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NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis

  • Authors:
    • Hong Zhou
    • Qun Zhang
    • Chenyang Liu
    • Jiahao Fan
    • Wen Huang
    • Nan Li
    • Mingxia Yang
    • Hong Wang
    • Weiping Xie
    • Hui Kong
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu 214023, P.R. China, Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of Pulmonary and Critical Care Medicine, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 25
    |
    Published online on: January 16, 2024
       https://doi.org/10.3892/ijmm.2024.5349
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Abstract

NOD-like receptor protein 3 (NLRP3) inflammasome is closely related to silica particle‑induced chronic lung inflammation but its role in epithelial remodeling, repair and regeneration in the distal lung during development of silicosis remains to be elucidated. The present study aimed to determine the effects of the NLRP3 inflammasome on epithelial remodeling and cellular regeneration and potential mechanisms in the distal lung of silica‑treated mice at three time points. Pulmonary function assessment, inflammatory cell counting, enzyme‑linked immunosorbent assay, histological and immunological analyses, hydroxyproline assay and western blotting were used in the study. Single intratracheal instillation of a silica suspension caused sustained NLRP3 inflammasome activation in the distal lung. Moreover, a time‑dependent increase in airway resistance and a decrease in lung compliance accompanied progression of pulmonary fibrosis. In the terminal bronchiole, lung remodeling including pyroptosis (membrane‑distributed GSDMD+), excessive proliferation (Ki67+), mucus overproduction (mucin 5 subtype AC and B) and epithelial‑mesenchymal transition (decreased E‑Cadherin+ and increased Vimentin+), was observed by immunofluorescence analysis. Notably, aberrant spatiotemporal expression of the embryonic lung stem/progenitor cell markers SOX2 and SOX9 and ectopic distribution of bronchioalveolar stem cells were observed in the distal lung only on the 7th day after silica instillation (the early inflammatory phase of silicosis). Western blotting revealed that the Sonic hedgehog/Glioma‑associated oncogene (Shh/Gli) and Wnt/β‑catenin pathways were involved in NLRP3 inflammasome activation‑mediated epithelial remodeling and dysregulated regeneration during the inflammatory and fibrotic phases. Overall, sustained NLRP3 inflammasome activation led to epithelial remodeling in the distal lung of mice. Moreover, understanding the spatiotemporal profile of dysregulated epithelial repair and regeneration may provide a novel therapeutic strategy for inhalable particle‑related chronic inflammatory and fibrotic lung disease.
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View References

1 

Christenson SA, Smith BM, Bafadhel M and Putcha N: Chronic obstructive pulmonary disease. Lancet. 399:2227–2242. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Aghapour M, Ubags ND, Bruder D, Hiemstra PS, Sidhaye V, Rezaee F and Heijink IH: Role of air pollutants in airway epithelial barrier dysfunction in asthma and COPD. Eur Respir Rev. 31:2101122022. View Article : Google Scholar : PubMed/NCBI

3 

Takada T, Moriyama H and Suzuki E: Elemental analysis of occupational and environmental lung diseases by electron probe microanalyzer with wavelength dispersive spectrometer. Respir Investig. 52:5–13. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Leung CC, Yu IT and Chen W: Silicosis. Lancet. 379:2008–2018. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Ma J, Cai Q, Yang D, Yang J, Xue J, Yu M, Liu Y, Ma F, Li F and Liu X: A positive feed forward loop between Wnt/β-Catenin and NOX4 promotes silicon dioxide-induced epithelial-mesenchymal transition of lung epithelial cells. Oxid Med Cell Longev. 2020:34041682020. View Article : Google Scholar

6 

Koudstaal T, Funke-Chambour M, Kreuter M, Molyneaux PL and Wijsenbeek MS: Pulmonary fibrosis: From pathogenesis to clinical decision-making. Trends Mol Med. 29:1076–1087. 2023. View Article : Google Scholar : PubMed/NCBI

7 

Aggarwal K, Arora S and Nagpal K: Pulmonary Fibrosis: Unveiling the pathogenesis, exploring therapeutic targets, and advancements in drug delivery strategies. AAPS PharmSciTech. 24:1522023. View Article : Google Scholar : PubMed/NCBI

8 

Yu Q, Fu G, Lin H, Zhao Q, Liu Y, Zhou Y, Shi Y, Zhang L, Wang Z, Zhang Z, et al: Influence of silica particles on mucociliary structure and MUC5B expression in airways of C57BL/6 mice. Exp Lung Res. 46:217–225. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Li S, Li Y, Zhang Y, Li S, Zhang M, Jin F, Wei Z, Yang Y, Gao X, Mao N, et al: N-Acetyl-Seryl-Asparyl-Lysyl-Proline regulates lung renin angiotensin system to inhibit epithelial-mesenchymal transition in silicotic mice. Toxicol Appl Pharmacol. 408:1152552020. View Article : Google Scholar : PubMed/NCBI

10 

Yang J, Wu S, Hu W, Yang D, Ma J, Cai Q, Xue J, Chen J, Li F, Zeng J and Liu X: Bmi1 signaling maintains the plasticity of airway epithelial progenitors in response to persistent silica exposures. Toxicology. 470:1531522022. View Article : Google Scholar : PubMed/NCBI

11 

Churg A and Wright JL: Bronchiolitis caused by occupational and ambient atmospheric particles. Semin Respir Crit Care Med. 24:577–584. 2003. View Article : Google Scholar

12 

Ferreira TP, de Arantes AC, do Nascimento CV, Olsen PC, Trentin PG, Rocco PR, Hogaboam CM, Puri RK, Martins MA and Silva PM: IL-13 immunotoxin accelerates resolution of lung pathological changes triggered by silica particles in mice. J Immunol. 191:5220–5229. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Crosby LM and Waters CM: Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol. 298:L715–L731. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Ptasinski VA, Stegmayr J, Belvisi MG, Wagner DE and Murray LA: Targeting alveolar repair in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 65:347–365. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, et al: Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature. 588:670–675. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Alanis DM, Chang DR, Akiyama H, Krasnow MA and Chen J: Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nature Commun. 5:39232014. View Article : Google Scholar

17 

Kawakita N, Toba H, Miyoshi K, Sakamoto S, Matsumoto D, Takashima M, Aoyama M, Inoue S, Morimoto M, Nishino T, et al: Bronchioalveolar stem cells derived from mouse-induced pluripotent stem cells promote airway epithelium regeneration. Stem Cell Res Ther. 11:4302020. View Article : Google Scholar : PubMed/NCBI

18 

Jones-Freeman B and Starkey MR: Bronchioalveolar stem cells in lung repair, regeneration and disease. J Pathol. 252:219–226. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Eisenhauer P, Earle B, Loi R, Sueblinvong V, Goodwin M, Allen GB, Lundblad L, Mazan MR, Hoffman AM and Weiss DJ: Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice. Stem Cells. 31:1330–1339. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Caseley EA, Lara-Reyna S, Poulter JA, Topping J, Carter C, Nadat F, Spickett GP, Savic S and McDermott MF: An atypical autoinflammatory disease due to an LRR domain NLRP3 mutation enhancing binding to NEK7. J Clin Immunol. 42:158–170. 2022. View Article : Google Scholar

21 

Swanson KV, Deng M and Ting JP: The NLRP3 inflammasome: Molecular activation and regulation to therapeutics. Nat Rev Immunol. 19:477–489. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Burdette BE, Esparza AN, Zhu H and Wang S: Gasdermin D in pyroptosis. Acta Pharm Sin B. 11:2768–2782. 2021. View Article : Google Scholar : PubMed/NCBI

23 

Liang Q, Cai W, Zhao Y, Xu H, Tang H, Chen D, Qian F and Sun L: Lycorine ameliorates bleomycin-induced pulmonary fibrosis via inhibiting NLRP3 inflammasome activation and pyroptosis. Pharmacol Res. 158:1048842020. View Article : Google Scholar : PubMed/NCBI

24 

Zheng R, Tao L, Jian H, Chang Y, Cheng Y, Feng Y and Zhang H: NLRP3 inflammasome activation and lung fibrosis caused by airborne fine particulate matter. Ecotoxicol Environ Saf. 163:612–619. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Lamkanfi M and Dixit VM: Inflammasomes and their roles in health and disease. Annu Rev Cell Dev Biol. 28:137–161. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Song M, Wang J, Sun Y, Pang J, Li X, Liu Y, Zhou Y, Yang P, Fan T, Liu Y, et al: Inhibition of gasdermin D-dependent pyroptosis attenuates the progression of silica-induced pulmonary inflammation and fibrosis. Acta Pharm Sin B. 12:1213–1224. 2022. View Article : Google Scholar : PubMed/NCBI

27 

Tapia-Abellán A, Angosto-Bazarra D, Martínez-Banaclocha H, de Torre-Minguela C, Cerón-Carrasco JP, Pérez-Sánchez H, Arostegui JI and Pelegrin P: MCC950 closes the active conformation of NLRP3 to an inactive state. Nat Chem Biol. 15:560–564. 2019. View Article : Google Scholar : PubMed/NCBI

28 

Lam M, Mansell A and Tate MD: Another One Fights the Dust: Targeting the NLRP3 inflammasome for the treatment of silicosis. Am J Respir Cell Mol Biol. 66:601–611. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Sayan M and Mossman BT: The NLRP3 inflammasome in pathogenic particle and fibre-associated lung inflammation and diseases. Part Fibre Toxicol. 13:512016. View Article : Google Scholar : PubMed/NCBI

30 

Clark JD, Gebhart GF, Gonder JC, Keeling ME and Kohn DF: Special Report: The 1996 Guide for the Care and Use of Laboratory Animals. ILAR J. 38:41–48. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Zou Z, Hu X, Luo T, Ming Z, Chen X, Xia L, Luo W, Li J, Xu N, Chen L, et al: Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor. Nat Commun. 12:22632021. View Article : Google Scholar : PubMed/NCBI

32 

Zhao S, Zhou L, Wang Q, Cao JH, Chen Y, Wang W, Zhu BD, Wei ZH, Li R, Li CY, et al: Elevated branched-chain amino acid promotes atherosclerosis progression by enhancing mitochondrial-to-nuclear H2O 2-disulfide HMGB1 in macrophages. Redox Biol. 62:1026962023. View Article : Google Scholar

33 

Szapiel SV, Elson NA, Fulmer JD, Hunninghake GW and Crystal RG: Bleomycin-induced interstitial pulmonary disease in the nude, athymic mouse. Am Rev Respir Dis. 120:893–899. 1979.PubMed/NCBI

34 

Hübner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, Freitag-Wolf S and Bewig B: Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques. 44:507–511. 514–507. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Campden RI, Warren AL, Greene CJ, Chiriboga JA, Arnold CR, Aggarwal D, McKenna N, Sandall CF, MacDonald JA and Yates RM: Extracellular cathepsin Z signals through the α5 integrin and augments NLRP3 inflammasome activation. J Biol Chem. 298:1014592022. View Article : Google Scholar

36 

Yin H, Fang L, Wang L, Xia Y, Tian J, Ma L, Zhang J, Li N, Li W, Yao S and Zhang L: Acute silica exposure triggers pulmonary inflammation through macrophage pyroptosis: An experimental simulation. Front Immunol. 13:8744592022. View Article : Google Scholar : PubMed/NCBI

37 

Shi J, Gao W and Shao F: Pyroptosis: Gasdermin-Mediated programmed necrotic cell death. Trends Biochem Sci. 42:245–254. 2017. View Article : Google Scholar

38 

Zhou YP, Mei MJ, Wang XZ, Huang SN, Chen L, Zhang M, Li XY, Qin HB, Dong X, Cheng S, et al: A congenital CMV infection model for follow-up studies of neurodevelopmental disorders, neuroimaging abnormalities, and treatment. JCI Insight. 7:e1525512022. View Article : Google Scholar : PubMed/NCBI

39 

Liu Y, Zhang X, Wang J, Yang F, Luo W, Huang J, Chen M, Wang S, Li C, Zhang W and Chao J: ZC3H4 regulates infiltrating monocytes, attenuating pulmonary fibrosis through IL-10. Respir Res. 23:2042022. View Article : Google Scholar : PubMed/NCBI

40 

Zhou H, Zhang Q, Huang W, Zhou S, Wang Y, Zeng X, Wang H, Xie W and Kong H: NLRP3 inflammasome mediates silica-induced lung epithelial injury and aberrant regeneration in lung Stem/Progenitor Cell-Derived organotypic models. Int J Biol Sci. 19:1875–1893. 2023. View Article : Google Scholar : PubMed/NCBI

41 

Chen S, Li K, Zhong X, Wang G, Wang X, Cheng M, Chen J, Chen Z, Chen J, Zhang C, et al: Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway. Stem Cell Res Ther. 12:3812021. View Article : Google Scholar : PubMed/NCBI

42 

Eenjes E, Tibboel D, Wijnen RMH, Schnater JM and Rottier RJ: SOX2 and SOX21 in lung epithelial differentiation and repair. Int J Mol Sci. 23:130642022. View Article : Google Scholar : PubMed/NCBI

43 

Belgacemi R, Danopoulos S, Deutsch G, Glass I, Dormoy V, Bellusci S and Al Alam D: Hedgehog signaling pathway orchestrates human lung branching morphogenesis. Int J Mol Sci. 23:52652022. View Article : Google Scholar : PubMed/NCBI

44 

Zhang J, Liu H, Song C, Zhang J, Wang Y, Lv C and Song X: Astilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway. Pulm Pharmacol Ther. 50:19–27. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Wang C, Cassandras M and Peng T: The role of hedgehog signaling in adult lung regeneration and maintenance. J Dev Biol. 7:142019. View Article : Google Scholar : PubMed/NCBI

46 

Li L, Bao J, Wang H, Lei JH, Peng C, Zeng J, Hao W, Zhang X, Xu X, Yu C, et al: Upregulation of amplified in breast cancer 1 contributes to pancreatic ductal adenocarcinoma progression and vulnerability to blockage of hedgehog activation. Theranostics. 11:1672–1689. 2021. View Article : Google Scholar : PubMed/NCBI

47 

Raslan AA and Yoon JK: WNT Signaling in lung repair and regeneration. Mol Cells. 43:774–783. 2020.PubMed/NCBI

48 

Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, et al: Reduced frizzled receptor 4 expression prevents WNT/β-Catenin-driven alveolar lung repair in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 196:172–185. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Cao H, Chen X, Hou J, Wang C, Xiang Z, Shen Y and Han X: The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis. Lab Invest. 100:363–377. 2020. View Article : Google Scholar

50 

Jiang R, Han L, Gao Q and Chao J: ZC3H4 mediates silica-induced EndoMT via ER stress and autophagy. Environ Toxicol Pharmacol. 84:1036052021. View Article : Google Scholar : PubMed/NCBI

51 

Song MY, Wang JX, Sun YL, Han ZF, Zhou YT, Liu Y, Fan TH, Li ZG, Qi XM, Luo Y, et al: Tetrandrine alleviates silicosis by inhibiting canonical and non-canonical NLRP3 inflamma-some activation in lung macrophages. Acta Pharmacol Sin. 43:1274–1284. 2022. View Article : Google Scholar

52 

Pang X, Shao L, Nie X, Yan H, Li C, Yeo AJ, Lavin MF, Xia Q, Shao H, Yu G, et al: Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesen-chymal transition. Int Immunopharmacol. 91:1072772021. View Article : Google Scholar

53 

Song Z, Wang L, Cao Y, Liu Z, Zhang M, Zhang Z, Jiang S, Fan R, Hao T, Yang R, et al: Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice. Int Immunopharmacol. 105:1085392022. View Article : Google Scholar : PubMed/NCBI

54 

Wujak L, Schnieder J, Schaefer L and Wygrecka M: LRP1: A chameleon receptor of lung inflammation and repair. Matrix Biol. 68-69:366–381. 2018. View Article : Google Scholar

55 

Beers MF and Morrisey EE: The three R's of lung health and disease: Repair, remodeling, and regeneration. J Clin Invest. 121:2065–2073. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Spella M, Lilis I and Stathopoulos GT: Shared epithelial pathways to lung repair and disease. Eur Respir Rev. 26:1700482017. View Article : Google Scholar : PubMed/NCBI

57 

Brandsma CA, de Vries M, Costa R, Woldhuis RR, Königshoff M and Timens W: Lung ageing and COPD: Is there a role for ageing in abnormal tissue repair? Eur Respir Rev. 26:1700732017. View Article : Google Scholar : PubMed/NCBI

58 

Nakao M, Kim K, Nagase K, Grainger DW, Kanazawa H and Okano T: Phenotypic traits of mesenchymal stem cell sheets fabricated by temperature-responsive cell culture plate: Structural characteristics of MSC sheets. Stem Cell Res Ther. 10:3532019. View Article : Google Scholar : PubMed/NCBI

59 

Hegdekar N, Sarkar C, Bustos S, Ritzel RM, Hanscom M, Ravishankar P, Philkana D, Wu J, Loane DJ and Lipinski MM: Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes. Autophagy. 19:2026–2044. 2023. View Article : Google Scholar : PubMed/NCBI

60 

Zhao Y, Hao C, Bao L, Wang D, Li Y, Qu Y, Ding M, Zhao A and Yao W: Silica particles disorganize the polarization of pulmonary macrophages in mice. Ecotoxicol Environ Saf. 193:1103642020. View Article : Google Scholar : PubMed/NCBI

61 

Xu T, Yan W, Wu Q, Xu Q, Yuan J, Li Y, Li P, Pan H and Ni C: MiR-326 inhibits inflammation and promotes autophagy in Silica-Induced pulmonary fibrosis through targeting TNFSF14 and PTBP1. Chem Res Toxicol. 32:2192–2203. 2019. View Article : Google Scholar : PubMed/NCBI

62 

Grazioli S, Gil S, An D, Kajikawa O, Farnand AW, Hanson JF, Birkland T, Chen P, Duffield J, Schnapp LM, et al: CYR61 (CCN1) overexpression induces lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 308:L759–L765. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Whitsett JA: Airway epithelial differentiation and mucociliary clearance. Ann Am Thorac Soc. 15(Suppl 3): S143–S148. 2018. View Article : Google Scholar : PubMed/NCBI

64 

Kim SH, Pei QM, Jiang P, Liu J, Sun RF, Qian XJ and Liu JB: Upregulation of MUC5AC by VEGF in human primary bronchial epithelial cells: Implications for asthma. Respir Res. 20:2822019. View Article : Google Scholar : PubMed/NCBI

65 

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, et al: XBP1S Regulates MUC5B in a promoter Variant-Dependent pathway in idiopathic pulmonary fibrosis airway epithelia. Am J Respir Crit Care Med. 200:220–234. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Kim E, Mathai SK, Stancil IT, Ma X, Hernandez-Gutierrez A, Becerra JN, Marrero-Torres E, Hennessy CE, Hatakka K, Wartchow EP, et al: Aberrant multiciliogenesis in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 67:188–200. 2022. View Article : Google Scholar : PubMed/NCBI

67 

Dobrinskikh E, Estrella AM, Hennessy CE, Hara N, Schwarz MI, Kurche JS, Yang IV and Schwartz DA: Genes, other than Muc5b, play a role in bleomycin-induced lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 321:L440–Ll450. 2021. View Article : Google Scholar : PubMed/NCBI

68 

Ma J, Rubin BK and Voynow JA: Mucins, mucus, and goblet cells. Chest. 154:169–176. 2018. View Article : Google Scholar

69 

Singanayagam A, Footitt J, Marczynski M, Radicioni G, Cross MT, Finney LJ, Trujillo-Torralbo MB, Calderazzo M, Zhu J, Aniscenko J, et al: Airway mucins promote immunopa-thology in virus-exacerbated chronic obstructive pulmonary disease. J Clin Invest. 132:e1209012022. View Article : Google Scholar

70 

Koeppen M, McNamee EN, Brodsky KS, Aherne CM, Faigle M, Downey GP, Colgan SP, Evans CM, Schwartz DA and Eltzschig HK: Detrimental role of the airway mucin Muc5ac during ventilator-induced lung injury. Mucosal Immunol. 6:762–775. 2013. View Article : Google Scholar

71 

Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, et al: The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nature Commun. 6:62812015. View Article : Google Scholar

72 

Keith JD, Henderson AG, Fernandez-Petty CM, Davis JM, Oden AM and Birket SE: Muc5b contributes to mucus abnormality in rat models of cystic fibrosis. Front Physiol. 13:8841662022. View Article : Google Scholar : PubMed/NCBI

73 

Hancock LA, Hennessy CE, Solomon GM, Dobrinskikh E, Estrella A, Hara N, Hill DB, Kissner WJ, Markovetz MR, Grove Villalon DE, et al: Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice. Nature Commun. 9:53632018. View Article : Google Scholar

74 

Danopoulos S, Alonso I, Thornton ME, Grubbs BH, Bellusci S, Warburton D and Al Alam D: Human lung branching morphogenesis is orchestrated by the spatiotemporal distribution of ACTA2, SOX2, and SOX9. Am J Physiol Lung Cell Mol Physiol. 314:L144–Ll149. 2018. View Article : Google Scholar

75 

Gajjala PR, Kasam RK, Soundararajan D, Sinner D, Huang SK, Jegga AG and Madala SK: Dysregulated overexpression of Sox9 induces fibroblast activation in pulmonary fibrosis. JCI Insight. 6:e1525032021. View Article : Google Scholar : PubMed/NCBI

76 

Danopoulos S, Thornton ME, Grubbs BH, Frey MR, Warburton D, Bellusci S and Al Alam D: Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse. J Pathol. 247:254–265. 2019. View Article : Google Scholar :

77 

Basil MC and Morrisey EE: BASC-ing in the glow: Bronchioalveolar stem cells get their place in the lung. EMBO J. 38:e1023442019. View Article : Google Scholar : PubMed/NCBI

78 

Aros CJ, Vijayaraj P, Pantoja CJ, Bisht B, Meneses LK, Sandlin JM, Tse JA, Chen MW, Purkayastha A, Shia DW, et al: Distinct spatiotemporally dynamic Wnt-secreting niches regulate proximal airway regeneration and aging. Cell Stem Cell. 27:413–429.e4. 2020. View Article : Google Scholar : PubMed/NCBI

79 

Sivakumar A and Frank DB: Paradigms that define lung epithelial progenitor cell fate in development and regeneration. Curr Stem Cell Rep. 5:133–144. 2019. View Article : Google Scholar

80 

Rock J and Königshoff M: Endogenous lung regeneration: Potential and limitations. Am J Respir Crit Care Med. 186:1213–1219. 2012. View Article : Google Scholar : PubMed/NCBI

81 

Chanda D, Otoupalova E, Smith SR, Volckaert T, De Langhe SP and Thannickal VJ: Developmental pathways in the pathogenesis of lung fibrosis. Mol Aspects Med. 65:56–69. 2019. View Article : Google Scholar :

82 

Deng M, Li J, Gan Y, Chen Y and Chen P: Changes in the number of CD31-CD45-Sca-1+ cells and Shh signaling pathway involvement in the lungs of mice with emphysema and relevant effects of acute adenovirus infection. Int J Chron Obstruct Pulmon Dis. 12:861–872. 2017. View Article : Google Scholar :

83 

Lau CI, Yánez DC, Papaioannou E, Ross S and Crompton T: Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation. FEBS J. 289:8050–8061. 2022. View Article : Google Scholar

84 

Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM and Morrisey EE: Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 526:578–582. 2015. View Article : Google Scholar : PubMed/NCBI

85 

Beachy PA, Karhadkar SS and Berman DM: Tissue repair and stem cell renewal in carcinogenesis. Nature. 432:324–331. 2004. View Article : Google Scholar : PubMed/NCBI

86 

Chen X, Jin Y, Hou X, Liu F and Wang Y: Sonic hedgehog signaling: Evidence for its protective role in endotoxin induced acute lung injury in mouse model. PLoS One. 10:e01408862015. View Article : Google Scholar : PubMed/NCBI

87 

Hu HH, Cao G, Wu XQ, Vaziri ND and Zhao YY: Wnt signaling pathway in aging-related tissue fibrosis and therapies. Ageing Res Rev. 60:1010632020. View Article : Google Scholar : PubMed/NCBI

88 

Lehmann M, Hu Q, Hu Y, Hafner K, Costa R, van den Berg A and Königshoff M: Chronic WNT/β-catenin signaling induces cellular senescence in lung epithelial cells. Cellular Signal. 70:1095882020. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou H, Zhang Q, Liu C, Fan J, Huang W, Li N, Yang M, Wang H, Xie W, Kong H, Kong H, et al: NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis. Int J Mol Med 53: 25, 2024.
APA
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W., Li, N. ... Kong, H. (2024). NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis. International Journal of Molecular Medicine, 53, 25. https://doi.org/10.3892/ijmm.2024.5349
MLA
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W., Li, N., Yang, M., Wang, H., Xie, W., Kong, H."NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis". International Journal of Molecular Medicine 53.3 (2024): 25.
Chicago
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W., Li, N., Yang, M., Wang, H., Xie, W., Kong, H."NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis". International Journal of Molecular Medicine 53, no. 3 (2024): 25. https://doi.org/10.3892/ijmm.2024.5349
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou H, Zhang Q, Liu C, Fan J, Huang W, Li N, Yang M, Wang H, Xie W, Kong H, Kong H, et al: NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis. Int J Mol Med 53: 25, 2024.
APA
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W., Li, N. ... Kong, H. (2024). NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis. International Journal of Molecular Medicine, 53, 25. https://doi.org/10.3892/ijmm.2024.5349
MLA
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W., Li, N., Yang, M., Wang, H., Xie, W., Kong, H."NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis". International Journal of Molecular Medicine 53.3 (2024): 25.
Chicago
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W., Li, N., Yang, M., Wang, H., Xie, W., Kong, H."NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis". International Journal of Molecular Medicine 53, no. 3 (2024): 25. https://doi.org/10.3892/ijmm.2024.5349
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