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Article Open Access

Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex

  • Authors:
    • Sangyu Hu
    • Zhigang Li
    • Huan Liu
    • Wenze Cao
    • Yilei Meng
    • Chang Liu
    • Siyu He
    • Qin Lin
    • Mengyue Shang
    • Fang Lin
    • Na Yi
    • Hanrui Wang
    • Agapios Sachinidis
    • Qilong Ying
    • Li Li
    • Luying Peng
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Physiology, Working Group Sachinidis, Center for Molecular Medicine, D-50931 Cologne, Germany, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 14
    |
    Published online on: December 7, 2023
       https://doi.org/10.3892/ijmm.2023.5338
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Abstract

The Kv11.1 potassium channel encoded by the Kcnh2 gene is crucial in conducting the rapid delayed rectifier K+ current in cardiomyocytes. Homozygous mutation in Kcnh2 is embryonically lethal in humans and mice. However, the molecular signaling pathway of intrauterine fetal loss is unclear. The present study generated a Kcnh2 knockout rat based on edited rat embryonic stem cells (rESCs). Kcnh2 knockout was embryonic lethal on day 11.5 of development due to a heart configuration defect. Experiments with human embryonic heart single cells (6.5‑7 weeks post‑conception) suggested that potassium voltage‑gated channel subfamily H member 2 (KCNH2) plays a crucial role in the development of compact cardiomyocytes. By contrast, apoptosis was found to be triggered in the homozygous embryos, which could be attributed to the failure of KCNH2 to form a complex with integrin β1 that was essential for preventing the process of apoptosis via inhibition of forkhead box O3A. Destruction of the KCNH2/integrin β1 complex reduced the phosphorylation level of AKT and deactivated the glycogen synthase kinase 3 β (GSK‑3β)/β‑catenin pathway, which caused early developmental abnormalities in rats. The present work reveals a basic mechanism by which KCNH2 maintains intact embryonic heart development.
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View References

1 

Warmke JW and Ganetzky B: A family of potassium channel genes related to eag in Drosophila and mammals. Proc Natl Acad Sci USA. 91:3438–3442. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Sanguinetti MC, Jiang C, Curran ME and Keating MT: A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81:299–307. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Sanguinetti MC and Tristani-Firouzi M: hERG potassium channels and cardiac arrhythmia. Nature. 440:463–469. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Jehle J, Schweizer PA, Katus HA and Thomas D: Novel roles for hERG K(+) channels in cell proliferation and apoptosis. Cell Death Dis. 2:e1932011. View Article : Google Scholar : PubMed/NCBI

5 

Bhuiyan ZA, Momenah TS, Gong Q, Amin AS, Ghamdi SA, Carvalho JS, Homfray T, Mannens MM, Zhou Z and Wilde AA: Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and functional characterization of a homozygous nonsense HERG Q1070X mutation. Heart Rhythm. 5:553–561. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Klaver EC, Versluijs GM and Wilders R: Cardiac ion channel mutations in the sudden infant death syndrome. Int J Cardiol. 152:162–170. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Pillozzi S, Brizzi MF, Bernabei PA, Bartolozzi B, Caporale R, Basile V, Boddi V, Pegoraro L, Becchetti A and Arcangeli A: VEGFR-1 (FLT-1), β1 integrin and hERG K+ channel for a macromolecular signalling complex in acute myeloid leukemia: Role in cell migration and clinical outcome. Blood. 110:1238–1250. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Broders-Bondon F, Paul-Gilloteaux P, Carlier C, Radice GL and Dufour S: N-cadherin and beta1-integrins cooperate during the development of the enteric nervous system. Dev Biol. 364:178–191. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Becchetti A, Crescioli S, Zanieri F, Petroni G, Mercatelli R, Coppola S, Gasparoli L, D'Amico M, Pillozzi S, Crociani O, et al: The conformational state of hERG1 channels determines integrin association, downstream signalling and cancer progression. Sci Signal. 10:eaaf32362017. View Article : Google Scholar

10 

Gonzalez-Juanatey JR, Iglesias MJ, Alcaide C, Pineiro R and Lago F: Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1-adrenergic blockade. Circulation. 107:127–131. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Staudacher I, Jehle J, Staudacher K, Pledl HW, Lemke D, Schweizer PA, Becker R, Katus HA and Thomas D: HERG K+ channel-dependent apoptosis and cell cycle arrest in human glioblastoma cells. PLoS One. 9:e881642014. View Article : Google Scholar : PubMed/NCBI

12 

Afrasiabi E, Hietamaki M, Viitanen T, Sukumaran P, Bergelin N and Tornquist K: Expression and significance of HERG (KCNH2) potassium channels in the regulation of MDA-MB-435S melanoma cell proliferation and migration. Cell Signal. 22:57–64. 2010. View Article : Google Scholar

13 

Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, et al: ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signalling. Stem Cells. 39:443–457. 2021. View Article : Google Scholar : PubMed/NCBI

14 

Abeyrathna P and Su Y: The critical role of Akt in cardiovascular function. Vasc Pharmacol. 74:38–48. 2015. View Article : Google Scholar

15 

Li Z, Meng Y, Liu C, Liu H, Cao W, Tong C, Lu M, Li L and Peng L: Kcnh2 mediates FAK/AKT-FOXO3A pathway to attenuate sepsis-induced cardiac dysfunction. Cell Proliferat. 54:e129622021. View Article : Google Scholar

16 

Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh CL, et al: Germline competent embryonic stem cells derived from rat blastocysts. Cell. 135:1299–1310. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Tong C, Li P, Wu NL, Yan Y and Ying QL: Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature. 467:211–213. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Tong C, Huang G, Ashton C, Li P and Ying QL: Generating gene knockout rats by homologous recombination in embryonic stem cells. Nat Protoc. 6:827–844. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P and Smith A: The ground state of embryonic stem cell self-renewal. Nature. 453:519–523. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Asp M, Giacomello S, Larsson L, Wu C, Fürth D, Qian X, Wärdell E, Custodio J, Reimegård J, Salmén F, et al: A Spatiotemporal Organ-wide gene expression and cell atlas of the developing human heart. Cell. 179:1647–1660. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Saelens W, Cannoodt R, Todorov H and Saeys Y: A comparison of single-cell trajectory inference methods. Nat Biotechnol. 37:547–554. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Funakoshi S, Fernandes I, Mastikhina O, Wilkinson D, Tran T, Dhahri W, Mazine A, Yang D, Burnett B, Lee J, et al: Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells. Nat Commun. 12:31552021. View Article : Google Scholar : PubMed/NCBI

24 

Teng GQ, Zhao X, Lees-Miller JP, Quinn FR, Li P, Rancourt DE, London B, Cross JC and Duff HJ: Homozygous missense N629D hERG (KCNH2) potassium channel mutation causes developmental defects in the right ventricle and its outflow tract and embryonic lethality. Circ Res. 103:1483–1491. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Evans-Anderson HJ, Alfieri CM and Yutzey KE: Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res. 102:686–694. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Becchetti A, Petroni G and Arcangeli A: Ion channel conformations regulate integrin-dependent signalling. Trends Cell Biol. 29:298–307. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Franco D, Demolombe S, Kupershmidt S, Dumaine R, Dominguez JN, Roden D, Antzelevitch C, Escande D and Moorman AF: Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development. Cardiovasc Res. 52:65–75. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Wang H, Zhang Y, Cao L, Han H, Wang J, Yang B, Nattel S and Wang Z: HERG K+ channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res. 62:4843–4848. 2002.PubMed/NCBI

29 

Feng N and Anderson ME: CaMKII is a nodal signal for multiple programmed cell death pathways in heart. J Mol Cell Cardiol. 103:102–109. 2017. View Article : Google Scholar :

30 

Lei L, Liu D, Huang Y, Jovin I, Shai SY, Kyriakides T, Ross RS and Giordano FJ: Endothelial expression of beta1 integrin is required for embryonic vascular patterning and postnatal vascular remodeling. Mol Cell Biol. 28:794–802. 2008. View Article : Google Scholar

31 

Millon-Fremillon A, Brunner M, Abed N, Collomb E, Ribba AS, Block MR, Albiges-Rizo C and Bouvard D: Calcium and calmodulin-dependent serine/threonine protein kinase type II (CaMKII)-mediated intramolecular opening of integrin cytoplasmic domain-associated protein-1 (ICAP-1alpha) negatively regulates beta1 integrins. J Biol Chem. 288:20248–20260. 2013. View Article : Google Scholar

32 

Frame MC, Patel H, Serrels B, Lietha D and Eck MJ: The FERM domain: Organizing the structure and function of FAK. Nat Rev Mol Cell Bio. 11:802–814. 2010. View Article : Google Scholar

33 

Torsoni AS, Constancio SS, Nadruz WJ, Hanks SK and Franchini KG: Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes. Circ Res. 93:140–147. 2003. View Article : Google Scholar : PubMed/NCBI

34 

He S, Moutaoufik MT, Islam S, Persad A, Wu A, Aly KA, Fonge H, Babu M and Cayabyab FS: HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential. Biochim Biophys Acta Rev Cancer. 1873:1883552020. View Article : Google Scholar : PubMed/NCBI

35 

Lees-Miller JP, Guo J, Somers JR, Roach DE, Sheldon RS, Rancourt DE and Duff HJ: Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Mol Cell Biol. 23:1856–1862. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Roden DM: Clinical practice. Long-QT syndrome. New Engl J Med. 358:169–176. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu S, Li Z, Liu H, Cao W, Meng Y, Liu C, He S, Lin Q, Shang M, Lin F, Lin F, et al: <em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. Int J Mol Med 53: 14, 2024.
APA
Hu, S., Li, Z., Liu, H., Cao, W., Meng, Y., Liu, C. ... Peng, L. (2024). <em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. International Journal of Molecular Medicine, 53, 14. https://doi.org/10.3892/ijmm.2023.5338
MLA
Hu, S., Li, Z., Liu, H., Cao, W., Meng, Y., Liu, C., He, S., Lin, Q., Shang, M., Lin, F., Yi, N., Wang, H., Sachinidis, A., Ying, Q., Li, L., Peng, L."<em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex". International Journal of Molecular Medicine 53.2 (2024): 14.
Chicago
Hu, S., Li, Z., Liu, H., Cao, W., Meng, Y., Liu, C., He, S., Lin, Q., Shang, M., Lin, F., Yi, N., Wang, H., Sachinidis, A., Ying, Q., Li, L., Peng, L."<em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex". International Journal of Molecular Medicine 53, no. 2 (2024): 14. https://doi.org/10.3892/ijmm.2023.5338
Copy and paste a formatted citation
x
Spandidos Publications style
Hu S, Li Z, Liu H, Cao W, Meng Y, Liu C, He S, Lin Q, Shang M, Lin F, Lin F, et al: <em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. Int J Mol Med 53: 14, 2024.
APA
Hu, S., Li, Z., Liu, H., Cao, W., Meng, Y., Liu, C. ... Peng, L. (2024). <em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. International Journal of Molecular Medicine, 53, 14. https://doi.org/10.3892/ijmm.2023.5338
MLA
Hu, S., Li, Z., Liu, H., Cao, W., Meng, Y., Liu, C., He, S., Lin, Q., Shang, M., Lin, F., Yi, N., Wang, H., Sachinidis, A., Ying, Q., Li, L., Peng, L."<em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex". International Journal of Molecular Medicine 53.2 (2024): 14.
Chicago
Hu, S., Li, Z., Liu, H., Cao, W., Meng, Y., Liu, C., He, S., Lin, Q., Shang, M., Lin, F., Yi, N., Wang, H., Sachinidis, A., Ying, Q., Li, L., Peng, L."<em>Kcnh2</em> deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex". International Journal of Molecular Medicine 53, no. 2 (2024): 14. https://doi.org/10.3892/ijmm.2023.5338
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