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The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)

  • Authors:
    • Weijuan Xin
    • Yue Wang
    • Keqin Hua
    • Songping Liu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200090, P.R. China, Department of Obstetrics and Gynecology, Jinshan Hospital of Fudan University, Shanghai 201508, P.R. China
    Copyright: © Xin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 73
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    Published online on: July 7, 2023
       https://doi.org/10.3892/ijmm.2023.5276
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Abstract

Long non‑coding RNAs (lncRNAs) represent a class of versatile molecules that exhibit the potential to regulate gene expression at various levels, namely transcriptional, post‑transcriptional and epigenetic, thereby influencing critical cellular processes such as proliferation, apoptosis, invasion and drug resistance. The lncRNA H19, among the earliest identified within this category, has emerged as a significant participant in the pathogenesis of a multitude of both malignant and benign gynecological diseases. An escalating body of evidence indicates a functionally pertinent network of lncRNA H19 coexpression linked with the extracellular matrix architecture and immune microenvironment during cancer progression. This association may provide insightful leads for the selection of innovative diagnostic biomarkers and assist in the delineation of potent pharmaceutical targets for gynecological oncology. The present comprehensive review presented a synthesis of the expression profiles and multifaceted implications of lncRNA H19 across a spectrum of gynecological pathologies.
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Copy and paste a formatted citation
Spandidos Publications style
Xin W, Wang Y, Hua K and Liu S: The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review). Int J Mol Med 52: 73, 2023.
APA
Xin, W., Wang, Y., Hua, K., & Liu, S. (2023). The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review). International Journal of Molecular Medicine, 52, 73. https://doi.org/10.3892/ijmm.2023.5276
MLA
Xin, W., Wang, Y., Hua, K., Liu, S."The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)". International Journal of Molecular Medicine 52.2 (2023): 73.
Chicago
Xin, W., Wang, Y., Hua, K., Liu, S."The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)". International Journal of Molecular Medicine 52, no. 2 (2023): 73. https://doi.org/10.3892/ijmm.2023.5276
Copy and paste a formatted citation
x
Spandidos Publications style
Xin W, Wang Y, Hua K and Liu S: The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review). Int J Mol Med 52: 73, 2023.
APA
Xin, W., Wang, Y., Hua, K., & Liu, S. (2023). The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review). International Journal of Molecular Medicine, 52, 73. https://doi.org/10.3892/ijmm.2023.5276
MLA
Xin, W., Wang, Y., Hua, K., Liu, S."The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)". International Journal of Molecular Medicine 52.2 (2023): 73.
Chicago
Xin, W., Wang, Y., Hua, K., Liu, S."The role of long noncoding RNA H19 in gynecological pathologies: Insights into gene regulation and immune modulation (Review)". International Journal of Molecular Medicine 52, no. 2 (2023): 73. https://doi.org/10.3892/ijmm.2023.5276
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