Open Access

Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)

  • Authors:
    • Li-Hua Shao
    • Li Zhu
    • Meng Wang
    • Yue Ning
    • Feng-Qin Chen
    • Xia-Qing Gao
    • Chun-Ting Yang
    • Hong-Wei Wang
    • Hai-Long Li
  • View Affiliations

  • Published online on: June 29, 2023     https://doi.org/10.3892/ijmm.2023.5272
  • Article Number: 69
  • Copyright: © Shao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Tumor multidrug resistance (MDR) remains one of the most challenging barriers to successful cancer treatment. Several previous studies have suggested that high mobility group box 1 (HMGB1) may be a promising therapeutic target for overcoming cancer drug resistance. Emerging evidence has indicated that HMGB1 functions as a ‘double‑edged sword’ that plays both pro‑ and anti‑tumor roles in the development and progression of multiple types of cancer. HMGB1 has also been found to be a key regulator of several cell death and signaling pathways, and is involved in MDR by mediating cell autophagy and apoptosis, ferroptosis, pyroptosis and multiple signaling pathways. Additionally, HMGB1 is regulated by a variety of non‑coding RNAs (ncRNAs), such as microRNAs, long ncRNAs and circular RNAs that are involved in MDR. Thus far, studies have been conducted to identify strategies with which to overcome HMGB1‑mediated MDR by the targeted silencing of HMGB1 and the targeted interference of HMGB1 expression using drugs and ncRNAs. Therefore, HMGB1 is closely associated with tumor MDR and is a promising therapeutic target.
View Figures
View References

Related Articles

Journal Cover

August-2023
Volume 52 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shao L, Zhu L, Wang M, Ning Y, Chen F, Gao X, Yang C, Wang H and Li H: Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review). Int J Mol Med 52: 69, 2023
APA
Shao, L., Zhu, L., Wang, M., Ning, Y., Chen, F., Gao, X. ... Li, H. (2023). Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review). International Journal of Molecular Medicine, 52, 69. https://doi.org/10.3892/ijmm.2023.5272
MLA
Shao, L., Zhu, L., Wang, M., Ning, Y., Chen, F., Gao, X., Yang, C., Wang, H., Li, H."Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)". International Journal of Molecular Medicine 52.2 (2023): 69.
Chicago
Shao, L., Zhu, L., Wang, M., Ning, Y., Chen, F., Gao, X., Yang, C., Wang, H., Li, H."Mechanisms involved in the HMGB1 modulation of tumor multidrug resistance (Review)". International Journal of Molecular Medicine 52, no. 2 (2023): 69. https://doi.org/10.3892/ijmm.2023.5272