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Article Open Access

E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer

  • Authors:
    • Jing Wen
    • Genggeng Qin
    • Zhaojing Jiang
    • Zixun Lin
    • Ruixin Zhou
    • Hui Dai
    • Zhanfa Xu
    • Weiguo Chen
    • Qiancheng Song
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Radiation Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Hospital Office, Ganzhou Hospital‑Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi 341000, P.R. China
    Copyright: © Wen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 75
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    Published online on: July 11, 2023
       https://doi.org/10.3892/ijmm.2023.5278
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Abstract

E74‑like ETS transcription factor 5 (ELF5) is known to regulate the specification and differentiation of epithelial cells in the embryonic lung. However, the pathological function of ELF5 in lung cancer has yet to be fully elucidated. In the present study, the expression of ELF5 was found to be significantly higher in lung adenocarcinoma compared with that in corresponding adjacent normal tissues. Subsequently, cell and animal experiments were performed to investigate the role of ELF5 in lung adenocarcinoma cells. The results indicated that the overexpression of ELF5 increased the proliferation of lung adenocarcinoma cells, whereas, by contrast, a reduction in the expression of ELF5 led to a decrease in their proliferation. Mechanistically, the hypothesis is advanced that ELF5 can promote lung cancer cell proliferation through inhibiting adenomatous polyposis coli 2 and increasing the expression of cyclin D1, which is a critical downstream target of the Wnt pathway. Taken together, these findings support the notion that ELF5 exerts an essential role in the proliferation of lung adenocarcinoma cells and may be a therapeutic target for the treatment of lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wen J, Qin G, Jiang Z, Lin Z, Zhou R, Dai H, Xu Z, Chen W and Song Q: E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer. Int J Mol Med 52: 75, 2023.
APA
Wen, J., Qin, G., Jiang, Z., Lin, Z., Zhou, R., Dai, H. ... Song, Q. (2023). E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer. International Journal of Molecular Medicine, 52, 75. https://doi.org/10.3892/ijmm.2023.5278
MLA
Wen, J., Qin, G., Jiang, Z., Lin, Z., Zhou, R., Dai, H., Xu, Z., Chen, W., Song, Q."E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer". International Journal of Molecular Medicine 52.3 (2023): 75.
Chicago
Wen, J., Qin, G., Jiang, Z., Lin, Z., Zhou, R., Dai, H., Xu, Z., Chen, W., Song, Q."E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer". International Journal of Molecular Medicine 52, no. 3 (2023): 75. https://doi.org/10.3892/ijmm.2023.5278
Copy and paste a formatted citation
x
Spandidos Publications style
Wen J, Qin G, Jiang Z, Lin Z, Zhou R, Dai H, Xu Z, Chen W and Song Q: E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer. Int J Mol Med 52: 75, 2023.
APA
Wen, J., Qin, G., Jiang, Z., Lin, Z., Zhou, R., Dai, H. ... Song, Q. (2023). E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer. International Journal of Molecular Medicine, 52, 75. https://doi.org/10.3892/ijmm.2023.5278
MLA
Wen, J., Qin, G., Jiang, Z., Lin, Z., Zhou, R., Dai, H., Xu, Z., Chen, W., Song, Q."E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer". International Journal of Molecular Medicine 52.3 (2023): 75.
Chicago
Wen, J., Qin, G., Jiang, Z., Lin, Z., Zhou, R., Dai, H., Xu, Z., Chen, W., Song, Q."E74‑like ETS transcription factor 5 facilitates cell proliferation through regulating the expression of adenomatous polyposis coli 2 in non‑small cell lung cancer". International Journal of Molecular Medicine 52, no. 3 (2023): 75. https://doi.org/10.3892/ijmm.2023.5278
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