Open Access

Role of dendritic cell‑derived exosomes in allergic rhinitis (Review)

  • Authors:
    • Chenglin Kang
    • Haipeng He
    • Peng Liu
    • Yue Liu
    • Xiaomei Li
    • Jin Zhang
    • Hong Ran
    • Xianhai Zeng
    • Hailiang Zhao
    • Jiangqi Liu
    • Shuqi Qiu
  • View Affiliations

  • Published online on: October 20, 2023     https://doi.org/10.3892/ijmm.2023.5320
  • Article Number: 117
  • Copyright: © Kang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Allergic rhinitis (AR) is a common pathological condition in otorhinolaryngology. Its prevalence has been increasing worldwide and is becoming a major burden to the world population. Dendritic cells (DCs) are typically activated and matured after capturing, phagocytosing, and processing allergens during the immunopathogenesis of AR. In addition, the process of DC activation and maturation is accompanied by the production of exosomes, which are cell‑derived extracellular vesicles (EVs) that can carry proteins, lipids, nucleic acids, and other cargoes involved in intercellular communication and material transfer. In particular, DC‑derived exosomes (Dex) can participate in allergic immune responses, where the biological substances carried by them can have potentially important implications for both the pathogenesis and treatment of AR. Dex can also be exploited to carry anti‑allergy agents to effectively treat AR. This provides a novel method to explore the pathogenesis of and treatment strategies for AR further. Therefore, the present review focuses on the origin, composition, function, and biological characteristics of DCs, exosomes, and Dex, in addition to the possible relationship between Dex and AR.
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December-2023
Volume 52 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Kang C, He H, Liu P, Liu Y, Li X, Zhang J, Ran H, Zeng X, Zhao H, Liu J, Liu J, et al: Role of dendritic cell‑derived exosomes in allergic rhinitis (Review). Int J Mol Med 52: 117, 2023
APA
Kang, C., He, H., Liu, P., Liu, Y., Li, X., Zhang, J. ... Qiu, S. (2023). Role of dendritic cell‑derived exosomes in allergic rhinitis (Review). International Journal of Molecular Medicine, 52, 117. https://doi.org/10.3892/ijmm.2023.5320
MLA
Kang, C., He, H., Liu, P., Liu, Y., Li, X., Zhang, J., Ran, H., Zeng, X., Zhao, H., Liu, J., Qiu, S."Role of dendritic cell‑derived exosomes in allergic rhinitis (Review)". International Journal of Molecular Medicine 52.6 (2023): 117.
Chicago
Kang, C., He, H., Liu, P., Liu, Y., Li, X., Zhang, J., Ran, H., Zeng, X., Zhao, H., Liu, J., Qiu, S."Role of dendritic cell‑derived exosomes in allergic rhinitis (Review)". International Journal of Molecular Medicine 52, no. 6 (2023): 117. https://doi.org/10.3892/ijmm.2023.5320