Open Access

Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review)

  • Authors:
    • Miaomiao Xu
    • Ying Cui
    • Siyuan Wei
    • Xuelong Cong
    • Yiying Chen
    • Shujie Tian
    • Anqi Yao
    • Weiwei Chen
    • Lixing Weng
  • View Affiliations

  • Published online on: December 6, 2023     https://doi.org/10.3892/ijmm.2023.5337
  • Article Number: 13
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Macrophages, as highly heterogeneous and plastic immune cells, occupy a pivotal role in both pro‑inflammatory (M1) and anti‑inflammatory (M2) responses. While M1‑type macrophages secrete pro‑inflammatory factors to initiate and sustain inflammation, M2‑type macrophages promote inflammation regression and uphold tissue homeostasis. These distinct phenotypic transitions in macrophages are closely linked to significant alterations in cellular metabolism, encompassing key response pathways such as glycolysis, pentose phosphate pathway, oxidative phosphorylation, lipid metabolism, amino acid metabolism, the tricarboxylic acid cycle and iron metabolism. These metabolic adaptations enable macrophages to adapt their activities in response to varying disease microenvironments. Therefore, the present review focused primarily on elucidating the intricate metabolic pathways that underlie macrophage functionality. Subsequently, it offers a comprehensive overview of the current state‑of‑the‑art nanomaterials, highlighting their promising potential in modulating macrophage metabolism to effectively hinder disease progression in both cancer and atherosclerosis.
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February-2024
Volume 53 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Xu M, Cui Y, Wei S, Cong X, Chen Y, Tian S, Yao A, Chen W and Weng L: Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review). Int J Mol Med 53: 13, 2024
APA
Xu, M., Cui, Y., Wei, S., Cong, X., Chen, Y., Tian, S. ... Weng, L. (2024). Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review). International Journal of Molecular Medicine, 53, 13. https://doi.org/10.3892/ijmm.2023.5337
MLA
Xu, M., Cui, Y., Wei, S., Cong, X., Chen, Y., Tian, S., Yao, A., Chen, W., Weng, L."Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review)". International Journal of Molecular Medicine 53.2 (2024): 13.
Chicago
Xu, M., Cui, Y., Wei, S., Cong, X., Chen, Y., Tian, S., Yao, A., Chen, W., Weng, L."Emerging nanomaterials targeting macrophage adapted to abnormal metabolism in cancer and atherosclerosis therapy (Review)". International Journal of Molecular Medicine 53, no. 2 (2024): 13. https://doi.org/10.3892/ijmm.2023.5337