 2017. View Article : Google Scholar : PubMed/NCBI | |
Payne JB, Reinhardt RA, Nummikoski PV and Patil KD: Longitudinal alveolar bone loss in postmenopausal osteoporotic/osteopenic women. Osteoporos Int. 10:34–40. 1999. View Article : Google Scholar : PubMed/NCBI | |
Brennan RM, Genco RJ, Hovey KM, Trevisan M and Wactawski-Wende J: Clinical attachment loss, systemic bone density, and subgingival calculus in postmenopausal women. J Periodontol. 78:2104–2111. 2007. View Article : Google Scholar : PubMed/NCBI | |
Dervis E: Oral implications of osteoporosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 100:349–356. 2005. View Article : Google Scholar : PubMed/NCBI | |
Katz J and Rotstein I: Prevalence of periapical lesions in patients with osteoporosis. J Endod. 47:234–238. 2021. View Article : Google Scholar | |
Wayama MT, Yoshimura H, Ohba S, Yoshida H, Matsuda S, Kobayashi J, Kobayashi M, Gomes Filho JE and Sano K: Diminished progression of periapical lesions with zoledronic acid in ovariectomized rats. J Endod. 41:2002–2007. 2015. View Article : Google Scholar : PubMed/NCBI | |
Ikeda M, Karakawa A, Takizawa H, Azetsu Y, Sakai N, Chatani M, Suzuki N and Takami M: Effects of anti-receptor activator of nuclear factor kappa B ligand antibody and zoledronic acid on periapical lesion development in mice. J Endod. 48:632–640. 2022. View Article : Google Scholar : PubMed/NCBI | |
Xiong H, Peng B, Wei L, Zhang X and Wang L: Effect of an estrogen-deficient state and alendronate therapy on bone loss resulting from experimental periapical lesions in rats. J Endod. 33:1304–1308. 2007. View Article : Google Scholar : PubMed/NCBI | |
Silva RAB, Sousa-Pereira AP, Lucisano MP, Romualdo PC, Paula-Silva FWG, Consolaro A, Silva LAB and Nelson-Filho P: Alendronate inhibits osteocyte apoptosis and inflammation via IL-6, inhibiting bone resorption in periapical lesions of ovariectomized rats. Int Endod J. 53:84–96. 2020. View Article : Google Scholar | |
Guan X, Guan Y, Shi C, Zhu X, He Y, Wei Z, Yang J and Hou T: Estrogen deficiency aggravates apical periodontitis by regulating NLRP3/caspase-1/IL-1β axis. Am J Transl Res. 12:660–671. 2020. | |
Zhang X, Peng B, Fan M, Bian Z and Chen Z: The effect of estrogen deficiency on receptor activator of nuclear factor kappa B ligand and osteoprotegerin synthesis in periapical lesions induced in rats. J Endod. 33:1053–1056. 2007. View Article : Google Scholar : PubMed/NCBI | |
Romualdo PC, Lucisano MP, Paula-Silva FWG, Leoni GB, Sousa-Neto MD, Silva RAB, Silva LAB and Nelson-Filho P: Ovariectomy exacerbates apical periodontitis in rats with an increase in expression of proinflammatory cytokines and matrix metalloproteinases. J Endod. 44:780–785. 2018. View Article : Google Scholar : PubMed/NCBI | |
Brasil SC, Santos RMM, Fernandes A, Alves FR, Pires FR, Siqueira JF Jr and Armada L: Influence of oestrogen deficiency on the development of apical periodontitis. Int Endod J. 50:161–166. 2017. View Article : Google Scholar | |
Lucisano MP, da Silva RAB, de Sousa Pereira AP, Romualdo PC, Feres M, de Queiroz AM, Nelson-Filho P and da Silva LAB: Alteration of the oral microbiota may be a responsible factor, along with estrogen deficiency, by the development of larger periapical lesions. Clin Oral Investig. 25:3651–3662. 2021. View Article : Google Scholar | |
Gomes-Filho JE, Wayama MT, Dornelles RCM, Ervolino E, Yamanari GH, Lodi CS, Sivieri-Araújo G, Dezan-Júnior E and Cintra LT: Raloxifene modulates regulators of osteoclastogenesis and angiogenesis in an oestrogen deficiency periapical lesion model. Int Endod J. 48:1059–1068. 2015. View Article : Google Scholar | |
Qian H, Guan X and Bian Z: FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis. Mol Med Rep. 14:2997–3006. 2016. View Article : Google Scholar : PubMed/NCBI | |
Liu S, Cheng Y, Xu W and Bian Z: Protective effects of follicle-stimulating hormone inhibitor on alveolar bone loss resulting from experimental periapical lesions in ovariectomized rats. J Endod. 36:658–663. 2010. View Article : Google Scholar : PubMed/NCBI | |
Braz-Silva PH, Bergamini ML, Mardegan AP, De Rosa CS, Hasseus B and Jonasson P: Inflammatory profile of chronic apical periodontitis: A literature review. Acta Odontol Scand. 77:173–180. 2019. View Article : Google Scholar | |
Matsuo T, Ebisu S, Shimabukuro Y, Ohtake T and Okada H: Quantitative analysis of immunocompetent cells in human periapical lesions: Correlations with clinical findings of the involved teeth. J Endod. 18:497–500. 1992. View Article : Google Scholar : PubMed/NCBI | |
Guerrero-Gironés J, Ros-Valverde A, Pecci-Lloret MP, Rodríguez-Lozano FJ and Pecci-Lloret MR: Association between pulpal-periapical pathology and autoimmune diseases: A systematic review. J Clin Med. 10:48862021. View Article : Google Scholar : PubMed/NCBI | |
Karataş E, Kul A and Tepecik E: Association of ankylosing spondylitis with radiographically and clinically diagnosed apical periodontitis: A cross-sectional study. Dent Med Probl. 57:171–175. 2020. View Article : Google Scholar | |
Barta Z: Apical periodontitis in patients with inflammatory bowel disease: A puppet master? Inflamm Bowel Dis. 26:280–282. 2020. View Article : Google Scholar | |
Nakamura K, Yamasaki M, Nishigaki N, Iwama A, Imaizumi I, Nakamura H and Kameyama Y: Effect of methotrexate-induced neutropenia on pulpal inflammation in rats. J Endod. 28:287–290. 2002. View Article : Google Scholar : PubMed/NCBI | |
Yoshinari N, Kameyama Y, Aoyama Y, Nishiyama H and Noguchi T: Effect of long-term methotrexate-induced neutropenia on experimental periodontal lesion in rats. J Periodontal Res. 29:393–400. 1994. View Article : Google Scholar : PubMed/NCBI | |
Yamasaki M, Kumazawa M, Kohsaka T and Nakamura H: Effect of methotrexate-induced neutropenia on rat periapical lesion. Oral Surg Oral Med Oral Pathol. 77:655–661. 1994. View Article : Google Scholar : PubMed/NCBI | |
Waterman PA Jr, Torabinejad M, McMillan PJ and Kettering JD: Development of periradicular lesions in immunosuppressed rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85:720–725. 1998. View Article : Google Scholar : PubMed/NCBI | |
Teixeira FB, Gomes BP, Ferraz CC, Souza-Filho FJ and Zaia AA: Radiographic analysis of the development of periapical lesions in normal rats, sialoadenectomized rats and sialoadenectomized-immunosuppressed rats. Endod Dent Traumatol. 16:154–157. 2000. View Article : Google Scholar | |
Wasserman A: Rheumatoid arthritis: Common questions about diagnosis and management. Am Fam Physician. 97:455–462. 2018.PubMed/NCBI | |
Karataş E, Kul A and Tepecik E: Association between rheumatoid arthritis and apical periodontitis: A cross-sectional study. Eur Endod J. 5:155–158. 2020. | |
Rotstein I and Katz J: Prevalence of periapical abscesses in patients with rheumatoid arthritis. A cross sectional study. Am J Dent. 34:211–214. 2021.PubMed/NCBI | |
Oh WM, Hwang IN, Son HH and Hwang YC: Rapid periapical bone destruction during endodontic treatment of a patient with rheumatoid arthritis. J Endod. 34:1261–1263. 2008. View Article : Google Scholar : PubMed/NCBI | |
Jalali P, Glickman GN, Schneiderman ED and Schweitzer JL: Prevalence of periapical rarefying osteitis in patients with rheumatoid arthritis. J Endod. 43:1093–1096. 2017. View Article : Google Scholar : PubMed/NCBI | |
Cotti E, Schirru E, Acquas E and Usai P: An overview on biologic medications and their possible role in apical periodontitis. J Endod. 40:1902–1911. 2014. View Article : Google Scholar : PubMed/NCBI | |
Malmström M: Immunoglobulin clases IgG, IgM, IgA and complement component C3 in dental periapical lesions of patients with rheumatoid disease. Scand J Rheumatol. 4:57–64. 1975. View Article : Google Scholar : PubMed/NCBI | |
Malmström M and Calonius PE: Teeth loss and the inflammation of teeth-supporting tissues in rheumatoid disease. Scand J Rheumatol. 4:49–55. 1975. View Article : Google Scholar : PubMed/NCBI | |
Malmström M and Jokinen EJ: Free rheumatoid factor in dental periapical lesions and gingivae of patients with rheumatoid disease. Scand J Rheumatol. 4:121–124. 1975. View Article : Google Scholar : PubMed/NCBI | |
Malmström M and Natvig JB: IgG rheumatoid factor in dental periapical lesions of patients with rheumatoid disease. Scand J Rheumatol. 4:177–185. 1975. View Article : Google Scholar : PubMed/NCBI | |
Malmström M and Husby G: Occurrence of amyloid in the teeth-supporting tissues of patients with rheumatoid diseases. An immunohistochemical study. Scand J Rheumatol. 4:186–192. 1975. View Article : Google Scholar : PubMed/NCBI | |
Ishii K, Hatori K, Takeichi O, Makino K, Himi K, Komiya H and Ogiso B: Expression of the Forkhead box transcription factor Foxo3a in human periapical granulomas. J Oral Sci. 60:479–483. 2018. View Article : Google Scholar : PubMed/NCBI | |
Vergani D and Mieli-Vergani G: Autoimmune manifestations in viral hepatitis. Semin Immunopathol. 35:73–85. 2013. View Article : Google Scholar | |
Bjørklund G, Pivin M, Hangan T, Yurkovskaya O and Pivina L: Autoimmune polyendocrine syndrome type 1: Clinical manifestations, pathogenetic features, and management approach. Autoimmun Rev. 21:1031352022. View Article : Google Scholar : PubMed/NCBI | |
Joyce E, Glasner P, Ranganathan S and Swiatecka-Urban A: Tubulointerstitial nephritis: Diagnosis, treatment, and monitoring. Pediatr Nephrol. 32:577–587. 2017. View Article : Google Scholar | |
Cohen G: Immune dysfunction in Uremia 2020. Toxins (Basel). 12. pp. 4392020, View Article : Google Scholar | |
Grønkjær LL and Vilstrup H: Oral health in patients with liver cirrhosis. Eur J Gastroenterol Hepatol. 27:834–839. 2015. View Article : Google Scholar : PubMed/NCBI | |
Coates EA, Brennan D, Logan RM, Goss AN, Scopacasa B, Spencer AJ and Gorkic E: Hepatitis C infection and associated oral health problems. Aust Dent J. 45:108–114. 2000. View Article : Google Scholar : PubMed/NCBI | |
Lins L, Bittencourt PL, Evangelista MA, Lins R, Codes L, Cavalcanti AR, Paraná R and Bastos J: Oral health profile of cirrhotic patients awaiting liver transplantation in the Brazilian Northeast. Transplant Proc. 43:1319–1321. 2011. View Article : Google Scholar : PubMed/NCBI | |
Barbero P, Garzino Demo MG, Milanesio M and Ottobrelli A: The dental assessment of the patient waiting for a liver transplant. Minerva Stomatol. 45:431–439. 1996.In Italian. PubMed/NCBI | |
Guggenheimer J, Eghtesad B and Stock DJ: Dental management of the (solid) organ transplant patient. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 95:383–389. 2003. View Article : Google Scholar : PubMed/NCBI | |
Helenius-Hietala J, Meurman JH, Höckerstedt K, Lindqvist C and Isoniemi H: Effect of the aetiology and severity of liver disease on oral health and dental treatment prior to transplantation. Transpl Int. 25:158–165. 2012. View Article : Google Scholar | |
Castellanos-Cosano L, Machuca-Portillo G, Segura-Sampedro JJ, Torres-Lagares D, López-López J, Velasco-Ortega E and Segura-Egea JJ: Prevalence of apical periodontitis and frequency of root canal treatments in liver transplant candidates. Med Oral Patol Oral Cir Bucal. 18:e773–e779. 2013. View Article : Google Scholar : PubMed/NCBI | |
Grønkjær LL, Holmstrup P, Schou S, Schwartz K, Kongstad J, Jepsen P and Vilstrup H: Presence and consequence of tooth periapical radiolucency in patients with cirrhosis. Hepat Med. 8:97–103. 2016. View Article : Google Scholar : PubMed/NCBI | |
Cantiga-Silva C, Estrela C, Segura-Egea JJ, Azevedo JP, de Oliveira PHC, Cardoso CBM, Pinheiro TN, Ervolino E, Sivieri-Araújo G and Cintra LTA: Inflammatory profile of apical periodontitis associated with liver fibrosis in rats: Histological and immunohistochemical analysis. Int Endod J. 54:1353–1361. 2021. View Article : Google Scholar : PubMed/NCBI | |
Echavarría-García AC, Pozos-Guillén A, Tejeda-Nava F, Flores Arriaga JC and Garrocho-Rangel A: Oral management of children with Henoch-Schönlein purpura and associated glomerulonephritis: A scoping review. Eur J Paediatr Dent. 19:134–138. 2018. | |
Inoue CN, Nagasaka T, Matsutani S, Ishidoya M, Homma R and Chiba Y: Efficacy of early dental and ENT therapy in preventing nephropathy in pediatric Henoch-Schönlein purpura. Clin Rheumatol. 27:1489–1496. 2008. View Article : Google Scholar : PubMed/NCBI | |
Al-Wahadni A and Al-Omari MA: Dental diseases in a Jordanian population on renal dialysis. Quintessence Int. 34:343–347. 2003.PubMed/NCBI | |
Souza CM, Braosi APR, Luczyszyn SM, Casagrande RW, Pecoits-Filho R, Riella MC, Ignácio SA and Trevilatto PC: Oral health in Brazilian patients with chronic renal disease. Rev Med Chil. 136:741–746. 2008. View Article : Google Scholar : PubMed/NCBI | |
Bayraktar G, Kurtulus I, Duraduryan A, Cintan S, Kazancioglu R, Yildiz A, Bural C, Bozfakioglu S, Besler M, Trablus S and Issever H: Dental and periodontal findings in hemodialysis patients. Oral Dis. 13:393–397. 2007. View Article : Google Scholar : PubMed/NCBI | |
Sobrado Marinho JS, Tomás Carmona I, Loureiro A, Limeres Posse J, García Caballero L and Diz Dios P: Oral health status in patients with moderate-severe and terminal renal failure. Med Oral Patol Oral Cir Bucal. 12:E305–E310. 2007.PubMed/NCBI | |
Buhlin K, Bárány P, Heimbürger O, Stenvinkel P and Gustafsson A: Oral health and pro-inflammatory status in end-stage renal disease patients. Oral Health Prev Dent. 5:235–244. 2007.PubMed/NCBI | |
Khalighinejad N, Aminoshariae A, Kulild JC, Sahly K and Mickel A: Association of end-stage renal disease with radiographically and clinically diagnosed apical periodontitis: A hospital-based study. J Endod. 43:1438–1441. 2017. View Article : Google Scholar : PubMed/NCBI | |
Caly WR and Strauss E: A prospective study of bacterial infections in patients with cirrhosis. J Hepatol. 18:353–358. 1993. View Article : Google Scholar : PubMed/NCBI | |
Nair PN: Apical periodontitis: A dynamic encounter between root canal infection and host response. Periodontol. 2000(13): 121–148. 1997. View Article : Google Scholar | |
Mizutani K, Mikami R, Gohda T, Gotoh H, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Sasaki Y and Iwata T: Poor oral hygiene and dental caries predict high mortality rate in hemodialysis: A 3-year cohort study. Sci Rep. 10:218722020. View Article : Google Scholar : PubMed/NCBI | |
Olsen I and Yamazaki K: Can oral bacteria affect the microbiome of the gut? J Oral Microbiol. 11:15864222019. View Article : Google Scholar : PubMed/NCBI | |
Ogura Y, Suzuki S, Shirakawa T, Masuda M, Nakamura H, Iijima K and Yoshikawa N: Haemophilus parainfluenzae antigen and antibody in children with IgA nephropathy and Henoch-Schönlein nephritis. Am J Kidney Dis. 36:47–52. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, et al: Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis. Sci Rep. 2:3322012. View Article : Google Scholar : PubMed/NCBI | |
Tahmassebi JF and Paterson SA: Development of acute Henoch-Schönlein purpura subsequent to endodontic treatment. Int J Paediatr Dent. 17:217–222. 2007. View Article : Google Scholar : PubMed/NCBI | |
Papageorgiou SN, Hagner M, Nogueira AVB, Franke A, Jäger A and Deschner J: Inflammatory bowel disease and oral health: Systematic review and a meta-analysis. J Clin Periodontol. 44:382–393. 2017. View Article : Google Scholar : PubMed/NCBI | |
Baumgart DC and Sandborn WJ: Crohn's disease. Lancet. 380:1590–1605. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kalmar JR: Crohn's disease: Orofacial considerations and disease pathogenesis. Periodontol. 2000(6): 101–115. 1994. View Article : Google Scholar | |
She YY, Kong XB, Ge YP, Liu ZY, Chen JY, Jiang JW, Jiang HB and Fang SL: Periodontitis and inflammatory bowel disease: A meta-analysis. BMC Oral Health. 20:672020. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Qiao D, Chen R, Zhu F, Gong J and Yan F: The association between periodontitis and inflammatory bowel disease: A systematic review and meta-analysis. Biomed Res Int. 2021:66924202021.PubMed/NCBI | |
Tan CXW, Brand HS, Kalender B, De Boer NKH, Forouzanfar T and de Visscher JGAM: Dental and periodontal disease in patients with inflammatory bowel disease. Clin Oral Investig. 25:5273–5280. 2021. View Article : Google Scholar : PubMed/NCBI | |
Piras V, Usai P, Mezzena S, Susnik M, Ideo F, Schirru E and Cotti E: Prevalence of apical periodontitis in patients with inflammatory bowel diseases: A retrospective clinical study. J Endod. 43:389–394. 2017. View Article : Google Scholar : PubMed/NCBI | |
Poyato-Borrego M, Segura-Egea JJ, Martín-González J, Jiménez-Sánchez MC, Cabanillas-Balsera D, Areal-Quecuty V and Segura-Sampedro JJ: Prevalence of endodontic infection in patients with Crohn’s disease and ulcerative colitis. Med Oral Patol Oral Cir Bucal. 26:e208–e215. 2021. View Article : Google Scholar | |
Poyato-Borrego M, Segura-Sampedro JJ, Martín-González J, Torres-Domínguez Y, Velasco-Ortega E and Segura-Egea JJ: High prevalence of apical periodontitis in patients with inflammatory bowel disease: An age- and gender-matched case-control study. Inflamm Bowel Dis. 26:273–279. 2020. View Article : Google Scholar | |
Johannsen A, Fored MC, Håkansson J, Ekbom A and Gustafsson A: Consumption of dental treatment in patients with inflammatory bowel disease, a register study. PLoS One. 10:e01340012015. View Article : Google Scholar : PubMed/NCBI | |
Segura-Sampedro JJ, Jiménez-Giménez C, Jane-Salas E, Cabanillas-Balsera D, Martín-González J, Segura-Egea JJ and López-López J: Periapical and endodontic status of patients with inflammatory bowel disease: Age- and sex-matched case-control study. Int Endod J. 55:748–757. 2022. View Article : Google Scholar : PubMed/NCBI | |
Lu Y, Li X, Liu S, Zhang Y and Zhang D: Toll-like receptors and inflammatory bowel disease. Front Immunol. 9:722018. View Article : Google Scholar : PubMed/NCBI | |
Ng YL, Mann V, Rahbaran S, Lewsey J and Gulabivala K: Outcome of primary root canal treatment: systematic review of the literature-part 2. Influence of clinical factors. Int Endod J. 41:6–31. 2008. View Article : Google Scholar | |
Bamias G, Martin C, Mishina M, Ross WG, Rivera-Nieves J, Marini M and Cominelli F: Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Gastroenterology. 128:654–666. 2005. View Article : Google Scholar : PubMed/NCBI | |
Fukada SY, Silva TA, Garlet GP, Rosa AL, da Silva JS and Cunha FQ: Factors involved in the T helper type 1 and type 2 cell commitment and osteoclast regulation in inflammatory apical diseases. Oral Microbiol Immunol. 24:25–31. 2009. View Article : Google Scholar : PubMed/NCBI | |
Stashenko P, Wang CY, Tani-Ishii N and Yu SM: Pathogenesis of induced rat periapical lesions. Oral Surg Oral Med Oral Pathol. 78:494–502. 1994. View Article : Google Scholar : PubMed/NCBI | |
Wei L, Xu M and Xiong H: An update of knowledge on the regulatory role of Treg cells in apical periodontitis. Oral Dis. 27:1356–1365. 2021. View Article : Google Scholar | |
Van Dyke TE, Dowell VR Jr, Offenbacher S, Snyder W and Hersh T: Potential role of microorganisms isolated from periodontal lesions in the pathogenesis of inflammatory bowel disease. Infect Immun. 53:671–677. 1986. View Article : Google Scholar : PubMed/NCBI | |
Chi AC, Neville BW, Krayer JW and Gonsalves WC: Oral manifestations of systemic disease. Am Fam Physician. 82:1381–1388. 2010.PubMed/NCBI | |
Rodriguez Herrero E, Boon N, Pauwels M, Bernaerts K, Slomka V, Quirynen M and Teughels W: Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms. Sci Rep. 7:11072017. View Article : Google Scholar : PubMed/NCBI | |
Read E, Curtis MA and Neves JF: The role of oral bacteria in inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 18:731–742. 2021. View Article : Google Scholar : PubMed/NCBI | |
Tavares CO, Rost FL, Silva RBM, Dagnino AP, Adami B, Schirmer H, de Figueiredo JAP, Souto AA, Maito FDM and Campos MM: Cross talk between apical periodontitis and metabolic disorders: Experimental evidence on the role of intestinal adipokines and akkermansia muciniphila. J Endod. 45:174–180. 2019. View Article : Google Scholar : PubMed/NCBI | |
Carding S, Verbeke K, Vipond DT, Corfe BM and Owen LJ: Dysbiosis of the gut microbiota in disease. Microb Ecol Health Dis. 26:261912015.PubMed/NCBI | |
Gan G, Lu B, Zhang R, Luo Y, Chen S, Lei H, Li Y, Cai Z and Huang X: Chronic apical periodontitis exacerbates atherosclerosis in apolipoprotein E-deficient mice and leads to changes in the diversity of gut microbiota. Int Endod J. 55:152–163. 2022. View Article : Google Scholar | |
Ideo F, Niazi S, Mezzena S, Mannocci F and Cotti E: Prevalence of apical periodontitis in patients with autoimmune diseases under immunomodulators: A retrospective cohort study. J Endod. 48:722–729. 2022. View Article : Google Scholar : PubMed/NCBI | |
Ardizzone S and Bianchi Porro G: Biologic therapy for inflammatory bowel disease. Drugs. 65:2253–2286. 2005. View Article : Google Scholar : PubMed/NCBI | |
Cotti E, Mezzena S, Schirru E, Ottonello O, Mura M, Ideo F, Susnik M and Usai P: Healing of apical periodontitis in patients with inflammatory bowel diseases and under anti-tumor necrosis factor alpha therapy. J Endod. 44:1777–1782. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ritchlin CT, Haas-Smith SA, Li P, Hicks DG and Schwarz EM: Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest. 111:821–831. 2003. View Article : Google Scholar : PubMed/NCBI | |
Joseph P, Leong D, McKee M, Anand SS, Schwalm JD, Teo K, Mente A and Yusuf S: Reducing the global burden of cardiovascular disease, part 1: The epidemiology and risk factors. Circ Res. 121:677–694. 2017. View Article : Google Scholar : PubMed/NCBI | |
Andersson C and Vasan RS: Epidemiology of cardiovascular disease in young individuals. Nat Rev Cardiol. 15:230–240. 2018. View Article : Google Scholar | |
Prabhakaran D, Jeemon P and Roy A: Cardiovascular diseases in india: current epidemiology and future directions. Circulation. 133:1605–1620. 2016. View Article : Google Scholar : PubMed/NCBI | |
Cotti E, Dessì C, Piras A and Mercuro G: Can a chronic dental infection be considered a cause of cardiovascular disease? A review of the literature. Int J Cardiol. 148:4–10. 2011. View Article : Google Scholar | |
Berlin-Broner Y, Febbraio M and Levin L: Association between apical periodontitis and cardiovascular diseases: A systematic review of the literature. Int Endod J. 50:847–859. 2017. View Article : Google Scholar | |
González Navarro B, Pintó Sala X and Jané Salas E: Relationship between cardiovascular disease and dental pathology. Systematic review. Med Clin (Barc). 149:211–216. 2017.In English, Spanish. View Article : Google Scholar : PubMed/NCBI | |
Koletsi D, Iliadi A, Tzanetakis GN, Vavuranakis M and Eliades T: Cardiovascular disease and chronic endodontic infection. Is there an association? A systematic review and meta-analysis. Int J Environ Res Public Health. 18:91112021. View Article : Google Scholar : PubMed/NCBI | |
Garg P and Chaman C: Apical periodontitis-is it accountable for cardiovascular diseases? J Clin Diagn Res. 10:ZE08–ZE12. 2016.PubMed/NCBI | |
Jakovljevic A, Duncan HF, Nagendrababu V, Jacimovic J, Milasin J and Dummer PMH: Association between cardiovascular diseases and apical periodontitis: An umbrella review. Int Endod J. 53:1374–1386. 2020. View Article : Google Scholar : PubMed/NCBI | |
Aloutaibi YA, Alkarim AS, Qumri EM, Almansour LA and Alghamdi FT: Chronic endodontic infections and cardiovascular diseases: Does the evidence support an independent association? Cureus. 13:e198642021. | |
Jiménez-Sánchez MC, Cabanillas-Balsera D, Areal-Quecuty V, Velasco-Ortega E, Martín-González J and Segura-Egea JJ: Cardiovascular diseases and apical periodontitis: Association not always implies causality. Med Oral Patol Oral Cir Bucal. 25:e652–e659. 2020. View Article : Google Scholar : PubMed/NCBI | |
Noites R, Teixeira M, Cavero-Redondo I, Alvarez-Bueno C and Ribeiro F: Apical periodontitis and cardiovascular disease in adults: A systematic review with meta-analysis. Rev Cardiovasc Med. 23:1002022. View Article : Google Scholar : PubMed/NCBI | |
Leão TSS, Tomasi GH, Conzatti LP, Marrone LCP, Reynolds MA and Gomes MS: Oral inflammatory burden and carotid atherosclerosis among stroke patients. J Endod. 48:597–605. 2022. View Article : Google Scholar : PubMed/NCBI | |
Garrido M, Cárdenas AM, Astorga J, Quinlan F, Valdés M, Chaparro A, Carvajal P, Pussinen P, Huamán-Chipana P, Jalil JE and Hernández M: Elevated systemic inflammatory burden and cardiovascular risk in young adults with endodontic apical lesions. J Endod. 45:111–115. 2019. View Article : Google Scholar : PubMed/NCBI | |
Conti LC, Segura-Egea JJ, Cardoso CBM, Benetti F, Azuma MM, Oliveira PHC, Bomfim SRM and Cintra LTA: Relationship between apical periodontitis and atherosclerosis in rats: Lipid profile and histological study. Int Endod J. 53:1387–1397. 2020. View Article : Google Scholar : PubMed/NCBI | |
Caplan DJ: Chronic apical periodontitis is more common in subjects with coronary artery disease. J Evid Based Dent Pract. 14:149–150. 2014. View Article : Google Scholar : PubMed/NCBI | |
Caplan DJ, Chasen JB, Krall EA, Cai J, Kang S, Garcia RI, Offenbacher S and Beck JD: Lesions of endodontic origin and risk of coronary heart disease. J Dent Res. 85:9962006. View Article : Google Scholar : PubMed/NCBI | |
Liljestrand JM, Mäntylä P, Paju S, Buhlin K, Kopra KA, Persson GR, Hernandez M, Nieminen MS, Sinisalo J, Tjäderhane L and Pussinen PJ: Association of endodontic lesions with coronary artery disease. J Dent Res. 95:1358–1365. 2016. View Article : Google Scholar : PubMed/NCBI | |
Costa THR, de Figueiredo Neto JA, de Oliveira AE, Lopes e Maia Mde F and de Almeida AL: Association between chronic apical periodontitis and coronary artery disease. J Endod. 40:164–167. 2014. View Article : Google Scholar : PubMed/NCBI | |
Paloma de Oliveira B, Câmara AC and Aguiar CM: Prevalence of asymptomatic apical periodontitis and its association with coronary artery disease in a Brazilian subpopulation. Acta Stomatol Croat. 51:106–112. 2017. View Article : Google Scholar : PubMed/NCBI | |
Milojevic Samanovic A, Jakovljevic V, Vasovic M, Mitrovic S, Rankovic M, Mihajlovic K, Bolevich S and Zivkovic V: Cardiac, biochemical and histopathological analysis reveals impaired heart function in hypertensive rats with apical periodontitis. Int Endod J. 54:1581–1596. 2021. View Article : Google Scholar : PubMed/NCBI | |
Katz J and Rotstein I: Prevalence of periapical abscesses in patients with hypertension: A cross-sectional study of a large hospital population. J Endod. 47:1070–1074. 2021. View Article : Google Scholar : PubMed/NCBI | |
Petersen J, Glaßl EM, Nasseri P, Crismani A, Luger AK, Schoenherr E, Bertl K and Glodny B: The association of chronic apical periodontitis and endodontic therapy with atherosclerosis. Clin Oral Investig. 18:1813–1823. 2014. View Article : Google Scholar : | |
Vidal F, Fontes TV, Marques TVF and Gonçalves LS: Association between apical periodontitis lesions and plasmatic levels of C-reactive protein, interleukin 6 and fibrinogen in hypertensive patients. Int Endod J. 49:1107–1115. 2016. View Article : Google Scholar | |
Rashmi N, Galhotra V, Goel P, Rajguru JP, Jha SK and Kulkarni K: Assessment of C-reactive proteins, cytokines, and plasma protein levels in hypertensive patients with apical periodontitis. J Contemp Dent Pract. 18:516–521. 2017. View Article : Google Scholar : PubMed/NCBI | |
Messing M, Souza LCD, Cavalla F, Kookal KK, Rizzo G, Walji M, Silva R and Letra A: Investigating potential correlations between endodontic pathology and cardiovascular diseases using epidemiological and genetic approaches. J Endod. 45:104–110. 2019. View Article : Google Scholar : PubMed/NCBI | |
Sebring D, Buhlin K, Norhammar A, Rydén L, Jonasson P; EndoReCo; Lund H and Kvist T: Endodontic inflammatory disease: A risk indicator for a first myocardial infarction. Int Endod J. 55:6–17. 2022. View Article : Google Scholar | |
Bordagaray MJ, Fernández A, Garrido M, Astorga J, Hoare A and Hernández M: Systemic and extraradicular bacterial translocation in apical periodontitis. Front Cell Infect Microbiol. 11:6499252021. View Article : Google Scholar : PubMed/NCBI | |
Jiménez C, Garrido M, Pussinen P, Bordagaray MJ, Fernández A, Vega C, Chaparro A, Hoare A and Hernández M: Systemic burden and cardiovascular risk to Porphyromonas species in apical periodontitis. Clin Oral Investig. 26:993–1001. 2022. View Article : Google Scholar | |
Kazanci E, Oguz KK, Gurgey A and Topçu M: Streptococcus oralis as a risk factor for middle cerebral artery thrombosis. J Child Neurol. 20:611–613. 2005. View Article : Google Scholar : PubMed/NCBI | |
Theofilis P, Sagris M, Oikonomou E, Antonopoulos AS, Siasos G, Tsioufis C and Tousoulis D: Inflammatory mechanisms contributing to endothelial dysfunction. Biomedicines. 9:7812021. View Article : Google Scholar : PubMed/NCBI | |
Cotti E, Dessì C, Piras A, Flore G, Deidda M, Madeddu C, Zedda A, Longu G and Mercuro G: Association of endodontic infection with detection of an initial lesion to the cardiovascular system. J Endod. 37:1624–1629. 2011. View Article : Google Scholar : PubMed/NCBI | |
Bergandi L, Giuggia B, Alovisi M, Comba A, Silvagno F, Maule M, Aldieri E, Scotti N, Scacciatella P, Conrotto F, et al: Endothelial dysfunction marker variation in young adults with chronic apical periodontitis before and after endodontic treatment. J Endod. 45:500–506. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chauhan N, Mittal S, Tewari S, Sen J and Laller K: Association of apical periodontitis with cardiovascular disease via noninvasive assessment of endothelial function and subclinical atherosclerosis. J Endod. 45:681–690. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hernández-Ríos P, Pussinen PJ, Vernal R and Hernández M: Oxidative stress in the local and systemic events of apical periodontitis. Front Physiol. 8:8692017. View Article : Google Scholar : PubMed/NCBI | |
Chapple IL: Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol. 24:287–296. 1997. View Article : Google Scholar : PubMed/NCBI | |
Tucker MA, Fox BM, Seigler N, Rodriguez-Miguelez P, Looney J, Thomas J, McKie KT, Forseen C, Davison GW and Harris RA: Endothelial dysfunction in cystic fibrosis: Role of oxidative stress. Oxid Med Cell Longev. 2019:16296382019. View Article : Google Scholar : PubMed/NCBI | |
Brilhante Wolle CF, de Aguiar Zollmann L, Etges A, Vitalis GS, Leite CE and Campos MM: Effects of the antioxidant agent tempol on periapical lesions in rats with doxorubicin-induced cardiomyopathy. J Endod. 38:191–195. 2012. View Article : Google Scholar : PubMed/NCBI | |
Vailhé B, Dietl J, Kapp M, Toth B and Arck P: Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion. Hum Reprod. 14:1628–1634. 1999. View Article : Google Scholar : PubMed/NCBI | |
Zygmunt M, Herr F, Münstedt K, Lang U and Liang OD: Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol. 110(Suppl 1): pp. S10–S18. 2003, View Article : Google Scholar | |
Plaisier M: Decidualisation and angiogenesis. Best Pract Res Clin Obstet Gynaecol. 25:259–271. 2011. View Article : Google Scholar | |
Bobetsis YA, Graziani F, Gürsoy M and Madianos PN: Periodontal disease and adverse pregnancy outcomes. Periodontol. 2000(83): 154–174. 2020. View Article : Google Scholar | |
Harjunmaa U, Järnstedt J, Alho L, Dewey KG, Cheung YB, Deitchler M, Ashorn U, Maleta K, Klein NJ and Ashorn P: Association between maternal dental periapical infections and pregnancy outcomes: results from a cross-sectional study in Malawi. Trop Med Int Health. 20:1549–1558. 2015. View Article : Google Scholar : PubMed/NCBI | |
Leal ASM, de Oliveira AEF, Brito LMO, Lopes FF, Rodrigues VP, Lima KF and de Araújo Martins IC: Association between chronic apical periodontitis and low-birth-weight preterm births. J Endod. 41:353–357. 2015. View Article : Google Scholar : PubMed/NCBI | |
Khalighinejad N, Aminoshariae A, Kulild JC and Mickel A: Apical periodontitis, a predictor variable for preeclampsia: A case-control study. J Endod. 43:1611–1614. 2017. View Article : Google Scholar : PubMed/NCBI | |
Bain JL, Lester SR, Henry WD, Naftel JP and Johnson RB: Effects of induced periapical abscesses on rat pregnancy outcomes. Arch Oral Biol. 54:162–171. 2009. View Article : Google Scholar | |
Bain JL, Lester SR, Henry WD, Pongetti JL, Blackman ME and Johnson RB: Association between maternal periapical lesions and brain inflammation in rat pups. Arch Oral Biol. 58:266–271. 2013. View Article : Google Scholar | |
Kc K, Shakya S and Zhang H: Gestational diabetes mellitus and macrosomia: A literature review. Ann Nutr Metab. 66(Suppl 2): S14–S20. 2015. View Article : Google Scholar | |
Shah H, Nisar N, Hassan A and Butt S: Association between maternal chronic apical periodontitis (CAP) and low birth weight preterm birth (LBWPT). J Pak Med Assoc. 72:436–439. 2022.PubMed/NCBI | |
Orstavik D, Kerekes K and Eriksen HM: The periapical index: A scoring system for radiographic assessment of apical periodontitis. Endod Dent Traumatol. 2:20–34. 1986. View Article : Google Scholar : PubMed/NCBI | |
Ao M, Miyauchi M, Furusho H, Inubushi T, Kitagawa M, Nagasaki A, Sakamoto S, Kozai K and Takata T: Dental Infection of Porphyromonas gingivalis induces preterm birth in mice. PLoS One. 10:e01372492015. View Article : Google Scholar : PubMed/NCBI | |
Doyle RM, Alber DG, Jones HE, Harris K, Fitzgerald F, Peebles D and Klein N: Term and preterm labour are associated with distinct microbial community structures in placental membranes which are independent of mode of delivery. Placenta. 35:1099–1101. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lin D, Smith MA, Champagne C, Elter J, Beck J and Offenbacher S: Porphyromonas gingivalis infection during pregnancy increases maternal tumor necrosis factor alpha, suppresses maternal interleukin-10, and enhances fetal growth restriction and resorption in mice. Infect Immun. 71:5156–5162. 2003. View Article : Google Scholar : PubMed/NCBI | |
Robertson SA, Care AS and Skinner RJ: Interleukin 10 regulates inflammatory cytokine synthesis to protect against lipopolysaccharide-induced abortion and fetal growth restriction in mice. Biol Reprod. 76:738–748. 2007. View Article : Google Scholar : PubMed/NCBI | |
Coultas L, Chawengsaksophak K and Rossant J: Endothelial cells and VEGF in vascular development. Nature. 438:937–945. 2005. View Article : Google Scholar : PubMed/NCBI | |
Awasthi S and Pandey M: Association of TLR4 and TNF-a gene polymorphisms and TLR4 mRNA levels in preterm birth in a Northern Indian population. Indian Pediatr. 56:202–204. 2019. View Article : Google Scholar : PubMed/NCBI | |
Jakovljevic A, Sljivancanin Jakovljevic T, Duncan HF, Nagendrababu V, Jacimovic J, Aminoshariae A, Milasin J and Dummer PMH: The association between apical periodontitis and adverse pregnancy outcomes: A systematic review. Int Endod J. 54:1527–1537. 2021. View Article : Google Scholar : PubMed/NCBI | |
Regier DA, Farmer ME, Rae DS, Locke BZ, Keith SJ, Judd LL and Goodwin FK: Comorbidity of mental disorders with alcohol and other drug abuse. Results from the epidemiologic catchment area (ECA) study. JAMA. 264:2511–2518. 1990. View Article : Google Scholar : PubMed/NCBI | |
Sundararajan S, Muthukumar S and Rao SR: Relationship between depression and chronic periodontitis. J Indian Soc Periodontol. 19:294–296. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chen P, Yao H, Su W, He Y, Cheng K, Wang Y, Peng W and Li P: Sleep deprivation worsened oral ulcers and delayed healing process in an experimental rat model. Life Sci. 232:1165942019. View Article : Google Scholar : PubMed/NCBI | |
Lavigne GJ, Khoury S, Abe S, Yamaguchi T and Raphael K: Bruxism physiology and pathology: An overview for clinicians. J Oral Rehabil. 35:476–494. 2008. View Article : Google Scholar : PubMed/NCBI | |
Maes M: Evidence for an immune response in major depression: A review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry. 19:11–38. 1995. View Article : Google Scholar : PubMed/NCBI | |
Haug SR and Marthinussen MC: Acute dental pain and salivary biomarkers for stress and inflammation in patients with pulpal or periapical inflammation. J Oral Facial Pain Headache. 33:227–233. 2019. View Article : Google Scholar | |
Wang YX, Kang XN, Cao Y, Zheng DX, Lu YM, Pang CF, Wang Z, Cheng B and Peng Y: Porphyromonas gingivalis induces depression via downregulating p75NTR-mediated BDNF maturation in astrocytes. Brain Behav Immun. 81:523–534. 2019. View Article : Google Scholar : PubMed/NCBI | |
Martínez M, Martín-Hernández D, Virto L, MacDowell KS, Montero E, González-Bris Á, Marín MJ, Ambrosio N, Herrera D, Leza JC, et al: Periodontal diseases and depression: A pre-clinical in vivo study. J Clin Periodontol. 48:503–527. 2021. View Article : Google Scholar : PubMed/NCBI | |
Martín-Hernández D, Martínez M, Robledo-Montaña J, Muñoz-López M, Virto L, Ambrosio N, Marín MJ, Montero E, Herrera D, Sanz M, et al: Neuroinflammation related to the blood-brain barrier and sphingosine-1-phosphate in a pre-clinical model of periodontal diseases and depression in rats. J Clin Periodontol. 50:642–656. 2023. View Article : Google Scholar : PubMed/NCBI | |
Saei Ghare Naz M, Ramezani Tehrani F, Behroozi Lak T, Mohammadzadeh F, Nasiri M, Kholosi Badr F and Ozgoli G: Quality of life and emotional states of depression, anxiety and stress in adolescents with polycystic ovary syndrome: A cross-sectional study. Psychol Res Behav Manag. 13:203–209. 2020. View Article : Google Scholar : PubMed/NCBI | |
Montoro J, Mullol J, Jáuregui I, Dávila I, Ferrer M, Bartra J, del Cuvillo A, Sastre J and Valero A: Stress and allergy. J Investig Allergol Clin Immunol. 19(Suppl 1): S40–S47. 2009. | |
Eisenhofer G, Lambie DG and Johnson RH: Beta-adrenoceptor responsiveness and plasma catecholamines as determinants of cardiovascular reactivity to mental stress. Clin Sci (Lond). 69:483–492. 1985. View Article : Google Scholar : PubMed/NCBI | |
Haug SR and Heyeraas KJ: Modulation of dental inflammation by the sympathetic nervous system. J Dent Res. 85:488–495. 2006. View Article : Google Scholar : PubMed/NCBI | |
Esteban MA, Rodríguez A, Ayala AG and Meseguer J: Effects of high doses of cortisol on innate cellular immune response of seabream (Sparus aurata L.). Gen Comp Endocrinol. 137:89–98. 2004. View Article : Google Scholar : PubMed/NCBI | |
do Nascimento IV, Rodrigues MIDQ, Isaias PHC, Barros-Silva PG, Sousa FB, Nunes Alves APN and Mota MRL: Chronic systemic corticosteroid therapy influences the development of pulp necrosis and experimental apical periodontitis, exacerbating the inflammatory process and bone resorption in rats. Int Endod J. 55:646–659. 2022. View Article : Google Scholar : PubMed/NCBI | |
Gomes ESB, Farias LC, Silveira LH, Jesus CÍ, Rocha RGD, Ramos GV, Magalhães HTAT, Brito-Júnior M, Santos SHS, Jham BC, et al: Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats. Arch Oral Biol. 97:35–41. 2019. View Article : Google Scholar | |
Minhoto GB, Khoury RD, Orozco EIF, Prado RF and Valera MC: Effect of chronic unpredictable stress on the progression of experimental apical periodontitis in rats. Int Endod J. 54:1342–1352. 2021. View Article : Google Scholar : PubMed/NCBI | |
Khoury RD, Prado RFD, Matos FDS, Meireles BR, Cardoso FGDR, Oliveira LD, Carvalho CAT and Valera MC: The influence of adrenergic blockade in rats with apical periodontitis under chronic stress conditions. Arch Oral Biol. 110:1045902020. View Article : Google Scholar | |
Van Someren EJW: Brain mechanisms of insomnia: New perspectives on causes and consequences. Physiol Rev. 101:995–1046. 2021. View Article : Google Scholar | |
Scott J, Kallestad H, Vedaa O, Sivertsen B and Etain B: Sleep disturbances and first onset of major mental disorders in adolescence and early adulthood: A systematic review and meta-analysis. Sleep Med Rev. 57:1014292021. View Article : Google Scholar : PubMed/NCBI | |
Park JS, Jeong Y, Jung J, Ryu JJ, Lim HK, Jung SK and Song IS: Shift work sleep disorder is closely associated with an increased risk for periodontal disease. J Clin Periodontol. 48:1066–1075. 2021. View Article : Google Scholar : PubMed/NCBI | |
Fang HF, Miao NF, Chen CD, Sithole T and Chung MH: Risk of cancer in patients with insomnia, parasomnia, and obstructive sleep apnea: A nationwide nested case-control study. J Cancer. 6:1140–1147. 2015. View Article : Google Scholar : PubMed/NCBI | |
Chen LL: Advances in circadian rhythms in oral maxillofacial tissues and oral-related diseases. Zhonghua Kou Qiang Yi Xue Za Zhi. 57:481–489. 2022.In Chinese. PubMed/NCBI | |
Lange T, Dimitrov S and Born J: Effects of sleep and circadian rhythm on the human immune system. Ann N Y Acad Sci. 1193:48–59. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chu FCS, Leung WK, Tsang PCS, Chow TW and Samaranayake LP: Identification of cultivable microorganisms from root canals with apical periodontitis following two-visit endodontic treatment with antibiotics/steroid or calcium hydroxide dressings. J Endod. 32:17–23. 2006. View Article : Google Scholar : PubMed/NCBI | |
Brzezinski A: Melatonin in humans. N Engl J Med. 336:186–195. 1997. View Article : Google Scholar : PubMed/NCBI | |
Reiter RJ, Rosales-Corral SA, Liu XY, Acuna-Castroviejo D, Escames G and Tan DX: Melatonin in the oral cavity: Physiological and pathological implications. J Periodontal Res. 50:9–17. 2015. View Article : Google Scholar | |
Tavares BS, Tsosura TVS, Mattera MSLC, Santelli JO, Belardi BE, Chiba FY, Cintra LTA, Silva CC and Matsushita DH: Effects of melatonin on insulin signaling and inflammatory pathways of rats with apical periodontitis. Int Endod J. 54:926–940. 2021. View Article : Google Scholar : PubMed/NCBI | |
Sarıtekin E, Üreyen Kaya B, Aşcı H and Özmen Ö: Anti-inflammatory and antiresorptive functions of melatonin on experimentally induced periapical lesions. Int Endod J. 52:1466–1478. 2019. View Article : Google Scholar |