Open Access

METTL14‑mediated RNA methylation in digestive system tumors

  • Authors:
    • Jiexuan Hu
    • Haishan Lin
    • Cong Wang
    • Qiang Su
    • Bangwei Cao
  • View Affiliations

  • Published online on: August 4, 2023     https://doi.org/10.3892/ijmm.2023.5289
  • Article Number: 86
  • Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

N6‑methyladenosine (m6A) RNA methylation is one of the most common post‑transcriptional modification mechanism in eukaryotes. m6A is involved in almost all stages of the mRNA life cycle, specifically regulating its stability, splicing, export and translation. Methyltransferase‑like 14 (METTL14) is a particularly important m6A methylation ‘writer’ that can recognize RNA substrates. METTL14 has been documented to improve the activity and catalytic efficiency of METTL3. However, as individual proteins they can also regulate different biological processes. Malignancies in the digestive system are some of the most common malignancies found in humans, which are typically associated with poor prognoses with limited clinical solutions. METTL14‑mediated methylation has been implicated in both the potentiation and inhibition of digestive system tumor growth, cell invasion and metastasis, in addition to drug resistance. In the present review, the research progress and regulatory mechanisms of METTL14‑mediated methylation in digestive system malignancies were summarized. In addition, future research directions and the potential for its clinical application were examined.
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September-2023
Volume 52 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Hu J, Lin H, Wang C, Su Q and Cao B: METTL14‑mediated RNA methylation in digestive system tumors. Int J Mol Med 52: 86, 2023
APA
Hu, J., Lin, H., Wang, C., Su, Q., & Cao, B. (2023). METTL14‑mediated RNA methylation in digestive system tumors. International Journal of Molecular Medicine, 52, 86. https://doi.org/10.3892/ijmm.2023.5289
MLA
Hu, J., Lin, H., Wang, C., Su, Q., Cao, B."METTL14‑mediated RNA methylation in digestive system tumors". International Journal of Molecular Medicine 52.3 (2023): 86.
Chicago
Hu, J., Lin, H., Wang, C., Su, Q., Cao, B."METTL14‑mediated RNA methylation in digestive system tumors". International Journal of Molecular Medicine 52, no. 3 (2023): 86. https://doi.org/10.3892/ijmm.2023.5289