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Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy

  • Authors:
    • Zhenkai Ma
    • Hui Lu
    • Xuemin Feng
    • Ting Du
    • Jianhua Li
    • Qiang Zhang
    • Xindong Gu
    • Yuandong Shao
    • Xingzhi Jing
    • Cheng Su
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Binzhou People's Hospital, Binzhou, Shandong 256600, P.R. China, Department of Endocrinology, Binzhou People's Hospital, Binzhou, Shandong 256600, P.R. China, Department of Medicine, Yidu Cloud (Beijing) Technology Co., Ltd., Beijing 100191, P.R. China, Department of Spine Surgery, Binzhou People's Hospital, Binzhou, Shandong 256600, P.R. China, Department of Spine Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250000, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 15
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    Published online on: December 7, 2023
       https://doi.org/10.3892/ijmm.2023.5339
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Abstract

Iron overload and ferroptosis are associated with intervertebral disc degeneration (IDD); however, the mechanism underlying the regulation of iron homeostasis remains to be elucidated. Nuclear factor erythroid 2‑related factor 2 (Nrf2) has been reported to regulate cellular iron homeostasis; however, its impact on IDD pathology and the underlying mechanism of action requires further investigation. In the present study, immunohistochemistry analysis of Nrf2 expression in the cartilage endplate (CEP) was conducted and it was demonstrated that Nrf2 expression was increased in the CEP at the early stages of the development of IDD, whereas it was decreased at the late stages of the development of IDD. The results of western blot analysis indicated that the inadequate activation of Nrf2 may aggravate mitochondrial dysfunction and oxidative stress, thus promoting CEP chondrocyte degeneration and calcification. It was also revealed that Nrf2 was involved in TNF‑α‑induced CEP chondrocyte iron metabolism dysfunction and ferroptosis. Inhibition of Nrf2 expression using Nrf2 small interfering RNA could enhance the process of nuclear receptor coactivator 4 (NCOA4)‑mediated ferritinophagy and increase ferrous ion content, which may promote CEP chondrocyte ferroptotic cell death and extracellular matrix degradation. Furthermore, a decrease in cellular iron concentration may inhibit CEP chondrocyte ferroptosis, and CEP degeneration and calcification. The present study highlights the role of the Nrf2/NCOA4 axis in chondrocyte ferroptosis and IDD pathogenesis, thus suggesting that activation of Nrf2 may be a promising strategy for IDD treatment.
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1 

Kos N, Gradisnik L and Velnar T: A brief review of the degenerative intervertebral disc disease. Med Arch. 73:421–424. 2019. View Article : Google Scholar

2 

Dowdell J, Erwin M, Choma T, Vaccaro A, Iatridis J and Cho SK: Intervertebral disk degeneration and repair. Neurosurgery. 80(3S): S46–S54. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Zhong R, Wei F, Wang L, Cui S, Chen N, Liu S and Zou X: The effects of intervertebral disc degeneration combined with osteoporosis on vascularization and microarchitecture of the endplate in rhesus monkeys. Eur Spine J. 25:2705–2715. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Li FC, Zhang N, Chen WS and Chen QX: Endplate degeneration may be the origination of the vacuum phenomenon in intervertebral discs. Med Hypotheses. 75:169–171. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Ashinsky BG, Bonnevie ED, Mandalapu SA, Pickup S, Wang C, Han L, Mauck RL, Smith HE and Gullbrand SE: Intervertebral disc degeneration is associated with aberrant endplate remodeling and reduced small molecule transport. J Bone Miner Res. 35:1572–1581. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Ding Y, Jiang J, Zhou J, Wu X, Huang Z, Chen J and Zhu Q: The effects of osteoporosis and disc degeneration on vertebral cartilage endplate lesions in rats. Eur Spine J. 23:1848–1855. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhang X, Yu Y, Lei H, Cai Y, Shen J, Zhu P, He Q and Zhao M: The Nrf-2/HO-1 Signaling Axis: A ray of hope in cardiovascular diseases. Cardiol Res Pract. 2020:56957232020. View Article : Google Scholar : PubMed/NCBI

8 

He F, Ru X and Wen T: NRF2, a transcription factor for stress response and beyond. Int J Mol Sci. 21:47772020. View Article : Google Scholar : PubMed/NCBI

9 

Yang G, Liu X, Jing X, Wang J, Wang H, Chen F, Wang W, Shao Y and Cui X: Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway. Int Immunopharmacol. 119:1101592023. View Article : Google Scholar : PubMed/NCBI

10 

Shao Y, Sun L, Yang G, Wang W, Liu X, Du T, Chen F, Jing X and Cui X: Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway. Front Pharmacol. 13:9375022022. View Article : Google Scholar : PubMed/NCBI

11 

Xiang Q, Zhao Y, Lin J, Jiang S and Li W: The Nrf2 antioxidant defense system in intervertebral disc degeneration: Molecular insights. Exp Mol Med. 54:1067–1075. 2022. View Article : Google Scholar : PubMed/NCBI

12 

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascon S, Hatzios SK, Kagan VE, et al: Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease. Cell. 171:273–285. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Galaris D, Barbouti A and Pantopoulos K: Iron homeostasis and oxidative stress: An intimate relationship. Biochim Biophys Acta Mol Cell Res. 1866:1185352019. View Article : Google Scholar : PubMed/NCBI

14 

Zeidan RS, Han SM, Leeuwenburgh C and Xiao R: Iron homeostasis and organismal aging. Ageing Res Rev. 72:1015102021. View Article : Google Scholar : PubMed/NCBI

15 

Jing X, Lin J, Du T, Jiang Z, Li T, Wang G, Liu X, Cui X and Sun K: Iron Overload is associated with accelerated progression of osteoarthritis: The role of DMT1 mediated iron homeostasis. Front Cell Dev Biol. 8:5945092020. View Article : Google Scholar

16 

Jing X, Du T, Li T, Yang X, Wang G, Liu X, Jiang Z and Cui X: The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress. J Cell Mol Med. 25:5671–5680. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Yang RZ, Xu WN, Zheng HL, Zheng XF, Li B, Jiang LS and Jiang SD: Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. J Cell Physiol. 236:2725–2739. 2021. View Article : Google Scholar

18 

Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y and Guo F: Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat. 27:33–43. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Wang F, Cai F, Shi R, Wang XH and Wu XT: Aging and age related stresses: A senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage. 24:398–408. 2016. View Article : Google Scholar

20 

Tang Z, Hu B, Zang F, Wang J, Zhang X and Chen H: Nrf2 drives oxidative stress-induced autophagy in nucleus pulposus cells via a Keap1/Nrf2/p62 feedback loop to protect intervertebral disc from degeneration. Cell Death Dis. 10:5102019. View Article : Google Scholar : PubMed/NCBI

21 

Zhang Y, Han S, Kong M, Tu Q, Zhang L and Ma X: Single-cell RNA-seq analysis identifies unique chondrocyte subsets and reveals involvement of ferroptosis in human intervertebral disc degeneration. Osteoarthritis Cartilage. 29:1324–1334. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Santana-Codina N, Gikandi A and Mancias JD: The Role of NCOA4-Mediated ferritinophagy in ferroptosis. Adv Exp Med Biol. 1301:41–57. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Wang W, Jing X, Du T, Ren J, Liu X, Chen F, Shao Y, Sun S, Yang G and Cui X: Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes. Free Radic Biol Med. 190:234–246. 2022. View Article : Google Scholar : PubMed/NCBI

24 

Song Y, Lu S, Geng W, Feng X, Luo R, Li G and Yang C: Mitochondrial quality control in intervertebral disc degeneration. Exp Mol Med. 53:1124–1133. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Zhang Z, Xu T, Chen J, Shao Z, Wang K, Yan Y, Wu C, Lin J, Wang H, Gao W, et al: Parkin-mediated mitophagy as a potential therapeutic target for intervertebral disc degeneration. Cell Death Dis. 9:9802018. View Article : Google Scholar : PubMed/NCBI

26 

Ariga K, Miyamoto S, Nakase T, Okuda S, Meng W, Yonenobu K and Yoshikawa H: The relationship between apoptosis of endplate chondrocytes and aging and degeneration of the intervertebral disc. Spine (Phila Pa 1976). 26:2414–2420. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Vergroesen PP, Kingma I, Emanuel KS, Hoogendoorn RJ, Welting TJ, van Royen BJ, van Dieën JH and Smit TH: Mechanics and biology in intervertebral disc degeneration: A vicious circle. Osteoarthritis Cartilage. 23:1057–1070. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Kang L, Liu S, Li J, Tian Y, Xue Y and Liu X: Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses. Life Sci. 243:1172442020. View Article : Google Scholar : PubMed/NCBI

29 

Gozzelino R and Arosio P: Iron homeostasis in health and disease. Int J Mol Sci. 17:1302016. View Article : Google Scholar : PubMed/NCBI

30 

Anderson CP, Shen M, Eisenstein RS and Leibold EA: Mammalian iron metabolism and its control by iron regulatory proteins. Biochim Biophys Acta. 1823:1468–1483. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Masaldan S, Clatworthy SAS, Gamell C, Meggyesy PM, Rigopoulos AT, Haupt S, Haupt Y, Denoyer D, Adlard PA, Bush AI and Cater MA: Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis. Redox Biol. 14:100–115. 2018. View Article : Google Scholar

32 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al: Ferroptosis: An iron-dependent form of nonapoptotic cell death. Cell. 149:1060–1072. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B and Wang G: Ferroptosis: Past, present and future. Cell Death Dis. 11:882020. View Article : Google Scholar : PubMed/NCBI

34 

Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, Kang R and Tang D: Ferroptosis: Process and function. Cell Death Differ. 23:369–379. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Siddique A and Kowdley KV: Review article: The iron overload syndromes. Aliment Pharmacol Ther. 35:876–893. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Han K, Jin X, Guo X, Cao G, Tian S, Song Y, Zuo Y, Yu P, Gao G and Chang YZ: Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice. Free Radic Biol Med. 162:592–602. 2021. View Article : Google Scholar

37 

Santana-Codina N and Mancias JD: The role of NCOA4-Mediated ferritinophagy in health and disease. Pharmaceuticals (Basel). 11:1142018. View Article : Google Scholar : PubMed/NCBI

38 

Zi Y, Wang X, Zi Y, Yu H, Lan Y, Fan Y, Ren C, Liao K and Chen H: Cigarette smoke induces the ROS accumulation and iNOS activation through deactivation of Nrf-2/SIRT3 axis to mediate the human bronchial epithelium ferroptosis. Free Radic Biol Med. 200:73–86. 2023. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C, Su C, et al: Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy. Int J Mol Med 53: 15, 2024.
APA
Ma, Z., Lu, H., Feng, X., Du, T., Li, J., Zhang, Q. ... Su, C. (2024). Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy. International Journal of Molecular Medicine, 53, 15. https://doi.org/10.3892/ijmm.2023.5339
MLA
Ma, Z., Lu, H., Feng, X., Du, T., Li, J., Zhang, Q., Gu, X., Shao, Y., Jing, X., Su, C."Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy". International Journal of Molecular Medicine 53.2 (2024): 15.
Chicago
Ma, Z., Lu, H., Feng, X., Du, T., Li, J., Zhang, Q., Gu, X., Shao, Y., Jing, X., Su, C."Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy". International Journal of Molecular Medicine 53, no. 2 (2024): 15. https://doi.org/10.3892/ijmm.2023.5339
Copy and paste a formatted citation
x
Spandidos Publications style
Ma Z, Lu H, Feng X, Du T, Li J, Zhang Q, Gu X, Shao Y, Jing X, Su C, Su C, et al: Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy. Int J Mol Med 53: 15, 2024.
APA
Ma, Z., Lu, H., Feng, X., Du, T., Li, J., Zhang, Q. ... Su, C. (2024). Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy. International Journal of Molecular Medicine, 53, 15. https://doi.org/10.3892/ijmm.2023.5339
MLA
Ma, Z., Lu, H., Feng, X., Du, T., Li, J., Zhang, Q., Gu, X., Shao, Y., Jing, X., Su, C."Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy". International Journal of Molecular Medicine 53.2 (2024): 15.
Chicago
Ma, Z., Lu, H., Feng, X., Du, T., Li, J., Zhang, Q., Gu, X., Shao, Y., Jing, X., Su, C."Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy". International Journal of Molecular Medicine 53, no. 2 (2024): 15. https://doi.org/10.3892/ijmm.2023.5339
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